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자가 근막 이완요법(self-myofascial release)이 근피로가 유도된 대퇴직근의 탄성과 경직도에 미치는 영향
김성대(Kim, Seong-Dae),홍수화(Hong, Soo-Hwa),서재남(Seo, Jae-Nam),신영륜(Shin, Young-Ryun),이희혁(Lee, Hee-Hyuk),정일규(Jeong, Il-Gyu) 한국사회체육학회 2016 한국사회체육학회지 Vol.0 No.65
The study was designed to evaluate the effect of self-myofascial release(SMR) technique on elasticity and stiffness of rectus femoris muscle which experienced the exhaustive fatigue induced by isokinetic endurance exercise. Total 25 college students(male: 14, female: 11) conducted two isokinetic endurance exercise(Biodex System 4, USA) with a week interval. In this cross-over study, each subject were asked to perform 6 sets of muscular endurance exercise(60°/sec, 10 times of maximal knee flexion and extension/each set) with 10seconds of resting interval. Each subject was asked to conduct SMR treatment on rectus femoris(experimental group) or take a complete resting(control group) for 5 minutes after 6 sets of isokinetic endurance exercise at each separated day with a week interval. In order to measure eth mechanical properties like muscle stiffness and elasticity, MyotonPro(Myoton AS, Tallinn, Estonia) was applied to muscle belly of rectus femoris muscle at pre-exercise, right after exercise, 5min. and 20min. after exercise. From the Myoton measurement, Five indexes(Frequency, Logarithmic Decrement, Dynamic Stiffness, Creep, Mechanical Stress Relaxation) were obtained. Electromyograph(EMG) on rectus fermoris m. was also measured during first set and 6th set of isokinetic exercise in order to obtained the muscle activity index and compare it with Myoton measurement indexes. The results were as follows: 1. The muscle tension and stiffness were significantly increased while the elasticity was decreased immediately and at 5 minutes after exercise. All mechanical properties of fatigued muscle were recovered to pre-exercise level at 20 minutes after exercise. 2. No significant effect of SMR on mechanical properties indexes of fatigued muscle was found at every time point after endurance exercise. 3. The changes of mechanical properties(tension, stiffness and elasticity) between pre-and post-exercise which were measured by Myoton-measurement had significant corelation with the changed muscle activities estimated by EMG.
금창구,서재석,남진경,이은주,조정원 충남대학교 약학대학 의약품개발연구소 2010 藥學論文集 Vol.25 No.-
Paclitaxel (PTX) is an anti-cancer agent extracted from the bark of the Pacific yew (Taxus brevifolia). In clinical trials, PTX has demonstrated significant activity against a variety of tumors such as drug-resistant ovarian cancer, metastatic breast cancer, non-small cell lung cancer and AIDS related Kaposi's sarcoma. However, the bioavailability of PTX is mainly limited by cytochrome P450 activity in gut wall and liver, and drug transporters, such as P-gp in gut wall and liver. As well as, PTX is very poor soluble in water (<0.5 mg/L) and other pharmaceutically acceptable solvents. The commercial formulation of PTX consists of micellar solution of the drug in cremophor EL (polyoxyethylated castor oil) containing 50% absolute ethanol. However, it is well known that the use of cremophor EL is associated with hypersensitivity reactions, neurotoxicity and nephrotoxicity and also the solubility of PTX is increasing with the addition of citric acid. Therefore, this study is to optimize the mixing order of individual components for stabilized paclitaxel injection.