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만성치주염 환자에 대한 저용량 독시싸이클린의 임상적 효과
김윤식,백정원,김창성,최성호,김종관,Kim, Yoon-Sik,Paik, Jeong-Won,Kim, Chang-Sung,Choi, Seong-Ho,Kim, Chong-Kwan 대한치주과학회 2002 Journal of Periodontal & Implant Science Vol.32 No.2
Periodontal disease is a complex infectious disease caused by bacteria in the oral mucosa, which results in gingival inflammation, breakdown of periodontal tissues, bone resorption, and finally tooth loss. Mechanical plaque control methods-scaling and root planing are effective methods to stop the progression of such periodontal disease. It was reported that subantimicrobial dose of doxycycline(SDD) regimen could improve clinical conditions of periodontal tissues without causing the overgrowth of opportunistic organisms that was a typical antibiotic side effect. Therefore pharmacological therapy, used in conjunction with mechanical therapy could be considered a useful treatment modality in the treatment of chronic periodontal disease. In this study, 30 patients diagnosed as moderate to advanced chronic periodontitis were divided into 2 groups. In this double-blind, placebo-controlled study, the patients were administered 20mg doxycycline capsule or placebo capsule b.i.d. for 4months, after scaling and root planing. Clinical parameters-bleeding on probing, pocket depth and clinical attachment level were compared and evaluated between these groups at periods of first visit, 1 month, 2 months, 3 months, 4 months. The results were as follows ; 1. In case of moderate periodontitis, pocket depth showed significant reduction after treatment in both the control & experiment groups, when compared with the baseline values(p<0.01), but in case of advanced periodontitis, only the experiment group showed significant reduction after treatment when compared with the baseline values(p<0.05). Statistically significant reduction in pocket depth was observed in the experiment group compared to the control group(p<0.05). 2. In case of moderate periodontitis, clinical attachment level showed significant reduction after treatment in both the control & experiment groups, when compared with the baseline values(p<0.01), but in case of advanced periodontitis, only the experiment group showed significant reduction after treatment when compared with the baseline values(p<0.05). Statistically significant reduction in clinical attachment level was observed in the experiment group compared to the control group(p<0.05). 3. Bleeding on probing improved after treatment in both the groups. In case of moderate periodontitis, the experiment group showed statistically significant reduction of bleeding on probing when compared with the control group at 1 and 4 months after treatment(p<0.05). In case of advanced periodontitis, treatment resulted in statistically significant reduction of bleeding on probing in both the groups(p<0.05). These results indicate that the use of subantimicrobial dose of doxycycline is a useful supplement to mechanical treatment for periodontal patients in ameliorating the clinical parameters such as periodontal pocket, attachment level, and bleeding on probing.
유전 알고리듬과 반응표면을 이용한 천음속 익형의 최적설계
김윤식,김종헌,이종수,Kim, Yun-Sik,Kim, Jong-Hun,Lee, Jong-Soo 대한기계학회 2002 大韓機械學會論文集A Vol.26 No.12
The design of airfoil had practiced by repeat tests in its first stage, though an airfoil has as been designed based on simulations according to techniques of computational fluid dynamics. Here, using of traditional optimization is unsuitable because a state of flux is hypersensitive to the shape of airfoil. Therefore the paper optimized the shape of airfoil in transonic region using a genetic algorithm (GA). Response surfaces are based on back propagation neural network (BPN) and regression model. Training data of BPN and regression model were obtained by computational fluid dynamic analysis using CFD-ACE, and each analysis has been designed by design of experiments.
H. pylori 감염 진단 시 <sup>14</sup>C-요소호기검사의 임상적 유용성
김윤식,Kim, Yoon-Sik 대한임상검사과학회 2007 대한임상검사과학회지(KJCLS) Vol.39 No.3
Helicobacter pylori (H. pylori) infection is common in korea and high incidence at gastric ulcer and duodenal ulcer. $^{14}C-urea$ breath test ($^{14}C-UBT$) is regarded as a highly reliable and non-invasive method for the diagnosis of H. pylori infection. The purpose of this study was to evaluate the diagnositc performance of a new and rapid $^{14}C-UBT$, which was equipped with Geiger-Muller counter and compared the results with those obtained by gastroduodenoscopic biopsies (GBx). One hundred sixty-eight patients (M : F = 118 : 50) underwent $^{14}C-UBT$, rapid urease test (CLO test), and GBx. The results of $^{14}C-UBT$ were classified as positive (>50 cpm), borderline (25<p<50 cpm), or negative (<25 cpm) and CLO tests were classified as positive or negative according to color change. The results of GBx on giemsa stain were distribution of H. pylori by the Wyatt method. We compared $^{14}C-UBT$ or CLO test results with GBx as a glod standard. In the assessment of the presence of H. pylori infection, the $^{14}C-UBT$ global performance yielded positive predictive value, negative predictive value and accuracy of 93.3% and 83.3%, respectively. However, the CLO test had performance yielded positive predictive value, negative predictive value and accuracy of 76.9%, 50.0%, respectively. In this study $^{14}C-UBT$ is a highly accurate, simple and non-invasive method or the diagnosis of follow up H. pylori infection.
병렬 컨버터에 의한 스위치모드 승압 정류기의 효율 개선
김윤식,김성환,오세진,이성근,전내석,Kim Yoon Sik,Kim Seong Hwan,Oh Sae Gin,Lee Sung Geun,Jeon Nae Sock 한국마린엔지니어링학회 2005 한국마린엔지니어링학회지 Vol.29 No.2
A new technique for improving the efficiency of single-Phase high-frequency switch-mode boost rectifiers is proposed. This rectifier includes an additional boost converter that parallels the main high-frequency switching device. The additional converter. which is controlled at lower frequencies. bypasses most of the current in the main switch and the high frequency switching loss is greatly reduced accordingly. The rectifier works cooperatively in high efficiency and as if it were a conventional rectifier with one switching device. The proposed scheme is verified by computer simulation using software PSIM.
임신 초기 임신양상에 따른 혈청 β-hCG의 결과 예측에 의한 희석배수 참고치 설정
김윤식,신장용,서영미,유신수,Kim, Yoon Sik,Shin, Jang Yong,Seo, Yeong Mi,Yoo, Shin Soo 대한임상검사과학회 2004 대한임상검사과학회지(KJCLS) Vol.36 No.2
This study was carried out to predict the value of serum ${\beta}$ subunit of humans chorionic gonadotropin(${\beta}$- hCG) in early pregnancy viability. This was performed among 85 women in vitro fertilization and embryo transfer(IVF-ET). The serum ${\beta}$-hCG levels were established for 30 normal singleton pregnancies, 10 twin and triplet pregnancies, 10 preclinical abortions, 10 clinical abortions, 20 biochemical abortions and 5 ectopic pregnancies. In comparison to normal singleton pregnancies, multiple pregnancies showed higher ${\beta}$-hCG. But clinical abortions, preclinical abortions and ectopic pregnancies showed lower ${\beta}$-hCG levels than singleton pregnancies. In conclusion, if we predict the value of serum ${\beta}$-hCG of variable early pregnancies and analyze it, we could predict the dilution protocol. Also, it can be useful in other ways.
김윤식,정규영,강명숙,전의식 ( Yun Shik Kim,Gyu Young Chung,Myoung Suk Kang,Eui Shik Jeon ) 한국환경생물학회 1994 환경생물 : 환경생물학회지 Vol.12 No.2
The flora of Kari-bong (1518.5m) was investigated to compare the flora of Mt. Sorak National Park, located close by this area. The vascular plants, collected from May, 1989 to October, 1992, were consisted of a total 652 taxa; 96 families, 348 genera, 569 species, 2 subspecies, 76 varieties and 5 forms. Among them, 554 taxa (85% of total taxa) were distributed in Mt. Sorak National Park. The Korean endemic plants of this area were 37 taxa, the rare and endangered plants were 27 taxa, the special wild plants designating by Environmental Agency were 12 taxa and the alpine plants were 34 taxa. Because many plants, being necessary to conserve, are distributed, Kari-bong should be include into Mt. Sorak National Park, but if development is indespensable, destruction of natrural ecosystem must be minimized.