http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
저용량의 Rocuronium을 사용한 기관내 삽관 시 사전예비정주법이 Rocuronium의 작용 발현시간과 삽관 조건에 미치는 영향
손윤숙 ( Yoon Suk Son ),정규돈 ( Kyu Don Chung ),조현숙 ( Hyun Sook Cho ),유승준 ( Sung Jun Yu ),김수화 ( Su Hwa Kim ),이상묵 ( Sang Mook Lee ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.4
Background: A priming dose of rocuronium can shorten the onset time of neuromuscular blockade. The purpose of this study was to evaluate the effect of priming with rocuronium on the onset time and intubation conditions during tracheal intubation with low-dose rocuronium (0.35 mg/kg) and to compare results with those for rocuronium 0.45 mg/kg. Methods: One hundred twenty four patients were randomly allocated to three groups. Following induction of anesthesia, groups I and III received normal saline while group II received a priming dose of rocuronium (0.05 mg/kg). Three minutes after priming, groups I, II and III received, respectively, 0.45 mg/kg, 0.3 mg/kg and 0.35 mg/kg rocuronium. Intubation was performed 2 minutes after the administration of an intubating dose and intubation conditions were evaluated. Neuromuscular blockade was assessed by accelerography. Results: The proportion of cases having optimal intubation conditions in group I was higher than in groups II and III. There was no significant difference in the onset times among groups. Neuromuscular blockade at 60, 90 and 120 seconds after an intubating dose was similar among all groups except at 60 sec. Maximal blockade for group I was deep compared to groups II and III. Conclusions: Rocuronium 0.35 mg/kg does not provide satisfactory intubation conditions. There are no effects on onset time and intubation conditions due to priming during tracheal intubation with rocuronium 0.35 mg/kg. (Korean J Anesthesiol 2009;57:444∼9)
증례보고 : 심한 척주관 협착증 환자에서 척추 마취 후 발생된 마미 증후군
정규돈 ( Kyu Don Chung ),유승준 ( Sung Jun Yu ),이상묵 ( Sang Mook Lee ),조현숙 ( Hyun Sook Cho ),손윤숙 ( Youn Suk Son ),윤건중 ( Keon Jung Yoon ),윤은경 ( Eun Kyeung Yoon ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.3
Cauda equina syndrome is a well-known but rare complication of spinal anesthesia. An 80-year-old man was scheduled for both herniorrhaphy. Spinal anesthesia was performed at the L3-4 interspinous space with 0.5% hyperbaric bupivacaine 12 mg. Eight hours after anesthesia, the patient complained bilateral sensorimotor deficits of the lower extremities and peroneal region. Urinary and fecal incontinence were also observed. MRI and myelography showed severe central spinal stenosis at L3-4 and L4-5. EMG showed cauda equina syndrome. Seven weeks after the procedure, left decompressive subtotal laminectomy L2-L5 was done. The patient still complains the neuropathic pain in the both lower extremities and ambulates using a walker. The local anesthetic was injected into thecal sac between maximum stenoses, and it is likely that there was poor upward spread leading to maldistribution of local anesthetic and resultant local anesthetic toxicity. (Korean J Anesthesiol 2009;57:364∼6)
백서 기도 평활근 장력에 미치는 Etomidate 의 효과
김혜자,이정은,손윤숙,윤석화 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.39 No.1
Background : Etomidate is an intravenous anesthetic which has properties of hemodynamic stability, minimal respiratory depression, and cerebral protection. Also, it is a useful induction agent for patients compromised by asthma and other reactive airway diseases. The aim of this study was to investigate the effect and sctioo mechanism of etomidate on isolated tracheal smooth muscle in rats. Methods : The rat's trachea was dissected free, cut into rings (2 mm) and mounted for isometric tension in Tris Tyrode soluticra. Cumolative dose- response curves for etomidate (3 x 10^7 - 3 x 10^(-4)M) were obtained from the tensian measutements of acetylcholine (10^(-5) M)-contracted rings. The effects of propranolol, L-NAME and indomethacin an the etomidate induced tracheal response were investigated. Also, the effect of etomidate on the extracellular Ca^(2-) influx and Ca^(2+)' release from intemal stores was investigated. Results : Etomidate produced relaxation of acetylcholine-ptecontracted trachea in a dose-dependent fashion. Petreatment with propranolol, 1-NAME had no effects on concentration-response curves to acetylcholine. Pretreatment with indomethacin had an effect on the concentration-response curve to acetylcholine. Pretreatment with etomidate inhibited acetylcholine-induced contractions in the absence of extracelluar Ca^(2-) and the presence of extracellular Ca^(2+). Conclusions : The tracheal smooth muscle relaxation by etomidate is not related with beta-adrenergic activation and NO synthesis but related with prostaglandin production. The relaxation effect of etomidate is induced by a decrease in concentration of intracellular Ca^(2+) through the blackade of extracellular Ca^(2+) influx and the simultaneous release of Ca^(2+) from intemal stores. (Korean J Anesthesiol 2000; 39: 105~110)
Vecuronium과 Pancuronium이 흰쥐의 기도 평활근에 미치는 영향
김상수,김혜자,윤석화,이정은,김윤희,손윤숙 대한마취과학회 1999 Korean Journal of Anesthesiology Vol.37 No.1
Background: Vecuronium and Pancuronium have been proven to be associated with nicotinic receptor of skeletal muscle. Generally, nondepolarizing muscle relaxant is associated with contraction of smooth tracheal muscle, but there have been few studies about effects of nondepolarizing muscle relaxant on the smooth tracheal muscle. Methods: We studied the acetylcholine dose response curve of the tracheal smooth muscle contraction and effects of propranolol, L-NAME after pretreating with vecuronium and pancuronium. Results: Vecuronium shifted the acetylcholine dose-response curve of the tracheal contraction to the left, and pancuronium shifted the curve to the right. Vecuronium and Pancuronium reduced the contraction of smooth tracheal muscle with the use carbachol. Propranolol and L-NAME had no effect on the contraction of smooth tracheal muscle after pretreating with vecuronium and pancuronium. Conclusion: We suggest that vecuronium has an anticholinergic effect, while pancuronium has some effect on the muscarinic receptor in addition to its anticholinergic effect. (Korean J Anesthesiol 1999; 37: 139∼143)