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새로운 백금 착체(II) 화합물의 흰쥐 혈장에서 대사체 확인
김종환,조요나,노영수,서성훈,정지창,장성구,이규홍,이주한,이경태,Kim, Jong-Whan,Jo, Yo-Na,Rho, Young-Soo,Seo, Seong-Hoon,Jung, Jee-Chang,Chang, Sung-Goo,Lee, Kyoe-Heung,Lee, Joo-Han,Lee, Kyung-Tae 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.3
KHPC-002 $[(trans-l-diaminocyclohexane-bis-l,2(diphenylphosphinoethane)platinum)\;{\cdot}2NO_3]$ and $KHPC-006[(cis-diaminocyclohexane-bis-1,2(diphenylphosphinoethane)platinum)\;{\cdot}2NO_3]$ were synthesized as candidates for third platinum antitumor agent. Before their pharmacokinetic study, we optimized the analytical condition with HPLC and identified the major metabolites in the rat plasma. HPLC analysis by $C_{18}$ reverse-phase column showed that standard peak of both compounds appeared rapidly at around 1 minutes, whereas metabolites of KHPC-002 and KHPC-006 which were extracted from plasma after single I.V. administration in rats or incubation for 24 hr at $37^{\circ}C$ showed retention time of $10{\sim}11$ minutes. These metabolites were identified as the major compound by Matrix Associated Laser Deposition/Ionization (MALDI), which only lose the 2 molecules of $NO_3$. Based on these results, we suggest that the major metabolites of KHPC-002 and KHPC-006 were [trans-l-diamino-cyclohexane-bis-l,2(diphenylphosphinoethane)platinum] and [cis-diaminocyclohexane-bis-l.2(diphenylphosphinoethane)platinum], respectively.
골다공증(骨多孔症)에 관(關)한 문헌적(文獻的) 고찰(考察) -주로 최근(最近)의 한의학적(韓醫學的) 임상(臨床) 및 실험논문(實驗論文)을 중심(中心)으로
김종환,Kim Jong-Hwan 대한침구의학회 1998 대한침구의학회지 Vol.15 No.2
Osteopotosis is a disease characterized by reduced amount of bone mass leading to enhanced bone flagility. The number of patients with osteoporotic vertebral fracture is increasing and it is one of the leading causes of morbidity in the elderly and postmenopausal women. It is a condition in which bone mass decrease, causing bones to be more susceptible to fracture. A trivial trauma can easily cause one or more bones to break in a person with severe osteoporosis. So it is a major health problem. Pysicians and patients are concerned with the optimum approach to the treatment and prevention of osteoporosis. Until a recent date, many oriental medicine studies were performed to find the preventive and curative efficacy on the osteoporosis, which is differ from therapeutics of Western-medicine. The proper use of Herb-med and role of Accupuncture are issues that have generated major research efforts. This study was carried out to investigate evaluation of clinical and experimental study on the osteoporosis. So, these are to be mentioned in this paper.
김종환,최성호,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 1996 Journal of Periodontal & Implant Science Vol.26 No.2
Regeneration of the periodontal tissue destroyed by periodontal disease is one of the final goals of periodontal therapy. In the past few years, periodontists have used various alloplastic grafting materials in an attempt to regenerate bone lost from periodontal disease. These materials have used widely because they have shown to be nontoxic, biologically compatible with surrounding host tissue and chemically similar to bone. The purpose of this study was to investigate the effect of Porous Resorbable Calcium Carbonate and Porous Replamineform Hydroxyapatite on the regeneration of the alveolar bone and the healing of roots transplanted into the periodontally diseased extraction sockets of dogs. The experimental chronic periodontitis was induced by elastic ligatures on the 2nd and 3rd mandibular premolars of 2 adult dogs for 8weeks after surgically creating periodontal defect. The extracted root were split in half along the long-axis, and the extend of plaque exposure was marked on the root surfaces with burs. The roots were inserted in extraction sockets with Porous Resorbable Calcium Carbonate(PRCC) in left side and with Porous Replaminefrom Hydroxyapatite(PRH) in right side. The flaps were sutured to cover the sockets completely. The animals were sacrificed after 12 weeks of healing, and the specimens were examined histologically. The results were as follows: 1. No inflammatory reactions were observed in either groups. 2. Hoot resorption was observed in both groups while the general outline of the roots were maintained. 3. PRCC was almost completely resorbed and replaced with new bone, while R.H.A. was not resorbed & remained encased in newly-formed C-T and alveolar bone. 4. PRH was encapsulated with alveolar bone which has been deposited from apical & lateral area of the sockets, while the coronal portion of the sockets were filled with C-T. 5. In both groups, the resorbed portions of the roots were replaced with new bone. These results suggest that either PRCC or PRH may not interfere with bone formation or healing in extraction sockets, and in some degree, retard the root resorption. Because the roots maintained in anatomy, we think that graft materials prevent the root resorption.
고분자 기판위에 다층 구조의 박막형 보호층을 적용한 투습률 향상
김종환,한진우,김영환,서대식,Kim Jong-Hwan,Han Jin-Woo,Kim Young-Hwan,Seo Dae-Shik 한국전기전자재료학회 2006 전기전자재료학회논문지 Vol.19 No.3
In this paper, the inorganic-organic thin film encapsulation layer was newly adopted to protect the organic layer from moisture and oxygen. Using the electron beam, Sputter and Spin-Coater system, the various kinds of inorganic and organic thin-films were deposited onto the Ethylene Terephthalate(PET) and their interface properties between organic and inorganic layer were investigated. In this investigation, the SiON and Polyimide(PI) layer showed the most suitable properties. Under these conditions, the WVTR(water vapour transition rate) for PET can be reduced from level of $0.57\;g/m^2{\cdot}day$ (bare subtrate) to $1{\times}10^{-5}\;g/m^2{\cdot}day$ after application of a SiON and Polyimide layer. These results indicates that the SiON/PI/SiON/PI/PET barrier coatings have high potential for flexible organic light-emitting diode(OLED) applications.
New Aggregation Algorithm for Tandem queue with Finite Buffers
김종환,Hur, Sung Kwan,徐承祿 大邱大學校附設 基礎科學硏究所 1991 基礎科學硏究 Vol.8 No.-
We consider a two-stage fmite tandem queueing system with Poisson arrivals and negative exponential service times. The customer who has completed his service at the first station has to go directlty to the second station. If the queue of the second station is full at the moment of the service completion of the customer at the first station, then the customer receives, another service at the first station. This is repeated until the customer completes a service at the first station at the moment that the second station is not fulL The problem of calculating the steady-state probabilities of this queueing system by the ordinary balance equations is time consuming. We develop an efficient algorithm to obtain the steady-state probabilities that utilize the two-way state aggregation techniques.
채매환자의 행태특성 분석을 통한 건축계획에 관한 연구 -시.도립 치매 전문병원 사례를 중심으로-
김종환,김명근,Kim, Jong-Whan,Kim, Myoung-Keun 한국디지털건축·인테리어학회 2006 한국디지털건축인테리어학회 논문집 Vol.6 No.2
The purpose of this study is to analyze the problems in assumption of the distinguished behaviors of hospitalized dementia patients- which can be easily emerged and recognized in senile dementia patients and their distinctive behavior characters in different physical environment per person. Furthermore, it is to suggest a fundamental data to improve physical environment of the different facilities and the design guidelines for reconstruction in terms of the new and therapeutic function of the dementia specialized department. For planning on the dementia specialized hospital, considerablely, security and safety, comfortableness, personal identification of the facility, emotional stability and the proper stimulation for the patients are emphasized according to the research on the frequent and major issues of the patients from their own dwelling place.
김종환,박준렬,최계근,Kim, Jong-Hwan,Park, Jun-Ryeol,Choe, Gye-Geun 대한전자공학회 1985 전자공학회지 Vol.22 No.3
Pad'e-Type 근사화법을 이용하여 새로운 기준모델 적응 제어계를 설계하였다. 공정의 파라미터를 모르는 상태에서 제어계를 설계하여 이로부터 제어목적을 만족시키는 등가 방정식을 유도하여 이조건을 만족시키는 파라미터를 반복적으로 추정하였다. 이결과 추정할 공정의 파라미터 갯수를 줄이는 효과를 얻을 수 있다. 기존의 방법과 새로운 방법을 컴퓨터 시뮬레이tus으로 나타내었다. A Novel design of MRAC for achieving independent tracking and regulation objectives by applying Pad e-Type approximation in the controller parameter estimation is presented. The design of the controller is done with the unknown plant parameters from the first. The result of the design is a simple control scheme with the reduction of estimation para-meters. The performance of rho proprosed contiol structure in tracking and regulation is compared with the other method by computer simulation.