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부산 일부 대학교 학생들의 니코틴 의존도와 구취의 연관성
김유린(외 5명) 신라대학교 자연과학연구소 2012 自然科學論文集 Vol.22 No.-
The purpose of this study is to examine the association of bad breath and nicotine dependency. By use of the findings from this study, This study conducted the survey of 53 smoker who visited dental hygiene lab for delivery from October to November 2012 with structured questionnaires(Fagerstrom Tolerance Questionnaire FTQ) and equipment(CO measuring instrument, Oral Chroma etc). The data were analyzed by using SPSS 20.0 program for χ2-test, ANOVA. Smokers' average age was 23 years old. The more higher nicotine dependence the more the average age was higher. The more higher nicotine dependence the less to nque brushing. No association of nicotine dependence and self-bad breath level. CO State was Significant differences(ND1(M=2.58), ND2(M=3.98), ND3(M=7.41), ND4(M=4.19), ND5(M=13.14))(F=2.616, p=.047). Dimethyl Sulfide was Significant differences(F=3.026, p=.026).
양영애(Young Ae Yang),조은주(Eun Ju Jo),박수희(Soo Hee Park),박수정(Su Jong Park),김혜린(Hye Rin Kim),이명화(Myung Hwa Lee),양미연(Mi Yeon Yang) 대한인간공학회 2008 大韓人間工學會誌 Vol.27 No.4
Objective: This study is to analyze the factor affecting elderly's speed of mobile phone ability. Method: Sixty healthy senior citizens who live in Kim-hye participated in Cognition, Visual perception, Speed of mobile phone ability and the collected data was analyzed by an independent multiple regression analysis. Result: The findings can be summarized as follows; 1. Although men were faster than women while using mobile phone, there was little satisfical significance(p<0.05). 2. Although people in their sixties were faster than people in their seventies while using mobile phone, there was minial difference(p<0.05). 3. The primary factor which affect mobile phone using speed is figure ground, visual memory, visual processing and the most beneficial discovery in the entire project is figure ground(p<0.05). Conclusion: The result of study showed that in order to enhance figure ground, visual memory, visual processing in mobile phone using speed. These results will be consider useful for elderly's mobile phone ability.
김성은 ( Sung Eun Kim ),김수진 ( Soo Jin Kim ),김형수 ( Hyoung Su Kim ),김희선 ( Hee Sun Kim ),남은숙 ( Eun Sook Nam ),이상규 ( Sang Kyu Lee ),신수린 ( Su Rin Shin ),김학양 ( Hak Yang Kim ) 대한소화기학회 2006 대한소화기학회지 Vol.48 No.6
Hepatitis A is generally regarded as a mild, self-limiting disease of the liver. Acute renal failure has rarely been reported in association with non-fulminant acute hepatitis A. Acute tubular necrosis is the most common form of renal injury in such patients. We recently experienced two cases of hepatitis A in which acute renal failure occurred early in the course of the illness and had a clinical course suggestive of acute tubular necrosis. In both patients, the clinical course of renal dysfunction was almost parallel to that of hepatic dysfunction. Hemodialysis was performed in patient 1 because of severe uremia despite maintaining urine output more than 2,000 mL per day. On the other hand, hemodialysis was not performed in patient 2 who showed a rapid recovery of renal dysfunction. The renal biopsy of patient 1 demonstrated typical findings of acute tubular necrosis on microscopy. (Korean J Gastroenterol 2006;48:421-426)
( Su Rin Shin ),( Young Seok Kim ),( Young-seok Lim ),( June Sung Lee ),( Jin Woo Lee ),( Sun Myung Kim ),( Sook-hyang Jeong ),( Joo Hyun Sohn ),( Myung Seok Lee ),( Sang Hoon Park ) 대한간학회 2017 Gut and Liver Vol.11 No.2
Background/Aims: Because of the limited geographic distribution, there have been insufficient data regarding hepatitis C virus (HCV) genotype 6 in Korea. This study aimed to investigate the clinical characteristics and available treatment outcomes of patients with genotype 6 HCV in Korea. Methods: From 2004 to 2014, data were collected from Korean patients infected with genotype 6 HCV in eight hospitals. Results: Thirty-two patients had genotype 6 HCV. The median age was 44 years, and 6c was the most common subtype. The baseline median alanine transaminase level was 88 (21 to 1,019) IU/mL, and the HCV RNA level was 1,405,000 (96,500 to 28,844,529) IU/mL. Twenty-five patients were treated with peginterferon (PEG-IFN) and ribavirin. Three follow-up losses occurred. Additionally, 13 patients attained a sustained virologic response (SVR), seven patients relapsed, and two patients exhibited a null response. The SVR rates were 40% and 75% for the 24- and more than 48- week treatments, respectively, and five of the six patients who achieved a rapid virologic response (RVR) attained a SVR. Conclusions: Korean patients infected with genotype 6 HCV are relatively young, and 6c is the most common subtype. When treated with PEG-IFN and ribavirin, the SVR rate was 52%. Similar to other genotypes, a longer duration of treatment and attainment of RVR are important for SVR. (Gut Liver 2017;11:270-275)
Hepatitis C, LC : A case of spontaneous bacterial peritonitis by achromobacter xylosoxidans (초)
( Su Rin Shin ),( Myung Seok Lee ),( Eun Jeong Choi ),( Sang Hoon Park ),( Hyoung Su Kim ),( Myoung Kuk Jang ),( Ki Tae Suk ),( Dong Joon Kim ),( Ji Won Park ),( Choong Kee Park ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)
Metabolic Engineering of Saccharomyces cerevisiae for Redox Balance of Xylose Fermentation
Kim, Soo Rin,Jin, Yong-Su 경북대학교 농업생명과학대학 2014 Current Research on Agriculture and Life Sciences Vol.32 No.4
The bioconversion of cellulosic biomass hydrolyzates consisting mainly of glucose and xylose requires the use of engineered Saccharomyces cerevisiae expressing a heterologous xylose pathway. However, there is concern that a fungal xylose pathway consisting of NADPH-specific xylose reductase (XR) and NAD+-specific xylitol dehydrogenase (XDH) may result in a cellular redox imbalance. However, the glycerol biosynthesis and glycerol degradation pathways of S. cerevisiae, termed here as the glycerol cycle, has the potential to balance the cofactor requirements for xylose metabolism, as it produces NADPH by consuming NADH at the expense of one mole of ATP. Therefore, this study tested if the glycerol cycle could improve the xylose metabolism of engineered S. cerevisiae by cofactor balancing, as predicted by an in-silico analysis using elementary flux mode (EFM). When the GPD1 gene, the first step of the glycerol cycle, was overexpressed in the XR/XDH-expressing S. cerevisiae, the glycerol production significantly increased, while the xylitol and ethanol yields became negligible. The reduced xylitol yield suggests that enough NAD+ was supplied for XDH by the glycerol cycle. However, the GPD1 overexpression completely shifted the carbon flux from ethanol to glycerol. Thus, moderate expression of GPD1 may be necessary to achieve improved ethanol production through the cofactor balancing.
Kim Sung Ran,Kang Hyeon Jeong,Jeong Hye Rin,Jang Su Yeon,Lee Jae Eun,Kim Da Eun,Lee Hae Ry,Cho Min Hee,Noh Ji Yun,Cheong Hee Jin,Kim Woo Joo,Song Joon Young 대한의학회 2022 Journal of Korean medical science Vol.37 No.35
The omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to have high infectivity and is more likely to evade vaccine immunity. However, booster vaccination is expected to strengthen cross-reactive immunity, thereby increasing the vaccine effectiveness (VE). This study aimed to evaluate the relative VE of the 3-dose (booster) vaccination compared with the 2-dose primary series vaccination in healthcare workers during omicron variant-dominant periods. During the omicron-dominant period from February 1, 2022 to February 28, 2022, a 1:1 matched case-control study was conducted. Healthcare workers with positive SARS-CoV-2 test results were classified as positive cases, whereas those with negative results served as controls. Compared with the 2-dose primary series vaccination, booster vaccination with mRNA vaccine showed moderate VE (53.1%). However, in multivariate analysis including the time elapsed after vaccination, the significant VE disappeared, reflecting the impact of recent vaccination rather than the third dose itself.
Interleukin-18 Receptor α Modulates the T Cell Response in Food Allergy
Kim Eun Gyul,Leem Ji Su,Baek Seung Min,Kim Hye Rin,Kim Kyung Won,Kim Mi Na,손명현 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.4
Purpose: The prevalence of food allergy, triggered by T-helper type 2 (Th2) cell-mediated inflammation, is increasing worldwide. Interleukin (IL)-18 plays an important role in inflammatory diseases by binding with the IL-18 receptor. IL-18/IL-18 receptor α (IL-18Rα) is a cofactor for immunoglobulin E (IgE) production and Th2 cell development. Studies have not investigated the association between the IL-18/IL-18Rα signaling pathway and food allergy. Here, we investigated the role of IL-18Rα in food allergy induction and development. Methods: Wild-type (WT) and IL-18Rα-null mutant (IL-18Rα−/−) C57BL/6 mice were sensitized and challenged using ovalbumin (OVA) for food allergy induction. Food allergy symptoms, T cell-mediated immune responses, and signal transducer and activator of transcription (STAT)/suppressors of cytokine signaling (SOCS) pathways were analyzed in mice. Results: IL-18Rα expression was increased in WT mouse intestines after OVA treatment. Food allergy-induced IL-18Rα−/− mice showed attenuated systemic food allergic reactions, OVA-specific IgE and mouse mast cell protease-1 production, inflammatory cell infiltration, and T cell activation. Ex vivo experiments showed that cell proliferation and Th2 cytokine production were lower in IL-18Rα−/− mouse splenocytes than in WT mouse splenocytes. IL-18Rα blockade in WT splenocytes attenuated cell proliferation and Th2 cytokine production. Moreover, STAT3 phosphorylation was reduced in IL-18Rα−/− mice, and SOCS3 and SOCS1 activation were diminished in IL-18Rα−/− intestinal T cells. Conclusions: IL-18Rα regulates allergic reactions and immune responses by regulating T cell responses in food allergies. Moreover, IL-18Rα is involved in the STAT/SOCS signaling pathways. Targeting IL-18Rα signaling might be a novel therapeutic strategy for food allergy.
( Hyoung Su Kim ),( Ji Won Park ),( Sung Eun Kim ),( Su Rin Shin ),( Ki Tae Suk ),( Myoung Kuk Jang ),( Sang Hoon Park ),( Dong Joon Kim ),( Myung Seok Lee ),( Choong Kee Park ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Hepatitis C virus (HCV) infection is screened by immunoassays. However, false positive results of anti-HCV occur with unacceptable frequency, especially in low-prevalence populations. This study was aimed to evaluate the efficacy of screening test for HCV infection and determine anti-HCV signal-to-cutoff (S/CO) ratios to discriminate true-positive from false-positive anti-HCV infection. Methods: A total of 77,571 patients who were tested anti-HCV from 2010 to 2015 were evaluated. False-positive (FP) anti-HCV was defined as samples with negative or indeterminate RIBA results and HCV RNA negativity. True-positive (TP) anti-HCV was defined as positive RIBA or positive HCV RNA. Receiver-operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic accuracy of anti-HCV S/CO ratio for predicting HCV viremia, and for discriminating true-positive from false-positive anti-HCV infection. Results: Anti-HCV positive rate was 1.45% (1126/77571). Among the 632 patients who were tested HCV RNA and/or RIBA, 32.1% (203/632) of the patients showed false-positive antibody results. There were significant differences in serum ALT level, anti-HCV S/CO ratio and RIBA results (viremia vs. non-viremia, TP vs. FP). Using ROC curves, the optimal cutoff values of anti-HCV S/CO ratio for HCV viremia and TP were 8 and 6, respectively. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for diagnosing HCV viremia at 8.0 of anti-HCV S/CO ratio were 98.0%, 88.4%, 91.6% and 97.2%, respectively. Those for TP at 6 of anti-HCV S/CO ratio were 90.7%, 99.0%, 99.5% and 83.4%, respectively. Using the level of 6 of anti-HCV S/CO ratio, anti-HCV positive rate was changed to 0.75%. Conclusions: False positive rate was very high. Therefore, diagnostic strategy of HCV infection should be changed according to anti-HCV S/CO ratio in Korean population.