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소아 기관지 천식 환아에서 Prednisolone 이 Theophylline 의 대사에 미치는 영향에 관한 연구
정혜영(Hyea Yeong Chung),이희정(Hee Jung Lee),윤운기(Un Ki Youn),오지섭(Ji Sub Oh),류환선(Hwan Seon Ryu),손기호(Kie Ho Sohn),(Charies D . Sands) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1993 소아알레르기 및 호흡기학회지 Vol.3 No.1
N/A Theophylline is widely used in pediatric patients for the treatment of asthma and neonatal apnea. To achieve adequate bronchodilation and avoid toxicity, it is generally accepted that the serum theophylline concentration should be maintained between 10 and 20㎍/ml. Concentrations greater than 20㎍/ml are associated with an increased incidence of toxicity. Clinical effectiveness and toxicity are clearly related to the serum concentrations. Thus, it is important to understand factors which might alter theophylline pharmacokinetics. Prednisolone has been reported to both increase and decrease theophylline serum concentrations. Clinical experience at our hospital (one case) suggested that there might be an interaction between prednisolone and theophylline that can potentially results in clinically significant changes in theophylline serum concentrations. Thus, we studied eleven asthmatic children, who were admitted to our hospital and received oral sustained release theophylline and prednisolone. The mean serum theophylline concentration of single therapy group (phase 1) was 8.10㎍/ml and of concomitant administered prednisolone group (phase 2) was 8.39㎍/ml. On basis of serum theophylline concentrations, we had taken the volume of distribution (Vd), half life (t1/2) and calculated clearance (Cl), in each of phase 1 and 2. The mean clearance of phase 1 was 67.37ml/㎏/hr and of phase 2 was 67.85ml/㎏/hr. The difference between mean serum theophylline concentration and clearance in the single therapy group (phase 1) compared with concomitant administered prednisolone therapy group (phase 2) was not statistically significant. (p>0.05) This suggests that prednisolone does not affect the metabolism of theophylline and does not alter serum concentration of theophylline.
한국 소아 기관지 천식 환아에서 연령에 따른 Theophylline 의 대사 변화에 관한 연구
이희정(Hee Jeong Lee),조혜영(Hye Young Cho),윤운기(Un Ki Youn),오지섭(Ji Sub Oh),류환선(Hwan Seon Ryu),손기호(Kie Ho Sohn),(Charles D . Sands) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1995 소아알레르기 및 호흡기학회지 Vol.5 No.1
N/A Theophylline is widely used in Korean pediatric patients in the treatment of asthma. To achieve adequate bronchodilation and avoid side effects , it is generally accepted that the serum theophylline concentration should be maintained between 10 and 20mcg/ml . Concentrations greater than 20mcg/ml are associated with an increased incidence of toxicity . Clinical effectiveness and toxicity are clearly related to understand factors which might altel theophylline pharmacokinetics . Age has been reported as a factor which might alter theophylline clearance. Thus we studied 287 asthmatic children who were admitted to our hospital and received intravenous aminophylline and oral theophylline. The average total clearance of theophylline was 30.00ml/kg/h in the infants under 6 months old and 53.14ml/kg/h in the infants between the age of 6 and 12 months . The average total clearance of theophylline was significantly increased in infants above 6 months old(p<0.001) . The average total clearance of theophylline of the children aged between 1 to 12 years was 65.77ml/kg/h and no significant difference according to age was noticed in this group . These suggest that age may be a factor which affects clearance of theophylline under 12 months old .