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마상용,전재철 ( Sang Yong Ma,Jae Chul Chun ) 한국환경농학회 1994 한국환경농학회지 Vol.13 No.3
Resistance to paraquat (1,1`-dimethyl-4,4`-bipyridilium ion) has developed in 12 species of 8 genera to which paraquat has been applied 6 to 10 times per year for 5 or more years. In recent years, tolerance to paraquat has been found in Rehmannia glutinosa (Gaertn.) Liboch. ex Fisch. & Mey. which has never been applied with any herbicides involving paraquat. In this review, we differentiate the terms, resistance and tolerance, on the basis of the paraquat-exposure history. Five hypotheses have been evaluated in several species as potential mechanisms of paraquat resistance and/or tolerance. In a species, the mode of action may be due to 1) reduced quantities of paraquat absorbed through the leaf surface, 2) detoxification of paraquat caused by the enhanced paraquat-metabolic activity, 3) rapid sequestration reducing level of paraquat at the site of action in chloroplast, 4) alteration of site of action in photosystem I resulting in interruption of electron transport to paraquat, and 5) rapid enzymatic detoxification of superoxide and other toxic forms of oxygen.
캠벨얼리(Vitis labruscana B.) 잎 에탄올 추출물이 신경세포에서 아밀로이드 전구 단백질의 발현과 아세틸콜린에스테라제 활성에 미치는 영향
최하연,김주은,마상용,조형권,김대성,임재윤,Choi, Ha Yeon,Kim, Ju Eun,Ma, Sang Yong,Cho, Hyung Kwon,Kim, Dae Sung,Leem, Jae Yoon 한국생약학회 2022 생약학회지 Vol.53 No.2
Alzheimer's disease (AD) is the most common form of dementia, and the accumulation of β-amyloid (Aβ) in the brain triggers AD, followed by hyperphosphorylation of tau protein, neurofibrillary tangles, and synapses loss, neuronal cell death, and cognitive decline occur in a chain. In APPswe neuronal cell line, 50 ㎍/ml of Campbell early (Vitis labruscana B.) leaves 50% ethanol extract (VLL) treatment inhibited the secretion of Aβ1-42 by about 63% and the secretion of Aβ1-40 by about 50%. VLL did not target the enzymatic activity of the amyloidogenic pathway and decreased the protein expression of APP. As a result of RT-qPCR (Reverse transcription-quantitative real-time PCR) of the APPswe cell line treated with VLL, it is thought that the protein expression of APP was reduced by inhibiting the transcription process of the APP gene. In addition, VLL inhibited acetylcholinesterase (AChE) enzyme activity in vitro by 27.6% and 54.7%, respectively, at 50 and 100 ㎍/ml concentrations. We found that VLL inhibited the production of Aβ, a dementia-inducing substance, by suppressing the transcription of the APP gene, and that VLL inhibited AChE activity. We suggest that VLL has the potential as a natural drug material that modulates the alleviation of dementia symptoms.
자동차용 엔진 냉각시스템의 방열특성에 관한 실험적 연구
방청세(Chung-Sei Bang),마상용(Sang-Yong Ma),박경석(Kyoung-Suk Park),원종필(Jong-Phil Won) 한국자동차공학회 1997 한국자동차공학회 춘 추계 학술대회 논문집 Vol.1997 No.6_1
The higher output levels attained by automotive engines recently have been accompanied by an increase in the amount of heat released by the engine. This higher heat release level has caused the thermal load in the engine compartment to rise. As a result, greater emphasis has been placed on thermal analysis of heat radiation from the radiator and of heat release from the engine. Heat release to the coolant from the engine is releated with heat transfer. It is, thus, the essential element to analysis of heat transfer process in cooling system for an automotive engine.<br/> However, most of the research about heat release to the coolant is performed from the standpoint of combustion, so this research is done from the standpoint of heat transfer to the cooling system including the engine coolant.<br/> This study is performed on the analysis of heat release chracteristics in cooling system for an automotive engine according to the operating and cooling conditions.<br/> The results are summarized as follows :<br/> 1. The heat release is increased according as coolant temperature is decreased and coolant flowrate is increased.<br/> 2. The heat release is increased and heat release per power is decreased according as engine load is increased with same engine speed<br/> 3. The heat release is increased by increasing fuel comsumption according as engine speed is increased.<br/>
이승현,이창현,김홍준,김영식,신민지,김지현,마상용,이세연,권진,오찬호,Lee, Seung-Hyeon,Lee, Chang-Hyun,Kim, Hong-Jun,Kim, Young-Sik,Shin, Min-Ji,Kim, Ji-Hyun,Ma, Sang-Yong,Lee, Se-Youn,Kwon, Jin,Oh, Chan-Ho 대한한의학방제학회 2021 大韓韓醫學方劑學會誌 Vol.29 No.2
Objectives : This study was conducted to evaluate the efficacy of a complex mixture of natural substances of ginseng and baeknyeoncho on the arthritic rats. Methods : In vitro experiments were conducted to ensure the stability of the complex. After setting toxicity and concentration by MTT assay, the antioxidant effect was measured through DPPH and ABTS radical scavenging activity. To confirm the anti-inflammatory effects of the complex, levels of nitric oxide (NO) and pro-inflammatory cytokines (IL-1β, TNF-α) were measured in LPS-treated macrophage cell lines (RAW264.7). We injected monosodium iodoacetate (MIA) 50 μl (60 mg/ml) into knee joints of rats to induce osteoarthritis. The rats were divided into three groups (normal (n=5), control (n=5), and OR (n=5) group). The control group consumed 2 mg/kg of physiological saline once a day for 4 weeks, and the OR group was mixed at a concentration of 416.5 mg/kg of Baengnyeoncho (O) and 208.25 mg/kg of red ginseng (R) and ingested 1 mL each 5 days a week. Results : This complex increased the DPPH and ABTS radical scavenging rate. The complex decreased NO production and pro-inflammatory cytokine production of macrophages. In the OR group, the secretion of cytokine in serum was decreased. In histopathological examination, the joint tissue of the composite showed less damage to the synovial membrane, cartilage, and fibrous tissue than the control group. Conclusions : As a result of this study, natural complexes have antioxidant, anti-inflammatory and cartilage protection effects. Therefore, we expect the complex to be effective in treating osteoarthritis.
꽃며느리밥풀 Ethyl acetate 분획물의 예쁜 꼬마선충에 대한 항산화 효과
김준형,박창범,박종현,권강무,황인현,마상용,오석흥,김대근,Kim, Jun Hyeong,Park, Chang Bum,Park, Jong Hyun,Kwon, Kang Mu,Hwang, In Hyun,Ma, Sang Yong,Oh, Suk-Heung,Kim, Dae Keun 한국생약학회 2022 생약학회지 Vol.53 No.2
Caenorhabditis elegans model system was used to investigate the antioxidant activity of methanol extract of Melampyrum roseum (Scrophulariaceae). The ethyl acetate soluble fraction of the M. roseum methanol extract showed the best DPPH radical scavenging activity. The ethyl acetate fraction was measured for the activity of superoxide dismutase (SOD), catalase, and oxidative stress tolerance by using C. elegans along with reactive oxygen species (ROS) level. In addition, to confirm that the regulation of the stress response gene is responsible for the increased stress tolerance of C. elegans treated by the ethyl acetate fraction, SOD-3 expression was measured using a transgenic strain. As a result, the ethyl acetate fraction increased SOD and catalase activity, and decreased ROS accumulation in a dose-dependent manner. In addition, the ethyl acetate fraction-treated CF1553 worm showed higher SOD-3::GFP intensity than the control worm.