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권중구 ( Joong Goo Kwon ),박경식 ( Kyung Sik Park ),박정호 ( Jung Ho Park ),박재명 ( Jae Myung Park ),박철희 ( Cheol Hee Park ),이광재 ( Kwang Jae Lee ),박효진 ( Hyo Jin Park ),이종철 ( Jong Chul Rhee ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.2
Traditional symptom-based therapies of irritable bowel syndrome (IBS) are directed at the relief of individual IBS symptoms, but they are often of limited efficacy in addressing the entire symptom complex. Combinations of drugs to target bothersome symptoms are suggested as the first-line pharmacologic treatment. Increasing knowledge of the pathophysiology and molecular mechanisms of IBS has resulted in the development of several new therapeutic approaches. Thirteen consensus statements for the treatment of IBS were developed using the modified Delphi approach. Exclusion diets have modest efficacy in improving symptoms in some IBS patients. Symptom-based therapies with dietary fiber, bulking agents, laxatives, antispasmodics and laxatives are effective in the improvement of some individual symptoms, e.g. dietary fiber and bulking agents for constipation, laxatives for constipation, antispasmodics for abdominal pain and discomfort, antidiarrheals for diarrhea. 5HT3 receptor antagonists and 5HT4 receptor agonists are effective in the relief of global IBS symptoms and individual symptoms such as abdominal pain and abnormal bowel habits. A short term course of nonabsorbable antibiotics may improve global IBS symptoms, particularly in patients with diarrhea- predominant IBS. Some probiotics appear to have the potential benefit in improving global IBS symptoms. Selective C-2 chloride channel activator is more effective than placebo at relieving global IBS symptoms in patients with constipation-predominant IBS. Both tricyclic antidepressants and selective serotonin reuptake inhibitors are equally effective in relieving global IBS symptoms, and have some benefits in treating abdominal pain. Certain types of psychologic therapy may be effective in improving global symptoms in some IBS patients. Further studies are strongly needed to develop better treatment strategies for Korean patients with IBS. (Korean J Gastroenterol 2011;57:82-99)
박철희 ( Cheol Hee Park ) 교육사학회 2004 교육사학연구 Vol.14 No.-
This research is a study of Go-deung-bo-tong school`s colonial character focused on assimilation and discrimination in the 1920s-1930s. Although Japanese government claimed to demolish discrimination in 1919 Independence Movement of Korea, the discriminatory treatment against Korean was never dealt properly in achieving an equal opportunity in Go-deung-bo-tong school education. Korean students had disadvantages compared to Japanese students in moving onto higher education because of the colonial discrimination in selecting students. Although the colonial discrimination, there were assimilating education elements in the educational process of Go-deung-bo-tong school. The assimilating education elements are found in various aspects of educational process, such as the curriculum, the discipline, the extra-curricular activities, etc. Japanese government denied the national identity of Korean, and discriminated Korean. Many Go-deung-bo-tong school students could not involved in colonial dominance system because of this contradictory policy of education. They became forces of resistance against Japanese government.
증례 : 진성다혈구증에 병발된 사구체간질 증식성 사구체 신염 1예
박철희 ( Cheul Hee Park ),정낙소 ( Nak So Chung ),정우경 ( Woo Kyung Chung ),방수미 ( Soo Mee Bang ),이종호 ( Jong Ho Lee ),정재걸 ( Jae Gul Chung ),이준승 ( Joon Seung Lee ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
진성다혈구증과 동반한 사구체신염의 병발은 매우 드문 것으로 보고되어 있다. 진성다혈구증에 병발한 사구체간질 증식성 사구체신염의 보고가 있었으나 면역형광 현미경 검사가 없어서 IgA 신증을 배제하지 못하였다. 저자들은 단백뇨 및 비장비대를 주소로 내원한 환자에서 면역형광 현미경검사를 포함한 신생검으로 사구체간질 증식성 사구체신염과 세계보건기구 진단 기준에 따른 진성다혈구증으로 진단된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. There are only a few reports of glomerulonephritis associated with polycythemia vera (PV). These cases include diffuse mesangial proliferative glomerulonephritis (mesPGN), Henoch-Schonlein purpura nephritis, focal segmental glomerulonephritis and IgA nephropathy. In 1983, Plomley et al. reported on 3 cases of mesPGN in patients with PV for the first time. However the possibility that these cases were IgA nephropathy could not be excluded since there was no data of electron microscopic or immnunofluorescent (IF) study. We report a case of idiopathic mesPGN combined with PV. A 46-year-old male was referred to our hospital because of proteinuria and splenomegaly on his routine medical examination. While undergoing investigation for the proteinuria, the patient was found to have a high hemoglobin (22.3 g/dL) and hematocrit (68.8%) levels. At that time, the urinary protein excretion was 3.0 g in 24 hour. We diagnosed the patient as a case of PV by World Health Organization criteria. The renal biopsy revealed focal mesangial proliferation with expansion of the matrix. On IF study, there was no deposition of IgA, IgG and C3 in the mesangium. (Korean J Med 69:S884-S889, 2005)