일산화탄소중독시(一酸化炭素中毒時) 폐(肺)로 부터의 일산화탄소(一酸化炭素) 방산(放散)에 관(關)하여

강반(Kang, Bann),김근주(Kim, Kun-Joo),여웅연(Ryo, Ung-Yun) 대한생리학회 1967 대한생리학회지 Vol.1 No.2

In order to evaluate the elimination of CO through the lung comparing with the decrease of CO content in the blood, authors had induced acute CO poisoning on 9 dogs. Arterial CO-Hb saturation, CO concentration, %, in expired gas and eliminated CO amount through the lung were measured at 1,5,10,30,60, and 120 minutes after acute CO poisoning in 6 dogs breathing room air and 3 dogs breathing room air and oxygen alternately. Results obtained are summarized as follows. In room air breathing group, arterial CO-Hb saturation averaged 50.8% , and 53.67 ml of CO was blew off through the lung during 120 minutes and in alternately air and oBygen breathing group, the arterial CO-Hb saturation averaged 65.6% and 95.6 ml of CO was blew off through the lung. The amount of CO eliminated in expired gas for 120 minute was much less than the amount of decreased CO in arterial blood which was calculated with the decreased CO-Hb content in the estimated circulating blood volume. Such difference between the amount of eliminated CO in expired gas and the decreased CO in blood might be attributed to the oxidation of CO to CO₂ in the tissues. Concentration of CO in expired gas was markedly increased and the rate of decrease in arterial CO-Hb saturation is enhanced by oxygen breathing. In early period of recovery from acute CO poisoning, neither the CO concentration in expired gas, nor, the rate of CO elimination (unlit 2 minutes after CO poisoning) showed close correlation with the blood CO-Hb saturation level. The reason seemed to be due to irregularly depressed or unevenly stimulated respiration which were induced by acute CO poisoning.

일산화탄소중독견(一酸化炭素中毒犬) 체내(體內)에서의 일산화탄소처리능(一酸化炭素處理能)에 관(關)하여

여웅연(Ryo, Ung-Yun),강반(Kang, Bann) 대한생리학회 1968 대한생리학회지 Vol.2 No.2

The Present study attempted to analyze the fate of CO diffused into the circulating blood through the alveoli. Dogs were induced to CO poisoning by rebreathing CO gas mixture contained in Krog s spirometer, by closed circuit method, for 60 minutes. The spirometer was filled initially with 282 ml of CO and 20 liters of air and oxygen, so the composition of gases were arranged as 1.4% in CO and 50% in O₂ at the begining of the rebreathing. Oxygen was added corresponding to the utilization of O₂ by the animal in proceeding of the experiment. At 60th minutes of CO rebreathing, the concentration of CO in arterial blood and in mixed venous blood were analysed and compared with each other after the CO contents were corrected with the hematocrit measured in the arterial and mixed venous blood. The distribution of CO gas to other tissues was estimated by the analysis of CO diffused into the cystic bile and into the peritoneal gas pocket which was formed by injection of 300 ml air into the peritoneal cavity prior to the CO gas rebreathing. The blood volume was measured by dilution method using ⁵¹Chromium tagged red cells. CO amount vanished in the animal body was calculated by subtraction of total CO content in blood stream and the CO remained in closed circuit breathing system from the CO amount given to the breathing system at the begining of the experiment. Results obtained are summarized as follows: 1. The content of CO corrected by the hematocrit value was slightly less in mixed venous blood than in arterial blood. The amount of CO diffused into the cystic bile and into the peritoneal cavity was averaged to 0.1% and 0.4% of the CO amount in 100 ml of blood, respectively. 2. For 60 minutes of CO rebreathing, CO-hemoglobin saturation reached about 77% at the 60th minutes, CO amount vanished in the experimental animal averaged 36.1 ml/dog/hr., or 21% of the total CO volume in the blood stream. The average vanishing rate of CO during 60 minutes of CO rebreathing per kg of body weight was 2.71 ml/hr. Production of CO measured in ten dogs under hypoxic condition averaged 0.023 ml/kg/hr. The major part of the CO vanished in the dogs seemed to be oxidized to CO₂ by various tissues of the animal. The conclusion might be delivered as such oxidation of CO to CO₂ by animal tissues can play a role in part of the process of recovery and protection of animal from CO-poisoning.

Gargoylism 의 임상적관찰 - 특히 Gargoyle 세포의 진단적 가치에 대하여

한용섭 ( Yong Sup Han ),박희명 ( Hi Myung Park ),강반 ( Bann Kang ),이규보 ( Kyu Bo Lee ) 대한내과학회 1969 대한내과학회지 Vol.12 No.6

Five cases of gargoylism seen in two brothers and their nephews were studied in regard to genetic pattern, clinical and laboratory findings, These cases revealed sex linked recessive inheritance and were genetic mucopolysaccharidosis II (Hurler syndrome3 i

흉부 및 복부암의 쇄골상임파선 전이에 대한 검토

김이호 ( Lee Ho Kim ),이상계 ( Sang Kay Lee ),이주원 ( Joo Won Lee ),최용직 ( Yong Jick Choi ),강반 ( Bann Kang ) 대한내과학회 1969 대한내과학회지 Vol.12 No.5

Scalene node metastasis was examined on 1, 831 cases of thoracic and abdominal cancers admitted to the Kyungpook University Hospital during the 6 years from Jan. 1962 to Dec. 1967 and the following results were obtained. 1) Scalene nodes were palpated in 1

Thiopental靜注로 誘導된 不整脈에 關하여

姜斑,呂雄淵 대한의학협회 1969 대한의학협회지 Vol.12 No.3

數種 Steroids의 白鼠赤血球 Fragility에 미치는 影響

呂雄淵,姜班 慶北大學校 醫科大學 1963 慶北醫大雜誌 Vol.4 No.1

徑口投與한 Co^60 Vitamin B_12의 흰쥐 各種臟器內分布狀에 對하여

琴東八,姜班,呂雄淵 최신의학사 1964 最新醫學 Vol.7 No.2

數種 Steroids의 白鼠赤血球 Fragility에 미치는 影響

呂雄淵,姜班 慶北大學校 醫科大學 1963 慶北醫大誌 Vol.4 No.1

The effects of Steroid, both injected intramusculary and added directly in vitro, on the red cell fragility were studied, and the following results were obtained. 1. In two groups where 1) 1.25㎎ of Cortisone and 2) 1.0㎎ of Prednisolone were injected intramusculary, the red cell osmotic fragility was significantly decreased 7 hours after the injection. 2. The Testosterone and Cortisone showed no remarkable effect on the red cell osmotic fragility in vitro during 20 hours. 3. As a control, the authors studied the red cell fragility in normal rats, and a relation curve of the hemoglobin percentage in hemolyzed solution and transmittancy in Spectrophotometer, were obtained.

갑상선기능항진증의 임상적 관찰

박희명,송석호,이규보,황기석,강반 대한핵의학회 1969 핵의학 분자영상 Vol.3 No.2

1962년 1월부터 1968년 6월까지 6년 6개월동안에 경북의대 부속병원 방사성동위원소과에서 진료한 갑상선질환 환자 가운데 갑상선기능항진증 161예 (14.5%)에 대한 임상적관찰에서 다음과 같은 성적을 얻었다. 1) 갑상선기능항진증의 남녀비는 1:4.6이었고 연령별로는 30∼39세가 전예의 35.4%로서 가장 많았으며 그 다음은 40대, 50대, 20대의 순이었다. 2) 선종은 미만성선종이 144예, 결절성선종이 17예였으며 미만성선종에서의 남녀비는 1:4.3이었고 결절성선종에서의 남녀비는 1:7.5이었다. 3) 임상증상은 허약감, 역피로감, 심계항진, 체중 감소, 신경과민, 발한, 열불내성, 식욕증진, 불면증, 월경불순등이었고 타학적 소견으로는 선종, 미세진전, 빈맥, 맥압차의 증가, 수척, 온습피부, 안구돌출증, 수축기성고혈압 및 심방세동등의 순으로 흔히 볼 수 있었으며 합병증으로는 ophthalmopathy 및 갑상선기능항진성 심장병이 각각 전예의 34.2% 및 5.6%에 있었고, 그밖에 갑상선분리가 1예, pretibial myxedema가 1예, thyrotoxic myopathy가 1예 있었다. 4) (131)^I 갑상선섭취율은 미만성선종에서는 6시간 및 24시간치의 평균치가 각각 67.5% 및 71.6%이었고 결절성선종에서는 평균 64.5% 및 65.0C가 가장 많았다. 6) 치료후에 임상증상이 호전 또는 소실하는 순위는 열불내성, 수척, 신경과민, 불면증, 역피로감, 허약감, 심계항진, 미세진전, 선종, 발한등의 순이었으며, 안구돌출증도 호전 또는 소실된 예도 있었다. 7) 치료후 점액수종이 발생한 예는 4예 (3%)였고 재발된 예는 9예 (6.8%)였다. A clinical analysis was made on 161 cases of hyperthyroidism seen at the Radioisotope Laboratory of Kyungpook National University Hospital. This series consisted of 144 cases of diffuse goiter and 17 cases of nodular goiter. 1) Hyperthyroidism was most prevalent in the 4th decade and male to female ratio was 1:4.6. 2) Cardinal symptoms in the order of frequency were weakness, easy fatigability, palpitation, weight loss, nervousness, perspiration, heat intolerance, increased appetite, insomnia and dysmenorrhea. 3) Major physical findings in the order of frequency were goiter, fine tremor, tachycardia, wide pulse pressure, emaciation, warm moist skin, exophthalmos, systolic hypertension and atrial fibrillation. 4) The complications were ophthalmopathy (34.2%), thyrotoxic heart disease (5.6%), thyroid crisis (1 case), pretibial myxedema (1 case) and thyrotoxic myopathy (1 case). ( 5) Mean values of the six hour and twenty-four hour (131)^I uptakes by the thyroid glands were 67.5% and 71.6%, respectively, in diffuse goiter and 64.5% and 65.0%, respectively, in nodular goiter. 6) Mean values of twenty-four PB(131)I conversion ratio were 76.3% in diffuse goiter and 70.2% in nodular goiter and those of the basal metabolic rate was +51% in the former and +41% in the latter. Mean serum cholesterol level was 152mg% in diffuse goiter and that in nodular goiter was 175mg%. 7) Among the 134 cases treated with 131I, 66 cases (49.3%) were successfully controlled with single dose and in the majority of the cases the initial therapeutic dose required was 4.1∼4.0mC in diffuse goiter and 5.1∼6.0mC in nodular goiter. 8) With (131)^I treatment the symptoms improved in the following order:heat intolerance, emaciation, nervousness, insomnia, easy fatigability, weakness, fine tremor, goiter, perspiration, exertional dyspnea and palpitaion. And in a few cases improvement of even exophthalmos was seen. 9) Following (131)^I treatment myxedema occurred in 4 cases (3%) and reccurrence in 9 cases (6.8%). $quot;