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증례 : 소화기 ; 위 MALT 림프종 완전관해 6개월 후 진단된 대장 MALT 림프종 1예
김석원 ( Seok Won Kim ),강성훈 ( Sung Hoon Kang ),강선형 ( Sun Hyoung Kang ),문희석 ( Hee Seok Moon ),성재규 ( Jae Kyu Sung ),정현용 ( Hyun Yong Jeong ),송규상 ( Gyu Sang Song ) 대한내과학회 2016 대한내과학회지 Vol.90 No.5
Most mucosa-associated lymphoid tissue (MALT) lymphomas are found in the gastrointestinal tract. The most common site is the stomach, whereas colon MALT lymphomas are rare. There are a few reports of simultaneously diagnosed stomach and colon MALT lymphomas. However, diagnosis of primary colonic MALT lymphoma after complete remission of gastric MALT lymphoma is extremely rare. Although the treatment protocol for gastric MALT lymphoma is well established, there is no consensus protocol for colonic MALT lymphoma owing to its rarity. Herein, we report a case of colonic MALT lymphoma incidentally diagnosed 6 months after completion of radiation therapy for gastric MALT lymphoma and treated via polypectomy, with no recurrence for 3 years. (Korean J Med 2016;90:416-420)
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정상임신과 임신성 고혈압, 자궁내 발육지연이 있는 태반에서의 세포고사와 bcl-2 발현의 비교
김흥서 ( Kim Heung Seo ),노흥태 ( No Heung Tae ),이윤이 ( Lee Yun I ),송규상 ( Song Gyu Sang ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.2
목적 : 본 연구는 지금까지 자궁 근종의 K_(ATP) channels 아형에 관한 연구가 없어, 자궁 근종이나 정상 자궁근에서 K_(ATP) channels의 존재와 아형의 종류를 확인하고, 또한 발현의 차이를 확인하고자 하였다. 연구 방법 : 자궁근종으로 전자궁 적출술을 시행하는 10예의 환자를 대상으로 자궁 근종과 인접한 정상 자궁 조직을 얻어 실험하였고, 또한 일차 세포배양을 하였다. 자궁내막의 주기는 증식기 5예와 분비기 5예로 하였다. 조직과 일차배양세포에서 K_(ATP) channels 아형의 RT-PCR, western-blot 분석을 하였으며, K_(ATP) 통로의 전기적인 활성도를 측정하기 위하여 patch clamp 기법의 whole-cell mode를 사용하였다. 결과 : RT-PCR을 통한 K_(ATP) channels의 아형의 검사에서 Kir6.1, Kir6.2, SUR 2B는 자궁 근종과 정상 자궁근에서 모두 발현이 있었으나, SUR1과 SUR2A의 발현은 보이지 않았고, 세포를 일차 배양한 세포에서도 동일한 결과를 보였다. Western Blot 분석에서는 Kit6.1, Kir6.2, SUR 2는 자궁 근종과 정상 자궁 근에서 모두 발현이 있었고, SUR1의 발현은 보이지 않았다. K_(ATP) channels의 아형의 발현 양상에서는 SUR2, Kir6.1과 Kir6.2는 자궁 근종에서 자궁 근조직보다 높은 발현을 보였다. whole-cell mode에서 K^(+)이온이 야기하는 내향성 전류가 관찰되었으며, 에스트로겐에 노출시 초기 신호전달에 세포막의 K_(ATP) channels을 통한 전류의 증가를 관찰하였다. 결론 : 본 연구에서는 K_(ATP) channels 아형을 동정하여 자궁 근종과 정상 자궁 근에서 Kir6.1/SUR2B와 Kir6.2/SUR2B가 존재하는 것을 밝혔으며, 또한 자궁 근종 세포에서 K_(ATP) channels의 발현이 증가함을 확인하였다. 이 결과를 이용하여 자궁 근종 세포 증식의 조절 기전을 밝히는데 도움이 되리라 생각되며, 향후 K_(ATP) channels 이온 통로 조절 인자를 이용한 자궁 근종의 치료에 이용할 수 있으리라 사료된다. Objective : The purpose of this study was to identify the ATP-sensitive potassium (K_(ATP)) chanel subtypes in uterine leiomyoma and normal myometrial cells, and to compare the difference in its expression between uterine leiomyoma and normal myometrial cells. Methods : Fresh ten uterine leiomyomas and their adjacent normal myometrial tissues were obtained from hysterectomies that were conducted on benign diseases. With the use of reverse transcription-polymerase chain reaction (RT-PCR) and Westem blot analysis, we analysed the expression of K_(ATP) channel subtypes in tissues and primary cultured leiomyoma cells. To demonstrate the K_(ATP) channel activity in uterine leiomyoma cells, whole cell patch-clamp recordings were made. Results : The uterine leiomyoma and normal myometrial tissues contained Kir6.1/SUR2B and Kir6.2/SUR2B mRNAs, although the expression of SUR1 and SUR2A mRNAs were not expressed in the uterine leiomyoma and normal myometrial tissues. Primary cultured uterine leiomyoma and normal myometrial cells demonstrated same patterns. To determine the expression levels of K_(ATP) channel subunits, high levels of Kir6.1, Kir6.2, and SUR2B were detected by western-blot analysis in uterine leiomyoma compared with normal myometrial tissues. K_(ATP) channel currents were increased by estrogen application in uterine leiomyoma cells. Conclusion : These studies provide new knowledge concerning K_(ATP) channels in uterine leiomyoma and normal myomtrial cells. We demonstrated uterine leiomyoma and normal myometrial tissues contained Kir6.1/SUR2B and Kir6.2/SUR2B subunits and showed an increased expression in uterine leiomyoma compared with normal myometrial tissues. These results suggest that K_(ATP) channels are important elements in growth of uterine leiomyoma.
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宋圭祥,姜大榮 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.1
For studies on the gastric carcinoma in the Chungnam area, the operation specimens were collected at the Department of pathology, Chungnam National University School of Medicine from January 1979 to December 1981, and analyzed the patient's age and sex, size and location of the lesion, and the gross and histological types. The results were as follows; 1. The total number of gastric carcinoma for 3 years were 280 cases, which were 110 cases (48%) in 1979, 72 cases (42.9%) in 1980, and 98 cases(46.4%) in 1981. 2. Among 280 cases the male cases were 189 (67.5%) and the females 91 (32.5%), and the ratio between male and female was 2.1 to 1. The mean age of the patients was 50.8 in the male cases and 50.2 in the female, and the age distribution was the highest in the 6th decade in both sexes. 3. The average diameter of the lesions was 5.1㎝ and the most frequent size distribution was in the range of 2.0-5.9㎝, in which 194 cases (69.3%) were included. 4. The most common location was the antrum; 98 cases (51.9%) in male and 43 cases (47.3%) in female, and the lesser curvature, 161 cases (57.5%). 5. The ulcerative type was the most frequent, 157 caes (38.1%) in male and 74 cases (81.3%) in female, there was no specific relationship between the gross type and age. 6. The adenocarcinoma was the most frequent histological type in both sexes, 145 cases (76.7%)in male and 59 cases (64.8%) in female. The less frequent type was diffuse carcinoma, and mucoid adenocarcinoma was infrequent, and the adenosquamous carcinoma was very rare. 7. In relationship between the gross types and the histological types, the adenocarcinoma was the most common type, 167 cases (72.3%) in the ulcerative type, 27 cases (84.4%) in the fungating type, and 8 cases (80%) in the superficial spreading type. But, in the diffuse infiltrating type the diffuse carcinoma was more frequent, 4 cases (57.1%), than the adenocarcinoma.
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