자외선을 조사한 C57BL Mice에서 자외선 조사부 및 차단부 표피내 멜라닌 세포의 변화에 관한 연구

김유찬,윤재일 ( You Chan Kim,Jai Il Youn ) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.3

In this experiment 40 adult male C57BL mice were used. The one ear of each animal was irradiated with high pressure mercury lamp (Burdick'UV-800) and the other ear was covered with nontransparent tape. Using split epidermal sheets treated with DOPA solution, a quatitiative study of epidermal melanocyte was carried out from the exposed and the shielded ear continuously on every second day during 14 daily exposures to 100 mJ/cm of UVB. The results were as follows : 1. Repeated radiation with ultraviolet light elicited a significant increase in population of melanocytes and the possible mechanism is a direct replication of the functioning melanocytes. 2. UVB irradiation induced increase in the number of epidermal melanocytes in covered ear as well as in irradiated ear. It is suggested that the population increase in the shielded skin is initiated by one or more systemic factors originating from the UVB irradiated skin.

적상 반상경피증 환자에서 발생한 속발성 피부 점액증

김유찬,전수일 ( You Chan Kim,Soo Il Chun ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1

The cutaneous mucinose are a group of connective disorders characterized by the deposition of mucin in the dermis. Thc disease may be a primary(metabolic) or secondary(catabolic). Secondary mucinosis is common in lupus erythematosus and dermatomyositis but rare in morphea. We report a case of guttate morphea with secondary cutaneous mucinosis. (Kor J Dermatol 1997;35(1): 165-168)

수술후 방사선 조사에 의한 켈로이드 예방

김유찬,김홍식,박향준,신용우,윤형근,정성훈 ( You Chan Kim,Hong Sik Kim,Hyang Joon Park,Yong Woo Cinn,Hyong Guen Yun,Sung Hoon Jung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.5

Keloids are benign fibrcus growths which extend beyond the original wound and rarely regress. Available methods of treatment include surgical excision, radiotherapy, intralesional steroid injection, cryotherapy, systemie. chemotherapy, zinc tape strapping, pressure, silicon gel and combined therapy. Postoperative irradiation is a useful and effective method of eradication or prevent.ion of keloid. We describe two cases of the prevention of keloids associated with post,operative irradiation. (Korean J Dermatol 1997;35(5): 1009-1012)

A Tender Heel Mass

김유찬 ( You Chan Kim ),박향준 ( Hyang Joon Park ),신용우 ( Yong Woo Cinn ),( Daniel P. Vandersteen ) 대한피부과학회 2003 초록집 Vol.41 No.10

소아에서의 백반증과 탈색모반 - 임상 및 DOPA 염색에 의한 비교연구 -

김유찬(You Chan Kim),김선훈(Seon Hoon Kim),박경찬(Kyoung Chan Park),이유신(Yoo Shin Lee) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.4

We performed analysis of 79 childhood patients diagnosed as vitiligo and nevus depigmentosus in Tediatric Dermatologie Department of Seoul National University Hospital from March 1987 to September 1987. The results were as follows : 1. Of the 79 patients, 31 patients(39.2%) were vitiligo 21 patients(26.6% )were nevus depigmentosus and 27 patients(34.2%)were uncertain by cliniral diagnostic ctriteri.. 2. Viiligo began rarely in infancy(6.4% )and most appeared evenly in all childhood over 1 year old. Nevus clepigmentosus was present at birth in 57.1% of patients and was discovered within the first 6 months after birth in 42.9% of patients. 3. In vitiligo, most lesions were multiple. The most common site of involvement was the face, and there was this tendency of periorficial predisposition. In nevus ciepigmentosus, most lesions were solitary. The most, common aites of involvement were the lowed limbs and trunk, but there was no tendency of periorfcial presposition. 4. We found focal type of vitiligo in,51,6% of patients, vulgaris type in 32. 3 % acrofacial type in 9.6% and segmerital type in 6.5%. We also found isolated pattern of nevus clepigrnento us in 76.2% of patients, ciermatomal p<:ttern in 19.0ki and whorlec1 pattern in 4.8% The contrast enhiancement between the hypopigmented skin and nomal surrounding skin by Wood's light, examinatior reflected the epiclermal melanin pig merit, i. e., the more marked loss of pigmentation, the more accentuatian of the contrast The before, Wood's light examination without I:3OPA staining could help to ciiagnose the atisculte type of vitiligo showing eidermal melanocytes and nevu c.Iepigmeritosus.

방추형 황색육아종 1 예

김유찬(You Chan Kim),김경호(Kyung Ho Kim),이증훈(Jeung Hoon Lee) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.3

The typical juvenile xanthogranuloma contains histiocytes with a variety of cellular features. Five types of juvenile xanthogranuloma have been described: vacuolated, xanthomatized, scalloped, oncocytic, and spindle-shaped. Spindle cell xanthogranuloma is a rare variant of juvenile xanthogranuloma characterized by predominance of spindle-shaped histiocytes. It occurs mainly in adults and less commonly in children. We report a case of spindle cell xanthogranuloma in a 4 month-old infant. (Korean J Dermatol 2001; 39(3): 385~387)

기저세포암과 편평세포암에서 세포각질의 발현에 관한 연구

김유찬 ( You Chan Kim ),한봉균 ( Bong Gyun Han ),박향준 ( Hyang Joon Park ),신용우 ( Yong Woo Cinn ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.12

Background : The histologic distinction between basal cell carcinoma(BCC) and squamous cell carcinoma(SCC) is sometimes difficult, but clinically important, because SCC has worse prognosis than BCC. Cytokeratins(CKs) are the major component of intermediate filaments and are subdivided into at least 20 different polypeptides. Monoclonal antibodies developed against these individual keratins become very useful in the classification of the major types of epithelial tumors. Objective : The purpose was to investigate the usefulness of CK staining in distinguishing BCC from SCC. Methods : We studied 10 cases of BCC and 10 cases of SCC with 6 anticytokeratin antibodies including AEI, CAM5.2, CK7, CKl6, CK10, and CK8. Results : All cases of BCC and SCC stained with AEI. Six and 5 cases out of 10 cases of BCC stained with CAM5,2 and CK7, respectively, but all cases of SCC stained with neither CAM5.2 nor CK7. All cases of SCC stained with CKl6, but all cases of BCC did not. Two out of 10 cases of SCC stained focally with CK10, while all cases of BCC did not stain with CK10. All cases of BCC and SCC did not stain with CK8. Conclusion : We conclude that a panel of antibodies for CKs including CK7, CAM5.2, and CKl6 may be useful in distinguishing BCC from SCC. In particular, CKl6 may be the most useful marker because it was positive for all cases of SCC while negative for all cages of BCC. (Korean J Dermatol 2002;40(12) : 1481∼1486)

색소성 피부질환에 대한 구리증기 레이저 치료후 임상, 조직, 면역조직화학적 소견

김유찬 ( You Chan Kim ),한봉균 ( Bong Gyun Han ),박향준 ( Hyang Joon Park ),신용우 ( Yong Woo Cinn ),이정구 ( Chung Ku Rhee ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.12

Background : There have been only a few morphological studies after laser treatment of pigmented skin lesions. Objective : The purpose was to investigate the clinicopathologic and immunohistochemical changes following copper vapor laser treatment of superficial pigmented skin lesions. Methods : Three patients with Becker`s nevus, 1 patient with partial unilateral lentiginosis, and 1 patient with nevus spilus were irradiated with copper vapor laser. Forty-two biopsies were taken before, immediately after, and 3 months after laser treatment. Hematoxylin-eosin, Fontana-Masson, and S-100 protein staining were performed for the evaluation of the histopathologic and immunohistochemical findings of the specimens. Results : Clinically, immediate greyish whitening, immediate erythema, and delayed edema were observed immediately after copper vapor treatment. Histopathologically, suprabasilar separation with elongated cells in the basal cell layer was observed immediately after laser treatment. A few vacuolated cells were found mainly in the basal cell layer. Fontana-Masson and S-100 protein staining positivity decreased a lot in the epidermis, but they hardly decreased in the dermis immediately after laser treatment. Conclusion : For the treatment of pigmented skin lesions, copper vapor laser was more effective in the epidermal pigmented structures than the dermal pigmented structures. Selective photothermolysis of melanosome was not so prominent after copper vapor laser treatment. (Korean J Dermatol 2002;40(12) : 1468∼1473)

한국 청년층에서 조사 부위에 따른 UVB의 최소홍반량 비교

김유찬 ( You Chan Kim ),송원근 ( Won Keun Song ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2

Background: The erythemal response of the skin to UVB radiation is used as a diagnostic phototest and guideline to phototherapy. Objective : The purpose of this study was to compare the UVB-induced MEDs to the back, arm, and thigh skin Methods: A sunlight fluorescenct lamp(Waldmann UV 7001K) was used as a UVB radiation source. The back, arm, and thigh skin were irradiated with the dose, from 40mJ/cm2 to 180mJ/cm2. The minimal doses for erythema responses to the skin were assessed visually at 24 hours after irradiation Results : MEDs of the back, arm and thigh skin were 92.6 + 17.3mJ/cm2(mean + S.D.), 123.0 + 24.2mJ/cm2, and 126.6+ 28.3mJ/cm2, respectively. The most frequent MED was 100mJ/cm2 for the back skin and 120mJ/cm' for the arm skin and thigh skin. Conclusion : In this study, UVB-induced MEDs to the back, arm, and thigh skin in young adult Koreans were assessed. A significant difference in the MED was found between the back and extremities skin, with a lower value for the back skin(92.6 + 17.3mJ/cm2) than for the arm skin(123.0 + 24.2mJ/cm2) or for the thigh skin(126.6 + 28.3mJ/cm2). (Korean J Dermatol 1998;36(2) : 261-265)

결절성 경화증의 초기 피부증상으로 나타난 전두부의 섬유성 판

김유찬(You Chan Kim),이정화(Jeong Hwa Lee),신용우(Yong Woo Cinn) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1

Tuberous sclerosis is a systemic disorder of hamartoma format on includes facial angiofibromas, subungal fibromas, hypomelanic maciles Shagreens patches. The earliest skin manifestation of tuberous sileiule, but it may appear later. We present a case of fibrous plaqu a recognized skin signs. Forehead plaque can be the earliest skin near in many organs. Skin involvement less forehead fibrous plaques, and vsis is usually hypornelanotic inacipearing before any of these more festation of tuberous sclerosis. Its presence may lead to early diagnosis and appropriate genetic couise hng hut may be a poor prognostic sign. (Kor J Dermatol 1995; 33(1): 201-205)