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배경남,신기혁,김훈수,고현창,김병수,김문범 대한피부과학회 2023 Annals of Dermatology Vol.35 No.2
Giant cellulitis-like Sweet syndrome (GCS) is the most recently defined variant of Sweet syndrome (SS) which could clinically mimic wide-spreading cellulitis. Although there has been only paucity of reports in the literature, it mostly appears at lower half of the body and histologically shows dense infiltration of neutrophils with occasional histiocytoid mononuclear cells. Although its exact etiology has not been clarified, abnormal conditions (e.g., infection, malignancy and drugs) could be related triggering factors and trauma itself can be one of the causative elements as a ‘pathergy phenomenon’. GCS could be confusing manifestation especially when appeared in postoperative condition. A 69-year-old female presented with an erythematous edematous papules and plaques on the right thigh after varicose vein surgery. Skin biopsy revealed diffuse neutrophilic infiltrates that was consistent with SS. To our knowledge, there has been no report of GCS as a postoperative complication after varicose vein surgery. Physicians should be aware of this uncommon reactive neutrophilic dermatoses mimicking infectious cutaneous disease.
건선환자에서 Adalimumab 과 Cyclosporine 사용 후 발생한 Follicular Lymphoma
배경남,하대룡,손진화,이정수,신기혁,김훈수,고현창,김문범,김병수 대한건선학회 2020 대한건선학회지 Vol.17 No.1
Biologics and conventional immunosuppressants are widely used for psoriasis. Among them, tumor necrosis factor-α inhibitors and cyclosporine are frequently implicated for moderate to severe plaque psoriasis. However, because of their immunoregulatory effect, both have been suspected to increase the risk of lymphomas, although each drug’s individual effect has never been definitively proven. Of course, little is known about the potential synergistic effect of them on the development of lymphoma. A 47-year old man, previously diagnosed with psoriasis, was treated with adalimumab for 9 months and received cyclosporine for 6 months thereafter. Three months later, he developed dyspnea and weight loss. Laboratory exam showed markedly elevated white blood cells and multifocal lymphadenopathy and pleural effusion were revealed by imaging studies. Bone marrow and lymph node biopsy confirmed the diagnosis of follicular lymphoma. Here, we report a case of follicular lymphoma in a patient with psoriasis treated with adalimumab followed by cyclosporine.
수정땀띠 양상의 물집병변으로 나타난 간 이식 후 급성 이식편대숙주병
배경남 ( Kyungnam Bae ),신기혁 ( Kihyuk Shin ),양민영 ( Minyoung Yang ),이원구 ( Won-ku Lee ),김태욱 ( Taewook Kim ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun-chang Ko ),김병수 ( Byung Soo Kim ),김문범 ( Moon-bum Kim ),김우일 ( Woo-il 대한피부과학회 2020 대한피부과학회지 Vol.58 No.5
Acute graft-versus-host disease (GVHD) is a common complication associated with bone marrow transplantation. In the rare cases where it occurs after solid organ transplantation, including that of the liver, pancreas, or heart, it often has fatal outcomes. A 50-year old man developed whole-body flaccid vesiculobullous eruption 6 weeks after living donor liver transplantation. Skin biopsy revealed epidermal necrosis with vacuolization of the basal layer and lymphocytic infiltration in the dermis. Stomach erosions were found during an endoscopy, and a concurrent biopsy revealed severe epithelial necrosis. GVHD was diagnosed, with mixed chimerism confirmed using short tandem repeat testing. Immunosuppressive agent therapy was instituted, but the patient expired from hematologic complications and brain damage 6 weeks after treatment initiation. Skin lesions in GVHD generally appear with erythematous maculopapular eruption, but some atypical cutaneous manifestations could be unnoticed by physicians. This report describes miliaria crystallina-like eruption of acute GVHD after liver transplantation. (Korean J Dermatol 2020;58(5):340∼343)
피어싱에 의한 귀 가성림프종 4예: 임상적 특징 분석 및 문헌고찰
배경남 ( Kyungnam Bae ),신기혁 ( Kihyuk Shin ),고현창 ( Hyun-chang Ko ),김병수 ( Byung Soo Kim ),김문범 ( Moon-bum Kim ),김훈수 ( Hoon-soo Kim ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.7
Cutaneous pseudolymphoma, also referred to as cutaneous lymphoid hyperplasia or lymphocytoma cutis, is an uncommon lymphoproliferative condition. Most lesions are idiopathic in origin; however, triggers such as tattoos, acupuncture, or venipuncture are known to be associated with pseudolymphomas. Owing to the widespread popularity of cosmetic piercings, post-piercing pseudolymphomas are being reported in recent times. Anatomically, most lesions appear on the ears and present with a variety of morphological features, although diagnosis is based on distinctive clinical findings. In this case series, we report four cases of post-piercing pseudolymphoma on the earlobe together with a literature review. We emphasize close and careful monitoring to differentiate this rare condition from other lesions of the earlobe. In view of the diverse clinical presentations and treatment approaches available for pseudolymphomas, we highlight some preliminary clinical indicators to enable early diagnosis and prompt treatment of this condition. (Korean J Dermatol 2021;59(7):544∼549)
재발성 카포시수두양발진의 임상적 특징과 유발요인에 대한 분석
배경남 ( Kyung-nam Bae ),김태욱 ( Taewook Kim ),박성민 ( Sungmin Park ),이현주 ( Hyun Joo Lee ),진현주 ( Hyunju Jin ),유향석 ( Hyangsuk You ),심우행 ( Woo-haing Shim ),김건욱 ( Gun-wook Kim ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun- 대한피부과학회 2019 대한피부과학회지 Vol.57 No.9
Background: Kaposi varicelliform eruption (KVE) is a disseminated viral infection primarily caused by the herpes simplex virus in the setting of an underlying chronic skin disease. Few studies have reported the clinical characteristics and predisposing factors for recurrent KVE. Objectives: To characterize the clinical features and predisposing factors for recurrent KVE. Methods: This retrospective comparative study of recurrent vs. single-episode KVE was performed at the Pusan National University Hospital between 2004 and 2017. Results: A total of 84 episodes occurred in 60 patients, and of these, 13 patients developed recurrence (21.7%). No statistically significant intergroup difference was observed in the mean age and sex distribution. The face was the most common site of involvement in both groups, followed by the trunk and the upper and lower extremities. Atopic dermatitis was the most common pre-existing disease in both groups; however, Darier’s disease was more common in the recurrent KVE group, and this difference was statistically significant. Most patients with KVE (66.7%) showed aggravation of the underlying skin disease within 3 months of KVE onset. This finding was more prominent in patients with recurrent episodes (91.7%) than in those with single-episode KVE (58.3%), (p=0.040). Conclusion: This study can contribute to a better understanding of recurrent KVE and guide clinicians in treating patients with conditions predisposing to KVE. (Korean J Dermatol 2019;57(9):519∼526)