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Sheng-Rui Jian,Hou-Guang Chen,Guo-Ju Chen,Jason S.C. Jang,Jenh-Yih Juang 한국물리학회 2012 Current Applied Physics Vol.12 No.3
The effects of O2 partial pressure during RF magnetron sputtering on the structural and nanomechanical properties of a-plane ZnO thin films were investigated by using X-ray diffraction (XRD) and nanoindentation techniques. The XRD and the transmission electron microscopy (TEM) selected area diffraction results indicate that the epitaxial relationship between ZnO thin films and Al2O3 substrates is ZnO ð1120Þ//Al2O3 ð1102Þ. The average values of the hardness and Young’s modulus of the a-plane ZnO films were found to decrease with increasing oxygen partial pressure. The cross-sectional TEM revealing the localized plastic deformation of ZnO thin films beneath the Berkovich indenter, indicating the prominent role played by the threading dislocations in the film deformation behavior. At higher indentation loadings, the sapphire substrate exhibits extensive deformation with narrow slip bands appearing on {0001} plane. However, no evidence of pressure-induced phase transformation, as well as cracking and/or delamination phenomena at the filmesubstrate interface was observed.
Sheng-Mou Hsiao,Chun-Hou Liao,Ho-Hsiung Lin,Hann-Chorng Kuo 대한배뇨장애요실금학회 2015 International Neurourology Journal Vol.19 No.3
Purpose: To determine the duration of antimuscarinic therapy for overactive bladder syndrome (OAB) appropriate for assessment of the efficacy of treatment, and to evaluate the possible predictive factors for response to therapy. Methods: All OAB patients who visited a urology outpatient clinic of a tertiary referral center and who were prescribed 5 mg of solifenacin or 4 mg of tolterodine extended release capsules daily were enrolled in the study. Patients were asked to continue therapy for 6 months. All enrolled patients completed the patient perception of bladder condition, overactive bladder symptom score (OABSS), and the modified Indevus Urgency Severity Scale questionnaires. All patients underwent uroflowmetry. Results: A total of 164 patients were enrolled and 125 patients (76%) had at least one follow-up visit. The mean follow-up interval was 1 month (range, 0.5–6 months). Sixty-two patients (49.6%; 95% confidence interval [CI], 40.7–58.5) responded to antimuscarinic treatment. The median time for the onset of response was 3 months (95% CI, 1–6). Multivariate Cox proportional- hazards model revealed that elevated baseline OABSS was an independent predictor of responsiveness to therapy. Receiver operating characteristic (ROC) curve analysis revealed an optimal OABSS cutoff value of ≥7, with an area under the ROC curve of 0.79 (95% CI, 0.70–0.88; sensitivity, 91.9%; specificity, 60.7%). Conclusions: The median time for a therapeutic response was 3 months, and OABSS was the only predictor for responsiveness. These findings may serve as a guideline when prescribing antimuscarinic treatment for OAB patients.
Shengli Li,Jianan Zhang,Xiaoqun Hou,Yongyi Wang,Tong Li,Zhiming Xu,Feng Chen,Yong Zhou,Weimin Wang,Mingxing Liu 대한신경외과학회 2024 Journal of Korean neurosurgical society Vol.67 No.1
Objective : The spontaneous intracerebral hemorrhage (ICH) remains a significant cause of mortality and morbidity throughout the world. The purpose of this retrospective study is to develop multiple models for predicting ICH outcomes using machine learning (ML). Methods : Between January 2014 and October 2021, we included ICH patients identified by computed tomography or magnetic resonance imaging and treated with surgery. At the 6-month check-up, outcomes were assessed using the modified Rankin Scale. In this study, four ML models, including Support Vector Machine (SVM), Decision Tree C5.0, Artificial Neural Network, Logistic Regression were used to build ICH prediction models. In order to evaluate the reliability and the ML models, we calculated the area under the receiver operating characteristic curve (AUC), specificity, sensitivity, accuracy, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR). Results : We identified 71 patients who had favorable outcomes and 156 who had unfavorable outcomes. The results showed that the SVM model achieved the best comprehensive prediction efficiency. For the SVM model, the AUC, accuracy, specificity, sensitivity, PLR, NLR, and DOR were 0.91, 0.92, 0.92, 0.93, 11.63, 0.076, and 153.03, respectively. For the SVM model, we found the importance value of time to operating room (TOR) was higher significantly than other variables. Conclusion : The analysis of clinical reliability showed that the SVM model achieved the best comprehensive prediction efficiency and the importance value of TOR was higher significantly than other variables.
Ice Disaster Prevention Measure Optimization Model
Hui Hou,Yuan-sheng Li,Joe Dong,Ning Lu,Ai-hong Tang 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.9
Based on some commonly used methods of deicing technology, this paper used the series-parallel network system to express the risk level and proposed a simplified mathematical optimization model to arrange the ice prevention measures properly to make the lowest input while achieve the best ice prevention effect. An example based on WSCC-9 system is calculated using MATLAB. It can be seen that the deicing tool input should be larger if the efficiency of deicing tools is low or the expected failure probability is low. And a higher failure probability indicates more deicing tool input.
Numerical Simulation of Spray Flow in Injector For the Steamjet Engine
( Xu Sheng Shang ),( Jiang Hong Li ),( Ren Hou Zhao ),( Xu Ze Shang ),( Jie Hong Li ) 한국액체미립화학회 2005 한국액체미립화학회 학술강연회 논문집 Vol.2005 No.-
In this paper, according to the work mechanism of SteamJet, With the certain small scaled turbojet for an influence, along flying trajectory calculating mass of import air and injection water, establishing the spray physics model/ mathematics model. Based on the equation of three-dimension Renault average N-S, air to adopt the limited physical volume method, the liquid adopts to the Lagrangian orbit model, with straight injecting the current method ,Simulate the field of air/ liquid two phase flow field to distribute of inlet to carry on mutually. The results indicate that spray have an effect on flow field configuration. It is concluded that the numerical model and CFD method for modeling spray flow processes in gas/liquid injector will be satisfactory. Similar to the SteamJet the United States puts forward, adopting water injection can satisfy to import the conditional request for pressure and temperature of compressor.
Chen Sheng-tao,Li Dong-ju,Tian Hao,Hou Jiao-yi,Ning Da-yong,Gong Yong-jun 대한조선학회 2022 International Journal of Naval Architecture and Oc Vol.14 No.1
Maneuverability, which is closely related to navigation safety, is an important part of the overall performance of an underwater vehicle. The purpose of this study is to analyze the dynamic response of an underwater vehicle to internal waves at different angles and speeds. A combination of experiments and numerical simulations is used to compare the forces on the underwater vehicle. In terms of fluidstructure coupling, the internal wave interface is tracked by the VOF method. In this paper, waves of the same amplitude ratio as the numerical results are simulated using a wave-making sphere. The validity of the numerical method is verified by comparing with the rotation moment test of the underwater vehicle. The results show that different angles of attack have significant effects on the forces and moments of the underwater vehicle and that choosing the right angle of attack and rotation speed can limit the dangerous depth. The conclusion is of certain significance for the safety of underwater navigation.
Jinlin Hou,Edward Gane,Rozalina Balabanska,Wenhong Zhang,Jiming Zhang,Tien Huey Lim,Qing Xie,Chau-Ting Yeh,Sheng-Shun Yang,Xieer Liang,Piyawat Komolmit,Apinya Leerapun,Zenghui Xue,Ethan Chen,Yuchen Zh 대한간학회 2024 Clinical and Molecular Hepatology(대한간학회지) Vol.30 No.2
Background/Aims: Four-week treatment of linvencorvir (RO7049389) was generally safe and well tolerated, and showed anti-viral activity in chronic hepatitis B (CHB) patients. This study evaluated the efficacy, safety, and pharmacokinetics of 48-week treatment with linvencorvir plus standard of care (SoC) in CHB patients. Methods: This was a multicentre, non-randomized, non-controlled, open-label phase 2 study enrolling three cohorts: nucleos(t)ide analogue (NUC)-suppressed patients received linvencorvir plus NUC (Cohort A, n=32); treatment-naïve patients received linvencorvir plus NUC without (Cohort B, n=10) or with (Cohort C, n=30) pegylated interferon-α (Peg-IFN-α). Treatment duration was 48 weeks, followed by NUC alone for 24 weeks. Results: 68 patients completed the study. No patient achieved functional cure (sustained HBsAg loss and unquantifiable HBV DNA). By Week 48, 89% of treatment-naïve patients (10/10 Cohort B; 24/28 Cohort C) reached unquantifiable HBV DNA. Unquantifiable HBV RNA was achieved in 92% of patients with quantifiable baseline HBV RNA (14/15 Cohort A, 8/8 Cohort B, 22/25 Cohort C) at Week 48 along with partially sustained HBV RNA responses in treatment-naïve patients during follow-up period. Pronounced reductions in HBeAg and HBcrAg were observed in treatment-naïve patients, while HBsAg decline was only observed in Cohort C. Most adverse events were grade 1–2, and no linvencorvir-related serious adverse events were reported. Conclusions: 48-week linvencorvir plus SoC was generally safe and well tolerated, and resulted in potent HBV DNA and RNA suppression. However, 48-week linvencorvir plus NUC with or without Peg-IFN did not result in the achievement of functional cure in any patient.
Effect of Heat Treatment on Microstructural Evolution of 13Cr Martensitic Stainless Steel
Ma, Hou Yu,He, Yin Sheng,Lee, Kwon Yeong,Shin, Kee Sam Trans Tech Publications, Ltd. 2017 Key Engineering Materials Vol.727 No.-
<P>13Cr martensitic stainless steels are widely used in gas industry, which are usually manufactured by quenching-tempering treatment. Microstructural study of 13Cr steel through various heat treatments was carried out for determining the optimum parameters for industry manufacture. After quenching treatment at 975 °C for 20 min, precipitation-free martensitic structures were formed. During tempering, recovery of martensite through grain boundaries migration and dislocations annihilation was found to soften the steel. In addition, transformation of needle-like Cr7C3 carbides to the irregular shaped Cr23C6 carbides was observed when tempering temperature is above 710 °C. The phase transformation induced precipitation strengthening is discussed. The optimum heat treatment parameters of 13Cr steel for avoiding over tempering and the precipitation hardening are found.</P>