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Jin, Xing-Hai,Lim, Juhyeon,Shin, Dong Hae,Maeng, Jeehye,Lee, Kyunglim MDPI 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.2
<P>Our previous study showed that dimerized translationally controlled tumor protein (dTCTP) plays a role in the pathogenesis of allergic diseases, such as asthma and allergic rhinitis. A 7-mer peptide, called dTCTP-binding peptide 2 (dTBP2), binds to dTCTP and inhibits its cytokine-like effects. We therefore examined the protective effects of dTBP2 in house dust mite-induced atopic dermatitis (AD)-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya (NC/Nga) mice. We found that topical administration of dTBP2 significantly reduced the AD-like skin lesions formation and mast cell infiltration in NC/Nga mice, similarly to the response seen in the Protopic (tacrolimus)-treated group. Treatment with dTBP2 also decreased the serum levels of IgE and reduced IL-17A content in skin lesions and inhibited the expression of mRNAs of interleukin IL-4, IL-5, IL-6, IL-13, macrophage-derived chemokine (MDC), thymus and activation-regulated chemokine (TARC) and thymic stromal lymphopoietin (TSLP). These findings indicate that dTBP2 not only inhibits the release of Th2 cytokine but also suppresses the production of proinflammatory cytokines in AD-like skin lesions in NC/Nga mice, by inhibiting TCTP dimer, in allergic responses. Therefore, dTCTP is a therapeutic target for AD and dTBP2 appears to have a potential role in the treatment of AD.</P>
P194 : Expression pattern and role of klotho in human hair follicles
( Xing Hai Jin ),( Long Quan Pi ),( Sungjoo Tommy Hwang ),( Won Soo Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Klotho is a newly identified anti-aging protein that plays a pivotal role in regulating ageing. However, whether klotho expresses in human hair follicles (HFs) and whether klotho expression correlates with hair growth have not yet been clearly shown. Objectives: To find the role of Klotho as a regulatory factor for human hair growth Methods: In this study, we examined the expression pattern of klotho in human scalp skin and its role in hair growth. Klotho was expressed in human scalp skin and HF both gene and protein levels. Results: In human scalp skin, prominent klotho expression was observed in the epidermis. Klotho expression in the epidermis was increased with keratinization from basal layer to stratrum coneaum. In human anagen HFs, prominent klotho expression was observed in the epithelium. Klotho expression in the epithelium was increased with keratinization in henle layer and hair cuticle. In human catagen HFs, klotho expression was observed in epithelial strand. Gene transfection of klotho siRNA was markedly inhibited the human hair growth and promoted apoptosis process in organ cultured human follicles. Conclusion: Altogether, these results indicate that klotho might be an important regulatory factor for human hair growth and hair cycle change.
Expression Pattern and Role of Klotho in Human Hair Follicles
( Xing-hai Jin ),( Long-quan Pi ),( Won-soo Lee ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.5
Background: Klotho protein plays a pivotal role in aging regulation. However, it is unclear whether klotho is expressed in human hair follicles and is correlated with hair growth. Objective: The purpose of this study was to determine the expression pattern and role of klotho in human hair follicles. Methods: We examined the klotho expression patterns in human hair follicles from young and aged donors. Furthermore, we examined the functional roles of klotho on human hair growth using klotho siRNA and klotho recombinant protein. Results: Interestingly, klotho was expressed in human hair follicles at both gene and protein levels. In hair follicles, prominent klotho expression was mainly observed in the outermost regions of the outer root sheath and hair bulb matrix cells. Quantification of klotho protein expression in young and aged donors showed that klotho expression decreased with aging. In human hair follicle organ culture, klotho silencing promoted premature catagen induction and inhibited human hair growth. Otherwise, klotho protein prolonged human hair growth. Conclusion: These results indicate that klotho might be an important regulatory factor for human hair growth and hair cycle change. (Ann Dermatol 31(5) 511∼517, 2019)
Hai-Long Xing,Jin-Han Jeon,Park, K. C.,Il-Kwon Oh IEEE 2013 IEEE/ASME transactions on mechatronics Vol.18 No.1
<P>Active disturbance rejection control method that can actively compensate nonlinear model uncertainties and unpredictable external disturbances is proposed for an accurate position tracking of an ionic polymer-metal composite actuator. An empirical model of the electroactive polymer actuator is constructed by fitting the step response of the actuator. Experimental results show that the present active disturbance rejection control scheme can substantially improve the control performance in the tracking of various reference motions including step, sinusoidal, trapezoidal, and sawtooth wave profiles. The proposed scheme offers an innovative solution for the position tracking of an ionic polymer-metal composite actuator with highly nonlinear dynamics.</P>
Hai Yan Zhang,Yingxi Lin,Danfeng Zhang,Wenguang Wang,Yuxiong Xing,Jin Lin,Haoqun Hong,Chunhui Li 한국물리학회 2016 Current Applied Physics Vol.16 No.12
Heat dissipation from light-emitting diodes (LEDs) has become a serious problem because of the LEDs' high luminosity and power. This problem could be solved by improving the dissipation efficiency of each LED system component. A microwave-reduced graphene nanosheet/silicone (GN/silicone) composite with a high thermal conductivity and stability was prepared by mechanical blending. The thermal conductivity of the composite reaches 2.7 W/(m K) with only 1.5 wt% loading, and is 12 times higher than the pure silicone matrix. When used as a thermal interface material between high-power LED chip module substrates and heat sinks, the thermal conductive GN/silicone composite could decrease the temperature difference between the substrate and shell. It could also improve the system heat transfer efficiency. The temperature gap between the heat slug and the heat sink was less than 2 C with a 1.5 wt% loading of GNs.
Xing Chun Wang,Xiao Yi Bi,Pei Shi Sun,Jin Quan Chen,Ping Zou,Xiao Ming Ma,Jing Zhang,Hai Yu Wang,Xiao Yi Xu 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.5
This study uses microbial methods to research the influence of oxygen (O2) content on the removal efficiency of sulfur dioxide (SO2) and nitrogen oxides (NOx) in a tandem twin-towers desulfurization and denitrification process system. Oxygen can play a significant role in biotrickling towers. Other important factors had already been optimized prior to the study, including inlet concentration, gas flow rate, and temperature. SO2 and NOx were prepared by a chemical method. A gas flow meter was used to regulate nitrogen (N2) that had been stored in steel cylinders. In this way, the O2 content was adjusted in the biotrickling towers by controlling the N2 flow rate. Five gradients of O2 content were selected for investigation, namely 4, 8, 12, 16, and 20%. Results indicated that the SO2 removal efficiency from mixed gas (SO2 and NOx) can reach 100%, from all of the five O2 gradients, in biotrickling towers. In a tandem twin-towers desulfurization and denitrification process system, the NOx removal efficiency and the inlet concentration of nitrogen dioxide (NO2) gradually increased as the O2 content increased. Specifically, the average removal efficiency of NOx increased from 49.28 to 80.85% as the O2 content changed from 4 to 20%. The oxygen levels influenced the removal of NOx but the SO2 removal efficiency in mixed gas was always stable.
Promoted Growth of Maize by the Phosphate Solubilizing Bacteria Isolated from North-east China
Hai-Yan Wu,Li-Chun Wang,Xing-Ai Gao,Rong-De Jin,Zuo-Wei Fan,Kil-Yong Kim,Lan-Po Zhao 한국토양비료학회 2011 한국토양비료학회지 Vol.44 No.1
A strain of phosphate solubilizing bacterium was isolated from rhizosphere and identified as Burkholderia sp. by 16S-rRNA gene sequence analyses. The bacterium was found to release gluconic acid and the solubilization of hydroxyapatite in the liquid medium by a significant drop in pH to 3.7 from an initial pH 7.0. The soluble-P concentration continuously increased during the incubation periods and the total amount of soluble P released in culture filtrate was detected at 990 mg L<SUP>-1</SUP> after 10 days of inoculation. Most promoted maize growth was found in the standard NPK (240-120-120 kg ha<SUP>-1</SUP>) soil inoculation with Burkholderia sp. (Twenty milliliters/ plant, 106 CFU) and also in the absence of Burkholderia sp. inoculation, the soil amended with only 2/3 levels of P gave significant higher plant yield compared to 1/3 levels of P or without P supplementation.
The Study of Pilot Process of Separation and Purification of Catechin Using Wood Fiber Resin
Xing-hai Zhang,Jin-wei Xu,Yue-fei Wang,Yin Gao,You-ying Tu 한국차학회 2015 한국차학회지 Vol.- No.S
This paper studies the pilot production of tea polyphenol (TP) from membrane filtered tea extract using wood fiber resin. We extract, isolate and purify TP using ultrasonic wave extraction, ultrafiltration membrane and wood fiber resin column chromatography techniques. We then use high performance liquid chromatography (HPLC) to filter optimal parameters and get the final product using spray drying method. The results show that after above process the content of caffeine, EGCg and catechin in 40% eluent is 0.607%, 60.7%, 86.95% separately and the low caffeine high catechin procuct yield rate is 7.0%. While in 10% eluent the content of caffeine, EGCg and catechin is 26.6%, 16.5%, 23.7% separately, and the high caffeine low catechin product yield rate is 7.3%. So the total summed yield rate is 14.3%. The pilot process may provide reference for future green TP production.
Yu Hai Wang,Zhe Dai,Chao Yue Zhang,Guo Wen Sun,Zhong Wei Lu,Xiu Ping Gao,Geng Zhi Sun,Wei Lan,Zhen Xing Zhang,Xiao Jun Pan,Jin Yuan Zhou 한국물리학회 2020 Current Applied Physics Vol.20 No.9
It was demonstrated that the electrochemical performance enhancements in KOH-activated carbon materials should be mainly due to the created polar oxygen-containing functional groups (OFGs, such as such as C–O, C–– O, –OH, and O–C–– O), while the role of each OFGs on the electrochemical enhancements is still unclear. In this work, KOH activation treatments were systematically conducted on carbon nanotubes (CNTs) to explore the role of each OFG on the performance enhancements of Li–S batteries (LSBs). Results showed that the capacity of activated-CNT-sulfur (a-CNT-S) cathodes is 33% higher than that of the pristine CNT-S cathodes, and their rate capability and cycling stability are also enhanced. And the electrochemical analysis combining with Fourier transform infrared spectroscopy indicated that the formed C–O bonds are the real factor for the enhanced electrochemical performances of a-CNT-S cathodes. Furthermore, the optimal activation conditions on CNTbased cathodes for LSBs were optimized to be 10 min at 700 ℃.