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5-Lipoxygenase의 활성과 Leukotriene B4 생합성 억제물질
민경락(Kyung Rak Min),신종만(Jong Man Shin),장윤숙(Yun Sook Chang),김영수(Young Soo Kim) 대한약학회 1989 약학회지 Vol.33 No.6
Polymorphonuclear leukocyte (PMNL) was obtained from peritoneal cavity in rat treated with casein. Effects of divalent cations and drugs on leukotriene B4 (LTB4) formation from arachidonic acid in the PMNL were determined by HPLC assay. 5-Lipoxygenase, a key enzyme for LTB4 formation from arachidonic acid, exhibited Vmax at 1 X 10-5M, and Km at 9.89 X 10-5M of arachidonic acid. Optimal Ca++ concentration for the enzyme activity was 1 x 10-5M but Zn++ did not show any significant effects on the LTB4 formation. Indomethacin and caffeic acid exhibited inhibitory effects on the LTB4 formation at 1 X 10-5M and 4 X 10-5M, respectively. However, 6-aminohexanoic acid did not show any significant effects on the LTB4 formation.