유향흑호단(乳香黑虎丹)이 난소적출로 유발된 흰쥐의 골다공증 모델에 미치는 영향

금창준 ( Chang Jun Kum ),조창영 ( Chang Young Cho ),임정민 ( Jeong Min Lim ),송대욱 ( Dea Uk Song ),김재현 ( Jae Hyun Kim ),이비나 ( Bi Na Lee ),정혁상 ( Hyuk Sang Jung ) 한방재활의학과학회 2014 한방재활의학과학회지 Vol.24 No.3

Objectives Osteoporosis is an impending problem in the rapidly aging society. The purpose of this study is to identify the effects of Yoohyangheukho-dan (Ruxiangheihu-dan) on osteoporosis induced by ovariectomy in rats. Methods 24 rats were randomly assigned to a SHAM group, a control group, and a Yoohyangheukho-dan (Ruxiangheihu-dan) group (n=8). Ovaries were extracted and for 8 weeks, the rats were given dry feeds and Yoohyangheukho-dan (Ruxiangheihu-dan) group were given a mixture of dry feeds and Yoohyangheukho-dan (Ruxiangheihu-dan). At 8 weeks, their body weight, femur mass, tibia ash per body ratio, overall surface area and thickness of the trabeculae, overall surface area of the osteoblasts, and the number of osteoclasts were measured and levels of albumin, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total-cholesterol, calcium and estradiol were recorded. Results There was no significant difference in the weight of the femur and the tibia ash per body ratio. The Yoohyangheukho-dan (Ruxiangheihu-dan) group had significantly thicker trabeculae than the control group and showed a minimal increase of overall surface area of the trabeculae. The overall surface area of the osteoblasts and the number of osteoclasts decreased in the Yoohyangheukho-dan (Ruxiangheihu-dan) group. There were no statistically significant differences in AST, ALT, ALP, total cholesterol, phosphorus, and estradiol levels. On the contrary the Yoohyangheukho-dan (Ruxiangheihu-dan) group had significantly higher levels of Albumin, triglyceride, and calcium. Conclusions It can be concluded that oral intake of Yoohyangheukho-dan (Ruxiangheihu- dan) prevents the thinning process of the trabeculae. Thus, it may have positive effects on the treatment and prevention of osteoporosis in postmenopausal women. (J Korean Med Rehab 2014;24(3):29-37)

요추 추간판 탈출증 증상을 호소하며 내원한 신체형장애 환자 1례

금창준(Chang-Jun Kum),오재우(Jae-woo Oh),김태윤(Tae-yoon Kim),이제균(Je-kyun Lee) 대한스포츠한의학회 2015 대한스포츠한의학회지 Vol.15 No.1

This study researches the progress of symptoms of patient with somatoform disorder who appealed lumbar herniated interverte-bral disc. During the initial stage of hospitalization, chief complaint of patient was low back pain with radiculotapthy. However, patient gradually have appealed the other various physical symptoms that are inconsistent with or cannot be fully explained by any underlying general neurologic or medical condition. Therefore, patient was diagnosed as somatoform disorder and transferred psychiatry clinic for psychiatric modalities. Usually, patients with somatoform disorders are spend a lot of time to itinerate clinics, because they firstly not visit psychiatry clinic, whereas visit primary healthcare clinics initially such as orthopedic surgery clinics or internal medicine clinics. On the other hand, early medical interventions could decrease significant impairment, so these patients requires an integrated medical and psychiatric treatment approach with accurate diagnosis in order to successfully decrease long-term morbidity and suffering by these disorders.

HC001의 아토피성 피부염에 대한 항염증 효능 및 기전 연구

최유연,김미혜,금창준,최영진,황만기,손영주,정혁상,양웅모,Choi, You-Youn,Kim, Mi-Hye,Kum, Chang-Jun,Choi, Young-Jin,Hwang, Man-Ki,Sohn, Young-Joo,Jung, Hyuk-Sang,Yang, Woong-Mo 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.1

본 실험에서는 피부질환을 위한 새로 구성된 HC001의 처방이 외용제로서 아토피성 피부질환에서의 항염증 효능을 확인하였다. H&E염색을 통한 조직학적 검사에서 DNCB로 유도된 진피 및 표피의 과각화증이 HC001 국소도포로 인해 호전되는 것을 관찰되었으며, 염증과정에서 중요한 지표인 NF-${\kappa}B$의 활성이 억제됨을 확인하였다. 이를 통해 HC001이 아토피성 피부질환의 외용제 사용에 있어 일정한 효과를 나타낼 수 있을 것으로 기대 된다. Objectives : The purpose of this study is to examine the effects of external application of HC001 on atopic dermatitis. HC001, newly composed herbal medicine combinations contains 9 medicinal herbs which are known to have anti-inflammatory and anti-allergic effects. We investigated the anti-inflammatory effects of HC001 on atopic dermatitis-like skin lesions in mice. Methods : Seven-week-old BALB/c mice were sensitized with DNCB to develop atopic dermatitis. Animals were divide into three group: Normal, DNCB (Negative control group), HC001 (Experimental group, treated with DNCB and HC001). Skin sections were stained with H&E to measure the thicknesses of the epidermis and dermis, respectively. The expression of NF-${\kappa}B$ protein was measured by western blotting analysis in skin lesion. Results : Topical HC001 treatment significantly restored the skin thickening and hyperplasia of the epidermis and dermis compared with DNCB-sensitized group in histopathological analyse. In addition, HC001 inhibited the expression of NF-${\kappa}B$ protein increased in DNCB-induced atopic dermatitis-like skin lesions in mice. Conclusions : These results suggest that HC001 may be useful as an external application agent for atopic dermatitis based on reductions of various inflammatory responses.

샤르코 마리투스 병 환자의 족관절 통증에 대한 족관절 추나를 병행한 한의학적 치료 증례보고

김태윤,한창,이제균,박종훈,금창준,오재우,주환수,Kim, Tae-Yoon,Han, Chang,Lee, Je-Kyun,Park, Jong-Hoon,Kum, Chang-Jun,Oh, Jae-Woo,Joo, Hwan-soo 척추신경추나의학회 2015 척추신경추나의학회지 Vol.10 No.1

Background : Charcot Marie Tooth disease can cause muscle weakness and foot deformity. Ankle pain induced by foot deformity affect patients' gait pattern and quality of life. Objectives : The purpose of this study is to evaluate the traditional Korean medicine treatment for ankle pain induced with Charcot-Marie Tooth Disease, especially Chuna manual therapy on ankle joints. Methods : One patient was treated with acupuncture, phamacopuncture, herbal medication and chuna manual therapy on ankle joints. To evaluate the pain of ankle, lower back and lower extremity, visual analog scale(VAS) was measured. Results : After treatment for 5 week, the pain of ankle joint was declined from VAS 6 to VAS 2. Conclusions : Traditional Korean medicine treatment including acupuncture, pharmacopuncture, herbal medication and Chuna manual therapy is effective for ankle pain with foot deformity. But further studies are required to prove the effectiveness of Chuna manual therapy on ankle joints.

한방신경정신과 영역의 Alzheimer형 치매 관련 연구현황

김태윤 ( Tae Yoon Kim ),금창준 ( Chang Jun Kum ),오재우 ( Jae Woo Oh ) 대한한방신경정신과학회 2014 동의신경정신과학회지 Vol.25 No.3

Objectives: Alzheimer`s Dementia is somewhat common in clinical stages, and there are many reports and papers regarding this subject. We explain the present state of Alzheimer`s Dementia in JON (The Journal of Oriental Neuropsychiatry) for the benefits of clinical practice. Methods: We searched for articles in JON from 1990 to 2014 and selected ones that were related to Alzheimer`s Dementia; then, we analyzed the data and placed it in four categories, like experimental study, case study, Clinical Data-Analysis study, and clinical trial. Results: 1) We found 47 articles relating to Alzheimer`s Dementia in JON from 1997 to 2014: 41 experimental studies, 1 case study, 1 Clinical Data-Analysis study, and 4 Clinical trials. 2) There were Chung-kyung Acupuncture Method, Auricular acupuncture, and Cha-rak Acupuncture Method to treat Alzheimer`s Dementia. 3) There were many additional treatments, like aroma therapy. 4) In the experimental study, they reported on several herbs, including herbal prescriptions that affected the suppression of related mRNAs and genes. 5) There were 4 clinical trials regarding herbal prescription that was effective for treating Alzheimer`s Dementia. Conclusions: In JON, regarding Alzheimer`s Dementia, the majority dealt with experimental studies. Therefore, we also have to expand our sight into other fields of study. We need more clinical trials and case studies for the treatment of Alzheimer`s Dementia in Oriental Neuropsychiatry.

퇴행성 슬관절염의 한의학적 치료에 대한 국내 연구 동향

김태윤,김정현,박종훈,이제균,한창,금창준,오재우,Kim, Tae-Yoon,Kim, Jung-Hyun,Park, Jong-Hoon,Lee, Je-Kyun,Han, Chang,Kum, Chang-Jun,Oh, Jae-Woo 척추신경추나의학회 2014 척추신경추나의학회지 Vol.9 No.2

Objectives : The purpose of this review is to investigate the trends of Traditional Korean Medicine treatments on degenerative knee arthritis. Methods : We investigated the studies on traditional Traditional Korean Medicine (TKM) treatments for degenerative knee arthritis via searching 5 Korean web databases. Results : 31 research papers were found to be analyzed according to their published year, the titles of journals, published institution, the types of study, the number of cases, the types of treatments. 31 papers were published since 1992. The studies on TKM treatments about degenerative knee arthritis were mainly published in The journal of korean acupuncture & moxibustion medicine. 13 Randomized Controlled Trials, 10 Case series, 4 Reviews, 3 Non RCTs, and 1 Case Report had been under research. In 22 cases of the studies, one method was used to treat the symptoms. Whereas in 5 cases of the studies, various TKM treatments were used to treat the symptoms. Visual analogue score(VAS) and patient's subjective complaints were used as primary assessments. Conclusion : In this study, we analyzed the trends of TKM treatments on degenerative knee arthritis. Reviewing the domestic trends of studies on Traditional Korean Medicine treatments on degenerative knee arthritis and examining the strong and weak points of those treatments are essential for the further studies.

강봉으로 보강된 프리캐스트 프리스트레스 옹벽의 동적 안정성 평가

이일화(Lee Il-Wha),이수형(Lee Su-Hyung),최찬용(Choi Chan-Yong),금창준(Kum Chang-Jun) 한국철도학회 2006 한국철도학회 학술발표대회논문집 Vol.- No.-

The advantages of precast production are fast construction, reduction of labor and insurance of good quality. In recently, the application of the precast production is increased in the earth retaining wall field. This paper presents the results of the numerical modelling that was carried out to evaluate the stability of precast and prestressed earth retaining wall under dynamic train loading. The two-dimensional explicit dynamic finite element method (ABAQUS) was used to carry our the numerical analyses. The train loading to act track is calculated by using the real measured phase angle data. Mainly, the displacement and acceleration of wall structure in time domain analyzed to evaluate the stability under the dynamic train load.

요추 추간판 탈출증 입원환자 208례를 통한 한방치료의 효과 연구

정재훈 ( Jae Hoon Jung ),김원우 ( Won Woo Kim ),성익현 ( Ik Hyun Seong ),이갑수 ( Kap Soo Lee ),조창영 ( Chang Young Cho ),금창준 ( Chang Jun Kum ),김희정 ( Hee Jung Kim ),하인혁 ( In Hyuk Ha ) 한방재활의학과학회 2013 한방재활의학과학회지 Vol.23 No.1

This study was introduced the short-term effectiveness of Oriental medicine treatment for lumbar disc herniation inpatients.We selected 208 inpatients with a magnetic resonance imaging(MRI)-confirmed lumbar disc herniation since June 2012 until August 2012.Their demographics characterisitics, numeric rating scale(NRS) and Oswestry back-related disability index(ODI) for low or leg pain, lumbar flexion and extension angle were assessed at baseline and when discharged from the hospital.When it measured the straight leg raisingscale(SLR), the low side of the angle was examined.Treatment every patient has received as follow; herbal medicine, bee venom, acupuncture and physical examination, spinal manipulation.NRS of low back pain and leg pain and ODI is 5.6±2.3, 4.9±2.8 and 45.5±20.0, respectively at baseline and 2.8±1.8, 2.7±1.9 and 27.2±14.1, respectively when discharged from the hospital.range of motion(ROM) of lumbar flexion and extension angle and SLR is 70.0±27.1, 15.4±7.2 and 61.3±23.0 respectively at baseline and 80.5±16.9, 18.25±4.1 and 73.2±14.0, respectively when discharged from the hospital.It shows that statistically significant improved(P<0.001).Furthermore, regarding patient satisfaction with the treatment, excellent(33.7%), good(55.4%), normal(10.4%), poor(0.5%), it suggests that most patients(89%) satisfied with the treatment.

요추기능제한을 동반한 입원 환자들에게 있어서 견인보행운동요법을 포함한 통합한의치료의 유효성: 후향적 의무기록 분석

강병구 ( Byeong-gu Gang ),전세환 ( Se Hwan Jeon ),조용규 ( Yongkyu Cho ),이근재 ( Keunjae Lee ),윤영석 ( Youngsuk Yoon ),김종호 ( Jongho Kim ),이원준 ( Won Jun Lee ),한수빈 ( Subin Han ),금창준 ( Chang Jun Kum ),고원일 ( Wonil Koh 한방재활의학과학회 2018 한방재활의학과학회지 Vol.28 No.4

Objectives Low back disability, along with low back pain, places a significant social burden in terms of work loss and medical expenses. Motion-Style-Acupuncture-Treatment using Traction (T-MSAT) is employed as one of the conservative treatments to such conditions. In the present study, effectiveness of Korean Medical treatments, including T-MSAT, was investigated in inpatients with low back disability and low back pain. Methods Among the patients who were admitted between January 2018 to June 2018 with disabled low back function, ones that were treated with T-MSAT were identified. Pain and function were compared at the point of admission and discharge, using Numerical Rating Scale (NRS) and Oswestry Disability Index (ODI), respectively. Results Over the hospitalization period of 34.55 days, pain intensity significantly decreased from NRS score of 6.14 to 3.26 and low back function also significantly improved from ODI score of 50.93 to 33.73 upon receiving Korean Medical treatments including T-MSAT. Conclusions Korean Medical treatments including T-MSAT were found to be effective in inpatients with low back disability with a statistical significance. To evaluate the sole effectiveness of T-MSAT, rigorous clinical trials are necessitated in future. (J Korean Med Rehabil 2018;28(4):51-57)