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A case of cloacogenic carcinoma mistaken to condyloma accuminatum
( Nu-ri Na ),( Hyungrok Kim ),( Osung Kwon ),( Yong-woo Choi ),( Joonsoo Park ),( Hyun Chung ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Cloacogenic carcinoma is a rare tumor of the anorectal region accounting for 20% of anorectal carcinoma. The tumor arises from the mucosa or the glands of a small zone of transitional epithelium at the anorectal junction as the remnant of the embryonic cloaca. Cloacogenic carcinoma must be differentiated from carcinomas of the anus and rectum, and from such inflammatory lesions as hemorrhoids and abscess but it may originate anywhere along the path of the ducts, they are occasionally found in the rectum or anus separate from the cloacogenic mucosa. And the many presentations and histologic appearance of cloacogenic carcinoma make clinical diagnosis difficult The patient was 79 years old man, who had hypertension ,diabetic mellitus, atrial flutter for several years. From 3month ago for visit, about 3cm sized soft erythematous plaque arised at Right perianal area. At first the patient had no symptom and the lesion looked like benign inflammatory disease, so it was mistaken for condyloma accuminatum. On biopsy, it was diagnosed with cloacogenic carcinoma with dual differentiation of pagetoid disease and Squamous cell carcinoma. On further evaluations, CEA level was normal, and there was no metastasis on radiologic evaluation. Because cloacogenic carcinoma can be easily mistaken for other anorectal disease like our case, and there have been only few reports of cloacogenic carcinoma, we report this case with our experience
Choi, Nu-Ri,Seo, Dong-Won,Choi, Ki-Myung,Ko, Na-Young,Kim, Ji-Ho,Kim, Hyun-Il,Jung, Woo-Young,Lee, Jun-Heon Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.3
The porcine major histocompatibility complex (MHC) is called swine leukocyte antigen (SLA), which controls immune responses and transplantation reactions. The SLA is mapped on pig chromosome 7 (SSC7) near the centromere. In this study, 3 class I (SLA-1, SLA-3, and SLA-2) and 3 class II (DRB1, DQB1, and DQA) genes were used for investigation of SLA haplotypes in Yucatan miniature pigs in Korea. This pig breed is a well-known model organism for biomedical research worldwide. The current study indicated that Korean Yucatan pig population had 3 Class I haplotypes (Lr-4.0, Lr-6.0, and Lr-25.0) and 3 class II haplotypes (Lr-0.5, Lr-0.7, and Lr-0.25). The combinations of SLA class I and II haplotype together, 2 homozygous (Lr-4.5/4.5 and Lr-6.7/6.7) and 3 heterozygous (Lr-4.5/6.7, Lr-4.5/25.25, and Lr-6.7/25.25) haplotypes were identified, including previously unidentified new heterozygous haplotypes (Lr-4.5/4.7). In addition, a new SLA allele typing method using Agilent 2100 bioanalyzer was developed that permitted more rapid identification of SLA haplotypes. These results will facilitate the breeding of SLA homozygous Yucatan pigs and will expedite the possible use of these pigs for the biomedical research, especially xenotransplantation research.
A case of herbal medicine induced arsenic keratosis
( Yong-woo Choi ),( Hyungrok Kim ),( Osung Kwon ),( Nu-ri Na ),( Hyun Chung ),( Joonsoo Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Medication induced arsenic keratosis has been recognized as the less common types of arsenic keratosis. The major cause of the disease relies on the chronic arsenic poisoning. As the hazardous effects of arsenic were disclosed, the material was classified as blastomogen by the International Agency for Research on Cancer (IARC) and US Environment Protection Agency (EPA) and its usage has been strictly prohibited since then. Arsenic has, however, shown some therapeutic levels that exhibit detoxifying, dehydrating, preserving abilities with the addition of controlling itch. It has been controversially used in treating some of the chronic inflammatory skin disorders. However, the window of therapeutic index for arsenic has not been clarified and the risk of arsenic poisoning exists, possibly causing condition such as arsenic keratosis. Herein, we report a case of arsenic keratosis by a 66-year-old man to provide clinical characteristics, and diagnostic measures along the treatments in order to enhance the precision and understanding of the disease. The number of arsenic keratosis induced by herbal medication in the Korean dermatological literature is scarcely limited to a single case. Thorough medical histories including the use of arsenic, with corroborative diagnostic measures to detect arsenic are the crucial factors in delivering the correct diagnoses.
청소년 문화체험 활동 지원을 위한 상업지역 공개공지 특화 방안
최보연(Choi, Bo-Yean),나수정(Na, Soo-Jeong),우지혜(Woo, Ji-Hye),유형경(Yu, Hyeong-Kyeong),최누리(Choi, Nu-Ri),박수민(Park, Su-min),장혜지(Jang, Hye-ji),김기수(Kim, Gi-Soo) 대한건축학회 2017 대한건축학회 학술발표대회 논문집 Vol.37 No.2
The purpose of this study was to suggest the plan for specialization of open space for public purposes in commercial area to support youth culture experience activities. We selected and analyzed Seongan-gil market in Cheongju as study area. Open spaces for public purpose in the area are classified into five types (for commerce, for parking, for arrangement of obstacles, for relaxation, and the others) depending on the purposes of use. To support youth culture experience activities, commercial activities in the open space should be regulated to a certain extent or cultural experience programs linked to sale items in shop should be developed. Besides, the space should be able to accommodate various youth activities through promotion of public transportation convenience, expansion of parking lots, and vehicle traffic restrictions.
A case of steroid induced perioral dermatitis
( Yong-woo Choi ),( Hyungrok Kim ),( Osung Kwon ),( Nu-ri Na ),( Hyun Chung ),( Joonsoo Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Perioral dermatitis is a common and oftenly found type of chronic dermatosis. Majority of the patients are women with age of 15 to 45, but there are also variants including lupus-like and granulomatous perioral dermatitis, while the latter is more common in childhood and affects mostly prepubescent boys. The etiopathogenesis of the disease remains unclear, but there is a frequent finding of prolonged use of topical corticosteroids in the treatment of rosacea and seborrheic dermatitis preceding the clinical manifestation of perioral dermatitis. Papulovesiclular eruption in the perioral region with a typical narrow spared zone around the edge of the lips is its characteristic clinical feature. Therapeutic approach should be individually addressed, depending on the severity of symptoms and the patient’s age, with special attention to education and continuous psychological support of the patient. In the initial treatment period, patients with steroid-induced perioral dermatitis should be closely followed up because the rebound phenomenon usually develops after cessation of previous topical treatment. There is concern about excessive misuse of topical steroids to uncharted dermatosis by non-dermatologist physicians. Moreover, misuse of topical steroids can aggravate dermatosis. There has been no reports of steroid induced granulomatous perioral dermatitis in Korean dermatologic literature so far.
A case of eccrine porocarcinoma in situ arising in a scar
( Yong-woo Choi ),( Hyungrok Kim ),( Osung Kwon ),( Nu-ri Na ),( Hyun Chung ),( Joonsoo Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Eccrine porocarcinoma is a rare form of skin cancer that is often confused with other types of skin malignancy. The most common presentation is that of a red, ulcerated, dome-shaped nodule with shiny surface. It could also show as a wart-like plaque. A 81-year-old woman came up with her 2.5cm x 1.5cm sized hyperkeratotic plaque with crust on her right thigh, which lasted for a year. She had a total knee replacement arthroplasty on June, 2013. When she discharged, scar developed at the site of surgery. The lesion started as a erythematous plaque a year before. Moreover, lesion showed ulceration and crust associated with pain for a month. The biopsy section from her right thigh showed nesting structure with cells that are smaller and more basophilic than keratinocyte. Inside of the nested cells, ductal structures were seen. Until now, she had a wide excision and went through close follow-up with hemato-oncology department. There are several reports about skin tumors arising in at the site of scars, but few cases have been reported about eccrine gland origined tumor. There have been no reports of eccrine porocarcinoma arising at the site of scars in Korean dermatologic literature so far.
A case of IgG4-related disease
( Hyun Chung ),( Yong-woo Choi ),( Hyungrok Kim ),( Osung Kwon ),( Nu-ri Na ),( Joonsoo Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
IgG4-related disease (IgG4-RD) is a new concept which is characterized by elevated serum IgG4 level and infiltration of IgG4+ plasma cells in target tissues. IgG4-RD can involve various organs including skin as well. The cutaneous features of IgG4-RD are not characteristic, but are known as pruritic multiple erythematous nodules or plaques. We report a case which was considered as erythema multiforme initially, but later diagnosed as IgG4-RD. A 64 year-old female had erythematous patches and papules with pruritus on her whole body. The skin lesion appeared 10 days before and exacerbated since then. She also had oral mucosal swelling, intermittent sorethroat and epigastric pain that could not be diagnosed at the departments of otorhinolaryngology and gastroenterology. Serum IgG4 level was elevated, and diffuse enlargement of pancreas with mild peripancreatic infiltration was shown. In this study, we report a IgG4-RD patient who showed dramatic improvement after receiving treatment with systemic steroid, even if no definite diagnosis was made with pathologic studies.
고추장용 메주 배합비를 달리하여 제조한 팥고추장의 품질 특성
권누리,윤향식,김익제,홍성택,김소영,길나영,한남수,엄현주,Kwon, Nu Ri,Yoon, Hyang-Sik,Kim, Ik Jei,Hong, Seong Taek,Kim, So-Young,Gil, Na Young,Han, Nam Soo,Eom, Hyun-Ju 한국식품영양학회 2018 韓國食品營養學會誌 Vol.31 No.5
This study was conducted to investigate quality characteristics of red bean gochujang prepared with different ratios of meju for eight weeks. We determined quality characteristics such as pH, moisture content, total microbial flora counts, amino-type nitrogen content, total polypenol content, and antioxidant activity. The pH decreased by fermentation period, whereas total acidity was 0.36~0.39% in the early stage of fermentation, 0.63~1.16% at four weeks of fermentation, and decreased to 0.43~0.65% after the eighth week of fermentation. Moisture content of the control (no red bean, no rice) decreased 62.13% to 50.93%, but in case of the treatment, it slightly decreased. Total cell counts revealed similar tendency at the beginning of fermentation, and at eight weeks of fermentation. In case of lactic acid bacteria, all samples except RB-1.5 (gochujang added meju made of mixing ratio of rice:soybean:red bean (1:2:1.5) slightly increased. Amino nitrogen and total polyphenol of all samples increased in the fermentation period, especially RB-1.5 sample had the highest levels than other samples. By increasing the amount of red bean, DPPH radical scavenging activities increased. In taste sensing analysis, all treat samples except RB-1.5 revealed lower sourness than the control. Also, in case of bitterness, all samples revealed low content than the control. So, by adding red bean, it can enhance taste and function of gochujang.