Total antioxidant status (TAS) 참고치 및 고콜레스테롤혈증, 당뇨병과의 관련성에 관한 연구

권영일 ( Young Il Kwon ),서은주 ( Eun Ju Seo ),홍효선 ( Hyo Sun Hong ),안희은 ( Hee Eun Ahn ),박찬호 ( Chan Ho Park ),노명희 ( Myung Hee Rho ) 대한임상검사과학회 1999 대한임상검사과학회지(KJCLS) Vol.31 No.2

Introduction : The Object of this study is to investigate the reference ranges of total antioxidant status(TAS) according to age and sex in korea. The human body is constantly under attack from free radicals. Free radica1s are highly reactive molecules and once formed, attack cell structures with the body. As a resu1t, free radicals have been implicated in numerous disease. In hea1thy individua1s, the antioxidant system defends tissues against free radica1 attack. Methods and materials : We measured the tota1 antioxidant status of 90 norma1 group, 30 diabetes group and 30 hypercholesterolemia group. (The each group sex ratio : ha1f to ha1ij For each test, age and sex related variations were assessed and reference values were estimated for three different age groups.(below 20, 21-40, above 41) TAS measured by Randox Tota1 Antioxidant reagent and Hitachi 7150. Results : ’fhe reference va1ues according to age were 0.930- 1.332mmolfL in below 20 years of age, 1.007 -1.391mmolfL in 21-40 years of age and 0.995- 1.295mmolfL inabove 41 year of age and showed statistica11y significant difference.(P<0.05) The Reference ranges of tota1 age group, ma1e and fema1e group were 0.991- 1.343mmolfL, 1.038- 1.370mmolfL, and 0.977 -1.285mmolfL respectively. Between the ma1e and fema1e group were statistically signficant difference.(P<0.05) The TAS means of diabetes and hypercholesterolemia were 1.26mmoljL and 1.23mmoljL respectively. TAS values of hypercholerterolemia an normal group were no significant difference whereas diabetes and normal group were significant difference.(P<O.OOl) Conclusions : We established that reference ranges were analyzed age and sex related variations for total antioxidant status. Between experimental groups showed generally significant differences. In the future, correct diagnosis of disease induced free radicals need to measure total antioxidant level and each antioxidants.

국한성 맥락막혈관종에서 발생한 장액망막박리에 대한 치료결과

권정민(Jeong Min Kwon),이승민(Seung Min Lee),권한조(Han Jo Kwon),박성후(Sung Who Park),이지은(Ji Eun Lee),변익수(Ik Soo Byon) 대한안과학회 2017 대한안과학회지 Vol.58 No.3

목적: 장액망막박리가 발생한 국한성 맥락막혈관종에서 항혈관내피성장인자 주사와 광역학치료 결과를 알아보고자 하였다. 대상과 방법: 국한성 맥락막혈관종 환자 중에서 황반부 장액망막박리가 발생하여 치료가 필요했던 환자들의 치료방법과 결과를 의무기록을 통해 후향적으로 조사하였다. 종양의 진단과 치료경과는 안저사진, 인도사이아닌그린 혈관조영술, 빛간섭단층촬영, 안초음파 검사를 시행하여 분석하였다. 결과: 총 9명 9안을 치료 후 평균 19.2개월 동안 경과관찰하였다. 평균 시력은 0.51 ± 0.52 (logMAR), 종양의 최대지름은 평균 6,154.4 ± 2,019.9 μm, 두께는 평균 2,224.4 ± 862.1 μm였다. 첫 치료로 항혈관내피성장인자 유리체내주사를 받은 6안 중 5안은 평균 3.16회의 치료에 반응이 없거나 재발하여, 추가적인 광역학치료와 경동공온열치료가 필요하였다. 광역학치료를 받은 3안은 평균 1.3회의 치료 후 망막내/하액이 소실되고 재발은 없었다. 최종적으로 8안에서 완전한 망막내/하액의 소실을 얻을 수 있었으나, 평균시력은 치료 전과 차이가 없었다. 결론: 국한성 맥락막혈관종에서 발생한 장액망막박리에 대하여 항혈관내피성장인자 유리체내주사의 효과는 제한적이었으며, 광역학 치료가 적은 치료횟수로 망막하액의 소실을 얻을 수 있었다. Purpose: To determine the clinical outcome of anti-vascular endothelial growth factor (anti-VEGF) and photodynamic therapy (PDT) for circumscribed choroidal hemangioma (CCH) with serous retinal detachment. Methods: The medical records of patients having CCH with serous retinal detachment in macula were retrospectively reviewed. CCH and serous retinal detachment were evaluated via fundus photography, optical coherence tomography, indocyanine green angiography, and ultrasonography. Results: A total of 9 eyes were enrolled in this study. The average follow-up period was 19.2 months. The mean visual acuity was 0.51 ± 0.52 (logMAR) and the mean maximum diameter and thickness of the tumor were 6,154.4 ± 2,019.9 μm and 2,224.4 ± 862.1 μm, respectively. Of the 6 eyes receiving anti-VEGF (mean number of injections: 3.16) as the first treatment for serous retinal detachment, 5 had sustained or recurred intraretinal/subretinal fluid (IRF/SRF) and needed additional PDT and transpupillary thermotherapy. In the 3 eyes that received PDT (mean number of treatments: 1.3) as an initial treatment, IRF/SRF was completely resolved. Finally, 8 eyes achieved complete resolution of SRF and IRF; however visual recovery was limited. Conclusions: PDT, even with a small number of treatments, can alleviate IRF/SRF in CCH, while anti-VEGF did not.

석유화학에서 환경과 안전 / 보건을 통합한 청정도 평가방법 개발

권은선(Eun Sun Kwon),김익(Ik Kim),허탁(Tak Hur) 한국전과정평가학회 2001 한국전과정평가학회 정기총회 연구논문집 Vol.2001 No.0

회상치료가 요양원 여성노인의 우울, 불안 및 회상기능에 미치는 효과

권은정(Eun Jung Kwon),이용호(Yong Ho Lee),김남송(Nam Song Kim) 한국노인복지학회 2011 노인복지연구 Vol.0 No.53

본 연구는 회상치료 프로그램이 요양원 여성노인의 우울, 불안 및 회상기능에 어떠한 효과가 있는지 알아보고자 하는 목적으로 진행되었다. 연구대상자는 요양원에 3개월 이상 입소하여 생활하고 있는 65세 이상 여성노인 중 실험군 7명과 대조군 7명을 무작위로 배정하였다. 연구기간은 2010년 3월 9일부터 2010면 5월 11일까지 실시하였으며, 우울 및 불안, 회상기능 검사는 사전, 사후로 나누어 시행하였다. 회상프로그램은 일주일에 하루 한 시간씩 총 10번의 회기로 진행되었다. 주요 연구결과는 다음과 같다. 첫째, 회상치료는 요양원 여성노인의 우울을 감소시키는 효과가 있었다. 둘째, 회상치료는 요양원 여성노인의 불안에 유의미한 영향을 미치지 못하였다. 셋째, 회상치료는 요양원 여성노인의 회상기능의 일부 기능을 향상시키는 효과적이었다. 이러한 연구 결과로 볼 때 지속적으로 회상치료를 시행하는 것이 요양원 여성노인의 우울과 회상기능 수준을 향상시키는데 도움이 될 것이다. One of the problems faced by the aging society is the increasing number of aged people. Reminiscence therapy, which is one of the treatments for elderly people, has been showing excellent results in curing mental symptoms. Reminiscence therapy involves the discussion of past activities, events and experiences with another person or group of people, usually with the aid of tangible prompts such as photographs, household and other familiar items from the past, music and archive sound recordings. Although many studies have been performed on the effects of reminiscence therapy inside and outside of the country, very few investigated the simultaneous improvement of reminiscence functions and emotional stability in aged people. This study tried to find that the reminiscence therapy program specially made for aged women is effective on improving mental conditions. In detail, 14 aged patients who stay at "A" nursing home were divided by half into experimental group and control group. The study conducted a session a week from March to May 2010, totaling 10 sessions. As pre- and post tests, depression, anxiety and reminiscence functions were applied the experimental group and the control group. In order to verify the changes in each group before and after the sessions, paired t-test was conducted and independent t-test was performed to compare changes in two groups. According to the research results, the experiment group showed improvement in reminiscence functions and decrease in depression. The experiment group displayed no significant change in anxiety. On the meantime, the control group showed the difference in all three tests without statistical significance. This study showed a significant meaning by presenting the results of the effects of reminiscence therapy on improving mental condition. Facing an aging society, people should prepare for elderly life. In order to resolve the problems with the sick elderly, appropriate treatment programs should be given at an appropriate time. Also, more specialized therapy program needs to be developed.

미용소비자의 이용특성에 따른 마케팅믹스 요인(7Ps)연구

권은실 ( Eun-sil Kwon ) 한국미용예술경영학회 2018 미용예술경영연구 Vol.12 No.2

미용 소비자들의 다양한 미의 욕구 충족을 위해 기업 간의 차별화된 경영 마케팅전략이 필요하다. 기존 마케팅전략의 상품, 가격, 경로, 촉진의 4P에서 종사자, 물리적 증거, 과정의 3P가 추가된 7P는 서비스업에서 필수 요소로 대두 되고 있다. 본 연구는 마케팅믹스의 어떠한 변수들이 미용소비자의 이용특성과 만족에 영향을 미치는지 알아봄으로써 미용소비자를 대상으로 하는 마케팅전략에 도움이 되고자 한다. 조사방법으로는 서울/경기지역의 헤어샵 소비자를 대상으로 자기기입식 설문지법을 통해 최종 731부가 사용되었고, SPSS 22.0 통계프로그램을 사용하여 빈도분석, 요인분석, 신뢰도 분석, t-test가 분석에 사용 되었다. 연구결과 첫째, 헤어샵 전환의향에 따른 마케팅믹스 요인의 차이에서는 상품과 가격요인에서만 평균값이 높게 나타났고, 헤어샵 권유의향에 따른 마케팅믹스 요인의 차이에서는 종사원, 상품, 가격, 과정에서 평균값이 높게 나타났으며, 헤어샵 만족에 따른 마케팅믹스 요인의 차이에서는 종사원, 상품, 가격요인에서 평균값이 높게 나타났다. 상품과 가격요인, 즉 디자이너의 기술과 합리적인 가격이 미용소비자의 이용특성에 따른 중요한 변수임을 알 수 있었다. In order to meet the beauty needs of beauty consumers, differentiated management marketing strategies are needed. 7P, which is based on 3P of People, physical evidence, and process in 4P of product, price, place, promotion of existing marketing strategy, is becoming an essential element in service industry. This study was to clarify the effects of marketing mix on users characteristics and satisfaction of beauty service customer. Based on the result, the purpose of this study is to suggest the ways of marketing strategies. As for the subject of this study, 731 customers of hair salons in Seoul and Kyonggi Province were selected to respond to and analyzed the self-administered questionnaire. Collected data was analyzed using SPSS 22.0. Analytical analysis was carried out on the data in the form of frequency analysis, factor analysis, reliability analysis, and regression analysis. Firstly, the effect of marketing mix on the intention of switching hair shop has high average in product and price. Secondly, influence of marketing mix on recommendation intention of hair shop has high average result in worker, product, price and course. Thirdly, the effect of marketing mix on satisfaction of hair shop has high average in worker, product, and price. In conclusion, on the basis of this research, it can be seen that product, price, in other words, technique of designer and reasonable price are the important variables of users characteristics of beauty service.

급성담관염의 원인균주와 항생제감수성의 시간흐름에 따른 변화

권정석 ( Jeong Seok Kwon ),한지민 ( Ji Min Han ),김태원 ( Tae Won Kim ),오지혜 ( Ji Hye Oh ),권현희 ( Hyun Hee Kwon ),정진태 ( Jin Tae Jung ),권중구 ( Joong Goo Kwon ),김은영 ( Eun Young Kim ),김호각 ( Ho Gak Kim ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.5

Background/Aims: We evaluated changes of causative pathogen in acute cholangitis and their antimicrobial susceptibility over six years and differences between community-acquired and hospital-acquired acute cholangitis at our institution. Methods: Medical records of 1,596 patients with acute cholangitis and biliary drainage between August 2006 and August 2012 were reviewed retrospectively. Cases were divided according to time: period 1 (August 2006-December 2008, n=645, 40.4%), period 2 (January 2009-August 2012, n=951, 59.6%). Cases were divided according to community-acquired cholangitis (n=1,397, 87.5%) and hospital-acquired cholangitis (n=199, 12.5%). Causative pathogens and antimicrobial susceptibility were investigated in each group. Results: Causative pathogen was isolated from bile culture in 1,520 out of 1,596 cases (95.2%). The three most frequently isolated Gram-negative bacteria were extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (n=485, 30.4%), E. coli (n=237, 13.2%), and Citrobacter freundii (n=110, 6.9%). Between periods 1 and 2, prevalence of ESBL-producing E. coli and Klebsiella pneumoniae did not show significant change (36.7% vs. 32.1%, p=0.073; 6.6% vs. 6.2%, p=0.732). C. freundii showed a significant increase from period 1 to period 2 (1.7% vs. 13.2%, p=0.000). In both time periods, imipenem was the antimicrobial agent showing the highest rate of susceptibility (93.3% vs. 93.9%, p=0.783). Higher prevalence of ESBL-producing E. coli and C. freundii was observed in the hospital-acquired cholangitis group (52.1% vs. 31.2%, p=0.000; 15.9% vs. 7.3%, p=0.001). Conclusions: The most common causative pathogen of acute cholangitis was ESBL-producing E. coli. Prevalence of C. freundii increased over the time period. Imipenem should be reserved as an alternative for resistant pathogens.

미백과 항산화에 미치는 백복령, 감초, 유백피 추출 혼합물의 영향

권은정(Eun-Jeong Kwon),박혜정(Hye-Jung Park),남향(Hyang Nam),이수경(Su-Gyeng Lee),홍수경(Su-gyoung Hong),김문무(Moon-Moo Kim),이경록(Kyeong Rok Lee),홍일(Il Hong),이도경(Do Gyeong Lee),오영희(Yunghee Oh) 한국생명과학회 2014 생명과학회지 Vol.24 No.10

활성산소는 피부손상을 일으키는 지질, 단백질, DNA의 산화를 유발시킨다. 더욱이활성산소는 기미, 검버섯, 주근깨를 생성하는 멜라닌생성과정을 촉진시킨다. 수많은 생약재중에서, 백복령, 감초, 유백피는 각각 parchymic acid, glabridin 및 flavonoid 를 함유하고 있다고 보고되어 있다. 본 연구의 목적은 기능성 미백화장품을 개발하기 위하여 B16F1 세포에서 백복령, 감초, 유백피 혼합추출물(PGUE)의 항산화 및 미백효과를 조사하는 것이다. PGUE는 높은 환원력 뿐만 아니라 DPPH radical 및 지질과산화 억제효과를 나타내었다. 항산화효과 뿐만 아니라 PGUE는 양성대조군으로 사용된 arbutin과 비교하여 melanogenesis와 관련 있는 tyrosinase 효소활성을 크게 감소 시켰다. 더욱이 PGUE는 살아있는 melanome세포에서 melanin합성을 억제하였다. 또한 PGUE는 superoxide dismutase-1 (SOD-1)및 tyrosinase related protein-1 (TRP-1) 단백질 발현을 억제시킨다는 것이 발견되었다. 이러한 결과들은 PGUE가 피부에 대한 항산화효과 및 미백효과를 가지고 있다는 것을 나타내어, 기능성 미백화장품의 개발을 위한 유효한 성분으로 이용되어 질 수 있다는 것을 암시하고 있다. Reactive oxygen species (ROS) are known to lead to oxidation of lipids, proteins, and DNA and cause skin damage. Moreover, ROS promote melanogenesis, which causes melasma, age spots, and freckle. The main compounds of the herbal medicines Poria cocas, Glycyrrhiza uralensis, and Ulmus macrocarpa were reported to be parchymic acid, glabridin, and flavonoids, respectively. The aim of this study was to investigate the whitening and antioxidant effects of a mixture of P. cocas, G. uralensis, and U. macrocarpa extracts (PGUE) in B16F1 cells to develop whitening cosmetics. PGUE inhibited DPPH radicals and lipid peroxidation, in addition to high reduction power, compared with Glycyrrhiza uralensis ethylacetate extracts (GUEE). Furthermore, PGUE exhibited a protective effect against DNA oxidation induced by the hydroxyl radicals. In addition to its antioxidant activity, the inhibitory activity of PGUE against tyrosinase, which is associated with melanogenesis, was greater than that of arbutin used as a positive control. Moreover, PGUE exerted an inhibitory effect on melanin synthesis in live melanoma cells and reduced the expression levels of superoxide dismutase-1 (SOD-1) and tyrosinase related protein-1 (TRP-1). These results indicate that PGUE has skin whitening and antioxidant effects, suggesting that this mixture can be used as the main ingredient in the development of effective whitening cosmetics.

자바 기반의 이동 에이전트를 이용한 분산 XML문서 검색 시스템 설계 및 구현

권은정(Eun-Jung Kwon),김백선(Baik-Sun Kim),용환승(Hwan-Seung Young) 한국멀티미디어학회 1999 한국멀티미디어학회 학술발표논문집 Vol.1999 No.2

한국 근대 미인의 형성과 화문(畵文)의 모더니즘 : 한국 근대 장편소설과 안석주의 신문삽화를 중심으로

권은(Kwon, Eun) 구보학회 2021 구보학보 Vol.- No.28

이 글은 한국 근대소설의 발전 과정에서 소설 삽화가 작품 속 인물의 외양 묘사 및 성격 형상화에 미친 영향 관계를 살피고자 한다. 이를 위해 안석주가 삽화를 담당한 신문연재 소설 속 ‘미인(美人)’ 여성 주인공의 재현 양상을 중심으로 살펴보고자 한다. 삽화는 단순히 소설의 내용을 보완하는 그림이 아니다. 소설에서 삽화가 등장함에 따라 소설을 읽는 과정뿐 아니라 쓰는 과정에서도 큰 변화가 나타나게 되었다. 독자들은 삽화가 등장한 이후 소설의 내용과 삽화 이미지를 교차하여 비교하면서 소설을 읽기 시작했고, 작가들은 삽화 못지않게 정교하고 세밀하게 인물과 주변환경을 묘사하고자 노력하게 되었다. 삽화는 소설의 리얼리즘이 형성되는 데도 중요한 역할을 담당했다. 그런 점에서 소설가와 삽화가는 협력적인 관계이면서 동시에 경쟁적인 관계이기도 했다. 미인도(美人圖)는 한 사회의 이상화된 여성을 그린 그림에 가깝다. 그런 점에서 미인은 단순히 한 개인의 취향에 의해 결정되는 것이 아니라, 특정 시기 한 집단의 이상적인 미의식이 반영된 인간상이라 할 수 있다. 신문연재소설의 삽화가 본격적으로 등장하던 시기는 서구의 영향을 받은 새로운 미의식 혹은 미적 기준이 형성되기 시작하던 시기였다. ‘미인’은 언어적 차원과 이미지적 차원의 두 개의 미학 체계를 기반으로 형성된다. 미인을 언어로 설명하게 되면 그 이미지를 머릿속에 구체적으로 떠올리게 되는 것이 쉽지 않고, 미인을 이미지로 표현하면 미인임으로 직관적으로 알 수 있지만, 그것을 언어로 설명하는 것이 쉽지 않다. 그런 점에서 신문연재소설의 삽화 속 ‘미인화’는 구체적이고 일관된 등장인물에 대한 언어적 묘사와 다양한 삽화가 어우러진다는 점에서 중요한 의미가 있다. 삽화 없이 연재된 이광수의 『무정』에서는 영채와 선형 등이 미인으로 설정되었을 뿐 구체적인 외양이 묘사되지 않았지만, 이후의 작품들인 『재생』이나 『흙』등에서는 점차 미인 여성인물들의 외양이 구체적으로 그려지지 시작했다. 1930년대부터 서구적인 기준에 부합하는 한국의 새로운 ‘미’에 대한 논의가 활발하게 이루어졌다. 그렇지만 외래적인 기준을 따른 ‘미’는 실제 현실과 조화를 이루지 못하고 충돌하는 경우가 종종 발생했다. 염상섭의 『광분』은 양장미인을 중심으로 근대와 전근대, 서구와 전통의 충돌과 파국을 다룬 작품이라 할 수 있고, 이광수의 『그 여자의 일생』은 조선과 일본의 미의식이 뒤섞이는 양상을 보여준다. 이상과 박태원 등의 작가들은 소설뿐 아니라 삽화도 직접 담당했던 작가들로 글과 그림이 혼합되어 새로운 의미를 창출하는 ‘화문(畵文)의 모더니즘’의 특성을 보여준다. This article seeks to examine the influence of illustrations on the characterization of characters in the work during the development of modern Korean novels. We would like to focus on the reproduction of the ‘beauty’ female protagonist in the roman-feuilleton illustrated by Ahn Seok-ju. An illustration is not just a complement to the literary texts. With the advent of illustrations in the novel, there was a big change not only in the process of reading the novel but also in the process of writing it. After the illustration appeared, readers began to read the novel by comparing the contents of the novel and the images of the illustrations, and writers began to try to describe the characters and the surrounding environment as elaborate and detailed as the illustrations. Illustrations also played an important role in the formation of realist novels. In this regard, novelists and illustrators were both cooperative and competitive. The paintings of beauties is more of a picture of an idealized woman in a society. In this regard, beauty is not simply determined by an individual’s taste, but rather reflects the ideal aesthetic of a group at a certain time. The time when illustrations of the roman-feuilleton appeared in earnest was when new aesthetic or aesthetic standards, influenced by the West, began to form. The beauty is formed based on two aesthetic systems: linguistic and imaging. If you explain beauty in language, it is not easy to think of the image in detail in your head, and if you express beauty as an image, you can intuitively see it as beauty, but it is not easy to explain it in language. In this regard, the ‘beauty’ in the illustrations of the roman-feuilleton is important in that it combines linguistic descriptions of specific and consistent characters and various illustrations. Lee Kwang-soo’s Mujeong, published without illustrations, did not depict the appearance of the portrait and linearity, but later works such as Jaesaeng and Soil gradually began to depict the appearance of beautiful female characters. Since the 1930s, discussions on Korea’s new ‘beauty’ have been active in meeting Western standards. However, the beauty according to foreign standards often conflicts with actual reality. Yeom Sang-seop’s Kwangboon is a work that deals with the conflicts and catastrophes between the Western and the traditions and Lee Kwang-soo’s The Woman’s Life shows a mixture of Korean and Japanese aesthetic. Writers such as Lee Sang and Park Tae-won are those who were directly in charge of illustrations as well as novels, and show the characteristics of literary-visual modernism.

에니어그램 성격유형 장 중심에 따른 미용종사자의 스트레스 유형이 대처방식에 미치는 영향

권은실 ( Eun-sil Kwon ),박은준 ( Eun-jun Pack ) 한국미용예술경영학회 2013 미용예술경영연구 Vol.7 No.3

This study was carried out to know the effect of stress types of hair industry Employee based on the intrinctive center of Enneargram personality types on coping strategies. The present study will suggest basic data for minimizing the stress and maximizing the efficiency. Firstly, the effect of job stress based on the intrinctive center of Enneargram on Stress has partly significant result in all stress. Above all, the higher level of dissatisfaction of working environment, dissatisfaction of opinion efficiency of job stress leads to the higher hopelessdepression of stress. And influence of job stress based on the intrinctive center of Enneargram on coping strategies of stress has partly significant result in all of the coping strategies. Above all, the higher level of dissatisfaction of excessive work, dissatisfaction of ego control, dissatisfaction of expectation of work rather than dissatisfaction of opinion efficiency of job stress leads to the tendency of the problem solving strategy. Thirdly, the influence of stress based on the intrinctive center of Enneargram on coping strategies of stress has partly significant result in all of the coping strategies. Above all, the higher level of emotional hypersensitivity of stress leads to the higher level of hostile management.