지식경영시대의 성과측정 모델의 관한 연구

신건권,조철연 경주대학교 2002 論文集 Vol.15 No.-

As we move further into the Knowledge economy, the value of business will depend more and more on intangible rather than tangible assets. But the traditional accounting systems have been interested in measuring the value of tangible assets only, and have given up on the issue of valuing intellectual assets(or intangible assets, intellectual capital). The accounting systems have not been able to explain the difference between the market value and the book values of firms. The major purpose of this study was to review and evaluate some performance measurement models(Balanced Scorecard, Economic Value- Added, Skandia Navigator, Intangible Assets Monitor, KM's Balance Sheet) in the era of knowledge management. Without an appropriate system for evaluation of intellectual assets, firms could not efficiently manage intellectual assets and strategically utilize them. Because intellectual assets(or intangible assets) are critical resources to management, this study would provide theoretical bases to the systematic evaluation and utilization of them and help firms overcome the limitations of traditional accounting system in handling intangible assets.

제 2형 당뇨병 환자에서 대사증후군의 유병률 및 관련요인의 특징

박철진,박거운,박일구,신지혜,김진화,배학연,김상용 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.3

Background: People with insulin resistance has a higher risk of developing cardiovascular disease. This leads to the importance in diagnosing metabolic syndrome. The incidence of metabolic syndrome has increased significantly in korea because of an increased population of obese people and also the incidence of DM. There have been many studies done on the incidence of metabolic syndrome in the general population. Therefore, the authors have designed this study to identify the incidence of metabolic syndrome in patients with type 2 DM and also the associated characteristics in that population. Methods: The study included 169 adults over the age of 20 (84 males and 85 females) admitted to the endocrinology department of Chosun University between Jan, 1st 2005 and May, 31st 2006. Out of the people diagnosed with type 2 DM people were excluded when any of the physical measurements (height, weight, blood pressure, abdominal circumference) and blood measurements (TG, HDL-cholesterol, fasting blood sugar) were insufficient and when the patient was taking any drugs other than anti-hy-pertensive agents and oral anti-diabetic agents. Obesity and the other risk factors were defined by the Asian-Pacific guideline and 2001 ATP III of NCEP, respectively. Result: The each prevalence according to the metabolic syndrome criteria of the type 2 DM patients showed low HDL cholesterolemia with the highest incidence of 57.4% followed by hypertng1yceridemia(52.0%), obesity(40.9%) and hypertension(33.0%). The each incidence of diagnostic criteria in metabolic syndrome according to sex was different, In males, hypertriglyceridemia was the highest with the incidence of 57.7% followed by low HDL-cho1estero1emia(49.5%), obesity(40.9%) and hypertension (30.0%). In women, the incidence were low HDL-cho1estero1emia(64.8%), hyperthg1yceridemia(47.6%), obesity(45.0%) and hypertension(36.0%), in a descending order. The analysis between the diagnosis of metabolic syndrome in type 2 DM patients and the criteria showed that hyperthglyceridemia (correlative value 0.575) had the highest correlation followed by low HDL-cholesterolemia (correlative value 0.446), obesity (correlative value 0.350) and hypertension (correlative value 0.410). All the correlations were statistically significant with a p-value less than 0.01. Conclusions: Type 2 DM is a important factor of metabolic syndrome based on insulin resistance. The control of blood glucose with prevention and early diagnosis of the other factors related to metabolic syndrome in type 2 DM is important for preventing cardiovascular complications.

赤何首鳥와 白何首鳥의 外部 및 內部形態

宋坰松,申喆均,朱榮丞 대한본초학회 2004 大韓本草學會誌 Vol.19 No.1

Objectives : This study was designed to establish a characteristic discrimination of internal and external morphological standard of original plants and herbal states in Polygoni Multiflori and Cynanchi Wilfordii Radix. Methods : In this studies, the external-internal morphological standards were determined by using stereoscope and butanol series. Results : 1. The external characteristics of original plants: Polygonum multiflorum has alternate leaves, and its flower with white color blooms at the shoot apex or leaf axil. In the other hand, Cymchum wilfor&i has opposite leaves, and its flower with yellowish green color blooms at the leaf axil. 2. The physical characteristics of herbal states: Polygoni Multiflori Radix is red-brown in outer surface, pink-brown in section. In the other hand, Cynanchi Wilfordii Radix is earthly-brown in outer surface, greyish white in section. 3. The physical characteristics according to the place of production: Demonstrable difference according to the place of production is not seen. Polygoni Multiflori Radix is brown or dark brown in outer surface, soft yellow-dark brown in section. In the other hand, Cynanchi Wilfordii Radix is white in outer surface, white-weak red in section, and has power type. 4. The internal characteristics: Pofygonum mulQt7orum has hetero-vascular bundle and lignification of cork layer is progressive. In the other hand, cynanchum wilfordii has not hetero-vascular bundle, and lignification of cork layer is weak. Conclusion : In the future, many fundamental study such as how to discriminate between Polygoni Multiflori Radix and Cynanchi Wilfordii Radix in origin and efficacy will be necessary. Also the standard of discrimination must be specific and distinct in that several kinds of fo-ti has been traded.

인슐린 자가면역 증후군 2예

박일구,박철진,신지혜,김진화,김상용,배학연 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.1

인슐린 자가면역 증후군은 항체에 결합되어 있던 인슐린이 혈당정도와 관계없이 유리됨으로써 저혈당이 야기되는 질환으로, 인슐린종 등과 감별을 필요로 하는 질환이다. 저자들은 고인슐린혈증과 인슐린 자가항체가 양성이면서 공복검사상에서 저혈당이 유발되며 경구 포도당 부하 검사에서 저혈당이 유발된 자가면역성 저혈당증을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hypoglycemia is one of the rare causes of hypoglycemia, and characterized by hyperinsulinemia. Insulin autoimmune syndrome is characterized by insulin autoantibody, hyperinsulinemia, and fasting hypoglycemia without previous insulin immunization. Insulin autoimmune syndrome is usually related to autoimmune disease such as Graves' disease and to previous exposure to drugs. This syndrome is a self-limited disorder. The hypoglycemia was treated with prednisolone and the patient recovered from this. Recently we experinenced two cases of insulin autoimmune syndrome that developed symptomatic hypoglycemia during both the fasting and oral glucose tolerance test. Here in, We present those cases with a review of the literature.

LETTERS TO THE EDITORS : Churg-Strauss syndrome that presented with mediastinal lymphadenopathy and calculous cholecystitis

( Jung Yoon Choi ),( Ji Eun Kim ),( In Young Choi ),( Ju Han Lee ),( Je Hyeong Kim ),( Chol Shin1 ),( Seung Heon Lee ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.1

Prevalence of insomnia and its relationship to menopausal status in middle-aged Korean women

SHIN, CHOL,LEE, SANGYEOL,LEE, TAEWOOK,SHIN, KYUNGRIM,YI, HYERYEON,KIMM, KUCHAN,CHO, NAMHAN Blackwell Science Pty 2005 Psychiatry and clinical neurosciences Vol.59 No.4

<P>Abstract </P><P>Although the prevalence of insomnia and the association of insomnia with menopause have been well reported, not much work has been conducted in population-based research on insomnia and menopause in Korea. The purpose of the present report was to determine overall and different prevalence of insomnia by menopausal status, and the relationship between insomnia and menopause in a population-based sample of middle-aged Korean women. A total of 96.1% of 2497 randomly selected middle-aged Korean women participated. Insomnia was defined as occurring three times a week or more in the previous month. Subjects were categorized into three groups: premenopaues, perimenopause, and postmenopause. The overall prevalence of insomnia in middle-aged Korean women was 14.3%. The most common symptom of insomnia was difficulty maintaining sleep (9.7%), followed by difficulty initiating sleep (7.9%), and early morning awakening (7.5%). Multiple logistic regression analysis revealed that menopause was independently associated with insomnia after adjusting for confounding factors such as age, income, and depression. Perimenopause was significantly associated with a dramatic increase in the risk of insomnia, but there was no significant association for postmenopause. The major finding is that insomnia is significantly associated with the menopausal transition. The prevalence of insomnia increases significantly by the transition from premenopause to perimenopause, but not to postmenopause. A further prospective study is needed to investigate the influence of menopause on insomnia.</P>

Sex-specific differences in the association of a common aldehyde dehydrogenase 2 gene polymorphism and alcohol consumption with stroke risk in a Korean population

Chol Shin,KyuBum Kwack,Nam H Cho,Seong Hwan Kim,Inkyung Baik 대한지역사회영양학회 2015 Nutrition Research and Practice Vol.9 No.1

BACKGROUND/OBJECTIVES: It is well-known that alcohol consumption is associated with stroke risk as well as with aldehyde dehydrogenase 2 gene (ALDH2) polymorphisms. However, it is unclear whether ALDH2 polymorphisms are associated with stroke risk independent of alcohol consumption and whether such association is modified by sex. We evaluated sex-specific associations of a common ALDH2 polymorphism and alcohol consumption with stroke risk in a Korean population. SUBJECTS/METHODS: We conducted a prospective cohort study involving 8,465 men and women, aged 40-69 years and free of stroke between June, 2001 and January, 2003, and followed for the development of stroke. We identified new cases of stroke, which were self-reported or ascertained from vital registration data. Based on genome-wide association data, we selected a single-nucleotide polymorphism (rs2074356), which shows high linkage disequilibrium with the functional polymorphism of ALDH2. We conducted Cox proportional hazards regression analysis considering potential risk factors collected from a baseline questionnaire. RESULTS: Over the median follow-up of 8 years, 121 cases of stroke were identified. Carrying the wild-type allele of the ALDH2 polymorphism increased stroke risk among men. The multivariate hazard ratio [95% confidence interval] of stroke was 2.02 [1.03-3.99] for the wild-type allele compared with the mutant alleles, but the association was attenuated after controlling for alcohol consumption. Combinations of the wild-type allele and other risk factors of stroke, such as old age, diabetes mellitus, and habitual snoring, synergistically increased the risk among men. Among women, however, the ALDH2 polymorphism was not associated with stroke risk. CONCLUSIONS: The prospective cohort study showed a significant association between a common ALDH2 polymorphism and stroke risk in Korean men, but not in Korean women, and also demonstrated that men with genetic disadvantages gain more risk when having risk factors of stroke. Thus, these men may need to make more concerted efforts to control modifiable risk factors of stroke.

Leukocyte Telomere Length is Associated With Serum Vitamin B12 and Homocysteine Levels in Older Adults With the Presence of Systemic Inflammation

( Chol Shin ),( Inkyung Baik ) 한국임상영양학회 2016 Clinical Nutrition Research Vol.5 No.1

Folate, vitamin B12, and homocysteine (HCY) are involved in the metabolism of nucleic acid precursors and it has been hypothesized that they also influence telomere length, a biomarker of aging. However, previous studies have reported inconsistent findings, and data for older adults are limited. Our study aimed to evaluate associations between leukocyte telomere length (LTL) and serum folate, vitamin B12, and HCY levels among adults aged 55 years and over. In a cross-sectional study in 798 men and women aged 55-79 years, serum folate, vitamin B12, and HCY levels were measured using chemiluminescent immunometric assays, and relative LTL was assessed using quantitative real-time polymerase chain reaction. To evaluate associations between LTL and serum folate, vitamin B12, and HCY levels, multiple linear regression models were used. In multiple models adjusted for age, sex, serum high sensitive C-reactive protein (hs-CRP) levels, and other potential confounding factors, we found no association between LTL and serum folate, vitamin B12, and HCY levels. However, we did find a significant inverse association between HCY levels and LTL in participants with serum hs-CRP levels of ≥ 2 mg/L (p < 0.05). Moreover, there was a trend toward an association between HCY and vitamin B12 levels in these individuals (p = 0.08). In those with serum hs-CRP levels of < 2 mg/L, HCY was inversely associated with vitamin B12 levels (p < 0.001) and had no association with LTL. Our findings suggest that increased serum HCY levels, when combined with the presence of systemic inflammation, may play a role in accelerating biological aging.

Bone Mineral Density and Risk Factors of Osteoporosis in Healthy Men and Women

Shin, Su-Jin,Shin, Kyung-Rim,Shin, Chol,Park, Sun-Young Korean Society for Health Education and Promotion 2008 보건교육건강증진학회지 Vol.25 No.5

목적. 본 연구의 목적은 골다공증의 유병률을 확인하고 건강증진 프로그램의 우선적 대상을 확인하고자 실시되었다. 방법. 연구대상자는 Ansan Health Study센터를 방문한 18-84세의 성인 남녀 1,269명이었다. 위험요인을 평가하기 위한 질문지를 이용하였고 DEXA(Dual Energy X-ray Absorptiometry)를 이용하여 2번 요추와 대퇴의 골밀도를 측정하였다. 수집된 자료는 SPSS12.0프로그램을 이용하여 분석하였다. 결과. 골밀도는 50대와 60대 여성에게서 급격히 감소하였으며, 골다공증 유병률은 대퇴와 요추를 기준으로 남성은 각각 0.8%, 6.3%, 여성은 0.9%와 7.1%로 나타났다. 골다공증 지식 정도는 골밀도와 유의한 순상관관계가 있는 것으로 나타났다. 결론. 본 연구의 결과는 골다공증 예방 프로그램을 위한 효과적이고 실제적인 중재전략을 위한 기초자료를 제공하였다. Aims. The aims of this study were to identify the prevalence of osteoporosis and confirm the priority for health promotion program on the osteoporosis. Methods. 1,269 adults aged 18-84 years participated in this study from the Ansan Health Study sample. A questionnaire was used to evaluate the risk factors, and a Dual Energy X-ray Absorptiometry was used to measure the bone mineral density in the anteroposterior lumbar spine and femur. Collected data were analyzed using the SPSS 12.0 program. Results. BMD was decreased rapidly in females in their 50s and 60s and the overall incidence of osteoporosis based on the femur and the lumbar spine was 0.8% and 6.3% for males and 0.9% and 7.1% for females. Osteoporosis knowledge was significantly correlated with BMD. Conclusions. The results of this study can be applied to provide effective and practical implementation guidelines for osteoporosis prevention program.

규칙적인 운동이 골다공증 발생 위험에 미치는 영향

(Chol Shin),(Bog Ja Joung) 한국체육학회 2001 The 2001 Seoul International Sport Science Congres Vol.- No.-