우리나라 핵의학의 현황과 전망

서일택,정준기,Seo, Il-Taek,Jeong, Jun-Gi 한국동위원소협회 2000 동위원소회보 Vol.15 No.3

방사역의 측정법에 의한 CA 15-3 종양마커의 기초적 검토

서일택 ( Ill Tack Seo ) 대한임상검사과학회 1988 대한임상검사과학회지(KJCLS) Vol.20 No.1

한국 핵의학 기술의 현황

서일택 ( I T Seo ) 대한임상검사과학회 1991 대한임상검사과학회지(KJCLS) Vol.23 No.1

The first clinical use of radioactive material in Korea started 32 years ago in June, 1959 when a patient with hyperthyroidism was sucessfully trea- ted ``with radioactive iodine. In April of following year, 1960 , the first nuclear medicine laboratory was installed at the Seoul N ational University Hospital. Since then, the seoul National Universi- ty ‘ Hospital has played a pioneering and pivotal role in the field of Korean nuclear`` medicine. Subsequently, the four provincial national univer- hospital were installed various kinds of sophi- scated nuclear medicine laboratory equipment. The Korean Society of Nuclear Medicine(KSNM) was organized in 1961, and the Korean Journal of N uclear Medicine published its first issue in 1967. The Korean Association of N uclear Medicine Technology was organized in 1977. After then, the active studies using radioisotope and the vigor- ous interchanges of information with foreign coun- tries had increased so steadily and remarkably that could hold the third Asia and Oceania Congre- of N uclear Medicine in 1984. The medical institutes dealing with radionuclide began to increase rapidly from the late 1970 ’s by the help of the outstanding economic growth and the increasing interests in nuclear medicine and there are 106 medical institutes through out as of 1990. In the case of in vivo study during 5 years from 1986 to 1990, 27.5% is liver scan and bone scan comes next (22.5%) then thyroid, renal, heart scan were followed. But nowadays SPECT for brain and heart is increasing. The distribution of the medical use of in vitro study was hepatitis Ag and Ab series (35.0%) is on the top of the list , and thyroid hormone assay (30.2%) , the other hormo- ne assay (l8.8%) , tumor Ag or marker assay (l4. 0%) and allergen test (2.0%) followed. The studies on medical cyclotron and positron emission tomography(PET) are rapidly progressi- ng as we lI as J apan in the western countries. In 1986 , medical cyclotron was instalIed at Korea Cancer Center Hospital , but we cannot availabel PET at present. The continuous development of nuclear medicine is more and more expected and demand. So we should do our best to develop and produce the domestic radionuclide and radiophar maceuticals in order to use them at any time wewant.

방사면역측정키트 성능평가 고찰

노경운,김태훈,김현주,서일택,Noh, Gyeong-Woon,Kim, Tae-Hun,Kim, Hyeon-Ju,Seo, Il-Taek 대한핵의학기술학회 2008 핵의학 기술 Vol.12 No.1

갑상선 호르몬의 외부정도 관리 분석 - 1989년 9월부터 1990년 8월까지 첫해 시행 결과 -

이동수,조보연,곽철은,서일택,정준기,이명철,고창순 ( Dong Soo Lee,Bo Youn Cho,Cheol Eun Kwark,Il Taek Seo,June Key Chung,Myung Chul Lee,Chang Soon Koh ) 대한핵의학회 1991 핵의학 분자영상 Vol.25 No.2

PET 검사 프러시저별 방사선 차폐기구의 유용성 평가

김영선,서명덕,이완규,정요천,김상욱,서일택,송재범,Kim, Yeong-Seon,Seo, Myeong-Deok,Lee, Wan-Kyu,Jeong, Yo-Cheon,Kim, Sang-Wook,Seo, Il-Teak,Song, Jae-Beom 대한핵의학기술학회 2010 핵의학 기술 Vol.14 No.2

1994년 PET의 국내 도입 이후, 현재까지 양적으로나 질적으로 많은 발전이 있었다. 하지만 이와 함께 방사성의약품의 사용량 또한 급증하면서 검사에 있어서 가장 중요한 역할을 하는 방사선사의 개인피폭선량이 높아지는 요인으로 작용했던 것이 사실이다. 식품의약품안전청의 피폭선량관리센터에서 발표한 자료에 따르면 2008년도 방사선작업종사자의 전체 평균 피폭선량은 0.67 mSv였고, 방사선사 전체 피폭선량은 1.33 mSv로 해마다 감소하는 것으로 나타났다. 설문결과를 살펴보면 PET 검사 담당자의 평균피폭선량은 1.69 mSv였고, 1.0 mSv를 초과하는 구간에 75.3%의 방사선사가 포함되어 있었다. 이는 고 노출구간에 속한 방사선사의 비율이 높다는 것을 의미하므로, 피폭저감을 위한 노력이 요구된다. 본 연구에서는 설문조사를 통하여 PET 검사 프러시저별 차폐기구의 활용에 따른 방사선 피폭 정도를 TLD 수치를 이용하여 분석하고, 실험을 통하여 각 차폐기구의 차폐율을 측정함으로써, 그 효용성을 입증하고 적합한 차폐방법을 강구하고자 하였다. 방사선 피폭의 위험에 대해서 어느 누구보다 잘 인지하고 있는 방사선사임에도 불구하고 안이하게 생각하는 경향이 있었다. 설문결과를 살펴보면 방사선 피폭의 위험성에 대한 인식도와 피폭선량과는 크게 관련이 없었으며, 차폐기구의 활용도에 따라서는 피폭선량의 차이가 확연하게 나타났다. 프러시저 중 피폭선량에 가장 많은 영향을 미치는 단계는 방사성의약품의 투여였으며, 투여시 차폐방법에 따라 이동시 차폐방법도 달라졌다. 투여 시 차폐기구 사용현황을 보면 Both shield는 58.5%, L-Block은 20%, Syringe shield는 9%, No shield는 12.3%를 차지하였다. TLD 수치에 따른 투여 시 차폐방법은 수치가 낮을수록 Both shield와 L-block을 많이 사용하였으며, 수치가 높을수록 Syringe shield와 차폐를 시행하지 않는 경우가 많았다. 실험결과, 가장 이상적인 차폐방법은 분배 시엔 L-block을 사용하고, 이동시엔 Syringe shield carrier를 사용하며, 투여 시엔 L-block과 Syringe shield를 함께 사용하는 것이다. 환자 포지셔닝 시 Apron의 차폐율은 평균 16.4%로 차폐효과가 있다. PET 검사를 시행함에 있어서 강한 실천의지를 가지고 프러시저별로 차폐기구를 적극 활용한다면 점증하는 방사선사의 피폭 수준을 크게 감소시킬 수 있을 것으로 판단된다. Purpose: he use of PET scanners and the number of patient in Korea have been increased for recent several years dramatically. For this reason, technologists have more possibilities to be exposed to the radiation. The hospitals using PET scanners should make an effort to reduce the radiation exposure dose. The purpose of this study was to evaluate the radiation exposure does when using radiation shielding devices. The evaluation was performed through questionnaire survey and experiment. Materials and Methods: First, the technologists who had experience working in PET center in 2008-2009 were surveyed with questionnaire and TLD Figures, personal opinion of utilization of radiation shielding devices are analyzed. Second, we measured the shielding rate of shielding devices which have been using in PET study procedures. We divided the procedures into four steps; distribution, moving, injection of $^{18}F$-FDG and patient setup. Results: First, the results of this survey, using of L-block+Syringe shield, L-block, Syringe shield, No shield during the injection, were each 58.5%, 20%, 9%, 12.3%. The TLD values according to utilization of radiation shield, using both L-block+Syringe Shield and L-block showed the lower TLD values, and Syringe shield only or No shield showed the higher TLD values. Second, the results of experiments according to PET study procedures measured the shielding rates as follows. The shielding rates during the distribution using L-block, L-block+Apron shield were measured 97.4%, 97.7%. The shielding rates during the $^{18}F$-FDG delivery to the injection room using mobile Syringe shield, Syringe holder, Syringe shield carrier were each 81.7%, 98.9%, 99.7%. The shielding rates during the injection using Syringe shield, L-block, L-block+Syringe shield were measured each 51.9%, 98.3%, 98.7%. The shielding rates of Apron were measured in each 30, 60, 90, 120, 150 cm distance. The measurement were each 16.9%, 14.2%, 16.6%, 17.1%, 18.1%, 18.6%. Conclusion: The most effective method for radiation shielding is to using L-block during the $^{18}F$-FDG distribution and Syringe shield carrier during in moving $^{18}F$-FDG. For the $^{18}F$-FDG injection, L-block+Syringe shield have to be used. The shielding effect of Apron has shown average 16.4%. According to the survey of questionnaire, the operators recognized well risk of the radiation exposure but, tended ignore in working. The radiation dose according to recognition of radiation exposure risk was not relevant. but radiation dose according to utilization of radiation shield lower the more use it. The main reason of no use of shielding devices is cumbersome, 55% of the respondents answered. I'm sure, by use of radiation shield in all PET procedure, radiation exposure will be reduced considerably.

방사면역측정법에 의한 갑상선 호르몬의 정상범위 측정

류만길 ( M K Ryu ),김현주 ( I T Seo ),진광호 ( H J Kim ),서일택 ( K H Jin ) 대한임상검사과학회 1992 대한임상검사과학회지(KJCLS) Vol.24 No.1

Concentration of thyroid hormone differ age and sex, and issue from technical and kit question but normal range determined range 2.5-97.5 percent in the Bayesian``s method. 1. Normal range of T3 uptake rate was found to be 23.8% to 32% in normal human 198. 2. Normal range of triiodothyronine(T3RIA) is 87 to 184 ng/dl in normal human 201. 3. Normal of range of thyroxine(T~IA) is 5.6 to 13.1.ug/dl in normal human 199. 4. Normal of range of TSH was 0.4 to 4.1 ,uiUIml.

방사면역측정법<Radioimmunoassay>에 의한 타액<saliva>의 cortisol 정량법

정윤영 ( Yoon Young Chung ),김현주 ( Hyen Joo Kim ),서일택 ( Ill Tack Seo ) 대한임상검사과학회 1985 대한임상검사과학회지(KJCLS) Vol.17 No.1

The determination of cortisol levels in saliva offers a number of significant advantages as. compared with plasma or serum measurements, and radioimmunoassay in the technique of choice because of the greater sensitivity required. We described some modification of commercial kit, designed for the assay of cortisol in serum and urine, which al10w direct and rapid determination of the steroid in saliva. These modifications enable any laboratory with access to a gamma counter to perform large numbers of salivary cortisol assays at relatively low cost. 1. There was a c1 0se and relatively constant relationship between serum and salivary cortisol levels in normal subjects. 2. The necessary improvement in sensitivity was achieved by slightly increasing the incubation time and markedly reducing the amounts of solid-phase antiserum and 1251-labelled cortisol added to each tube.

자동검체분주기의 신뢰성 평가 보고

노경운 ( K W Rho ),원우재 ( U J Won ),김현주 ( H J Kim ),서일택 ( I T Seo ) 대한임상검사과학회 1994 대한임상검사과학회지(KJCLS) Vol.26 No.1

방사수용체 측정법에 의한 아세틸콜런 수용체 항체 (Ach R Ab) 의 측정 실험

류만길 ( M K Ryu ),김현주 ( H J Kim ),서일택 ( I T Seo ) 대한임상검사과학회 1991 대한임상검사과학회지(KJCLS) Vol.23 No.1

Assay of acetylcholine receptor antibody by radioreceptorassay is n~essory test to diagnostic of mysthe11ia gravis. 1. In the normal serum samples of 17 display 0. 000-0. 040nmol/l. 2. In the myastheniagravis patient serum samples display 0. 053- 3. 921nmol/l. 3. Dilution test is almost a straight line less than 1. OOnmol. 4. Washing test is stabilized to wash 2nd. in result. 5. By testing for both binding and blocking AchR antibodies, a positive result is found in about 90% of patients with generalized MG and in about 80% of those with ocular MG.