KIDS VOICE를 활용한 AAC 중재가 뇌성마비아동의 어휘표현에 미치는 효과

고진복,전병운 한국특수교육학회 2006 한국특수교육학회 학술대회 Vol.2006 No.-

단백질 수준이 암ㆍ숫쥐의 단백질대사에 미치는 영향

고진복 신라대학교 자연과학연구소 1995 自然科學論文集 Vol.1 No.-

The female(30-week-old) and male(60-week-0ld) Sprague-Dawley rats were fed experimental diets containing 10%, 18% and 24% protein for 4 weeks. Total protein and albumin concentrations in serum as well as hemoglobin and hematocrit value in blood were not affected by dietary protein levels. The concentrations of Urea nitrogen in serum of female and male rats were significantly higher in 18% and 24% protein diets compared with those in 10% protein diet. The levels of urinary urea nitrogen excretion of male rats were increased according to the increase in dietary protein levels. But the ratio of urea nitrogen to total urinary nitrogen was not influenced by dietary protein levels. The ratio of urea nitrogen/creatinine in serum and urinary excretion of female and male rats increased with increasing levels of protein intake. The ratio of urea nitrogen/creatinine in serum and urinary excretion of female and male rats increased with increasing levels of protein intake. The ratio of urea nitrogen/creatinine in urine of male rats for 10% protein diet group was 7.3, that was showed poor nutritive condition of protein. The concentrations of uric acid in liver of female and male rats fed high protein (24% protein) diet were significantly higher than those of the 10% and 18% protein diets. The apparent absorption and balance of nitrogen were significantly higher in high protein than those in low protein than those in low protein diet. Nitrogen absorption rates were as follows : 85.4%(female), 85.5%(male) for 10% protein diet, 89.4%, 91.3% for 18% protein diet and 92.8%, 93.5% for 24% protein diet in female and male rats respectively All experimental groups mere positive in nitrogen balance.

새송이버섯이 성숙한 흰쥐의 단백질과 무기질 농도 및 효소활성에 미치는 영향

고진복 신라대학교 자연과학연구소 2006 自然科學論文集 Vol.15 No.-

고지방식이에 새송이버섯 분말첨가 식이를 섭취한 성숙한 숫쥐의 체중변화, 장기무게, 단백질과 무기질 농도 및 효소활성에 미치는 영향을 조사하고자, 숫쥐에 표준식이를 급여한 정상군, 표준식이에 20% 돈지를 첨가한 식이를 급여한 대조군, 대조식이에 새송이버섯 분말을 3% 및 5%씩 첨가한 식이를 급여한 군(3% 및 5% 새송이버섯군)등 4군으로 나누어 10주간 사육한 결과는 다음과 같다. 실험동물의 체중변화 및 식이효율은 대조군에 비해 3% 및 5% 새송이버섯군이 유의하게 감소되었다. 간, 신장, 비장 및 고환의 무게는 정상군과 각 실험군들이 비슷하였으나, 부고환지방은 대조군에 비해 5% 새송이버섯군은 유의하게 감소되었다. 혈청의 단백질, 혈색소, 혈당, 칼슘, 무기인 및 마그네슘 농도는 정상군과 각 실험군이 비슷한 수준으로 새송이버섯 섭취에 따른 영향은 나타나지 않았다. 혈청의 GOT, GPT, r-GTP, LDH 및 alkaline phosphatase의 활성은 정상군과 각 실험군이 유의한 차이는 나타나지 않았다. 이상의 결과로 보아 고지방식이에 새송이버섯 분말을 첨가한 식이가 성숙한 흰쥐의 체중증가와 부고환지방 축적을 억제하는 효과가 나타났다. 혈청의 단백질, 혈색소, 혈당, 칼슘농도 및 효소활성은 정상수준을 유지하였다 The effects of Pleurotus (P.) eryngii on the weight gains, food efficiency ratios, and serum protein and mineral levels, and serum enzyme activities were investigated in adult male rats. Twenty one weeks old Sprague-Dawley rats were given four different types of diet for 10 weeks, respectively: a normal diet (5% corn oil), a control diet (high fat; 20% lard), and two kinds of P. eryngii diet supplemented with 3% or 5% of dry P. eryngii powder in substitutes for the same amounts of cellulose in the control diets. The body weight gains and food efficiency ratios of the rats fed 3% and 5% P. eryngii diets were significantly lower than those of the rats fed the control diet. The epididymal fat pad weights of the rats fed 5% P. eryngii diets were significantly lower than those of the rats fed the control diet. The weights of hepatic, kidney, spleen and epididymis in the rats fed P. eryngii diets were similar to those in the rats fed the control diet. There were no differences in the serum concentrations of protein, albumin, and calcium, phosphorus, magnesium, and enzyme activity among the experimental groups. These results showed that the 5% P. eryngii diet feeding decreased the body weight and epididymal fat pad weight.

신령버섯(아가리쿠스) 분말이 고지방을 섭취한 흰쥐의 단백질과 무기질 농도 및 효소활성에 미치는 영향

고진복 신라대학교 자연과학연구소 2005 自然科學論文集 Vol.14 No.-

고지방식이에 신령버섯 분말 첨가 식이를 섭취한 숫쥐의 성장률, 장기무게, 단백질과 무기질 농도 및 효소활성에 미치는 영향을 조사하고자, 성숙한 숫쥐에 표준식이를 급여한 정상군, 표준식이에 20% 돈지를 첨가한 식이를 급여한 고지방군, 고지방 식이에 신령버섯 자실체 분말을 3% 및 5%씩 첨가한 식이를 급여한 군(3% 및 5% 신령버섯군) 등 4군으로 나누어 10주간 사육한 결과는 다음과 같다. 실험동물의 체중증가량 및 식이효율은 고지방군에 비해 3% 신령버섯군이 다소 감소되었으나, 5% 신령버섯군은 유의하게 감소되었다. 간, 신장, 비장 및 고환의 무게는 고지방군과 신령버섯군들이 비슷하였으나, 부고환지방은 고지방군에 비해 신령버섯군들이 유의하게 감소되었다. 혈청의 단백질, 혈색소, 혈당, 칼슘, 무기인 및 마그네슘 농도는 정상군과 각 실험군이 비슷한 수준으로 신령버섯 섭취에 따른 영향은 나타나지 않았다. 혈청의 GOT, GPT, r-GTP, LDH 및 alkaline phosphatase의 활성은 정상군과 각 실험군이 유의한 차이는 나타나지 않았다. 이상의 결과로 보아 고지방식이에 신령버섯분말을 5% 첨가한 식이가 성숙한 흰쥐의 체중증가와 부고환지방 축적을 억제하는 효과가 나타났다. 혈청의 단백질, 혈색소, 혈당, 칼슘농도 및 효소활성은 정상수준을 유지하였다. The effects of the fruiting body of Agaricus blazei Murill on the weight gains, food intakes, food efficiency ratios, serum and hepatic lipids concentrations were investigated in male rats. Sprague-Dawley adult rats, were given four different types of diets for a succeeding period of 10 weeks: either a normal diet (5% corn oil), a high fat diet (high fat; 20% lard), a 3% or 5% Agaricus diet (high fat diet + 3% or 5% Agaricus powder). The body weight gains and food efficiency ratios of the rats fed 5% Agaricus diet were significantly lower than those of the rats fed the high fat diet. The epididymal fat pad weights of the rats fed 3% or 5% Agaricus diets were significantly lower than those of the rats fed the high fat diet. The weights of hepatic, kidney, spleen and epididymis in the rats fed Agaricus diets were similar to those in the rats fed the high fat diet. There were no differences in the serum concentrations of protein, albumin, and calcium, phosphorus, magnesium, and enzyme activity among the experimental groups. These results showed that the 5% Agaricus diet feeding decreased the body weight and epididymal fat pad weight.

이화명충의 變態에 따른 生理學的 硏究

高鎭福 건국대학교 1979 論文集 Vol.9 No.1

The concentration of total nitrogen and non-protein nitrogen, whole body protein patterns, trehalose, lipids and the activities of acid · alkaline phosphatase, glutamic pyruvic transaminase, glutamic oxalcacetic transaminase and succinic acid dehydrcgenase, mineral salts arid nucleic acid during the metamorphcsis of the rice stem bores, Chilo suppressalis Walker was measured using micro-Kjeldahl method, polyacrylamide gel electrophoresis method, gas chromatographic method, thin layer chromatographic method, Warburg's manometric method, King's method, Reitman's method and Thunberg's method, Schneider methods. Healthy specimens were chosen as samples of each developmental stages: a final instar larva, a newly molted pupa, pupae at 2,4,6,8 and 10 days, newly emerged adult and adults. The total nitrogen concentration decreased gradually until the two day pura stage was reached and increased from the four day pupa. In the final instar larval stage, the newly emerged adult and two day adult stage the concentration reached a maximum. The non·protein nitrogen concentration increased gradually until the newly molted pupa stage was reached and decreased from the two day pupa. The protein bands were numbered 1~14 according to their mobilities. A total of 14 protein patterns were detectable on the electrophotograms of whole body homogenates. Each develop mental stage shows qualitative differences in their protein bands. In general, the protein bands increased with the growth of larva, decreased at the newly molted pupal stage, and at the pupal and adults stages increased gradually again. The hemolymph trehalose concentration decreased gradually until the four day pupa stage and increased from the six day pupa. In the last instar larval arid the newly emerged adult stage the concentration reached a maximum. Phospholipid, monoacylglycerol, diacylglyrerol, triacylglycerol, free cholesterol and ester cholesterol were identified at each stage. Triacylgycerol at the final instar larva the concentration leached a maximum. Triacylycerol decreased gradually at each of the following stages prepupa, two day pupa, four and six day pupa and increased at the eight day pupal stage. The nucleic acid concentration decreased at the last instar larval stage and increased to reach a maximum at the adult stage. The mineral salts present are calcium, phosphorus, potassium, sodium and lithium which are identified at each stage. The activities of acid phosphatase generally increased until the two day pupa stage and decreased at the four day pupal stage, and they increased again at the eight day pupa and the newly emerged adult stages. The activity of alkaline phosphatase is by far lower than that of acid phosphatase. And at all the stages there are no significant differences between both control and treatment groups of alkaline phosphatase. The activities of glutamic pyruvic transaminase and glutamic oxaloacetic transaminase decreased gradually from the final instar larva until the ten day pupa stage and increased at the newly emerged adult stage. The activity of succinic acid dehydrogenase decreased gradually until the six day pupa stage and increased at the eight day pupal stage. In the final instar larva stage and the two day adult stage the activities reached a maximum. Endogenous respiration was very high at the two day pupal stage, and decreased at the six day pupa, followed by an increased at the late pupal stages. Succinate in the respiratory substrate increased respiratory activity in all stages and had a striking influence on both the late pupal stage and the adult. Hence, changes in total protein concentration, protein patterns, trehalose, lipids, mineral salts, nucleic acid, acid · alkaline phosphatase activity, activities of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase and succinic acid dehydrogenase through the course of the physiological cycle form a U-shaped curve when graphed against the histolysis of larval organs and the histogenesis of adult organs. In view of controlling pest, the U-shaped pattern of physiological activity indicates that control will be the most effective at the time of the most physiological weakness manifested at the four day pupal stage.

감귤 부산물을 급여한 제주 재래돼지고기의 섭취가 흰쥐의 지질대사, 단백질 농도 및 효소 활성에 미치는 영향

고진복,양승주,정인철,현재석,문윤희,Koh Jin-Bog,Yang Seung-Joo,Jung In-Chul,Ryon Jae-Suk,Moon Yoon-Hee 한국축산식품학회 2006 한국축산식품학회지 Vol.26 No.2

감귤 부산물을 급여하지 않은 제주 재래돼지고기($T_0$)와 육성기와 비육기에 각각 8%와 15% 급여한 돼지고기($T_1$)를 흰쥐의 사료에 단백질로 환산하여 12%되도록 첨가하였다. 이 사료를 생후 17주령의 흰쥐에 4주간 급여하여 영양대사에 미치는 영향을 조사하였다. 흰쥐의 사료 섭취량, 사료효율 및 체중 증가량은 $T_0$와 $T_1$사이에 유의적 차이를 나타내지 않았다. 흰쥐의 간, 신장, 비장 및 부고환 등 장기의 무게와 간의 중성지질 및 총 콜레스테롤 함량은 $T_0$와 $T_1$ 사이에 유의적 차이가 없었다. 혈청의 총지질, 인지질, 중성지질, 총콜레스테롤, 동맥경화지수, 단백질, 혈당, 혈색소, 무기질 함량, 그리고 ${\gamma}$-GTP, ALT, AST 및 ALP 활성은 $T_0$와 $T_1$이 비슷한 경향이었다. 혈청의 HDL 및 LDL-콜레스테롤 함량은 $T_1$이 $T_0$에 비하여 증가되는 경향으로 나타났다. Diets consist of two different pork samples: pork of a Jeju native pig ( 260 days old, $101{\sim}103kg$ ) not fed tangerine byproduct during finishing period ($T_0$), and pork fed 8% and 15% tangerine byproduct during growing and finishing period ($T_1$), respectively. The effects of the diet on the physiological activities of rats were studied by feeding 17-week old rats with the two diets for 4 weeks. There was no significant difference between $T_0$ and $T_1$ in the rat's feed intake, feed efficiency ratio, and weight gain. Furthermore, there was no significant difference between $T_0$ and $T_1$ in the rat's weight of liver, kidney, spleen, epididymal fat pad, triglyceride and cholesterol of liver. Both $T_0$ and $T_1$ showed similar trends in terms of total lipid, phospholipid, triglyceride, total cholesterol, atherogenic index, protein, glucose, hemoglobin level, mineral level, and ${\gamma}$-GTP, ALT, AST and ALP activities. However, $T_1$ showed the trend of increasing amount of the serum's HDL and LDL cholesterol level, compared with $T_0$.

발효홍차 음료가 콜레스테롤을 급여한 흰쥐의 지질대사 및 효소활성에 미치는 영향

고진복 신라대학교 자연과학연구소 2003 自然科學論文集 Vol.12 No.-

The effects of tea fungus/kombucha beverage (TF) on the body weight gain, lipid metabolism, protein levels, and enzyme activities in growing male rats fed high cholesterol diet were studied. Sprague-Dawley rats were received 4 types of diets for 4 weeks, respectively: a control diet group, a control TF diet group (control diet + 20% TF in water), a cholesterol diet group (control diet + 1% cholesterol) and a cholesterol TF diet group (cholesterol diet + 20% TF in water). The body weight gains, food intake, food efficiency ratios, and kidney and spleen weights of the rats fed all experimental diets were similar to those of the rats fed control diet. There were no differences in the concentrations of triglyceride, HDL-cholesterol, total protein, and glucose, and the activities of GOT, GPT, LDH and alkaline phosphatase in the serum among the experimental diet groups. The hepatic weights and the concentrations of hepatic total lipid, cholesterol and triglyceride of the rats fed cholesterol diet and cholesterol TF diet were significantly higher than those of the rats fed control diet. The concentration of L DL-cholesterol and HDL-cholesterol/total cholesterol ratio in the serum of the rats fed cholesterol TF diet were similar to those of the rats fed cholesterol diet. The concentrations of total lipid, total cholesterol and free cholesterol, and atherogenic index in serum of the rats fed cholesterol TF diet were significantly decreased compared with the rats fed the cholesterol diet. In conclusion, the 20% tea fungus/kombucha beverage feeding decreased the concentrations of the total lipid, total cholesterol and free cholesterol, and the atherogenic index in the serum of the rats fed high cholesterol diets, but, it could not decrease the concentrations of the total lipid, cholesterol and triglyceride in the liver.

발효홍차 음료가 암쥐의 성장률, 단백질, 지질대사 및 효소활성에 미치는 영향

고진복,노민희 신라대학교 자연과학연구소 2002 自然科學論文集 Vol.10 No.-

This study investigated the effect of tea fungus/kombucha beverage (TF) on the body weight gain, protein levels, lipid metabolism and enzyme activities in growing female rats. The rats (Sprague-Dawley) were divided into three groups; control (TP free water), 20 or 40% TF groups (20 or 40% TF in water) according to the levels of TF supplementation. The rats were fed ad libitum each of the experimental beverage for 7 weeks. The body weight gain, the liver and pancreas weights, the hemoglobin concentration and hematocrit value, and the serum total lipid, triglyceride, total cholesterol and phospholipid concentrations, HDL-cholesterol/total cholesterol ratio, and the serum total protein and albumin levels of the 20 or 40% TF groups were similar to those of the control group. The serum glucose and liver phospholipid concentrations of 40% TF group were significantly increased compared with those of the control group. The serum HDL-cholesterol concentration of the 20% TF group was significantly higher than that of the control group, but the seam LDL-cholesterol concentration and the atherogenic index were significantly lower. The liver cholesterol concentration of the 40% TF group and the liver triglyceride concentration of the 20 or 40% TF groups were significantly lower than those in the control group. The liver total protein level of the 40% TF group was more significantly decreased than that of the control group. The serum GPT activity of the 20 or 40% TF groups were significantly lower than that of the control group. These results indicated that the serum LDL-cholesterol and liver triglyceride concentrations, and the atherogenic index of the female rats fed 20% tea fungus/kombucha beverage were decreased, but the seam HDL-cholesterol concentration was increased. There were no differences in the growth, organ weight, serum protein, triglyceride and total cholesterol concentrations, GPT and ALP activities

뇌성마비 학생을 위한 말소리 산출 도구 프로그램 구현

고진복,전병운 한국콘텐츠학회 2009 한국콘텐츠학회논문지 Vol.9 No.12

This study suggested speech generation device(SGD) program to materialize the proper communication aids which address to language abilities by students with cerebral palsy in the stage of word recognition achievement. This SGD program aim at function of learning mediation and communication expression by synchronization not restrict aim of AAC aids' employment to the only function of communication expression. And this SGD was designed to evaluate language abilities of student with cerebral palsy through analysis of the date offered at this program, and then might utilize to set learning goals and objects, modify teaching contents. This SGD program have a meaning on contribution to possible teaching the user AAC aids, students with cerebral palsy by whole language approach in natural environment but in artificial situation at script. 이 연구에서는 문자를 해득한 뇌성마비 학생들의 언어능력에 적절한 의사소통 도구를 구현할 목적으로 말소리 산출 도구(speech generation device: SGD) 프로그램을 제안하였다. 이 연구에서 제안하는 SGD 프로그램은 학습 도구로써의 기능과 의사표현을 위한 수단을 동시에 만족시킬 수 있는 프로그램으로 현재까지의 AAC 도구 사용 목적과 적용이 의사소통 보조기기의 고유한 기능에 한정되어 있었던 것과는 차별화된다. 또한, SGD 프로그램을 기반으로 시스템에서 제공하는 데이터를 분석하여 뇌성마비 학생의 언어능력을 측정해 볼 수 있으며, 이를 근거로 언어지도 목표를 설정하고 학습 콘텐츠를 수정하여 제공할 수 있도록 구현하였다. 기존의 관련 소프트웨어와 비교해 볼 때, 이 연구에서 구현된 SGD는 인위적 스크립트 상황이 아닌 실제 교수·학습 상황에서 SGD를 통해 제공되는 학습 콘텐츠를 활용하여 보완·대체의사소통(augmentative and alternative communication)을 사용하는 뇌성마비 학생들에게 총체적 언어 지도가 가능하도록 구현하였다는 점에서 의의가 있다.

蛋白質水準이 血淸 및 肝 脂質濃度에 미치는 영향

高鎭福 新羅大學校 1988 論文集 Vol.25 No.-

This expriment was conducted to study the effect of different levels of protein on serum and liver lipids in rats. The concentrations of serum and liver total lipid, total cholesterol and serum high density lipoprotein(HDL) cholesterol as well as hemoglobin and hematocrit value were measured after feeding mature male (60 week-old) and female (30 week-old) Sprague-Dawley rats for 4 weeks. The three dietary protein levels used were 10, 18 and 24%. Serum and liver total lipid concentrations of male rats in 10% protein group were higher than those in 18% and 24% protein group, but the female rats had no difference in each diet group. Hemoglobin and hematocrcit value as well as serum and liver total cholesterol concentrations of the male and female rats were not affected by dietary protein levels. Serum HDL-cholesterol concentrations and HDL-cholesterol per total cholesterol ratio ofmale rats significantly increased in 18% protein group compared with 10% and 24% protein groups, but the female rats had no difference in the levels of protein.