자외선을 조사한 C57BL Mice에서 자외선 조사부 및 차단부 표피내 멜라닌 세포의 변화에 관한 연구

김유찬,윤재일 ( You Chan Kim,Jai Il Youn ) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.3

In this experiment 40 adult male C57BL mice were used. The one ear of each animal was irradiated with high pressure mercury lamp (Burdick'UV-800) and the other ear was covered with nontransparent tape. Using split epidermal sheets treated with DOPA solution, a quatitiative study of epidermal melanocyte was carried out from the exposed and the shielded ear continuously on every second day during 14 daily exposures to 100 mJ/cm of UVB. The results were as follows : 1. Repeated radiation with ultraviolet light elicited a significant increase in population of melanocytes and the possible mechanism is a direct replication of the functioning melanocytes. 2. UVB irradiation induced increase in the number of epidermal melanocytes in covered ear as well as in irradiated ear. It is suggested that the population increase in the shielded skin is initiated by one or more systemic factors originating from the UVB irradiated skin.

수술후 방사선 조사에 의한 켈로이드 예방

김유찬,김홍식,박향준,신용우,윤형근,정성훈 ( You Chan Kim,Hong Sik Kim,Hyang Joon Park,Yong Woo Cinn,Hyong Guen Yun,Sung Hoon Jung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.5

Keloids are benign fibrcus growths which extend beyond the original wound and rarely regress. Available methods of treatment include surgical excision, radiotherapy, intralesional steroid injection, cryotherapy, systemie. chemotherapy, zinc tape strapping, pressure, silicon gel and combined therapy. Postoperative irradiation is a useful and effective method of eradication or prevent.ion of keloid. We describe two cases of the prevention of keloids associated with post,operative irradiation. (Korean J Dermatol 1997;35(5): 1009-1012)

적상 반상경피증 환자에서 발생한 속발성 피부 점액증

김유찬,전수일 ( You Chan Kim,Soo Il Chun ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1

The cutaneous mucinose are a group of connective disorders characterized by the deposition of mucin in the dermis. Thc disease may be a primary(metabolic) or secondary(catabolic). Secondary mucinosis is common in lupus erythematosus and dermatomyositis but rare in morphea. We report a case of guttate morphea with secondary cutaneous mucinosis. (Kor J Dermatol 1997;35(1): 165-168)

모발로 분화하는 종양에 대한 임상 및 병리조직학적 소견 -대한피부과학회 피부병리 연구분과위원회 공동연구-

김유찬 ( You-Chan Kim ),강원형 ( Won-Hyoung Kang ),고재경 ( Jai-Kyoung Koh ),김낙인 ( Nack-In Kim ),김방순 ( Bang-Soon Kim ),김상원 ( Sang-Won Kim ),김수남 ( Soo-Nam Kim ),김수찬 ( Soo-Chan Kim ),노영석 ( Young-Suck Ro ),명기범 ( 대한피부과학회 2003 대한피부과학회지 Vol.41 No.9

Background : Data on the clinicopathologic features of hair follicle tumors in Korea are limited. Objective : The purpose was to investigate the clinical and histopathologic characteristics of hair follicle tumors in Korea. Methods : Two hundred sixty four cases of hair follicle tumors seen from 1999 to 2001 in Korea were analyzed clinically and histopathologically. Results and Conclusion : 1. The most common hair follicle tumor in Korea was pilomatricoma(81.0%), followed by trichoepithelioma(6.4%), dilated pore of Winer(3.8%), and proliferating trichilemmal tumor(2.2%). 2. Hair follicle tumors usually occurred as a solitary skin-colored nodule. The most commonly involved site was the face, and the peak age of presentation was 10 to 19. 3. Pilomatricoma usually occurred as a solitary skin-colored nodule. The most commonly involved site was the arm, and more than 50% of tumors occurred before the age of 20. Histopathologically, the tumor was often surrounded by fibrous capsule and was composed of basophilic and shadow cells. It was usually located in the dermis and extended into the subcutis. Retraction spaces between tumor nests and stroma were frequently observed. 4. Trichoepithelioma usually occurred as multiple skin-colored papules on the face. Histopathologically, the tumor was usually located in the dermis with sometimes connected to the epidermis. It frequently showed peripheral palisading. 5. Dilated pore of Winer usually occurred as a solitary brownish to pigmented papule on the face in middle-aged persons. 6. Proliferating trichilemmal tumor occurred as a solitary or multiple tumors. Histopathologically, the tumor was usually surrounded by incomplete fibrous capsule. Tumor cells frequently showed clear cell formation, nuclear atypia, mitosis, peripheral palisading, trichilemmal keratinization, and individual keratinization. (Korean J Dermatol 2003;41(9) : 1177~1186)

외과적 절제술로 호전된 신경종성 상피병을 보이는 신경섬유종증

김유찬 ( You Chan Kim ),이정화 ( Jeong Hwa Lee ),신용우 ( Young Woo Cinn ),정민 ( Min Chung ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1

We report a case of elephantiasis neurofibromatosa in a 50-year-old female patient treated by in walking excision. She had difficulty in walking due to a huge mass on the abdomen. After surgical excision, she is leading a normal life and is very satisfied. (Kor J DErmatol 1996;34(1):136~140)

결절성 경화증의 초기 피부증상으로 나타난 전두부의 섬유성 판

김유찬(You Chan Kim),이정화(Jeong Hwa Lee),신용우(Yong Woo Cinn) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1

Tuberous sclerosis is a systemic disorder of hamartoma format on includes facial angiofibromas, subungal fibromas, hypomelanic maciles Shagreens patches. The earliest skin manifestation of tuberous sileiule, but it may appear later. We present a case of fibrous plaqu a recognized skin signs. Forehead plaque can be the earliest skin near in many organs. Skin involvement less forehead fibrous plaques, and vsis is usually hypornelanotic inacipearing before any of these more festation of tuberous sclerosis. Its presence may lead to early diagnosis and appropriate genetic couise hng hut may be a poor prognostic sign. (Kor J Dermatol 1995; 33(1): 201-205)

윤활유의 강력분사에 의해 발생한 지방 육아종

김유찬(You Chan Kim),신용우(Yong Woo Cinn),이정화(Jeong Hwa Lee) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1

Oil granuloma is a foreignbody reaction which occurs after injection of lipid usually for cosmetic or therapeutic reasons. I present a case of eyelid oil granuloma caused by accidental high pressure injury in a 39-year-old man. The patient had a 2 x 0.5cm sized, firm, normardear subcutaneous nodule on the Rt. upper eyelid. Histopathologic examination showed a characteris swiss-cheese appearance. Eyelid oil granuloma caused by high pressure injury is very rare and my case is the first described in Korean medical literatures. (Kor J Dermatol 1995; 33(1): 197-200)

국소 광역동요법으로 치료된 첨규 콘딜롬 1예

김유찬 ( You Chan Kim ),정필상 ( Phil Sang Chung ),이정구 ( Chung Ku Ree ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.9

A Tender Heel Mass

김유찬 ( You Chan Kim ),박향준 ( Hyang Joon Park ),신용우 ( Yong Woo Cinn ),( Daniel P. Vandersteen ) 대한피부과학회 2003 초록집 Vol.41 No.10

한국인에서 가계도 분석에 의한 백반증의 유전 양상 고찰

김유찬 ( You Chan Kim ),김욱 ( Wook Kim ),한승경 ( Seung Kyung Hann ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.6

Background: Vitiligo is a cornmon disorder whose cause is not well understood. Up to 30% of patients had another family member with vitiligo which means that vitiligo is a heritable condition. We could not find any study for the genetics of vitiligo in Korean literature. Objective : The purpose of this study was to clarify how genetic factors are involved in the pathogenesis of vitiligo in Korean patients. Methods : We analyzed the 65 Korean vitiligo probands and their families. Each family was ascertained through a proband afflicted with vitiligo. Results : 1. Focal type of vitiligo(44.6%) appeared to be with the highest frequency followed by the non-segmental generalized type(35.4%) and segmental type(20.0%). 2. The t,ype of vitiligo was not related with sex (p>0.9, X2 = 0.14). 3. There was a clear pattern of a familial aggregation of the vitiligo disease. In 29(44.6%) of these 65 proband families, at least one first-degree relative of the proband had vitiligo. The inci- dence of people affect.d among their 789 relatives (first, second and third-degree) was also found to be 9.13 1.03% 4. Several families in this study were shown to have father-son transmission of vitiligo, which indicates that vitiligo does not fit an x-linked inheritance. 5. There is a statistically significant departure frorn the expected which is inconsistent with a utosomal dominant inheritance (p<0.001, X2 = 52.32). 6. A single recessive model at the autosomal locus is not an explanation in deter mining the cause of vitiligo. The threshold trait among first-degree relatives(8.8%) shows a tendency to approach the square root of the frequency in the general population(10%) compared to those of dominant(50%) or recessive(25%) models. This. result is consistent with a model of multifactorial inheritence for vitiligo. Conclusion : These result indicate that vitiligo is determined by a polygenic nature. (Kor J Dermatol 1996;34(6): 968-972)