http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
박철민,백송현,김승우,송종환,이선경,김민 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.9
Protease activated receptor 1 (PAR1) has been considered as a promising antiplatelet target to prevent thrombotic cardiovascular events in patients with prior myocardial infarction or peripheral arterial diseases. Previously, we found a series of octahydroindene analogues to have high potency on PAR1 and no significant cytotoxicity but poor metabolic stability in human and rat liver microsomes. We designed and synthesized substituted analogues of octahydroindenes at C5 or C6 aiming to improvement of metabolic stability, and identified that trans-fused 5-[(tertbutoxtycarbonyl) amino]octahydroindene analogues showed improved metabolic stability withmaintaining good activity on PAR1. Especially, 2-methanesulfonate 57 (IC50 = 0.006 μM; R50 = 126.3 min in human, 83.3 min in rat), sulfamate 58 (IC50 = 0.020 μM; R50 = 52.8 min in human, 106.0 min in rat), and N-(cyclopropyl)methylsufonamide 63 (IC50 = 0.010 lM; R50 = 51.4 min in human, 90.5 min in rat) exhibited excellent activity andmetabolic stability both on human and rat liver microsomes, comparable to those obtained for varapaxar (IC50 = 0.0015 lM; R50 = 83.2 min in human, 32.4 min in rat). Additionally, these compounds (57, 58, and 63) represented significant efficacy (IC50 = 0.0022, 0.0062, and 0.015 lM, each) in human washed platelet aggregation (WPA) assay without cytotoxicity and CYP3A4 inhibitory activity.
포항시립도서관 모바일 웹 페이지 사용성 분석 및 개선 방안 제안
천그루(Groo Cheon),연은진(Eunjin Yeon),이승현(Seunghyun Lee),방주현(Juhyeon Bang),백송이(Songyi Baek),박현우(Hyeonwoo Park),이원섭(Wonsup Lee) 한국HCI학회 2023 한국HCI학회 학술대회 Vol.2023 No.2
Objective : The aim of the study is to improve usability in the use of Pohang City Library and accessibility of information. Background : Pohang City Library Mobile Web is a site that provides essential and general information for the cultural life of people living in Pohang. Users usually use the function of lending books or managing books that have already been lended. However, Pohang City Library’s mobile web is not user-friendly and does not properly provide the functions users need. There is a need for improvement. Method : We prototyped using many visual elements so that users could intuitively check and access the information they needed. In addition, by improving accessibility to essential information, a user-friendly interface was provided, and based on this, experiments were conducted to improve usability and evaluate user satisfaction. Result : In the process of performing the task, errors and clicks are reduced to reduce the total usage time, making it easy, fast, and accurate to reach the users goal. It also improves the user’s subjective satisfaction over the previous web. Conclusion: Improve usability and improve user satisfaction with prototypes. Application: The results of the study might help to develop the Pohang City Library web site with better usability.