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( Sehyun Jung ),( Soojin Lee ),( Yaerim Kim ),( Semin Cho ),( Hyuk Huh ),( Yong Chul Kim ),( Seung Seok Han ),( Hajeong Lee ),( Jung Pyo Lee ),( Kwon Wook Joo ),( Chun Soo Lim ),( Yon Su Kim ),( Dong 대한신장학회 2024 Kidney Research and Clinical Practice Vol.43 No.2
Background: Further study is warranted to determine the association between estimated glomerular filtration rate (eGFR) or albuminuria and the risk of death from diverse causes. Methods: We screened >10 million general health screening examinees who received health examinations conducted in 2009 using the claims database of Korea. After the exclusion of those previously diagnosed with renal failure and those with missing data, 9,917,838 individuals with available baseline kidney function measurements were included. The primary outcome was mortality and cause-specific death between 2009 and 2019 identified through death certificates based on the diagnostic codes of International Classification of Diseases, 10th revision. Multivariable Cox regression analysis adjusted for various clinicodemographic and social characteristics was used to assess mortality risk. Results: The hazard ratio of death was significantly high in both the eGFR <60 mL/min/1.73 m<sup>2</sup> and in the eGFR ≥120 mL/min/1.73 m<sup>2</sup> groups in univariable and multivariable regression analyses when compared to those within the reference range (eGFR of 90-120 mL/min/1.73 m<sup>2</sup>). The results were similar for death by cardiovascular, cancer, infection, endocrine, respiratory, and digestive causes. We also found that albuminuria was associated with higher risk of death regardless of eGFR range, and those in the higher categories of dipstick albuminuria showed higher risk. Conclusion: We reconfirmed the significant association between eGFR, albuminuria, and mortality. Healthcare providers should keep in mind that albuminuria and decreased eGFR as well as kidney hyperfiltration are independent predictors of mortality.
Jung, Chang-Hwa,Choi, Jin-Kyu,Yang, Yoosoo,Koh, Hyun-Ju,Heo, Paul,Yoon, Kee-Jung,Kim, Sehyun,Park, Won-Seok,Shing, Hong-Ju,Kweon, Dae-Hyuk Informa Healthcare 2012 PHARMACEUTICAL BIOLOGY Vol.50 No.9
<P><I>Context: Botulinum</I> neurotoxins (BoNTs) are popularly used to treat various diseases and for cosmetic purposes. They act by blocking neurotransmission through specific cleavage of soluble <I>N</I>-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins. Recently, several polyphenols were shown to interfere with SNARE complex formation by wedging into the hydrophobic core interface, thereby leading to reduced neuroexocytosis.</P><P><I>Objective</I>: In order to find industrially-viable plant extract that functions like BoNT, 71 methanol extracts of flowers were screened and BoNT-like activity of selected extract was evaluated.</P><P><I>Materials and methods</I>: After evaluating the inhibitory effect of 71 flower methanol extracts on SNARE complex formation, seven candidates were selected and they were subjected to SNARE-driven membrane fusion assay. Neurotransmitter release from neuronal PC12 cells and SNARE complex formation inside the cell was also evaluated. Finally, the effect of one selected extract on muscle contraction and digit abduction score was determined.</P><P><I>Results</I>: The extract of <I>Potentilla chinensis</I> Ser. (Rosaceae)(Chinese cinquefoil) flower inhibited neurotransmitter release from neuronal PC12 cells by approximately 90% at a concentration of 10 μg/mL. The extract inhibited neuroexocytosis by interfering with SNARE complex formation inside cells. It reduced muscle contraction of phrenic nerve-hemidiaphragm by approximately 70% in 60 min, which is comparable to the action of the Ca<SUP>2+</SUP>-channel blocker verapamil and BoNT type A.</P><P><I>Discussion and conclusion</I>: While BoNT blocks neuroexocytosis by cleaving SNARE proteins, the <I>Potentilla chinensis</I> extract exhibited the same activity by inhibiting SNARE complex formation. The extract paralyzed muscle as efficiently as BoNT, suggesting the potential versatility in cosmetics and therapeutics.</P>
Efficacy of Caffeine in Promoting Hair Growth by Enhancing Intracellular Activity of Hair Follicles
Kim, Sehyun,Kim, Su Na,Jeong, Gyusang,Hong, Min Jung,Lee, Yonghee,Shin, Seung Hyun,Park, Hyeokgon,Jung, Yu Chul,Kim, Eun Joo,Park, Byung Cheol,Kim, Hyoung-June Society of Cosmetic Scientists of Korea 2019 Korean journal of cosmetic science Vol.1 No.1
Caffeine is widely used in cosmetics and hair care products. Although its efficacy in stimulating hair growth has been confirmed in recent studies, its mechanism of action remains unelucidated. The present study aimed to determine the effects of caffeine on hair growth, with a focus on intracellular hair follicle activity. Experiments included in vitro and ex vivo tests, and a clinical study. Caffeine enhanced the cellular activity and potassium channel opening. It also promoted human hair follicle elongation. Immunohistochemical staining showed that the Ki-67 signal was significantly higher in cells treated with caffeine. These efficacies of caffeine were comprehensively demonstrated in clinical results, wherein caffeine-containing shampoo improved hair density after 24 weeks of testing. Collectively, the results of this study demonstrated that caffeine promoted hair growth and inhibited the progression of hair loss by enhancing intracellular activity of hair follicles.
Heo, Youn-Jung,Jung, Yen-Sook,Hwang, Kyeongil,Kim, Jueng-Eun,Yeo, Jun-Seok,Lee, Sehyun,Jeon, Ye-Jin,Lee, Donmin,Kim, Dong-Yu American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.45
<P>For the first time, the photovoltaic modules composed of small molecule were successfully fabricated by using roll-to-roll compatible printing techniques. In this study, blend films of small molecules, BTR and PC71BM were slot-die coated using a halogen-free solvent system. As a result, high efficiencies of 7.46% and 6.56% were achieved from time-consuming solvent vapor annealing (SVA) treatment and roll to-roll compatible solvent additive approaches, respectively. After successful verification of our roll-to-roll compatible method on small-area devices, we further fabricated large-area photovoltaic modules with a total active area of 10 cm(2), achieving a power conversion efficiency (PCE) of 4.83%. This demonstration of large-area photovoltaic modules through roll-to roll compatible printing methods, even based on a halogen-free solvent, suggests the great potential for the industrial-scale production of organic solar cells (OSCs).</P>
Lee, Donmin,Jung, Yen-Sook,Heo, Youn-Jung,Lee, Sehyun,Hwang, Kyeongil,Jeon, Ye-Jin,Kim, Jueng-Eun,Park, Jiyoon,Jung, Gun Young,Kim, Dong-Yu American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.18
<P>Recently, many kinds of printing processes have been studied to fabricate perovskite solar cells (PeSCs) for mass production. Among them, slot-die coating is a promising candidate for roll-to-roll processing because of high-throughput, easy module patterning, and a premetered coating system. In this work, we employed mixed lead precursors consisting of PbAc<SUB>2</SUB> and PbCl<SUB>2</SUB> to fabricate PeSCs via slot-die coating. We observed that slot-die-coated perovskite films based on the mixed lead precursors exhibited well-grown and uniform morphology, which was hard to achieve by using only a single lead source. Consequently, PeSCs made with this precursor system showed improved device performance and reproducibility over single PbAc<SUB>2</SUB>. Lastly, a large-area module with an active area of 10 cm<SUP>2</SUP> was fabricated with a power conversion efficiency of 8.3%.</P> [FIG OMISSION]</BR>
Choi, Hyo-Jung,Yoon, Yu-Jeong,Kwon, Yong-Kook,Lee, Yu-Jung,Chae, Sehyun,Hwang, Daehee,Hwang, Geum-Sook,Kwon, Tae-Hwan American Chemical Society 2012 Journal of proteome research Vol.11 No.7
<P>To investigate the effects of changes in extracellular osmolality on the function of kidney collecting duct cells, particularly on water and sodium reabsorption in the conditions of diuresis and antidiuresis, we generated transcriptome and metabolome profiles of primary cultured inner medullary collecting duct (IMCD) cells. They were grown in hyperosmolar culture medium (640 mOsm) for 4 days and then exposed to either reduced (300 mOsm) or same osmolality for 1 or 2 days more. Integrated analysis of the transcriptome and metabolome revealed that decreased extracellular osmolality was associated with decreased levels of organic osmolytes, glucose, intermediates of citric acid cycle, and branched-chain amino acids (BCAA) in IMCD cells, along with significantly decreased gene expression and protein abundance of P-type transporters (ATP1B1), ABC transporters (ABCC5 and ABCG1), and insulin signaling pathways (IRS2). Quantitative real-time RT-PCR and semiquantitative immunoblotting confirmed the changes of transcript levels of differentially expressed genes and protein levels. Taken together, integrated analysis of omics data demonstrated that water and sodium reabsorption could be reduced by decreased extracellular osmolality per se, through decreased levels of ABC transporters and IRS2, which play a potential role in the transport of organic osmolytes, BCAA, glucose, and trafficking of epithelial sodium channel.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2012/jprobs.2012.11.issue-7/pr300309d/production/images/medium/pr-2012-00309d_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr300309d'>ACS Electronic Supporting Info</A></P>
Yang, Yoosoo,Shin, Jae Yoon,Oh, Jung-Mi,Jung, Chang Hwa,Hwang, Yunha,Kim, Sehyun,Kim, Jun-Seob,Yoon, Kee-Jung,Ryu, Ji-Young,Shin, Jaeil,Hwang, Jae Sung,Yoon, Tae-Young,Shin, Yeon-Kyun,Kweon, Dae-Hyuk National Academy of Sciences 2010 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.107 No.51
<P>Neuronal SNARE proteins mediate neurotransmitter release at the synapse by facilitating the fusion of vesicles to the presynaptic plasma membrane. Cognate v-SNAREs and t-SNAREs from the vesicle and the plasma membrane, respectively, zip up and bring about the apposition of two membranes attached at the C-terminal ends. Here, we demonstrate that SNARE zippering can be modulated in the midways by wedging with small hydrophobic molecules. Myricetin, which intercalated into the hydrophobic inner core near the middle of the SNARE complex, stopped SNARE zippering in motion and accumulated the trans-complex, where the N-terminal region of v-SNARE VAMP2 is in the coiled coil with the frayed C-terminal region. Delphinidin and cyanidin inhibited N-terminal nucleation of SNARE zippering. Neuronal SNARE complex in PC12 cells showed the same pattern of vulnerability to small hydrophobic molecules. We propose that the half-zipped trans-SNARE complex is a crucial intermediate waiting for a calcium trigger that leads to fusion pore opening.</P>