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신장발육 및 재생에 따른 insulin-like growth factor(IGF)-I 및 IGF-binding protein의 변화
박성광,고규영,이대열,Park Sung-Kwang,Koh Gou-Young,Lee Dae-Yeol 대한소아신장학회 1999 Childhood kidney diseases Vol.3 No.2
Purpose: Insulin-like growth factor(IGF)-I and -II are peptide growth factor whose activity is modulated by interaction with the family of six IGF-binding proteins(IGFBPs). IGF-I is detected in rat kidney and has metabolic and growth effects. This study was designed to examine temporal expression of IGFBPs in kidney during renal development and postischemic regeneration in rat. Method: The expression of IGFBPs in kidney during renal development from 15th day of gestation to adult life by using Northern blot analysis. We also examined the renal IGF-IGFBP axis in uremic rat by using Northern blot and immunohistochemistry. Results: The mRNA of IGFBP-1 and -3 were not or barely detected in fetal stages. However, the mRNA level of IGFBP-1 and -3 were increased gradually from day 7 after birth to adult. In contrast, the mRNA of IGFBP-2 and -5 were highly expressed in fetal stages and maintained almost same levels until day 7 (IGFBP-2) or day 30 (IGFBP-5) after birth, then their levels decreased markedly. The mRNA of IGFBP-4 were expressed moderately in fetal kidney and increased gradually after birth. Interestingly, the mRNA of IGFBP-1 and-4 were induced up to 3-5 fold during maximum regeneration period and were recovered to normal levels after acute ischemic injury. In contrast, the mRNA level of IGFBP-3 and-IGFBPrP-1 were decreased slightly at 1 day after ischemic injury, then recovered to normal level during maximum regeneration period. Conclusion: There were differential expressions of IGFBPs in kidney that can modulate IGF action on developing, differentiating, maintaining, and regenerating renal structure and function. 목적 : Insuln-like growth factor(IGF)-I및 -II는 성장인자로 일군의 IGF-binding protein(IGFBP)에 의하여 그 작용이 조절된다. IGF-I은 백서 신장에서 발견되고 대사효과와 성장효과를 갖고 있다. 이번 연구는 백서에서 신장발육과 허혈성 신손상 후 재생과정 동안에 IGFBP의 발현이 변화하는지를 보고자 한다. 방법 : 태생 15주부터 성숙 할때까지 백서 신장에서 IGFBP 발현의 변화를 알아보기 위해 Northern blotting을 시행하였고, 급성신부전 백서의 신장에서 IGF-IGBP axis의 변화를 보기 위해 Northern blotting과 Immunohisto-chemistry를 이용하였다. 결과 : IGFBP-1과 -3는 태생기에는 거의 발현되지 않다가 출생 후 7일째부터 성숙이 끝날 때까지 점진적으로 증가하였다. 반면에 IGFBP-2와 -5는 태생기에 많이 발현되고, IGFBP-2는 출생 후 7일째까지 IGFBP-5는 30일째까지 높은 농도를 유지하다가 급격히 감소하였다. 한편 IGFBP-4는 태생기에 중등도로 발현되는데 출생 후 증가하기 시작하여 7일째 가장 많이 발현되다가 급격히 감소하였다. 신손상 후 IGFBP의 변화를 보면 IGFBP-1과 -4는 재생기간 동안 3-5배 증가되다가 정상으로 회복된 반면 IGFBP-3와 IGFBP Related Protein-1(IGFBPrP-1) 은 신손상 1일째에는 약간 감소하다가 그후 증가하여 정상보다 약간 높은 수준을 유지하였다. 결론 : 백서 신장에서 신장구조나 기능의 발달, 분화 및 재생에 대한 IGF의 작용을 조절할 수 있는 IGFBP 발현에 현저한 변화가 있었다.
6 MV 광자선의 측정데이터와 치료계획장치에 의한 계산데이터의 비교
박성광,조병철,조흥래,안기정,Park Sung Kwang,Cho Byung Chul,Cho Heung Lae,Ahn Ki Jung 한국의학물리학회 2005 의학물리 Vol.16 No.3
입체조형방사선치료와 세기조절방사선치료를 위해 여러 셈법을 포함한 치료계획장치가 임상에 사용되고 있다. 본 연구에서는 조사면 1$\times$1cm$^{2}$에서 최대 조사면 40$\times$40까지의 빔 데이터를 측정하여 이를 치료계획장치에 넣어 빔 모델링을 수행한 후 측정된 빔 데이터와 계산된 빔 데이터의 차이를 비교 분석하였다. 6 MV 광자선의 빔 데이터를 피형 실리콘 검출기와 radiochromic 필름을 사용하여 측정하였고 측정된 빔 데이터의 빔 모델링은 Pinnalce 7.4f의 자동화 모델링을 사용하였다. 작은 조사면의 경우 측정된 데이터와 계산된 데이터가 측방선량분포에 있어 선량 내 영역에서는 적게 평가되고 반음영 영역에서는 크게 평가됨을 알 수 있었다. 또한 심부선량백분율 곡선의 경우 D$_{max}$ 깊이가 작은 조사면의 경우 2 mm 정도 더 줄어듦을 알 수 있었다. 그러나 조사면 4$\times$4 cm$^{2}$에서 최대 조사면 40$\times$40 cm$^{2}$ 까지의 측방선량분포에 대해서는 측정된 데이터와 계산된 데이터가 잘 일치하였다. The first step in the commissioning procedure of a treatment planning system is always verification of the basic beam data. In this work, we have measured POD curves and beam profiles between 1 $\times$ 1 cm$^{2}$ and 40 $\times$ 40 cm$^{2}$ . In an attempt, Pinnacle 7.4f detect discrepancies between predicted dose distribution and delivered dose distribution. The discrepancies between measurement data and caculation data was found. The delivered dose was underestimated in field but overestimated out of field. The D$_{max}$ depth of 1 $\times$ 1 cm$^{2}$ was reduced about 2 mm. For the larger field size ($\geq$4$\times$4 cm$^{2}$, the beam profile and PDD curve showed good agreement between measurement data and calculation data.
만성요통환자의 레이져 수술전과 수술6주후의 요부신전근력에 관한 비교
박성광,석혜경,김명준,Park, Sung-Kwang,Sok, Hye-Kyong,Kim, Myung-Joon 대한물리치료과학회 2000 대한물리치료과학회지 Vol.7 No.1
The purpose of this study were to compare the lumbar extensor strength between pre op patients group and after 6 weeks post op patients group. To evaluate lumbar extensor strength of total 273 patients with HIVD. Lumbar extensor strength was measured in 151 male patients and 122 female patients(Lumbar extensor strength was measured in 91 PELD patients group and 182 OLM group patients) by Medx lumbar extension machine. Maximum voluntary lumbar extension strength was appear $149.36{\pm}61.92ft$-lbs in pre op of PELD group, $158.47{\pm}54.67ft$-lbs in post op of PELD group and $135.54{\pm}54.24ft$-lbs in pre op of OLM group. $147.19{\pm}52.42ft$-lbs in post op of OLM group in male. Maximum voluntary lumbar extension strength was appear $83.85{\pm}30.22ft$-lbs in pre op of PELD group. $92.99{\pm}28.66ft$-lbs in post op of PELD group and $75.16{\pm}24.98ft$-lbs in pre op of OLM group, $79.88{\pm}25.25ft$-lbs in post op of OLM group in female. Male and female lumbar extension strength was statistically significant difference(P<.05). Lumbar flexion/extension ratio of the two group was 2.14:1 pre op and 2.05:1 post op in lumbar flexion 72 and 0 degree. The ratio of post op group was lesser than pre op group.
강성귀(Sung Kyew Kang),박성광(Sung Kwang Park),김원(Won Kim),이정민(Jung Min Lee),마명신(Myeong Sin Ma) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.1
Huge hepatic cysts are rarely encountered in autosomal dominant polycystic kidney disease. Huge hepatic cyst bothers the patient either by compression or complications such as intracystic infections or hemorrhages. We report, here, alcohol instillation to treat a huge hepatic cyst causing compression symptom with improvement in size & symptom. A 49-year-old female patient presented with a 4-week history of indigestion and epigastric discomfort. Physical examination was remarkable for tender hepatomegaly. Computerized tomography revealed huge hepatic and kidney cysts. Ultrasonographic guided percutaneous drainage and four times alcohol sclerotherapy of the huge heptic cyst was successful. Relief of the symptoms was maintained after 18 days. This case shows that alcohol sclerotherapy can be a effective nonsurgical method of treating symptomatic huge hepatic cysts.