두개인두종의 감마나이프 치료 후 장기 추적 결과

김윤석,이도희,라동숙,전영일,안재성,전상룡,김정훈,노성우,나영신,김창진,권양,임승철,이정교,권병덕,Kim, Yun Sok,Lee, Do Heui,Ra, Dong Suk,Chun, Young Il,Ahn, Jae Sung,Jeon, Sang Ryong,Kim, Jeong Hoon,Roh, Sung Woo,Ra, Young Shin,Kim, Chang Jin 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.2

Objectives : The optimal treatment of craniopharyngioma is controversial. Despite recent advances in microsurgical management, complete surgical removal of craniopharyngioma remains very difficult. Radiation added to surgery is effective, but radiation therapy resulted in untoward side effect in young patient. Gamma knife radiosurgery offers the theoretical advantage of a reduced radiation dose to surrounding structures during the treatment of residual or recurrent craniopharyngioma compared with fractionated radiotheraphy. We described retrospective analysis of tumor size and clinical symptoms of patients after gamma knife radiosurgery in residual or recurrent craniopharyngioma were performed. Material and Methods : From September 1990 to January 2000, 18 patients of craniopharyngioma were treated by gamma knife radiosurgery. All patient had undergone surgery, but residual or recurrent tumor was found and all of them treated postoperative gamma knife radiosurgery. The mean age was 19(from 6 to 66) and male to female ratio was 10 to 8 and 8 patients were below 15 years old. In young age group(below age 15), the average volume of the tumor was $2904.8mm^3$ and mean maximal gamma knife dose was 34.9Gy. In old age group(older than 15), the average volume of the tumor was $2590.4mm^3$ and mean maximal gamma knife dose was 45.2Gy. The size of the tumor was average $2730.1mm^3$($88-12000mm^3$), mean average radiation dose was 40.7Gy and the mean prescription dose was 17.6 Gy(4-35Gy) delivered to a median prescription 50.7% isodose. Results : The follow up was from 1 year to 9 years(mean 59.1 months) after gamma knife radiosurgery. The tumor was controlled in 13(72.2%) patients. The tumor decreased in 9 patients and not changed in 4 patients. The tumor size increased in 4(22.2%) patients during follow up period. In two cases the tumor size increased because of its cystic portion was increased, but their solid portion of the tumor was not changed. In another two patients, the solid portion of the tumor was increased. So, one patient underwent reoperation and the other patient underwent operation and repeated gamma knife radiosurgery. The tumor recurred in one case(5.6%) that is a outside of irradiated site. The presenting symptoms were improved in 4 patients(improved visual acuity in 1, controlled increased intracranial presure sign in 3 patients). In one case, visual acuity decreased after gamma knife radiosurgery. The endocrine symptoms were not influenced by gamma knife radiosurgery. Conclusion : Craniopharyngioma can be treated successfully by gamma knife radiosurgery. Causes of the tumor regrowth are inadequate dose planning because of postoperatively poor margination of the tumor, close approximation of optic nerve and residual tumors outside the target lesion. Recurrence can develop 4 years after gamma knife radiosurgery. Volume is important, but the accurate targeting is more important to prevent tumor recurrence. If the tumor definition is not clear during planning gamma knife surgery, long-term image follow up is required.

사장교의 동적 내풍안정성 검토를 위한 기본고유진동수 산정법 소개

김윤석,김기남,조상원,Kim, Yun-Seok,Kim, Gi-Nam,Jo, Sang-Won 한국도로교통협회 2005 도로교통 Vol.102 No.-

밀폐계 가연성 목재분진의 폭발에너지와 산소소모율에 관한 연구 - Part I: 폭발에너지의 정량화 및 폭발효율

김윤석,이민철,이근원,이동호,Kim, Yun Seok,Lee, Min Chul,Lee, Keun Won,Rie, Dong Ho 한국안전학회 2016 한국안전학회지 Vol.31 No.4

A dust explosion is a phenomenon of strong blast wave propagation involving destruction which results from dust pyrolysis and rapid oxidation in a confined space. There has been some research done to find individual explosion characteristics and common physical laws for various dust types. However, there has been insufficient number of studies related to the heat of combustion of materials and the oxygen consumption energy about materials in respect of dust explosion characteristics. The present study focuses on the relationship between dust explosion characteristics of wood dust samples and oxygen consumption energy. Since it is difficult to estimate the weight of suspended dust participating in explosions in dust explosion and mixtures are in fuel-rich conditions concentrations with equivalent ratios exceeding 1, methods for estimating explosion overpressure by applying oxygen consumption energy based on unit volume air at standard atmospheric pressure and temperature are proposed. In this study an oxygen consumption energy model for dust explosion is developed, and by applying this model to TNT equivalent model, initial explosion efficiency was calculated by comparing the results of standardized dust explosion experiments.

Improvement of Attenuation Characteristics for Multiple Coupled Line Structure on the Specific Lossy Media

김윤석,김민수,Kim, Yoon-Suk,Kim, Min-Su The Institute of Electronics and Information Engin 2011 電子工學會論文誌-TC (Telecommunications) Vol.40 No.6

본 논문에서는 손실매질의 다층구조로 이루어진 마이크로 스트립선로의 손실특성의 개선을 위한 새로운 구조를 제안한다. MIS 구조로 된 전송선로의 Si와 SiO2층 사이에 0전위를 가진 도체를 일정한 간격의 주기적인 배열로 고안된 새로운 모델의 MIS구조에 대한 유한차분법을 이용한 해석방법이 사용된다. 특히 전송선로에 대한 유전체의 영향을 줄이기 위하여 0전위를 가진 주기적인 결합의 도체로 이루어진 구조가 시간영역의 신호를 통해 시험된다. 다양한 0전위 도체의 간격(갭)에 따른 주파수 의존적인 추출된 전송선로 파라미터와 등가회로 파라미터가 주파수 함수로서 나타내진다. 또한 본 논문에서 고안된 구조에 대해 특성임피던스와 유효유전상수의 큰 변화 없이 대칭 결합선로의 quality factor가 개선됨을 볼 수 있다. In this paper, an analysis for a new substrate shielding symmetric coupled MIS structure consisting of grounded crossbar at the interface between Si and SiO2 layer using the Finite-Difference Time-Domain(FDTD) method is presented. In order to reduce the substrate effects on the transmission line characteristics, a shielding structure consisting of grounded crossbar lines over time-domain signal has been examined. Parameters of symmetric coupled MIS transmission line with various gaps between crossbars for even- and odd-mode are investigated as the functions of frequency, and the extracted distributed frequency-dependent transmission line parameters and corresponding equivalent circuit parameters as well as quality factor for the new MIS crossbar embedded structure are also presented. It is shown that the quality factor of the symmetric coupled transmission line can be improved without significant change in the characteristic impedance and effective dielectric constant.

장대 현수교의 보강형 가설시 내풍안정성에 관한 소고

김윤석,김기남,Kim, Yun-Seok,Kim, Gi-Nam 한국도로교통협회 2007 도로교통 Vol.107 No.-

일본의 해협횡단도로 프로젝트와 기술개발현황

김윤석,김기남,Kim, Yun-Seok,Kim, Gi-Nam 한국도로교통협회 2006 도로교통 Vol.103 No.-

중소기업의 기술개발

김윤석,Kim, Yun-Seok 한국레미콘공업협회 1987 레미콘 Vol.6 No.-

우분 퇴비화의 주발효과정 중 이화학적 및 미생물학적 파라미터의 변화

김윤석,강명규,배경숙,이규승,이영하,Kim, Yoon Seok,Kang, Myoung Kyu,Bae, Kyung Sook,Lee, Kyu Seung,Rhee, Young Ha 한국미생물학회 1997 미생물학회지 Vol.33 No.4

Various physico-chemical and microbiological parameters of a composting system were compared with respect to their potential use for the monitoring and evaluation of composting processes for cattle manure. The temperature changed within a range of $30-65^{\circ}C$ during the whole composting process, and the period of active composting (>$40^{\circ}C$) persisted for 16 days. The concentrations of total carbon, total nitrogen, and organic matter decreased by 15% during active composting, but significant changes in C/N ratio were not observed. The decrease of temperature in the latter period of active composting caused a decrease of $NH_4^+-N$ and an increase of $NO_3^--N$ in the composting pile. When temperature exceeded $50^{\circ}C$, the population of thermophiles was higher than that of mesophiles by more than 1 or 2 orders of magnitude. Correlation analyses showed that amylase activity correlated positively with the population of mesophiles and reducing sugar content, but negatively with the population of thermophiles. Amylase activity was higher at the beginning of active composting, whereas cellulase, xylanase and ligninase activities which showed close relationship with each other, increased continually during active cornposting, suggesting the distinction of temporal niches between amylose-degrading and lignocellulose-degrading bacteria in the same habitat. 주재료와 부재료로서 각각 우분과 톱밥이 함유된 유기성 폐기물 퇴비화의 주발효과정 중 이화학적 및 미생물학적 파라미터의 변화양상을 조사하고, 이로부터 퇴비화의 평가에 이용할 수 있는 각 파라미터간의 상관관계를 분석하였다. 퇴비화 전과정동안 온도는 $30-65^{\circ}C$, pH는 7.5-9.5, 함수율은 50-60% 정도의 범위에서 변하였으며, 이 중 $40^{\circ}C$ 이상의 고온이 유지되는 주발효 기간은 약 16일 정도 지속되었다. 주발효 기간 중 시료내 총탄소, 총질소 및 유기물 함량은 모두 15% 이상 감소되었으나, C/N ratio는 뚜렷한 변화를 보이지 않았다. 주발효 후기에는 암모니아성 질소 함량이 급격히 감소하고 질산성 질소가 증가되는 경향이 나타났다. 미생물 군집내 중온균과 고온균의 개체수는 퇴비화 과정동안의 온도변화와 밀접한 관계를 보였다. 중온균은 $50^{\circ}C$ 이상의 고온발효 기간에 급격히 감소하다가 온도가 낮아지는 주발효 후기에 다시 증가하는 반면에, 고온균은 이와 반대의 변화를 보였으며 주발효 기간 중 고온균의 개체수는 중온균에 비하여 $10-10^2$배 높았다. 조사된 토양효소 중 amylase 활성은 중온균의 개체수 및 환원당량과 높은 양의 상관관계를, 고온균의 개체수와는 음의 상관관계를 나타냈다. 이와는 달리 상호 유의할만한 양의 상관관계를 보인 cellulase, xylanase 및 ligninase의 활성은 주발효 기간 중 지속적으로 증가하는 양상을 보임으로써, 주발효 기간 중 lignocellulose 분해미생물과 amylose 분해미생물간의 출현양상이 크게 다름을 보여 주었다.

Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases

김윤석,Sang Geon Kim 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.4

Alcoholic and non-alcoholic liver diseases begin from an imbalance in lipid metabolism in hepatocytes as the earliest response. Both liver diseases share common disease features and stages (i.e., steatosis, hepatitis, cirrhosis, and hepatocellular carcinoma). However, the two diseases have differential pathogenesis and clinical symptoms. Studies have elucidated the molecular basis underlying similarities and differences in the pathogenesis of the diseases; the factors contributing to the progression of liver diseases include depletion of sulfhydryl pools, enhanced levels of reactive oxygen and nitrogen intermediates, increased sensitivity of hepatocytes to toxic cytokines, mitochondrial dysfunction, and insulin resistance. Endoplasmic reticulum (ER) stress, which is caused by the accumulation of misfolded proteins and calcium depletion, contributes to the pathogenesis, often causing catastrophic cell death. Several studies have demonstrated a mechanism by which ER stress triggers liver disease progression. Autophagy is an evolutionarily conserved process that regulates organelle turnover and cellular energy balance through decomposing damaged organelles including mitochondria, misfolded proteins, and lipid droplets. Autophagy dysregulation also exacerbates liver diseases. Thus, autophagy-related molecules can be potential therapeutic targets for liver diseases. Since ER stress and autophagy are closely linked to each other, an understanding of the molecules, gene clusters, and networks engaged in these processes would be of help to find new remedies for alcoholic and non-alcoholic liver diseases. In this review, we summarize the recent findings and perspectives in the context of the molecular pathogenesis of the liver diseases.

강풍에 의한 구조물의 사고로부터 얻은 교훈

김윤석,최동호,김기남,Kim, Yun-Seok,Choe, Dong-Ho,Kim, Gi-Nam 한국도로교통협회 2005 도로교통 Vol.100 No.-