http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
천식으로 입원한 소아에서 호흡기 바이러스 감염의 유병률
노의정 ( Eui Jung Roh ),진용만 ( Yong Man Jin ),정은희 ( Eun Hee Chung ),임인수 ( In Soo Rheem ),김재경 ( Jae Kyung Kim ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.4
Background: Respiratory viral infections are common exacerbating factors for asthma in children. Recently the detection of respiratory viruses can be improved by using molecular biology techniques, which providing a method capable of detecting an increasing number of viruses. Objective: The aim of this study was to evaluate the causative viral infections and their seasonal trends in children who were admitted with the exacerbation of their asthma by multiplex polymerase chain reaction (PCR) assay. Method: Nasopharyngeal aspirates were obtained from hospitalized asthmatic children at Dankook University Hospital from November 2005 through Febraury 2007. Multiplex PCR assay was used for the detection of respiratory viruses. The demographic and clinical characteristics were reviewed retrospectively from the patients`` medical records. Result: During the study period, 58 were hospitalized due to acute asthma exacerbations. Of these, infectious agents were detected in 38 (65.5%) of the patients. Resipiratoy syncytial virus was detected in 18 (31%), influenza virus in 10 (17.2%), rhinovirus in 7 (12.1%), coronavirus in 5 (8.6%), adenovirus in 4 (6.9%), parainfluenza virus in 5 (8.6%) and human metapneumovirus in 2 (3.4%). Conclusion: It is suggested that the causative virus in hospitalized children with asthma exacerbations follow may the epidemic of respiratory virus in hospitalized children with respiratory infection. (Korean J Asthma Allergy Clin Immunol 2007;27:241-247)
국내 유통되는 인플루엔자 백신에서 ELISA에 의한 계란 단백의 정략적 비교
노의정 ( Eui Jung Roh ),정은희 ( Eun Hee Chung ),김재경 ( Jae Kyung Kim ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2009 소아알레르기 및 호흡기학회지 Vol.19 No.4
목적: 인플루엔자는 매년 중대한 영향을 끼치는 질병이므로 특히 소아와 같은 고위험군에서는 인플루엔자 예방접종이 강조된다. 인플루엔자 백신은 계란 단백을 함유하므로 계란 알레르기 환자에게 투여시 심각한 부작용을 우려하여 적극적인 백신투여가 이루어지지 못한다. 따라서 본 연구에서는 국내 유통되는 인플루엔자 백신의 계란 단백의 정량을 분석하고자 한다. 방법: 2004년, 2005년, 2006년에 국내 유통되고 있는 인플루엔자 백신을 각 회사별로 같은 lot 번호별로, 다른 lot 번호별로 준비하여 각 백신에 포함된 ovalbumin이 coating되어 있는 microtiter plates에 백신 원액부터 2배로 단계 희석한 백신과 ovalbumin을 분주하였고, 2차 항체로 horse radish peroxidase-conjugate rabbit anti-ovalbumin을 분주하였다. 450 nm에서 흡광도를 측정한 후 standard curve를 통해 ng/mL로 변환시켰다. 결과: 백신에 가장 많이 측정된 ovalbumin 농도는 101.24 ng/mL였고, 가장 낮은 농도는 21.23 ng/mL였다. ovalbumin 농도는 제약 회사간 차이를 보였고, 같은 제조회사에서 같은 년도에 제작되었지만 다른 lot 번호를 가진 백신의 ovalbumin 농도가 모두 달랐으며 같은 lot 번호를 가진 백신에서도 ovalbumin 농도는 차이를 보였다. 결론: 본 인구에서 조사한 국내 유통되고 있는 백신에 함유되어 있는 ovalbumin의 양은 모두 l.2 μg/mL 이하로 측정되었다. 따라서 심각한 계란 알레르기가 있는 환자에서 본 연구 결과는 인플루엔자 백신 접종시 참고자료가 될 수 있겠다. Purpose: Influenza infection is a major public health concern, especially in young children and in high risk groups such as asthma patients. Traditionally, influenza vaccines are produced from infertilized eggs. Therefore, patients with severe egg allergy can show adverse reactions after vaccination and be dalayed in active immunization. The aim of this study was to determine the ovalbumin concentration of a commercially available influenza vaccines in Korea. Methods: The ovalbumin content in each vaccine was determined by enzyme linked immunosorbent assay. The ovalbumin content was compared among the different manufactures, the different lot numbers and the same lot numbers of vaccines. The microtiter plates coated with goat anti-chicken egg albumin antibody were inoculated with serial diluted vaccines and ovalbumin. After incubation with horse radish peroxidase-conjugate rabbit anti-ovalbumin, absorbance was read at 450 nm and fitted to the standard curve. Results: The highest ovalbumin content was 101.24 ng/mL, and the lowest ovalbumin content was 21.23 ng/mL. The amount of ovalbumin differed not only among the different vaccines, but also different lot numbers of individual vaccines and even the same lot numbers of vaccines. Conclusion: In none of the vaccines tested in our study, ovalbumin content reached the maximum values for ovalbumin (1.2 μg/mL). Therefore, in severe egg allergic patients, our results provide the useful information on influenza vaccination. [Pediatr Allergy Respir Dis (Korea) 2009;19:345-353]
전국 146개 응급실에 내원한 급성 세기관지염 환자에 대한 통계적 관찰
노의정 ( Eui Jung Roh ),원연경 ( Youn Kyung Won ),이미희 ( Mi Hee Lee ),정은희 ( Eun Hee Chung ) 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.5
Purpose: This study was aimed to investigate the clinical and epidemiological characteristics of the patients with acute bronchiolitis who visited in 146 Emergency Departments (EDs) in Korea in 2012. Methods: We used the NEDIS (National Emergency Department Information System) database to obtain all children with acute bronchiolitis who visited ED under the age of 3 between January 1, 2012 and December 31, 2012. Results: Totally 18,313 children with acute bronchiolitis were enrolled at this study. The male to female ratio was 1.55:1 and mean age was 10 months. The peak proportion was 17.3% in November during the whole year. The most common chief complaints were fever (38.5%), cough (37.4%), dyspnea (9.5%), gastrointestinal symptom (6.7%), and wheezing (2.5%). The most common accompanying disease was pneumonia (13.3%). The rate of hospital admission and intensive care unit admission were 34.5% and 0.3%, respectively. A predictor for admission via ED was respiratory difficulty. Conclusion: These data expand our understanding of clinical characteristics of patients with acute bronchiolitis who visited all ED in Korea in 2012. (Allergy Asthma Respir Dis 2015;3:334-340)
노의정 ( Eui Jung Roh ),홍경식 ( Kyoung Sik Hong ),정은희 ( Eun Hee Chung ),장영표 ( Young Pyo Chang ),이영석 ( Young Seok Lee ) 대한소아알레르기호흡기학회 2009 소아알레르기 및 호흡기학회지 Vol.19 No.3
Congenital syphilis is a completely preventable disease, but it still occurs. It usually involves multiple organs, which may cause neurological or skeletal disabilities or death in the fetus or newborn. Although lung involvement is rare in congenital syphilis, we should consider pneumonia alba when respiratory symptoms or radiologic findings are abnormal. We first report herein two cases of pneumonia alba with high resolution computerized tomography (HRCT) findings. [Pediatr Allergy Respir Dis(Korea) 2009;19:300-306]
강지희,진용만,노의정,강소영,유지숙,정은희,Kang, Jihui,Jin, Young Man,Roh, Eui Jung,Kang, So Young,Yu, Jeesuk,Chung, Eun Hee 대한소아감염학회 2007 Pediatric Infection and Vaccine Vol.14 No.2
대상포진 수막염은 대상포진 후 발생할 수 있는 신경학적 합병증으로 주로 면역 기능이 저하된 상태의 환자에게서 발생한다. 저자들은 면역 기능이 정상인 환아에서 피부 병변 없이, 수두 백신 접종을 한 경우 드물게 발생하는 대상포진 수막염 2례를 경험하였기에 보고하는 바이다. Varicella-zoster virus is a human herpesvirus that causes chickenpox (varicella), becomes latent in cranial nerve and dorsal root ganglia, and frequently reactivates to produce shingles (zoster) and postherpetic neuralgia. Varicella zoster meningitis is a rare complication after varicella zoster infection. It usually affects a patient of immunocompromised or impaired cellular immunity, is rare in a immunocompetent child. We report two cases of aseptic meningitis in association with varicella zoster, not having any complication in the immunocompetent children.
단일 의료기관에서 진단된 아나필락시스 환자의 임상적 특성
박향미 ( Hyang Mi Park ),노진철 ( Jin Chul Noh ),박종현 ( Jong Hyun Park ),원연경 ( Youn Kyoung Won ),황세희 ( Se Hee Hwang ),김재윤 ( Jae Yoon Kim ),김유영 ( You Young Kim ),노의정 ( Eui Jung Roh ),정은희 ( Eun Hee Chung ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2012 소아알레르기 및 호흡기학회지 Vol.22 No.3
Purpose: The studies concerning the clinical features of patients with anaphylaxis, who meet the newly established diagnostic criteria, are reported in Korea, but comparative studies regarding the clinical features of children and adult patients with anaphylaxis are lacking. The purpose of this study is to compare the clinical features of the children and adults with anaphylaxis, who meet the new diagnostic criteria at a single hospital. Methods: We reviewed the medical records of patients who were diagnosed with anaphylaxis, anaphylactic shock, urticaria, and angioedema, including inpatients, outpatients and emergency room visited patients, at the National Medical Center from July, 2005 to August, 2011. The clinical characteristics of children and adults, who met the new diagnostic criteria for anaphylaxis, were analyzed. Results: We identified 91 patients with anaphylaxis. Sixteen were children and 75 were adults. The sex ratio (male:female) and the mean age were 1:1.7 and 9.6 years among children, respectively, and 1:2.3 and 42.3 years, respectively, among adults. The most common cause of anaphylaxis based on clinical history was foods in 15 children (93.7%) and 35 adults (46.7%). Twelve children (75%) and 36 adults (48%) were rediagnosed with anaphylaxis. Patients with cardiovascular symptoms and severe severity were 1 (6.3%) and 1 (6.3%), respectively, among children, and 28 (37.3%) and 23 (30.3%), respectively, among adults. Conclusion: We rediagnosed some cases of anaphylaxis, using the new diagnostic criteria and most of the cases were diagnosed initially as urticaria or angioedema. The adults had more severe and more cardiovascular symptoms than children. In the future, a nationwide, multiinstitutional research will be necessary for the prevalence and the clinical features of anaphylaxis by the new diagnostic criteria in Korea.