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식도절제술 환자에서 식도내압 및 위배출시간에 대한 고찰
이철종(Cheol Jong Lee),최석렬(Seok Reyol Choi),지삼룡(Sam Ryong Jee),김광진(Kwang Jin Kim),금동주(Dong Joo Keum),홍기봉(Ki Bong Hong),이종훈(Jong Hun Lee),한상영(Sang Young Han),최필조(Pill Jo Choi) 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.2
N/A Backgroud/Aims: Resection of the esophagus for malignant disease or a benign stenosis, has a choice not only of palliative surgery, but also of replacement of the esophagus with a transposed stomach, jejunum, or colon. The first-line method is replacement with a tubulized stomach. The purpose of this study was to investigate the association of esophageal motor dysfunction and gastric emptying time with symptoms after esophagectomy. Methods: We performed the esophageal manometry and gastric emptying time after esophagectomy for esophageal cancer in 12 patients and for benign esophageal disease in 2 patients. Results: In manometric studies, a zone of high pressure in the esophago-gastric anastomosis distal to the upper esophageal sphincter was associated with symptoms after esophagectomy. The gastric emptying rate was slowed in 7 out of 14 patients, but not associated with symptoms after esophagectomy. Conclusions: Our data suggest that a high-pressure zone distal to the upper esophageal sphincter was associated with symptoms after esophagectomy in manometric study. The gastric emptying rate was not associated with postoperative symptoms. (Korean Journal of Gastrointestinal Motility 2001;7:197-203)
포스터 발표 : 간 ; 만성 B형 간염환자에서의 라미부딘 단독치료의 효과
김광진 ( Kwang Jin Kim ),신우원 ( Woo Won Shin ),정동엽 ( Dong Yup Jung ),조정환 ( Jung Hwan Jo ),이종훈 ( Jong Hun Lee ),한상영 ( Sang Young Han ),최석렬 ( Seok Ryeol Choi ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 라미부딘은 뉴클레오사이드 유도체로서 B형 간염바이러스의 증식을 억제하여 간기능과 조직학적 소견의 혼전을 일으키는 것으로 알려져 있다. 투약의 간편성과 부작용이 별로 없다는 장점이 있으나, 일부에서 약제 내성이 유발된다는 단점이 있다. 본 연구는 만성B형 간염환자들에서 라미부딘 단독투여로 치료효과와 내성 발생을 및 각각의 예측인자에 대해서 알아보기로 하였다. 〈대상과 방법〉 동아의대 동아대학교병원에 내원하여 만성 B형 간염을 진단받은 환자들 중
위선암에서 Helicobacter pylori 독성인자와 유전자 아형의 관련성
신종민,한상영,금동주,김광진,지삼룡,홍기봉,이종훈,최석렬,신우원,Shin Jong Min,Han Sang Young,Keum Dong Joo,Kim Kwang Jin,Jee Sam Ryong,Hong Gi Bong,Lee Jong Hun,Choi Seok Ryeol,Shin Woo Won 대한위암학회 2002 대한위암학회지 Vol.2 No.1
Purpose: The H. pylori cagA gene, vacA gene and iceA gene are considered to be important virurence factors that have been implicated in the development of gastric adenocarcinoma. It was reported that the presence of IS605 elements may be responsible for rearrangements and lead to partial or total deletions of the cag pathogenicity island (PAI) and the virulence of cag PAI may be changed. However, different results regarding the association between these virulence factors and clinical disease have been reported from different geographic regions. This study evaluated the relationship between H. pylori virulence factors such as cagA, vacA, iceA, IS605 and gastric adenocarcinoma. Materials and Methods: H. pylori isolates were obtained from 54 infected patients (24 cases of gastric adenocarcinoma, 30 cases of control). H. pylori isolates were identified by PCR with ureC gene and 16S rRNA. PCR was performed to examine cagA, vacA, iceA and IS605 genotypes. Results: Significant difference was found in the negative rates of cagA between gastric adenocarcinoma group and control ($62.5\%\;vs.\;33.3\%$ P=0.033). No significant difference was found in the prevalence of iceA, vacA between gastric adenocar cinoma and control. The genotype of cagA+ vacA s1-m1 iceA1 was predominant in H. pylori isolates irrespective of the clinical outcome. IS605 in PAI was not found in gastric adenocarcinoma gruop and control. The positive rates of IS605 in genome were $33.3\%$ in gastric adenocarcinoma group and $36.7\%$ in control (P>0.05). In gastric carcinoma, the positive rate of $cagA^{+}/IS605$ was lower than in control ($12.5\%\;vs\;40.0\%$, P=0.025) and the positive rate of cagA-/IS605 was higher than in control ($54.2\%\;vs\;23.3\%$, P=0.02). Conclusion: H. pylori virulence factors had not related significantly with gastric adenocarcinoma. Further study is needed to examine the specificity of H. pylori strains.
식도절제술 환자에서 식도내압 및 위배출시간에 대한 고찰
지삼룡 ( Sam Ryong Jee ),최석렬 ( Seok Reyol Choi ),김광진 ( Kwang Jin Kim ),금동주 ( Dong Joo Keum ),홍기봉 ( Ki Bong Hong ),이종훈 ( Jong Hun Lee ),한상영 ( Sang Young Han ),최필조 ( Pill Jo Choi ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 식도절제술은 식도암에 있어서 장기생존 및 증상의 호전을 위하여 치료원칙이 되며, 증상의 호전을 위한 고식적 수술로도 시행된다. 또한, 식도의 양성 협착 질환이나 식도 천공의 치료법으로도 행해진다. 그러나, 식도절제술후의 식도 운동기능의 양상과 위배출능에 대한 국내문헌은 찾아보기 힘든 실정이다, 이에 저자들은 식도절제술후 호소하는 증상과 식도내압 및 위배출시간과의 연관성을 알아보고자 하였다. 〈방법〉 1994년 10월부터 1998년 11월 사이에
십이지장 궤양에서 Helicobacter pylori 독성인자 유전자 아형과 IS605의 역할
금동주 ( Dong Joo Keum ),한상영 ( Sang Young Han ),김광진 ( Kwang Jin Kim ),지삼룡 ( Sam Ryong Jee ),이종훈 ( Jong Hun Lee ),최석렬 ( Seok Ryeol Choi ),신우원 ( Woo Won Shin ),김정만 ( Jeong Man Kim ),홍숙희 ( Sook Hee Hong ),김 대한소화기학회 2003 대한소화기학회지 Vol.41 No.2
Background/Aims: The Helicobacter pylori (H. pylori) cagA, vacA, and ieeA are considered to be important virulence factors that have been implicated in the development of duodenal ulcers. It was reported that the presence of IS605 elements might be respon
반복적인 하부위장관 출혈을 동반한 공장 평활근종 1 예
한상영(Sang Young Han),노명환(Myung Hwan Roh),최석렬(Seok Ryeol Choi),신우원(Woo Won Shin),강기태(Ki Tae Kang),김광진(Kwang Jin Kim),지삼룡(Sam Ryong Jee),이종훈(Jong Hun Lee) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.2
Small bowel tumors are rare, constituting 1.7-6.5% of all gastrointestinal tract neoplasms. Leiomyomas are uncommon benign tumors of smooth muscle and may occur wherever smooth muscle is present. The small bowel is the most frequent site and leiomyomas make up 20-30% of all benign small intestinal neoplasms. Bleeding is the most commom symptom and is usually recurrent. A 33-year-old man who came to emergency room complained of 3-day history of melena and hematochezia. An arteriogram revealed significant hemorrhage from jejunal branch of the superior mesenteric artery. Arterial embolization was performed, followed by laparoscopy-assisted small bowel resection after 17 days. Pathologic examinaton confirmed a diagnosis of leiomyoma. (Korean J Gastroenterol 2001;38:128-131)
포스터 전시 : 위장관 ; Neostigmine을 이용해 치료한 급성 대장 가성폐쇄증 1예
김완수 ( Wan Su Kim ),한상영 ( Sang Yung Han ),배이지 ( Ea Sy Bae ),장진석 ( Se Jun Jang ),최석렬 ( Jin Seok Jang ),신우원 ( Seok Ryeol Choi ),이종훈 ( Woo Won Shin ),김광진 ( Jong Hun Lee ),( Kwang Jin Kim ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
급성 대장 가성폐쇄증은 어떤 기계적 폐색의 원인이 없이 대장이 급격히 확장하는 질환으로 1948년 Ogilvie에 의해 처음 보고되어 Ogilvie`s 증후군이라고 알려져 있기도 하다. 가장 위험한 합병증으로는 자발성 대장천공으로서 약 3%에서 발생하며 사망률은 50%까지 이른다. 이 증후군은 보존적 요법에 대부분 반응을 하나 때론 대장내시경하 감압술 및 수술이 필요하기도 하다. 최근 연구에서 acetylcholinesterase 억제제인 neostig