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Small molecule two-photon probes for biomedical applications
김환명 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.0
During the past decade, two-photon microscopy (TPM) has emerged as a new, indispensable imaging tool to study of biology and medicine. TPM uses two near-infrared (NIR) photons as the excitation source and offers several advantages, including inherent sectioning capability, low photo-damage, longer observation time, and greater tissue penetration depth. Recently, we have developed ratiometric TP probes possessing a significant two-photon excited fluorescence, a marked emission color change, easy loading, high photostability, and low cytotoxicity. These probes can precisely detect thiols, H2S, ROS, pH, and enzyme activity6 in live cells as well as living tissues. The design and evaluation of a selection of our recent studies, and their use in medical research will be presented.
김환명(Hwan Myung Kim) 한국청정기술학회 2011 청정기술 Vol.17 No.3
이광자 현미경(two-photon microscopy)은 다양한 생명현상을 살아있는 조직의 깊은 곳에서 관찰할 수 있다는 장점 때문에 차세대 영상기술로 발전하고 있다. 이에 따라 다양한 목적에 사용할 수 있는 이광자 센서의 개발이 활발하게 진행 중이다. 이 총설에서는 금속이온 이광자 센서에 관한 최근의 연구 결과를 소개하고자 한다. Two-photon microscopy (TPM) is attracting much attention in biological imaging due to the capability of imaging deep inside the living tissues for a long period of time. For maximum utilization of TPM, it is essential to develop efficient twophoton sensors. Regarding this, many research groups are developing two-photon sensors for specific applications. In this review, we summarize recent results on selected examples of two-photon sensors for intracellular free metal ions in the live cells and tissues to provide a guideline for various imaging applications.
Antibacterial mechanism of ZnO nanoparticles under dark conditions
조아라,박세호,심규동,김다정,지광환,이효원,허철호,김환명,장의순 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.45 No.-
To evaluate the antibacterial activity of zinc oxide (ZnO) in the absence of a light source, we examinedthree different types of nanoparticles that vary in size and the number of oxygen defect sites. Colonyforming units (CFU) and various microscopic investigations revealed that the antibacterial activity of ZnOnanoparticles under dark conditions was not related to reactive oxygen species (ROS) generation andnanoparticles transfection, but depended on the ZnO attachment to bacterial cell walls and increasingconcentrations of Zn2+ ions in the bacterial cytoplasm due to local dissolution of the attached ZnO.