http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Gao, Jian-Kun,Wang, Li-Xia,Long, Bo,Ye, Xian-Tao,Su, Jing-Na,Yin, Xu-Yuan,Zhou, Xiu-Xia,Wang, Zhi-Wei Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Arsenic trioxide (ATO) has been found to exert anti-cancer activity in various human malignancies. However, the molecular mechanisms by which ATO inhibits tumorigenesis are not fully elucidated. In the current study, we explored the molecular basis of ATO-mediated tumor growth inhibition in pancreatic cancer cells. We used multiple approaches such as MTT assay, wound healing assay, Transwell invasion assay, annexin V-FITC, cell cycle analysis, RT-PCR and Western blotting to achieve our goal. We found that ATO treatment effectively caused cell growth inhibition, suppressed clonogenic potential and induced G2-M cell cycle arrest and apoptosis in pancreatic cancer cells. Moreover, we observed a significant down-regulation of Skp2 after treatment with ATO. Furthermore, we revealed that ATO regulated Skp2 downstream genes such as FOXO1 and p53. These findings demonstrate that inhibition of Skp2 could be a novel strategy for the treatment of pancreatic cancer by ATO.
Gao, Xia,Fu, Xuping,Li, Tao,Zi, Jian,Luo, Yao,Wei, Qing,Zeng, Erliang,Xie, Yi,Li, Yao,Mao, Yumin 생화학분자생물학회 2003 Journal of biochemistry and molecular biology Vol.36 No.6
In microarray data mining, one of the key problems is how to handle weak signals. Based on a bent piecewise linear accumulated distribution generally found in the microarray data, a new detectable threshold finding method is proposed to filter genes with unreliable information in this paper. More reliable and reproducible data is produced for the subsequent data mining.
Knockdown of Bcl-3 Inhibits Cell Growth and Induces DNA Damage in HTLV-1-infected Cells)
Gao, Cai,Wang, Xia,Chen, Lin,Wang, Jin-Heng,Gao, Zhi-Tao,Wang, Hui Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Oncoprotein Bcl-3 is perceived as an unusual member of $I{\kappa}B$ family since it can both stimulate and suppress NF-${\kappa}B$ activation. Aberrant Bcl-3 results in increased cell proliferation and survival, suggesting a contribution to malignant potential and elevated levels of Bcl-3 have been observed in many HTLV-1-infected T cell lines and ATL cells. To investigate the specific roles of Bcl-3 in HTLV-1-infected cells, we knocked down Bcl-3 expression using shRNA and then examined the consequences with regard to DNA damage and cell proliferation, as well as NF-${\kappa}B$ activation. The HTLV-1 encoded protein Tax promotes Bcl-3 expression and nuclear translocation. In HTLV-1-infected cells, Bcl-3 knockdown obviously induced DNA damage. Cell growth and NF-${\kappa}B$ activation were reduced in HTLV-1-infected or Tax positive cells when Bcl-3 expression was decreased. Together, our results revealed positive roles of Bcl-3 in DNA stabilization, growth and NF-${\kappa}B$ activation in HTLV-1-infected cells.
( Xia Gao ),( Xu Ping Fu ),( Tao Li ),( Jian Zi ),( Yao Luo ),( Qing Wei ),( Er Liang Zeng ),( Yi Xie ),( Yao Li ),( Yu Min Mao ) 생화학분자생물학회 2003 BMB Reports Vol.36 No.6
In microarray data mining, one of the key problems is how to handle weak signals. Based on a bent piecewise linear accumulated distribution generally found in the microarray data, a new detectable threshold finding method is proposed to filter genes with unreliable information in this paper. More reliable and reproducible data is produced for the subsequent data mining.
How Does Peer Feedback Training Work in EFL Writing?
( Ming Xia Gao ) 한국외국어대학교 외국어교육연구소 2014 외국어교육연구 Vol.28 No.2
Peer feedback, in which students work together in pairs or small groups to critique and provide comments on one another’s writing, is compatible with communicative approaches to second language acquisition (SLA) and process approaches to foreign language writing. This study, drawing on Vygotsky’s sociocultural learning theory, conducted a pretest -posttest comparison group quasi experimental design with multiple data being collected and analyzed quantitatively by using SPSSWID (ver. 17.0), to explore what role trained peer feedback plays in EFL writing context. Results of a series of t-tests in quantitative analysis showed that peer feedback training had positive effects on participants in various aspects. The experimental group students gained more than control group students in their posttest writing task. They outperformed the control group students in terms of comment quantity and quality, especially generating more specific and relevant comments on global issues and implementing more peer comments into their revisions. Peer feedback training also helped students cultivate more positive attitudes towards EFL writing. These findings suggest that peer feedback training has shown strong positive effects on EFL learners, that is, EFL students can perform peer feedback both efficiently and effectively as long as they are well-trained.
SOI radiation‑hardened 300 V half‑bridge date driver IC design with high dv/dt noise immunity
Yuexin Gao,Xiaowu Cai,Zhengsheng Han,Yun Tang,Liqiang Ding,Ruirui Xia,Mali Gao,Fazhan Zhao 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.5
Noise immunity is a critical index of high-voltage half-bridge gate driver integrated circuits (IC). Various noise cancelation technologies have been proposed to improve dv/dt noise immunity with sacrifices in terms of area and propagation delay time. Besides, when it is applied to an inductive load, the half-bridge driver is vulnerable to negative surges at the VS terminal, which is the offset ground of the high-side channel. A 300 V half-bridge gate driver IC with noise rejection module is designed in this paper. The noise immunity can be improved to 87.5 V/ns. The VS negative swing region can be extended to − 5.1 V. In addition, the proposed driver IC can work normally at a working frequency of 500 kHz and the delay matching time between the high-side and the low-side is less than 4 ns. The propagation delay time of the high-side channel is measured at 71.6 ns. Furthermore, gamma ray irradiation experimental results show that the proposed structure presents a good radiation tolerance of 100 krad (Si). The presented half-bridge gate driver IC is fabricated with the silicon-on-insulator (SOI) bipolar-CMOS-DMOS (BCD) process, which occupied an area of 1.86 mm2.
Feng-Shan Gao,Xian-zhu Xia,Yu-Wei Gao,Ya-Duo Bai,Xiao-Huan Zou,Gui-Xue Hu 대한수의학회 2009 Journal of Veterinary Science Vol.10 No.3
Two giant pandas (Ailuropoda melanoleuca) died of unknown causes in a Chinese zoo. The clinical disease profile suggested that the pandas may have suffered a viral infection. Therefore, a series of detection including virus isolation, electron microscopy, cytobiological assay, serum neutralization and RT-PCR were used to identify the virus. It was determined that the isolated virus was a canine coronavirus (CCV), on the basis of coronavirus, neutralization by canine anti-CCV serum, and 84.3% to 100% amino acid sequence similarity with CCV. The results suggest that the affected pandas had been infected with CCV.
Chengfang Qiao,Xia Gao,Qi Tang,Jianfang Wang,Yulin Gao,Meili Zhang,Zhengqiang Xia,Haitao Han,Chunxin Zhao,Chunsheng Zhou 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.12
A bifunctional lead(II)-acylhydrazone coordination polymer featuring 3D hydrogen-bonded framework exhibits intense blue luminescence and remarkable inhibitory effect on the fusarium fungi.
A Security Assessment Framework and Selection Method for Outsourcing Cloud Service
Xiaochen Liu,Chunhe Xia,Jiajin Cao,Jinghua Gao,Zhao Wei 보안공학연구지원센터 2014 International Journal of Security and Its Applicat Vol.8 No.6
Cloud services have become state of the art of resource sharing and interoperability among different service providers. The federated cloud seek to reduce costs and maximize efficiency, provide flexible and reliable services composed of various external cloud service and internal services, but this would introduce a risk of security due to outsourcing. For organization which provide an integrity cloud service must rely on SLA to illustrate the capacity of risk and performance, the various providers involved in the federations or services compositions should effectively distribute the organizational responsibilities and SLA. To solve the fears and deal with the threats associated with outsourcing, new method for selection of outsourcing cloud service providers(CSP) based on assessment of security and performance is urgently needed. This paper presents an approach on how to select the proper CSP to guarantee organizational SLA, which quantify the SLA terms and calculate a security weight, the organization can choose the appropriate CSP based on security weight, meanwhile minimize the business cost. This paper make contribution on modeling the capacity of the CSP, considering the business cost and historical performance. The proposed approach is validated through case study that shows selected CSP through our approach can best meet the organizational security and cost needs.