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박현철,박현식,안상천,조상현,김상수,장진,Park, Hyun-Chul,Park, Hyun-Sik,Ahn, Sang-Cheon,Cho, Sang-Hyun,Kim, Sang-Soo,Chang, Jin The Korean Society for Microsurgery 2011 Archives of reconstructive microsurgery Vol.20 No.1
Purpose: We compared wound healing between the conventional tie-over dressing and silicone sheeting after skin grafting in patients with skin defects. Materials and Methods: Of a total of 30 cases of skin defects, 15 underwent conventional tie-over dressing and the remaining 15 underwent silicone sheeting skin grafting, we compared hematoma formation and infection status between the 2 techniques 1 and 2 weeks after operation Results: Hematoma was not observed in all cases. The wound infection rate decreased in silicone group. Conclusions: Silicone sheeting skin graft may be helpful in reducing wound infection.
박현철(Hyun Chul Park),문기찬(Kee Chan Moon),김수남(Soo Nam Kim) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.5
The present study was carried out to find a simple and safe in. vitro test for phtotoxic drugs. Authors selected two strains of Salmonella typhimurium(TA98 and TA102) which have been used in Ames test for the detsction of mutagenecity af various chemical substances. Both strains are genuine products of genetic enzineering. The etrain TA98 should be highly vulnerable to ultraviolet radition because it lacks normal I)NA excision repair gene. The strain TA102 was chosen as control since it maintained the DNA repair gene. These strains were subjected to increasing dosea of UVA with or without pretreatment of 8 methoxypsoralsn(8-MOP) which is a prototype of photatoxic druge. The authors made use of a perforated stain-less steel template which provided a simple and eosy monitoring of ultraviolet irradiation effects i.e. clear zones due to inhibition of the atrains could be determined. By using this methad, the authors acquired the following results .' I. 8-MOP alone exerted no inhibition on both strains at concentration upto 100mg /ml. 2. UVA irradiation alone showed no growth inhibition at dose upto 5J/cm. 3. UVA irradiation after pretreatment with 8 MOP resulted varying growth inhibition in proportion to irradiation doses. 4. Authors found a suitable concentration of 8-MOP for this test is 10pg/ml. With this ccncentrstion, minimal phatatoxic dose of UVA were O.l J/cm for the strain TA98 and 1.0J/cm for the strain TA102 respectively.
경인지역 건강검진자의 Helicobacter pylori 항체 양성률
박현철(Hyun Chul Park),김주현(Ju Hyun Kim),강동훈(Dong Hoon Kang),김선숙(Sun Suk Kim),박종재(Jong Jae park),박동균(Dong Kyun Park),최덕주(Duk Ju Choi),김유경(Yu Kyung Kim),윤형선,조경환(Kyung Hwan Cho) 대한내과학회 1999 대한내과학회지 Vol.56 No.5
N/A H. pylori infection is now widely recognized as one of the causes of peptic ulcer, antral gastritis, and gastric cancer. Many data from cross-sectional seroprevalence studies have confirmed that H. pylori seropositivity varies between different area and race of the same country. The aim of this study is to evaluate the H. pylori seropositivity in 3,488 healthy subjects who reside in Metro-Inchon. Methods : H. pylori IgG antibodies were assayed by enzyme linked immunosorbent assay(ELISA) in healthy Koreans who underwent health examination in Gil Hospital from January to September, 1997. Subjects who had past history of peptic ulcer and previous gastric or duodenal operation and used antibiotics in 1 month were excluded. We compared H. pylori seropositivity between sex, age group, and ABO blood group using Chi-square test and Mantel-Haenszel Chi-square test. Results : 1) The overall seropositivity of H. pylori infection was 70.0%. 2) The seropositivity of H. pylori infection by age groups was 28.6% in 10-19, 63.3% in 20-29, 65.5% in 30-39, 70.7% in 40-49, 73.3% in 50-59, and 74.8% in over 60. 3) The seropositivity of H. pylori infection was 72.1% in male and 65.8% in female. 4) The seropositivity of H. pylori infection among ABO blood groups were 69.4% in A, 69.8% in B, 70.7% in O, and 70.1% in AB. Conclusion : The seropositivity of H. pylori infection in healthy persons living in Metro-Inchon was 70.0% and increased with age and was higher in male.
박현철 ( Hyun Chul Park ),오영재 ( Young Jae Oh ),노영석 ( Young Suck Ro ),고주연 ( Joo Yeon Ko ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.3
The proliferative nodules within a giant congenital melanocytic nevus (GCMN) are generally benign and may regress. However, atypical features cause great interest in dermatopathology. Especially, in neonate proliferative nodules with bleeding, ulceration on GCMN makes it difficult to differentiate the nodules from congenital malignant melanoma. Herein, we describe an interesting case of proliferative nodules in a GCMN of a newborn, which has not been previously reported in Korea. (Korean J Dermatol 2012;50(3):243~247)
손가락 바닥쪽 피부에서 발생한 쌀소체(Rice Body) 낭종
박현철 ( Hyun Chul Park ),김현우 ( Hyun Woo Kim ),이창우 ( Chang Woo Lee ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.12
``Rice body`` is a soft tissue nodule resembling shiny white rice-bean, which is occasionally observed at the juxta-articular area among patients with rheumatic arthritis and tuberculosis arthritis. A 45-year-old man was presented with tender cystic tumor on the volar aspect of the left third finger, which was noted 5 months prior to the visit. When performing a biopsy, numerous, whitish granular, 5∼10 mm in size, and ovoid substances were observed, and found to be the major component of the cystic tumor. Histologically, the granules were consistent with the so-called ``rice bodies`` (granules of inner acidophilic material surrounded by fibrin/collagen). With these findings, we report a case of rice body-containing cystic tumor clinically reminiscent of other cystic lesions, which can be seen on the finger around the joint structure. (Korean J Dermatol 2012;50(12):1047∼1049)
피부질환 치료에서의 경구 사이클로스포린의 부작용에 대한 연구
박현철 ( Hyun Chul Park ),김은진 ( Eunjin Kim ),김정은 ( Jeong Eun Kim ),고주연 ( Joo Yeon Ko ),노영석 ( Young Suck Ro ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.12
Background: Cyclosporine (CS) is being successfully used for various skin diseases including psoriasis, atopic dermatitis, and chronic idiopathic urticaria. However, dermatologists have hesitated to use CSs in clinical practices due to possible adverse effects. Objective: The aim of this study is to investigate the adverse effects of CS for dermatological uses. Methods: We performed a retrospective study by including 1,335 patients with CS treatment. Results: From 1,335 patients, 208 (15.6%) showed adverse effects and obvious laboratory changes. Twenty five patients experienced either two or more adverse effects. Gastrointestinal (GI) symptoms were the most common side effects. Other side effects included hypercholesterolemia (2.2%), hypertrichosis (2.2%), headache (1.3%), hypertension (0.9%), and hypertriglyceridemia (0.9%). Hypercholesterolemia is more frequently found in men but, GI symptoms and hypertrichosis are more frequent in women. Hypercholesterolemia, hypertriglyceridemia, and GI symptoms are more common in adults but hypertrichosis is more common in children and adolescents. Hypertension, hypercholesterolemia, and hypertriglyceridemia have been remarkable in psoriasis patients, and GI symptoms and hypertrichosis are found in patients with atopic dermatitis. GI symptoms and headaches occur more often within three months of the CS treatment; however, hypertension, hypercholesterolemia, and hypertriglyceridemia usually occur three months after. With regards to CS dose, the hypertrichosis is more common in the group with low initial dose. GI symptoms occur more often in the lower CS cumulative dose group; however, hypertension and hypertriglyceridemia are higher in the CS cumulative dose group. Conclusion: As compared with previous studies, the frequency of adverse effects after CS treatment in this study is proved to be low. Therefore, under dermatological fields, we suggest that CS is a relatively safe drug with periodic follow-ups and laboratory tests. (Korean J Dermatol 2013;51(12):960∼969)
박현철(Hyun Chul Park),박종재(Jong Jae Park),손민수(Min Su Son),이성광(Sung Kwang Lee),김주현(Ju Hyun Kim),박동균(Dong Kyun Park),김유경(Yu Kyeong Kim),최덕주(Deok Ju Choi),김선숙(Seon Sook Kim),박성혜(Sung Hye Park) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.2
Collagenous eolitis is an uncommon condition of unknown etiology, charactcrized by chronic watery diarrbea and thickening of the subepithelial collagen band with chronic inflammation. We report two cases of collagenous colitis in a 23-year-old male and 35-year-old female who complain of chronic diarrhea and weight loss. Laboratory and radialogie studies were not remarkable. Colonoscopic examination showed no gross abnarmality but colonoscopic mucosal biopsy showed thickening of subepithelial collagen band and chmnic inflammation. (Korean J Gastroenterol 1997; 29: 252 - 257)
박현철 ( Hyun Chul Park ),김영훈 ( Young Hoon Kim ),김정은 ( Jeong Eun Kim ),고주연 ( Joo Yeon Ko ),남궁선주 ( Sun Ju Nam Goung ),이철민 ( Cheol Min Lee ),김윤신 ( Yoon Shin Kim ),노영석 ( Young Suck Ro ) 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.3
Purpose: High level of indoor air pollutant may cause aggravation of atopic diseases long with various allergic respiratory diseases especially in people who spend mostly of their lives indoors. The aim of this study was to evaluate the effect of air purifier on the reduction of relevant hazards in indoors and the improvement of atopic dermatitis (AD). Methods: A total of 24 families, consisted of 18 AD families and 6 normal control families, were enrolled in this study. We examined air quality and AD severity before the installation of air purifiers and after twenty-four weeeks. The assessment of air quality included fine particles (particulate matter, PM2.5 and PM10), gaseous contaminants (CO, CO2, volatile organic compounds [VOCs], formaldehyde, NO2) and density of offloating microorganisms. Severity of AD was assessed by SCORing atopic dermatitis (SCORAD) index and transepidermal water loss (TEWL). Results: At the end of study, particular air pollutants and VOCs of gaseous air pollutants decreased in both groups (P<0.01). In AD group, SCORAD index decreased from 23.45±4.34 to 15.42±6.53 (.18.5%) and TEWL decreased from 33.78±5.16 to 26.89±5.66 (.18.7%) (P<0.01 and P<0.01, respectively). However, the value of total immunoglobulin E and eosinophil did not show significant changes in both groups compared with baseline. Conclusion: These results suggested that air purifier may improve severity of AD by reducing air pollutants like fine particles and VOCs. Our preliminary study could provide a basis for using air purifier to prevent aggravation of AD. (Allergy Asthma Respir Dis 2013;1:248-256)