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- 저자 : 김유찬 ( You Chan Kim ) (검색결과 149 건)
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자외선을 조사한 C57BL Mice에서 자외선 조사부 및 차단부 표피내 멜라닌 세포의 변화에 관한 연구
김유찬,윤재일 ( You Chan Kim,Jai Il Youn ) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.3
In this experiment 40 adult male C57BL mice were used. The one ear of each animal was irradiated with high pressure mercury lamp (Burdick'UV-800) and the other ear was covered with nontransparent tape. Using split epidermal sheets treated with DOPA solution, a quatitiative study of epidermal melanocyte was carried out from the exposed and the shielded ear continuously on every second day during 14 daily exposures to 100 mJ/cm of UVB. The results were as follows : 1. Repeated radiation with ultraviolet light elicited a significant increase in population of melanocytes and the possible mechanism is a direct replication of the functioning melanocytes. 2. UVB irradiation induced increase in the number of epidermal melanocytes in covered ear as well as in irradiated ear. It is suggested that the population increase in the shielded skin is initiated by one or more systemic factors originating from the UVB irradiated skin.
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모발로 분화하는 종양에 대한 임상 및 병리조직학적 소견 -대한피부과학회 피부병리 연구분과위원회 공동연구-
김유찬 ( You-Chan Kim ),강원형 ( Won-Hyoung Kang ),고재경 ( Jai-Kyoung Koh ),김낙인 ( Nack-In Kim ),김방순 ( Bang-Soon Kim ),김상원 ( Sang-Won Kim ),김수남 ( Soo-Nam Kim ),김수찬 ( Soo-Chan Kim ),노영석 ( Young-Suck Ro ),명기범 ( 대한피부과학회 2003 대한피부과학회지 Vol.41 No.9
Background : Data on the clinicopathologic features of hair follicle tumors in Korea are limited. Objective : The purpose was to investigate the clinical and histopathologic characteristics of hair follicle tumors in Korea. Methods : Two hundred sixty four cases of hair follicle tumors seen from 1999 to 2001 in Korea were analyzed clinically and histopathologically. Results and Conclusion : 1. The most common hair follicle tumor in Korea was pilomatricoma(81.0%), followed by trichoepithelioma(6.4%), dilated pore of Winer(3.8%), and proliferating trichilemmal tumor(2.2%). 2. Hair follicle tumors usually occurred as a solitary skin-colored nodule. The most commonly involved site was the face, and the peak age of presentation was 10 to 19. 3. Pilomatricoma usually occurred as a solitary skin-colored nodule. The most commonly involved site was the arm, and more than 50% of tumors occurred before the age of 20. Histopathologically, the tumor was often surrounded by fibrous capsule and was composed of basophilic and shadow cells. It was usually located in the dermis and extended into the subcutis. Retraction spaces between tumor nests and stroma were frequently observed. 4. Trichoepithelioma usually occurred as multiple skin-colored papules on the face. Histopathologically, the tumor was usually located in the dermis with sometimes connected to the epidermis. It frequently showed peripheral palisading. 5. Dilated pore of Winer usually occurred as a solitary brownish to pigmented papule on the face in middle-aged persons. 6. Proliferating trichilemmal tumor occurred as a solitary or multiple tumors. Histopathologically, the tumor was usually surrounded by incomplete fibrous capsule. Tumor cells frequently showed clear cell formation, nuclear atypia, mitosis, peripheral palisading, trichilemmal keratinization, and individual keratinization. (Korean J Dermatol 2003;41(9) : 1177~1186)
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What`s the diagnosis? The tricky things we dermatologists should know
김유찬 ( You Chan Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
There are so many similar pigmentary diseases, thus differential diagnosis is frequently difficult. However, for proper treatment, accurate diagnosis is important. Clinically and/or histologically mimicking pigmentary diseases including lichen planus pigmentosus/ashy dermatosis, acanthosis nigricans/confluent and reticulated papillomatosis, melasma/Rhiel`s dermatosis, Becker`s nevus/ erythromelanosis follicularis faciei and colli, idiopathic guttate hypomelanosis/hypopigmented hyperkeratosis, and other interesting pigmentary diseases will be discussed. The main clinical and histopathologic findings of these diseases and important differential diagnostic points for accurate diagnosis will be illustrated.
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PDT for AK, BCC, and Bowen`s disease
김유찬 ( You Chan Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Photodynamic therapy (PDT) involves activation of a photosensitizer by visible light to create cytotoxic oxygen species and free radicals, which selectively destroy rapidly proliferating cells. PDT is increasingly used in the treatment of oncologic conditions such as actinic keratosis (AK), basal cell carcinoma (BCC), and Bowen`s disease (BD). Various studies have tested the efficacy and safety of PDT in these conditions. PDT is effective both as a lesion- and field-directed treatment for AK. It has role where AKs are multiple and/or confluent and at sites of poor healing. Efficacy is relatively poorer for acral lesions. Cosmetic outcome following PDT for AK is superior to cryotherapy. PDT has been shown to be effective for BCC, with higher complete clearance rate for superficial BCCs than nodular BCCs. Therefore, for BCCs of more than 2-3mm in thickness, exophytic component of the lesions should first be removed. PDT is not suitable for morpheaform BCC and pigmented lesions. PDT is effective in BD and is at least as effective as cryotherapy or 5-FU, with superior cosmetic results. PDT has particular advantages on large or multiple BD lesions and lesions at poor healing sites. In Asians the complete clearance rates of AK, BCC, and BD after PDT was lower than those of Caucasians. A possible explanation may be the frequent pigmentation of BCC and BD lesions in Asians, which absorbs and prevents the penetration of light. Treatment is generally well-tolerated, but tingling discomfort or pain is common during PDT. The relatively long incubation time is one of the disadvantages of PDT. Reduced discomfort and/or enhanced effectiveness have been observed with novel protocols including shorter photosensitizer application time, daylight PDT and fractional carbon dioxide laser pretreatment. This presentation provides the effectiveness, side effects, and new method of PDT in AK, BCC, and BD lesions.
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