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청심온담탕(淸心溫膽湯)의 효능(效能)에 관(關)한 문헌적(文獻的) 고찰(考察)
김인섭,신길조,조기호,김영석,배형섭,Kim, In-Sup,Sin, Gil-Jo,Jo, Gi-Ho,Kim, Yeong-Seok,Bae, Hyeong-Seop 대한한방내과학회 1992 大韓韓方內科學會誌 Vol.13 No.1
In order to study oriental medical literature and clinical effects of Chungsimondamtang, the experiments of analgesic action, sedative action, anticonvulsive action, action on the isolated ileum, action on the circulatory system and hyperlipidaemia were observed. The results were as follows: 1. The analgesic effects were significantly noted. 2. The prolongaton of hypnotic time was noted. 3. The inhibitory effects on the convulsion induced by strychnine, picrotoxin and caffeine were significantly recognized. 4. The spontaneous momentum of isolated ileum was evidently inhibited, and recognized anti Ach. and anti Ba. effects. 5. The effects of descending blood pressure in normal rats and anesthetized rabbits were strongly recognized. 6. The effects of inhibition on the increase of TG. and TC. levels in hyperlipidaemia rats induced by Triton WR-1339 was significantly recognized. 7. The effects of inhibition on the increase of TG. and TC. levels in hyperlipidaemia rats induced by 75% fructose was significantly recognized. With the genelalization of the above-mentioned experimental results, literatual and clinical effects of Chungsimondamtang were approximate to actual experimental results.
부분 무치악의 고정성 임플랜트 보철의 저위교합에 관한 3차원 유한요소법적 연구
김인섭,최충국,정재헌,Kim, In-Seob,Choi, Choong-Kug,Chung, Chae-Heon 대한치과보철학회 1996 대한치과보철학회지 Vol.34 No.3
The purpose of this study was to examine, by the method of 3-dimentional finite element analysis. how infraocclusion affected the stress distribution in surrounding bone and osseointegrated prosthesis. The 3-dimentional finite element mandibular models were made, in which the first and second molars were removed and the two osseointegrated implants were placed in the first and second molar sites and implant supported fixed prostheses were constructed. Analysis of equivalent stress and displacement induced by strong occlusion or infraocclusion was performed under vertical or inclined distributed loads. The results were as follows; 1. Under vertical load of 50N or 500N, the model in which infraocclusion had not been allowed showed greater stress on implants and the supporting bone than on natural teeth. 2. In the model in which infraocclusion of $30{\mu}m$ had been allowed, implant-prosthesis on the molars had no contact with opposing teeth under vertical load of 50N, However with the same allowed infraocclusion and the model under vertical load of 500N, implant prosthesis on the second molar had contact with opposing teeth, and stress distribution occured properly on natural teeth and implants. 3. Under $45^{\circ}$ inclined load, the model in which infraocclusion had not been allowed showed greater stress on implants and the supporting bone than on natural teeth. There was greater stress in the case of $45^{\circ}$ inclined load than in the case of vertical load. 4. Under $45^{\circ}$ inclined load of 50N or 500N, the model in which infraocclusion of $30{\mu}m$, had been allowed showed no occlusal contact on the implants and occlusal contact on the natural teeth. 5. In partially edentulous cases with implant supported prosthesis, we can prevent excessive load on implants by allowing infraocclusion.
바이러스 불활화 공정에 대한 Hepatitis A Virus와 Murine Encephalomyocarditis Virus의 민감도 비교
김인섭,Kim, In-Seop 한국미생물학회 2003 미생물학회지 Vol.39 No.4
Murine encephalomyocarditis virus (EMCV)는 혈장유래의약품의 바이러스 안전성 검증을 위해 hepatitis A virus (HAV)의 모델 바이러스로 사용되어왔다. 근래에 혈액응고인자제제에 의한 HAV 감염사례가 보고되면서 혈장유래의약품의 HAV 안전성 검증에 대한 국제적인 규제가 강화되어가고 있다. 본 연구에서는 HAV와 EMCV의 바이러스 불활화 공정에 대한 민감도를 평가하여, 혈장유래의약품 제조공정에서 HAV 불활화 공정의 검증법을 표준화하고자 하였다. HAV와 EMCV의 바이러스 불활화 공정에 대한 민감도를 평가한 결과 HAV가 60$^{\circ}C$ 열처리, low pH 처리(pH 3.9), 0.1 M NaOH 처리, 동결건조 공정 모두에서 EMCV보다 더 저항성이 큰 것을 확인할 수 있었다. EMCV는 특히 열처리와 0.1 NaOH 처리에 민감하게 불활화 되었지만, HAV는 큰 저항성을 나타내었다. 열처리의 경우 2시간 안에 EMCV는 검출한계 이하로 감소하였지만, HAV는 5시간 후에 검출한계 이하로 감소하였다. 0.1 M NaOH 처리시 EMCV는 15분 안에 검출한계 이하로 감소하였지만, HAV는 120분 정도의 처리에도 감염성 바이러스가 검출되었다. pH 3.9에서 25$^{\circ}C$로 14일 동안 항온하였을 때 HAV와 EMCV의 log 감소인수는 각각 1.63, 3.84이었다. 또한 혈액응고 8인자 제조공정의 동결건조 과정에서 HAV와 EMCV의 log 감소인수는 각각 1.21, 4.57이었다. 이와 같은 결과는 혈장유래의약품 제조공정의 HAV 불활화 또는 제거 검증시 모델 바이러스로 사용된 EMCV의 검증 결과를 해석함에 있어 보다 신중함을 가져야 한다는 것을 보여준다. 또한 보다 정확한 HAV검증 결과를 얻고자 한다면 모델 바이러스인 EMCV 보다 HAV를 사용하는 것이 보다 더 타당하다고 사료된다. Murine encephalomyocarditis virus (EMCV) has been used as a surrogate for hepatitis A virus (HAV) for the validation of virus removal and/or inactivation during the manufacturing process of biopharmaceuticals. Recently international regulation for the validation of HAV safety has been reinforced because of the reported cases of HAV transmission to hemophiliac patients who had received ntihemophilic factors prepared from human plasma. The purpose of the present study was to compare the resistance of HAV and EMCV to various viral inactivation processes and then to standardize the HAV validation method. HAV was more resistant than EMCV to pasteurization (60oC heat treatment for 10 hr), low pH incubation (pH 3.9 at 25oC for 14 days), 0.1 M NaOH treatment, and lyophilization. EMCV was completely inactivated to undetectable levels within 2 hr of pasteurization, however, HAV was completely inactivated to undetectable levels after 5 hr treatment. EMCV was completely inactivated to undetectable levels within 15 min of 0.1 M NaOH treatment, however, residual infectivity of HAV still remained even after 120 min of treatment. The log reduction factors achieved during low pH incubation were 1.63 for HAV and 3.84 for EMCV. Also the log reduction factors achieved during a lyophilization process of antihemophilic factor VIII were 1.21 for HAV and 4.57 for EMCV. These results indicate that HAV rather than EMCV should be used for the virus validation study and the validation results obtained using EMCV should be precisely reviewed.
3차원 컴퓨터 그래픽 기술을 이용한 KONUS 내관의 설계와 제작
김인섭,김병오,유관희,강동완,Kim, In-Sup,Kim, Byung-Oh,Yoo, Kwan-Hee,Kang, Dong-Wan 대한치과보철학회 2000 대한치과보철학회지 Vol.38 No.4
A fabrication method of inner and outer crown using CAD/CAM is presented. The information of abutment teeth is transferred to a computer through a 3-dimensional scanner. A Konus inner and outer crown is designed on a computer and a real crown is machined based on this design using CAM. This method can save laboratory time and reduce inaccuracies compare to conventional casting procedure. A stone model with six prepared abutment teeth from a patient was used in this study. Three dimensional information from the model was transferred to a computer using a contact type 3-dimensional scanner with a $25{\mu}m$ accuracy. All margins were identified on a computer image where there is a change in surface taper of a model. To provide a cement space, the image of a inner sur face of a Konus inner crown was duplicated $25{\mu}m$ apart from the surface of a prepared abutment teeth image. The cement space was $20{\mu}m$ at the cervical margin. All Konus crowns were machined with a $10{\mu}m$ accuracy. It was concluded that this method can reduce working-time for the laboratory process and increase accuracy. A further research is required to make a simplified process for a more complex prosthesis.
김인섭,강동완,Kim In-Sup,Kang Dong-Wan 대한치과보철학회 2002 대한치과보철학회지 Vol.40 No.1
This study was to evaluate the fabrication method and marginal adaptation of the conical inner crown fabricated with CAD/CAM. The informations on abutment teeth were transferred to a computer with a micro contact digitizer, which had a $50{\mu}m$ accuracy on the master die. A conical inner crown was designed on a computer and a real crown was machined based on this design using CAM. The marginal fit of a computer-machined conical inner crown was assessed using electron microscopy Measurement of the marginal gap between the conical inner crown and the abutment was performed on four different locations (mesial, distal, buccal, and lingual surfaces) of the finish line. The evaluation was based on 10 test specimens. The results were as follow. 1 The mean marginal gap between the conical inner crown and abutment tooth was $83.2{\pm}43{\mu}m$, 28.9% of the specimen showed marginal gap over $100{\mu}m$. 2. The fabrication method using CATRS and CAM provided clinically acceptable marginal fitness compared to conventional casting method (P<0.05).