축소 규모의 부속실 단독 제연구역 화재시뮬레이션 결과 분석

김수영(Su Young Kim),유우준(Woo Jun You) 한국화재소방학회 2023 한국화재소방학회 학술대회 논문집 Vol.2023 No.1

이트라코나졸(itraconazole)액의 첨가물에 의해 발생한 지연형 두드러기 및 혈관부종 1예

김수영 ( Soo Young Kim ),최길순 ( Gil Soon Choi ),김희규 ( Hee Kyoo Kim ),김제훈 ( Je Hun Kim ),김철수 ( Cheol Su Kim ),양정욱 ( Joung Wook Yang ),유가인 ( Ga In You ),이진영 ( Jin Young Lee ) 대한천식알레르기학회(구 대한알레르기학회) 2014 Allergy Asthma & Respiratory Disease Vol.2 No.2

Itraconazole, new triazole agent with a broader antifungal spectrum than fluconazole, has been prescribed widely in the treatment and prophylaxis for fungal infection. Itaconazole has been reported to have gastrointestinal disturbance (4%) and headache (1%) as its most common side-effects. However, allergic reactions caused by this drug are rare. A 53 year-old woman with myelodysplastic syndrome received prophylactic antibiotic therapy including itraconazole solution before chemotherapy. She complained of hive on the face with angioedema at 6 hours after taking them. The symptoms were more aggravated on the next day and reversed by stopping itraconazole solution and injection of antihistamine and steroids. Skin prick tests with itraconazole solution, itraconazole tablet, and ketoconazole showed all the negative responses. The oral challenge test with itraconazole solution was performed and resulted in urticaria and angioedema 6 hours later. Next, the oral challenge test with intraconazole tablet was performed and showed negative response. The patient was finally diagnosed as adverse reaction by additives contained intraconazole solution. We report, a case of delayed onset urticaria and angioedema caused by components of itraconazole solution. (Allergy Asthma Respir Dis 2014;2:138-141)

망막중심정맥폐쇄환자에서 안구생체계측치에 관한 분석

이유경(You Kyung Lee),양지욱(Ji Wook Yang),이영춘(Young Chun Lee),김수영(Su Young Kim) 대한검안학회 2011 Annals of optometry and contact lens Vol.10 No.2

목적: 단안 망막중심정맥폐쇄환자에서 이환된 눈과 반대측 정상안의 안구생체계측치 비교를 통해서 안구생체계측치가 망막중심정맥폐쇄의 발생과 연관이 있는지를 알아보고자 한다. 대상과 방법: 단안 망막중심정맥폐쇄로 진단받은 환자 20명을 대상으로, 이환된 눈과 반대측 정상안의 각막곡률, 전방 깊이, 유리체 깊이, 수정체 두께, 안축장을 비교하였다. 결과: 단안 망막중심정맥폐쇄 환자에서 이환된 눈은 정상안에 비해 전방 깊이와 유리체 깊이가 통계학적으로 유의하게 짧았으며(p=0.01, p=0.002), 수정체 두께가 유의하게 두꺼웠다(p=0.012). 각막곡률, 안축장은 통계학적으로 유의한 차이가 없었다(p>0.05). 결론: 단안 망막중심정맥폐쇄 환자에서 전방 깊이와 유리체 깊이가 이환된 눈에서 정상안에 비해 더 짧고, 수정체 두께가 더 두꺼웠다. 유리체 깊이가 짧고, 수정체가 두꺼운 것은 공막사상판에서 망막중심정맥과 동맥의 밀집을 일으켜 망막중심정맥폐쇄를 유발하는 원인이 될 수 있다. Purpose: To evaluate the association of biometric indices with central retinal vein occlusion (CRVO). Methods: The study group consisted of 20 patients with unilateral CRVO. The mean keratometry (mean K), anterior chamber depth (ACD), vitreous length (VL), lens thickness (LT) and axial length (AL) were measured in both eyes. Results: The anterior chamber depth and vitreous length of affected eyes were significantly shorter than those of unaffected eyes in the CRVO group (p=0.01, p=0.002). The lenses of affected eyes were significantly thicker than those of unaffected eyes (p=0.012). Although affected eyes had higher mean keratometry and shorter axial length, the differences were not significant (p>0.05). Conclusions: Anterior chamber depth and vitreous length of eyes with CRVO may be shorter than unaffected eyes. And lens of eyes with CRVO may be thicker than unaffected eyes. The causal relationship between shallow anterior chamber and CRVO is not clear. So, further studies are needed. Short vitreous length and thick lens may predispose them to more crowding of central retinal vein and artery in lamina cribrosa, and developing CRVO.

필터의 기공율 크기 변화를 고려한 불티 포집 기초 실험

이재운(Jae Woon Lee),김수영(Su Young Kim),유우준(Woo Jun You) 한국화재소방학회 2023 한국화재소방학회 학술대회 논문집 Vol.2023 No.1

한방병원에 입원한 환자군에서 간기능 검사 이상자의 빈도 조사

한창우(Chang-Woo Han),김수영(Su-Young Kim),민관식(Kwan-Sik Min),이진혁(Jin-Hyuk Lee),이상호(Sang-Ho Lee),윤유석(You-Suk Youn) 대한한의학회 2010 대한한의학회지 Vol.31 No.2

일개 부산지역 3차 병원에서 관찰한 다제내성 결핵의 실태, 2005~2009

윤늘봄 ( Neul Bom Yoon ),이성우 ( Sung Woo Lee ),박수민 ( Su Min Park ),정일환 ( Il Hwan Jeong ),박소영 ( So Young Park ),한송이 ( Song Yee Han ),이유림 ( Yu Rim Lee ),정진규 ( Jin Kyu Jung ),김준모 ( Joon Mo Kim ),김수영 ( Su You 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.2

Background: Although the prevalence of pulmonary tuberculosis has progressively decreased all over the world, drug-resistant tuberculosis is major obstacle in treating tuberculosis. This study was performed to examine the current prevalence and risk factors of drug resistant tuberculosis in a single tertiary hospital in Busan, Korea. Methods: We enrolled 367 patients with active pulmonary tuberculosis on a retrospective basis who had undergone mycobacterium culture and drug sensitivity tests between January 2005 and December 2009. We analyzed all clinical and radiographic parameters to find predictors related to drug resistant tuberculosis. Results: At least one incident of drug resistance was found in 75 (20.4%) patients. Isoniazid (18.8%) was the most frequent resistant drug, followed by rifampin (10.9%), ethambutol (7.1%), streptomycin (4.9%), and fluoroquinolone (2.7%). Resistance to second-line drugs was found in 37 (10.1%) patients. Multidrug resistance and extensively drug resistance was evident in 39 (10.6%) and 4 (1.1%) patients, respectively. Using multiple logistic regression analysis, history of previous treatment including relapse (odd ratio [OR], 11.3; 95% confidence interval [CI], 4.92~ 26.08; p<0.01), treatment failure (OR, 24.1; 95% CI, 5.65~102.79; p<0.01) and an age of below 46 years-old (OR, 3.8; 95% CI, 1.62~8.65; p<0.01) were found to be independent predictors of multidrug resistant tuberculosis. Conclusion: We found that the prevalence of drug resistant tuberculosis was considerably high. A careful consideration for possible drug resistant tuberculosis is warranted in patients with a history of previous treatment or for younger patients.

악성 담도협착증에서 내시경적 쇄자세포진 검사의 진단적 유용성

김병호,이동근,김효종,김수영,이병욱,장린,동석호,장영운,박병헌,황유철,이정일 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.3

Backgrounds/Aims: In patients with obstructive jaundice due to malignant biliary tract stricture, a tissue diagnosis is essential because the various treatment options are available. The tissue biopsy form the biliary tree is difficult because of the focal, sclerotic, small annular nature and lower celluarity. Brush cytology is and effective method for obtaining a tissue from bile duct stricture, and the diagnostic sensitivity of endoscopic brush cytology is reported as between 40% and 70% form malignant bile duct strictures. In this study, we analyzed the diagnostic value of endoscopic brush cytology in patient with extrahepatic bile duct strictures. Methods: The eight patients with extrahepatic bile duct strictures diagnosed with endoscopic retrograde cholangiopancretography underwent endoscopic brush cytology and aspiration bile cytology. Brushing were taken using a Greenen cytology brush passed with a guide wire through the stricture. Results: The final diagnoses were made by surgical pathology and clinical follow-up. The sensitivity of brush cytology (62.5%, 5/8) was significantly higher than the sensitivity of bile cytology (0%; 0/8). No procedure related complication occurred. Conclusions: Endoscopic brush cytology would be an effective and a relatively safe method for tissue diagnosis in patients with malignant biliary obstruction.

Klebsiella 균혈증에 대한 임상적 고찰

이병욱,박병헌,오혜림,이호종,김수영,민선기,황유철,김경진,서환조 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.4

1988년 1월부터 1997년 12월까지 10년간 경희의료원에 입원했던 환자 중, 세균학적 검사로 확진된 157예의 Klebsiella 균혈증에 대한 임상적 관찰을 하여 다음과 같은 결과을 얻었다. 1) Klebsiella 균혈증의 발생빈도는 입원환자 1000명 3당, 0.79건이었다. 2) 성별로는 남자가 88(56%)명이었고, 여자가 69(44%)명이었으며, 연령별로는 신생아가 19명, 1세에서 39세 사이가 28명, 40세에서 59세 사이가 53명, 60세 이상은 57명이었고 평균 나이는 47.6세였다. 3) 분리빈도는 K. pneumoniae(146명 ; 94%), K. oxytoca(10명 ; 6.4%), K. ozaenae(1명 ; 0.6%)순이었고, 다균주가 배양된 경우는 8예(5.1%)에서 있었다. 4) 원외감염은 87명(55.4%)이었고, 원외감염은 70명(44.6%)이었다. 5) 원발병소는 비뇨기계(35명;22.3%), 간담도계(33명;21%), 호흡기계(27명;17.2%), 복막(6명;3.8%), 정막카데터(5명;3.2%), 기타(3명;1.9%) 순이었고, 원발병소가 밝혀지지 않은 경우는 48명(30.6%)이었다. 6) 기저질환으로는 당뇨병, 고형암, 뇌혈관질환, 담석증, 간경변, 미숙아, 혈액암, 알콜중독증, 만성신부전 등의 순으로 많았다. 7) 가장 흔한 임상양상은 발열(129명;82.2%)이었고, 백혈구 증다증은 117(74.5%)명에서 나타났으며, 범발성혈관내응고증, 패혈성쇽, 급성신부전은 각각 18.5%, 17.8%, 14.6%에서 나타났다. 8) 항균제 감수성 검사에서 β-lactam계열의 ampicillin, carbenicillin, cephlothin에는 각각 87.9%, 91.7%, 27.6%의 내성률을 나타냈고, aminoglycoside계통의 getamicin, tobramycin, kanamycin, amikacin에는 각각 22.3%, 22.9%, 17.4%, 1.3%의 내성률을 나타낸 반면, quinolone 계통의 ciprofloxacin과 ofloxacin에는 각각 3.6%, 0.9%의 내성을 보였으며 imipenem에 대해서는 모든 균주가 감수성을 보였다. 9) Klebsiella 균혈증의 사망률은 22.3%이었다. 10) 원발병소가 호흡기계와 복막인 경우, 부적절한 항균제 치료를 한 경우, 치료 도중 범발성혈관내응고증, 패혈성쇽, 급성신부전이 발생한 경우는 높은 사망률을 보였다. 11) 본 연구기간의 후반기에는 전반기보다 중증감염의 빈도가 많았다. 결론 : 이상의 결과에서 Klebsiella 균혈증은 신생아와 여러 가지 기저질환이 있는 성인환자에서 주로 발생하였고, 최근 들어 다약제 내성 균주의 급속한 출현에 의한 중증 감염이 증가하는 양상을 보이고 있으므로, 감수성 검사에 의한 적절한 항균제 선택이 환자의 치료 및 예후에 중요할 뿐만 아니라 내성 균주의 출현을 줄이는데 기여할 것이다. A clinical review on 158 patients with Klebsiella bacteremia among the patients who admitted to Kyunghee University Hospital from January 1988 to December 1997 was done. The incidence of Klebsiella bacteremia was 0.79 cases per 1000 admitted patients. The disease was community acquired in 55.4%. nosocomically acquired in 44.6%. 146 cases were caused by Klebsiella pneumoniae, 10 cases by Klebsiella oxytoca, one case by Klebsiella ozaenae, and 8 episodes were a part of a polymicrobial bacteremia. Portals of entry were urinary tract (22.3%), hepatobiliary tract (21%), pulmonary tract (17.2%), peritoneum (3.8%), intravenous tract (3.2%), and others (1.9%) in decreasing order of frequency. In 30.6% of patients, site of origin of the bacteremia could not be identified. Underlying diseases frequently encountered were diabetes, solid cancers, cerebrovascular accident and cholelithiasis. The most frequent clinical finding was fever (15 patients) , and the second was leukocytosis (117 patients). Disseminated intravascular coagulation septic shock and acute renal failure occurred in 18.5%. 17.8%. and 14.6% respectively. The isolated strains were resistant to ampicillin in 87.9% and to gentamicin in 22.3%, and all the isolates were sensitive imipenem. The overall mortality was 22.3%. THe higher mortality was shown in cases that patients received inappropriate antibiotic treatment, and disseminated intravascular coagulation, septic shock, and acute renal failure occurred during the disease courses, and portals of entry were pulmonary tract and peritoneum. In conclusion, Klebsiella bacteremia commonly occurred in neonates and adult patients with underlying diseases. Recently, the incidence of severe infections caused by multi-drug resistant strains is increasing. Appropriate antibiotic therapy is important in the prognosis and may reduce the appearance of resistant strains.