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- 저자 : ( Qingyan Zhang ) (검색결과 5 건)
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Xiaoyun Chai,Qingyan Sun,Shichong Yu,Yongwei Jiang,Yan Zou,Qiuye Wu,Dazhi Zhang,Yuan-Ying Jiang,Yongbing Cao 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.11
A series of novel 1, 2, 4-triazole derivatives (9a-p) have been designed and synthesized as the potential antifungal agents. All compounds were characterized by 1H-NMR, 13C-NMR, and LCMS. Their antifungal activities against seven human pathogenic fungi were evaluated in vitro by measuring the minimal inhibitory concentrations. Most of the tested compounds were found to be more potent against Candida albicans than the control drug fluconazole.
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Marein Prevented LPS-Induced Osteoclastogenesis by Regulating the NF-κB Pathway In Vitro
( Yuling Li ),( Jing Zhang ),( Caiping Yan ),( Qian Chen ),( Chao Xiang ),( Qingyan Zhang ),( Xingkuan Wang ),( Ke Jiang ) 한국미생물생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.2
Many bone diseases such as osteolysis, osteomyelitis, and septic arthritis are caused by gramnegative bacterial infection, and lipopolysaccharide (LPS), a bacterial product, plays an essential role in this process. Drugs that inhibit LPS-induced osteoclastogenesis are urgently needed to prevent bone destruction in infective bone diseases. Marein, a major bioactive compound of Coreopsis tinctoria, possesses anti-oxidative, anti-inflammatory, anti-hypertensive, antihyperlipidemic, and anti-diabetic effects. In this study, we measured the effect of marein on RAW264.7 cells by CCK-8 assay and used TRAP staining to determine osteoclastogenesis. The levels of osteoclast-related genes and NF-κB-related proteins were then analyzed by western blot, and the levels of pro-inflammatory cytokines were quantified by ELISA. Our results showed that marein inhibited LPS-induced osteoclast formation by osteoclast precursor RAW264.7 cells. The effect of marein was related to its inhibitory function on expressions of pro-inflammatory cytokines and osteoclast-related genes containing RANK, TRAF6, MMP-9, CK, and CAII. Additionally, marein leads to markedly inhibited NF-κB signaling pathway activation in LPS-induced RAW264.7 cells. Concurrently, when the NF-κB signaling pathway was inhibited, osteoclast formation and proinflammatory cytokine expression were decreased. Collectively, marein could inhibit LPS-induced osteoclast formation in RAW264.7 cells via regulating the NF-κB signaling pathway. Our data demonstrate that marein might be a potential drug for bacteria-induced bone destruction disease. Our findings provide new insights into LPS-induced bone disease.
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Hot Deformation and Workability of a CrCoNi Medium Entropy Alloy
Haijun Wang,Zhitong Hu,Junsheng Cao,Shuai Zhang,Tao Cheng,Qingyan Wang 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.2
Hot compression behaviors of CrCoNi medium entropy alloy are were performed on the Gleeble-3800 thermal simulator inthe strain rate range from 0.01 to 10 s−1 and the temperature range from 800 to 1100 °C. According to the true stress-truestrain curves, the true stress decreases with the decreasing of strain rate and the increasing of deformation temperature. Theexperimental parameters were fitted, and a modified model based on Arrhenius hyperbolic sine was established. Amongthem, material constants such as, n, A, and Q are functions of strain. Meanwhile, the processing map of CrCoNi mediumentropy alloy under different strain conditions are established. Importantly, the optimal domain of apparent flow stabilitycan be determined as the deformation temperature from 900 to 1100 °C and the strain rate from 0.01 to 10 s−1. The resultsindicate that the stability domain of the CrCoN medium entropy alloy has a wider range, and the strain has little effect onits processing performance.
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Shaodan Jia,Lun Ma,Xinke Chen,Qingyan Fang,Cheng Zhang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.116 No.-
Rotary spray drying technology with bypass flue is widely adopted to realize the zero-discharge of desulfurizationwastewater in coal-fired power stations. Significantly, the deflector structure of the dryingtower is an essential factor affecting the evaporation performance of desulfurization wastewater. Thispaper is aimed to study the effect of the angle and number of the deflectors on the evaporation performancein a drying tower of a 600 MW coal-fired station. Results show that the gas distributor dividesthe flue gas into internal and external parts, and the flue gas in the internal channel is the main factoraffecting the evaporation performance. The deflector angles (especially for the internal deflector) havea remarkable impact on the evaporation behaviors, while the deflector numbers just have a minor effecton that. When the deflector number is 24 and the angles of internal and external deflectors are set at 0and 45, respectively, a better evaporation performance is obtained with the weighted average time ofapproximately 0.17 s and the complete evaporation distance of approximately 3.93 m. These optimal settingsare adopted in the actual operation, and the industrial measured results show good performance isobtained.
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Li Ying,Lin Yuan,Jia Bing,Chen Geng,Shi Huineng,Xu Rui,Li Xuejiao,Tang Junrong,Tang Qingyan,Zhang Guanghui,Yang Jianli,Fan Wei,Yang Shengchao 한국식물학회 2022 Journal of Plant Biology Vol.65 No.1
Methyl jasmonate (MeJA) has been widely used to improve the biosynthesis of secondary metabolites such as triterpenoid saponins in medicinal plants. However, the underlying molecular mechanisms remain poorly understood. Differing from roots that accumulate protopanaxatriol-type saponins, Panax notoginseng leaves with a lower biomass mainly contain protopanaxadiol (PPD)-type saponins. Therefore, it is interesting to explore whether MeJA can activate the biosynthesis of PPD-type saponins in P. notoginseng leaves. In this study, we found MeJA could effectively induce the accumulation of PPD-type saponins, including ginsenoside Rb1, Rc, Rb2, Rb3 and notoginsenoside Fa, Fe in P. notoginseng leaves based on a newly established high-performance liquid chromatography method. Transcriptome analysis showed that differentially expressed genes (DEGs) induced by MeJA were mainly enriched in “terpenoid backbone biosynthesis”, “biosynthesis of unsaturated fatty acids”, “sesquiterpenoid and triterpenoid biosynthesis”, “fatty acid metabolism”, and “phenylpropanoid biosynthesis”. Furthermore, the expression profile and quantitative real-time PCR analysis of DEGs showed that MeJA could positively induce the molecular response of endogenous jasmonic acid (JA) signaling pathway, and increased PPD-type saponins mediated by MeJA in P. notoginseng leaves may be related to the high expression of FPS, SS, SE, DS and UGTs, and the low expression of CYP716A53v2 and β-AS. The results provide a molecular understanding for MeJA-elicited biosynthesis of triterpenoid saponins and facilitate the further characterization of the genes responsible for biosynthesis of PPD-type saponins in P. notoginseng leaves.
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