The Impact of Neoadjuvant Chemotherapy Associated with Intraoperative Radiation Therapy (IORT) in Pancre- atic Cancer = The Impact of Neoadjuvant Chemotherapy Associated with Intraoperative Radiation Therapy (IORT) in Pancre- atic Cancer

다국어 초록 (Multilingual Abstract)

Aims: To analyze the impact of multimodal treatment strategy with neoadjuvant chemotherapy and intraoperative radiation therapy (IORT), on overall median survival in patients with pancreatic cancer.
Methods: We analyzed 128 patients, from 1995 to 2016, who underwent multimodal treatment with and without neoadjuvant chemotherapy, surgery and intraoperative radiation therapy (IORT). The patients were stratified in two groups based in multimodality therapy. The data analyses were carried out using the chi-squared test, and the median survival was estimated according to the Kaplan-Meier method.
Results: The mean age was 65 years, 71 men (55%) and 58 women (45%), the mean follow-up was 32.5 months with a median of 15.5 months. 19.5% received complete treatment and 41 patients were also treated with IORT, 23 patients (56.1%) were treated as part of the multimodal treatment versus 18 (43.9%), P=<0.001). The overall survival was 57.90 +/- 12.59 months for the neoadjuvant treatment group compared to 39.05 +/- 6.76 months in the control group without neoadjuvant treatment, (P=0, 05). IORT vs Not IORT was 62.05 +/- 13.34 months VS 38.65 +/- 6.58 months, P=0.027 respectively.
Conclusions: Neoadjuvant and local therapy with intraoperative radiation therapy (IORT) are feasible strategies and associated with a longer overall median survival.