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Human Papilloma Virus Detection by INNOLiPA HPV in Prostate Tissue from Men of Northeast Mexico
Rodriguez, Martha I Davila,Morales, Cesar V Ignacio,Tovar, Anel R Aragon,Jimenez, Delia Olache,Maldonado, Edmundo Castelan,Miranda, Sandra Lara,Gutierrez, Elva I Cortes Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.11
Background: Prostatic adenocarcinoma by Prosate cancer (PCa) is the most prevalent cancer and the second cause of cancer-related death among men in the Western world. Human papilloma virus (HPV) may be considered as a preventable risk factor. In this study, we assessed the frequencies of HPV infection in prostatic adenocarcinoma and benign prostatic hyperplasia (BPH) cases in Northeast Mexico. Materials and Methods: A total of 87 paraffin-embedded blocks (from 25 and 62 patients with definite diagnoses of BPH and adenocarcinoma, respectively) were selected and subjected to INNOLiPA HPV Genotyping to detect 28 high- and low-risk HPV types. The rates of infection were compared in the two studied groups. Results: INNOLiPA HPV demonstrated great sensitivity for HPV detection on paraffin-embedded tissue. Global prevalence was 14.9% (13/87). HPV infection was positive in 19.4% (12/62) of patients with adenocarcinoma and 4.0% (1/25) of patients with BPH. HPV-11, which is considered to be low risk, was more prevalent. Interestingly, one patient with BPH and six with prostate cancer showed examples considered to be high risk (HPV-18, -51, -52, and -66). Conclusion: A higher rate of HPV infection among Mexican patients with prostatic carcinoma than among those with BPH was observed. HPV infections may thus contribute to the risk of prostate cancer. Further studies are required to elucidate any roles of HPV infection in prostate disease in Mexico and the effect of prevention and treatment of HPV infection on prostatic adenocarcinoma.
Advances in neoadjuvant therapy for resectable pancreatic cancer over the past two decades
Alvaro Gregorio Morales Taboad,Pablo Lozano Lominchar,Lorena Martin Roman,Pilar Garcia-Alfonso,Andres Jesus Munoz Martin,Jose Antonio Blanco Rodriguez,Jose Manuel Asencio Pascual 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.2
In the last two decades, pancreatic cancer has been undergoing important changes in its perioperative management due to the great interest in multidisciplinary management and preoperative multimodal therapy, which in numerous studies have shown promising clinical results. Although the standard of treatment for resectable pancreatic ductal adenocarcinoma (PDAC) today is surgery followed by adjuvant therapy, as it is a biologically aggressive disease, even with complete resection, it has high rates of local and distant relapse. Several retrospective and prospective phase I/II studies have opened the window for neoadjuvant therapy with chemotherapy (CT), chemoradiotherapy (CRT), or both, as an alternative treatment for resectable pancreatic cancer, with promising results. Neoadjuvant therapy could has some advantages, including early administration of systemic treatment, in vivo assessment of response to treatment, increase resectability rate in borderline patients, increase resection rate with negative margin and survival benefit. While it seems clear that even potentially resectable disease would benefit from preoperative multimodal therapy, the optimal neoadjuvant therapeutic strategy is still controversial and currently there are only recommendations for neoadjuvant treatment, in clinical guidelines such as the NCCN and ESMO, for borderline and/or locally advanced PDAC. This review provides an overview of recent studies available and how they relate to systemic treatment of resectable PDAC in the neoadjuvant setting.
( Alvaro G. Morales Taboada ),( Jose Manuel Asencio Pascual ),( Pablo Lozano Lominchar ),( Jose Angel Lopez Baena ),( Enrique Velasco ),( Luis Rodriguez-bachiller ),( Benjamin Diaz Zorita ),( Arturo C 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: To analyze the impact of multimodal treatment strategy with neoadjuvant chemotherapy and intraoperative radiation therapy (IORT), on overall median survival in patients with pancreatic cancer. Methods: We analyzed 128 patients, from 1995 to 2016, who underwent multimodal treatment with and without neoadjuvant chemotherapy, surgery and intraoperative radiation therapy (IORT). The patients were stratified in two groups based in multimodality therapy. The data analyses were carried out using the chi-squared test, and the median survival was estimated according to the Kaplan-Meier method. Results: The mean age was 65 years, 71 men (55%) and 58 women (45%), the mean follow-up was 32.5 months with a median of 15.5 months. 19.5% received complete treatment and 41 patients were also treated with IORT, 23 patients (56.1%) were treated as part of the multimodal treatment versus 18 (43.9%), P=<0.001). The overall survival was 57.90 +/- 12.59 months for the neoadjuvant treatment group compared to 39.05 +/- 6.76 months in the control group without neoadjuvant treatment, (P=0, 05). IORT vs Not IORT was 62.05 +/- 13.34 months VS 38.65 +/- 6.58 months, P=0.027 respectively. Conclusions: Neoadjuvant and local therapy with intraoperative radiation therapy (IORT) are feasible strategies and associated with a longer overall median survival.
The erector spinae plane block: a narrative review
Pablo Kot,Pablo Rodriguez,Manuel Granell,Beatriz Cano,Lucas Rovira,Javier Morales,Ana Broseta,Jose De Andrés 대한마취통증의학회 2019 Korean Journal of Anesthesiology Vol.72 No.3
Regional anesthesia and pain management have experienced advances in recent years, especially with the advent of fascial plane blocks. The erector spinae plane block is one of the newest techniques to be described. In the past two years, publications referring to ESP block have increased significantly. The objective of this review is to analyze the articles about ESP block that have been published to date. We performed a search in the main databases and identified 368 articles. After a selection of the relevant articles, 125 studies were found eligible and were included in the review. The ESP block is performed by depositing the local anesthetic in the fascial plane, deeper than the erector spinae muscle at the tip of the transverse process of the vertebra. Many cases of its use have been described with satisfactory results in the treatment of both acute pain and chronic pain. The applicability of the technique covers many clinical scenarios. Of the 98 case reports reviewed, 12 and 87 articles, respectively described the technique as a treatment for chronic pain and acute pain. The single-shot was the most frequently used technique. As described in the articles published to date, the technique is easy to perform and has a low rate of complications. However, despite the effectiveness of the technique, further studies are necessary to obtain more evidence of its actions.
The Ambulatory Integration of the Medical and Social (AIMS) model: A retrospective evaluation
( Jeannine M. Rowe ),( Victoria M. Rizzo ),( Gayle Shier Kricke ),( Kate Krajci Grisel ),( Rodriguez Morales ),( Michelle Newman ),( Robyn Golden ) 한국행정학회 2016 한국행정학회 학술발표논문집 Vol.2016 No.-
An exploratory, retrospective evaluation of Ambulatory Integration of the Medical and Social (AIMS), a care coordination model designed to integrate medical and non-medical needs of patients and delivered exclusively by social workers was conducted to examine mean utilization of costly health care services for older adult patients. Results reveal mean utilization of 30-day hospital readmissions, emergency department (ED) visits, and hospital admissions are significantly lower for the study sample compared to the larger patient population. Comparisons with national population statistics reveal significantly lower mean utilization of 30-day admissions and ED visits for the study sample. The findings offer preliminary support regarding the value of AIMS.
The Ambulatory Integration of the Medical and Social (AIMS) model
Jeannine M. Rowe,Victoria M Rizzo,Gayle Shier Kricke,Kate Krajci,Grisel Rodriguez Morales,Michelle Newman,Robyn Golden 한국정책분석평가학회 2016 한국정책분석평가학회 학술대회발표논문집 Vol.2016 No.2
An exploratory, retrospective evaluatfon of Ambulatory Integration of the Medical and Social (AIMS), a care coordination model designed to integrate medical and non-medical needs of patients and delivered exclusively by social workers was conducted to examine mean utilization of costly health care services for older adult patients. Results reveal mean utilization of 30-day hospital readmissions, emergency department (ED) visits, and hospital admissions are significantly lower for the study sample compared to the larger patient population. Comparisons with national population statistics reveal significantly lower mean utilization of 30-day admissions and ED visits for the study sample. The findings offer preliminary support regarding the value of AIMS.
Alida Ospina-Orejarena,Ricardo Vera-Graziano,Maria Monica Castillo-Ortega,Juan Paulo Hinestroza,Mabel Rodriguez-Gonzalez,Laura Palomares-Aguilera,Marissa Morales-Moctezuma,Alfredo Maciel-Cerda 한국조직공학과 재생의학회 2016 조직공학과 재생의학 Vol.13 No.4
Increasing bioactivity and mechanical properties of polymers to produce more suitable scaffold for tissue engineering is a recurrent goal in the development of new biomedical materials. In this study, collagen-functionalized poly (lactic acid), PLA, was obtained by means of a simple grafting route, and electrospun scaffolds were produced to grow cells in vitro; their bioactivity was compared with scaffolds made of physical blends of PLA and collagen. Grafting was verified via nuclear magnetic resonance, attenuated total reflection-Fourier transform infrared and X-ray photoelectron spectroscopy. The cell adhesion performance of the scaffolds was studied using macrophages. Elastic modulus (74.7 megapascals) and tensile strength (3.0 megapascals) of the scaffold made from PLA grafted with collagen were substantially higher than the scaffolds made from physical blends of collagen and PLA: 32 and 2.16 megapascals, respectively, implying a more resistant material because of the chemical bond of the polypeptide to PLA. Besides, the fibers had more uniform diameter without defects. Scaffolds made from PLA grafted with collagen presented four-fold increase in cell adhesion than those of PLA blended with collagen. Furthermore, cell spreading within the scaffolds occurred only when collagen-functionalized poly (lactic acid) was used. These results open a new option for the easy tailoring of nanofiber-based scaffolds in three dimensions for tissue engineering.