http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
흰쥐 다형핵백혈구의 fMLP로 유도한 유주현상에 대한 신나믹산 유사체의 억제효과
민경락(Kyung Rak Min),김진준(Jin Jun Kim),박선규(Sun Gyoo Park),이정래(Jeong Rai Lee),강세훈(Seh Hoon Kang),김영수(Young Soo Kim) 대한약학회 1998 약학회지 Vol.42 No.2
Inhibitory effects of 16 cinnamic acid analogs on formyl-Met-Leu-Phe(fMLP)-induced chemotaxis of rat polymorphonuclear leukocytes were determined by using a microchemotaxis apparatus. 3,4-Dlhydrocinnamic acid called as caffeic acid exhibited the highest inhibitory effect on the chemotaxis among cinnamic acid analogs tested in this study. Hydroxycinnamic acids exhibited stronger inhibitory effects on the chemotaxis than cinnnamic acid. Hydroxycinnamic acids with one hydroxy group at ortho, meta or para position exhibited similar inhibitory effects on the chemotaxis with corresponding methoxy cinnamic acids, but 3,4-dihydroxycinnamic acid did stronger inhibitory effects than 3,4-dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exhibited weaker inhibitory effects on the chemotaxis than 1,2-dimethoxy-4-propenylbenzene and 3,4-dimethoxy cinnamonitrile with -CH=CHCN or -CH=CHCH3, group instead of -CH=CHCOOH group. 4-Hydroxy cinnamic acid and 3,4-dihydroxycinnamic acid exhibited stronger exhibitory effects on the chemotaxis than 3-(4-hydroxyphenyl) propionic acid and 3,4-dihydroxyhydrocinnamic acid with -CH2CH2COOH group instead of -CH=CHCOOH group.
5-Lipoxygenase의 활성과 Leukotriene B4 생합성 억제물질
민경락(Kyung Rak Min),신종만(Jong Man Shin),장윤숙(Yun Sook Chang),김영수(Young Soo Kim) 대한약학회 1989 약학회지 Vol.33 No.6
Polymorphonuclear leukocyte (PMNL) was obtained from peritoneal cavity in rat treated with casein. Effects of divalent cations and drugs on leukotriene B4 (LTB4) formation from arachidonic acid in the PMNL were determined by HPLC assay. 5-Lipoxygenase, a key enzyme for LTB4 formation from arachidonic acid, exhibited Vmax at 1 X 10-5M, and Km at 9.89 X 10-5M of arachidonic acid. Optimal Ca++ concentration for the enzyme activity was 1 x 10-5M but Zn++ did not show any significant effects on the LTB4 formation. Indomethacin and caffeic acid exhibited inhibitory effects on the LTB4 formation at 1 X 10-5M and 4 X 10-5M, respectively. However, 6-aminohexanoic acid did not show any significant effects on the LTB4 formation.
김영수,민경락 ( Young Soo Kim,Kyung Rak Min ) 생화학분자생물학회 1990 BMB Reports Vol.23 No.2
K-ras oncogene and proto-oncogene sequence have been characterized in a spontaneous leg tumor and corresponding normal tissue by application of PCR-cloning and sequencing methods. Sequence analysis of exon 1 in K-ras gene has revealed that a putative K-ras oncogene was found in the spontaneous leg tumor but absent in the normal tissue. The activation mode was a single nucleotide change (GGT to GTT) at codon 12, which resulted in replacement of normal glycine by valine in the transforming ras protein. This single amino acid substitution is likely to be implicated in neoplastic development of the spontaneous leg tumor.
The K-ras Oncogene in A Spontaneous Rat Leg Tumor
김영수,민경락,Kim, Young-Soo,Min, Kyung-Rak 생화학분자생물학회 1990 한국생화학회지 Vol.23 No.2
흰쥐의 다리에 생긴 종양조직 및 정상조직내의 케이라스 유전자를 폴리머레이즈 연쇄반응, 클로닝 및 염기배열 결정 방법 등을 도입하여 검색하였다. 종양조직내에서 케이라스 암유전자가 발현되었으나 정상조직내에서는 이 암유전자가 검색되지 않았다. 이 케이라스 암유전자의 발현기전은 12번 코돈의 염기변이 $(GGT{\rightarrow}GTT)$로 정상적인 케이라스 단백질의 글라이신 잔기를 발린 잔기로 아미노산 잔기 치환을 일으킨다. 이 아미노산 잔기치환을 가지고 있는 케이라스 단백질이 자발적으로 생성된 흰쥐의 다리종양 발달에도 관여하는 것으로 사료된다. K-ras oncogene and proto-oncogene sequence have been characterized in a spontaneous leg tumor and corresponding normal tissue by application of PCR-cloning and sequencing methods. Sequence analysis of exon I in K-ras gene has revealed that a putative K-ras oncogene was found in the spontaneous leg tumor but absent in the normal tissue. The activation mode was a single nucleotide change (GGT to GTT) at codon 12, which resulted in replacement of normal glycine by valine in the transforming ras protein. This single amino acid substitution is likely to be implicated in neoplastic development of the spontaneous leg tumor.
Min, Kyung Rak,Kim, Youngki,Kang, Seh-Hoon,Mar, Woongchon,Lee, Kyong Soon,Ro, Jae Seup,Lee, Seung Ho,Kim, Youngsoo 영남대학교 약품개발연구소 1997 영남대학교 약품개발연구소 연구업적집 Vol.7 No.-
Prostaglandin H₂synthase is the pharmacological target site of nonsteroidal antiinflammatory drugs. Inhibitory effects on cyclooxygenase activity of the synthase by extracts prepared from herbal medicines and wild plants in Korea have been estimated. Sixteen species out of 612 species exhibited more than 50% of inhibition on the enzyme activity. The active extracts prepared from Carex humilis, Celastrus orbiculatus, Eugenia caryophyllata, Gleditsia japonica var. koraiensis, Glycyrrhiza grabra, Glycyrrhiza uralensis, Gyrophora exculenta, lespedeza maximowiczii, Morus alba, Persicaria conspicua, Prunus salicina, Pterocarya stenoptera, Rheum undulatum, Vitis amurensis, and Vitis coignetiae have been sequentially washed with methylene chloride, ethyl acetate, n-butanol. Among the solvent fractions of the active herbal extracts, ethyl acetate fraction of Carex humilis exhibited the highest inhibitory effect on the cyclooxygenase activity of prostaglandin H₂ synthase.
Min, Kyung Rak,Kim, Youngki,Kang, Seh-Hoon,Mar, Woongchon,Lee, Kyong Soon,Ro, Jai Seup,Lee, Seung Ho,Kim, Youngsoo 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-
Prostaglandin H₂ synthase is the pharmacological target site of nonsteroidal antiinflammatory drugs. Inhibitory effects on cyclooxygenase activity of the synthase by extracts prepared from herbal medicines and wild plants in Korea have been estimated. Sixteen species out of 61s species exhibited more than 50% of inhibition on the enzyme activity. The active extracts prepared from Carex humikus, Celastrus orbiculatus, Eugenia caryophyllata, Gleditsia japonica var. koraieosis, Glycyrrhiza grabra, Glycyrrhiza uralensis, Gyrophora exculenta, Lespedeza maximowiczii, Morus alba, Persicaria conspicua, Prunus salicina, Pterocarya stnoptera, Rheum undulatum, Vitis amurensis, and Vitis coignetiae have been sequentially washed with methylene chloride, ethyl acetate, n-butanol. Among the solvent fractions of the active herbal extracts, ethyl acetate fraction of Carex humilis exhibited the highest inhibitory effect on the cyclooxygenase activity of prostaglandin H₂ synthase.
Lee, Yong Rok,Kweon, Hyuk Il,Koh, Wha Soo,Min, Kyung Rak,Kim, Youngsoo,Lee, Seung Ho 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
An efficient synthesis of pyranoquinolinones is achieve by ytterbium(III) triflate-catalyzed reaction of 4-hydroxy-2-quinolones with a variety of α,β-unsaturated aldehydes in moderate yields. This new method has been applied to the synthesis of pyranoquinolinone alkaloids.