소아에서 발생한 Regional Lymphomatoid Papulosis 1 예

노영석 ( Young Suck Ro ),문득곤 ( Deug Gon Moon ) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.12

Lymphomatoid papulosis(LyP) is a chronic recurrent self-healing condition, with histological features suggestive of a malignant lymphoma. LyP usually develops in adults and lesions occur episodically over the trunk and limbs. Lymphomatoid papulosis has been reported only rarely in children. Furthermore localized and regional forms of lymphomatoid papulosis have been described very rarely. We report a case of CD30(Ki-1) positive LyP developed in childhood who had recurrent skin lesions confined to the face. (Korean J Dermatol 2001;39(12):1404~1406)

Gonococcal and nongonococcal urethritis

노영석 ( Young Suck Ro ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Overview: Urethritis - Infections/inflammation of the urethra - Categorized into those types caused by Neisseria gonorrhea and by other organisms ( Chlamydia trachomatis, Ureaplasma urealyticum, Trichomonas vaginalis, and herpes simplex virus) - Approximately, 30% of men infected with N. gonorrhea will have concomitant infection with C. trachomatis. - Most cases are acquired during sexual intercourse. Clinical presentations - Urethral discharge (varying significantly from profuse to scant amounts) and dysuria - Important to note that approximately 40% of patients with gonococcal urethritis are asymptomatic Diagnosis - Diagnosis of urethritis is confirmed by demonstrating an excess of polymorphonuclear cells in a stained smear. - It is critical to obtain the specimen from within the urethra, rather than from just the discharge. Management - Pathogen-directed antibiotic therapy is required. - In patients with gonococcal urethritis, ceftriaxone (125 mg intramuscularly) or cefixime (400 mg) may be used. - For patients with nongonococcal urethritis, treatment is with azithromycin (1 g) as a single dose or doxycycline (100 mg twice daily) for 7 days. - Sexual partners of the affected patients should be treated, and protective sexual practices are recommended.

Effect of dermatologic drugs in my experience

노영석 ( Young Suck Ro ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2

균상 식육종에서 발생한 Ki-1 양성 대형세포 림프종 1예

노영석 ( Young Suck Ro ),김윤석 ( Yun Suck Kim ),박찬금 ( Chan Keum Park ) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.5

Mycosis fungoides(MF) is a cutaneous T-cell lymphoma of low-grade malignancy characterized by the proliferation of small to medium-sized cerebriform lymphoid cells confined to the skin. It usually shows favorable prognosis, but morphologic transformation occurs in some cases and is often associated with a more aggressive clinical course. Herein we report a case of Ki-1 positive large cell lyrnphoma (Ki-1 LCL) which developed in the plaque stage of mycosis fungoides. Although the lesions responded well to low-dose methotrexate therapy and there was no evidence of local or systemic recurrence until now, continuous follow-up is needed because the prognosis of transformed MF is known to be poor compared with primary cutaneous Ki-1 LCL. We also discussed the differential diagnosis of primary cutaneous Ki-1 positive lymphoproliferative disorders. (Korean J Dermatol 1999;37(5) : 641-645)

임균의 항생제 감수성 검사에서 원판 확산법과 평판 희석법과의 상관관계에 관한 연구

노영석(Young Suck Ro),김영태(Young Tae Kim),김재홍(Jae Hong Kim),김중환(Joong Hwan Kim) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.2

In this study, we compared the MIC by agar plate dilution method with the inhibition zone diameters by ordinary disc diffusion method and 24 hr-prediffusion disc method on five antibiotics, respectively. The results were summarized as follows; 1. The agar plate dilution method and the ordinary disc diffusion method gave a satisfactory degree of correlation by linear regression. The correlation coeffecients were highly significant for penicillin (r= -0.88) and ampicillin(r = -0.91) but less significant for tetracyclin(r= -0.34), kanamycin(r= -0.55) and spectinomycin (r = -0.46). 2. Between the agar plate dilution method and the 24 hour-prediffusion disc method the correlation coeffecients were highly significant for penicillin(r= -0.9) and ampicillin (r= -0.91) but less so for tetracyclin(r= -0.4), kanamycin (r=-0.57) and spectinomycin(r=-0.5), 3. In relation to the MIC values by agar pate dilution method, the correlation coefficients were slightly higher and the slopes of linear regression were steeper for the 24 hour-prediffusion disc method than the ordinary disc diffusion method, but the differences were statistically not significant.

Patient consultation using ingredient information

노영석 ( Young Suck Ro ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

As there are increasing interests in cosmetics, the cosmetic industry is rapidly growing. Large number of cosmetic products is produced and available in the market. However, many of them are not strictly regulated and consumers are often exposed to skewed product information that is not evidenced by reliable clinical studies. Dermatologists are required to be asked more questions about cosmetics by patients, but it is not often easy to give them appropriate answer due to the lack of knowledge. Thus, dermatologists need to be aware of the theoretic actions of these cosmetic ingredients to guide patients to the best options and to protect them from expensive, ineffective, or even potentially harmful reaction. Many ingredients are used in including vitamins, ceramides, hydroxyl acids, peptides, sugar amines and metals. Although the biophysical effects may be slight after short use of cosmetics, they could improve skin texture and appearance with continuous use. For example, vitamin A (trans-retinoic acid) contributes to diminish fine wrinkles by increasing epidermal proliferation and inhibiting production of excess ground substance in photoaged skin. Ceramides, essential lipids for a normal stratum corneum water barrier, are shown to improve barrier function of damaged skin when applied topically. Other variable ingredients also have beneficial effects on skin. However, the actual effects could be different according to the mixture of ingredients, formulations of vehicles and individual skin characteristics. Dermatologists should recommend the best cosmetics to patients using the information by understanding variable factors of cosmetic ingredients and personal skin characteristics. In this lecture, I will discuss about the patient consultation using ingredient information with optimal skin care recommendations.

Dermatology medical litigation in precautionary approach

노영석 ( Young Suck Ro ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Luncheon Symposium 1 (LS 1) : Clinical efficacy of alitretinoin in patients with chronic hand eczema in Korea

노영석 ( Young Suck Ro ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

·Hand eczema (HE) is a common inflammatory skin disorder, characterized by erythema, edema, papules, vesicles, scaling, fissures, hyperkeratosis with pruritus or pain. ·Chronic hand eczema is defined as HE that persists for more than 3 months or returns twice or more within 12 months despite adequate dermatological therapy. ·Alitretinoin has recently been accepted as the only licensed systemic agent for treatment of CHE in patients unresponsive to potent topical corticosteroids. ·Several clinical trials including ``Benefit of Alitretinoin in Chronic Hand Eczema (BACH) study`` have demonstrated that taking alitretinoin is effective and well tolerated in the treatment of severe CHE. ·Taking 30 mg of oral alitretinoin for 12 weeks found to be effective in treating Korean patients with CHE.

Keratosis Follicularis Squamosa (Dohi)

노영석 ( Young Suck Ro ),황동규 ( Dong Kyu Hwang ) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.9

N/A

Alitretinoin for chronic hand eczema and other dermatological diseases

노영석 ( Young Suck Ro ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Alitretinoin, 9-cis retinoic acid, is a panagonist that binds to retinoid acid receptors and retinoid X receptors. It has recently been accepted as the only FDA-approved systemic agent for treatment of CHE in patients unresponsive to potent topical corticosteroids. Our clinical trials in Korean patients have demonstrated that taking alitretinoin is effective and well tolerated in the treatment of severe CHE. Recently, in many case reports, the treatment efficacy of oral alitretinoin has been increasingly reported in various inflammatory dermatoses such as atopic dermatitis, pityriasis rubra pilaris, oral lichen planus, nail lichen planus, palmoplantar pustular psoriasis, lichen amyloidosis, cutaneous lupus erythematosus, palmoplantar mycosis fungoides, disseminated superficial actinic porokeratosis, as well as CHE. In this lecture, I will discuss the efficacy of alitretinoin for the treatment of CHE and other various dermatological diseases based on clinical experience and literatures that have been reported until now.