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( Kyeongdeok Kim ),( Okjoo Lee ),( Sang Jin Kim ),( Manuel Lim ),( Jieun Kwon ),( Eunsung Jeong ),( Jaehun Yang ),( Jinsoo Rhu ),( Jong Man Kim ),( Gyu-seong Choi ),( Jae-won Joh ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Recently, hepatitis B core antibody (anti-HBc) positive liver grafts are used as extended criteria donor organs. However, prophylaxis methods to prevent de novo hepatitis B virus (HBV) infection after liver transplantation (LT) are still controversial. Thus, the purpose of our study is to evaluate the risk and outcomes of receiving anti-HBc positive grafts with prophylactic hepatitis B immunoglobulin (HBIG) monotherapy. Methods: All adult patients who underwent LT at Samsung Medical Center in Seoul, Korea, between January 2001 and December 2018 were gathered from a prospectively maintained database and reviewed retrospectively. HBV patients received the combination treatments with antiviral prophylaxis and HBIG. Prophylactic HBIG monotherapy was given for patients without HBV receiving grafts from anti-HBc positive donors. Results: A total of 1355 patients underwent LT during this period. Among them, 457 (33.7%) were anti-HBc positive and 898 (66.3%) were anti-HBc negative donors, who underwent follow-up for a median time of 5.7 years. Perioperative outcomes (mortality in 30 days, complications and postoperative ICU stay period) were similar between the two groups. Also, there were no significant difference in the 1-, 5-, 10- and 15-year patient survival rates between the anti-HBc positive (87.5%, 73.5%, 67.7% and 61.2%) and the anti-HBc negative groups (88.5%, 77.7%, 70.7% and 69.6%, P=0.080). All of the 117 recipients who were HBsAg negative and received anti-HBc positive grafts were given prophylactic HBIG monotherapy. Only one patient (0.9%, 1/117) developed de novo HBV during follow-up. There were 972 HBsAg-positive patients and 348 (35.8%) received anti-HBc positive grafts. The risk of HBV recurrence was similar between 2 groups (P=0.308). The donor anti-HBc status did not have a significant influence on the long-term survival or the risk of de novo or recurrent HBV infection after LT. Conclusions: De novo HBV was very rare especially with HBIG prophylaxis in non-HBV patients received anti-HBc positive liver graft. There was no significant influence of anti-HBc positive grafts on the perioperative and long-term outcomes after LT.
사물인터넷 환경에서 지리적 응집도를 고려한 동적 서비스 검색방법
백경덕(KyeongDeok Baek),김민협(MinHyeop Kim),고인영(InYoung Ko) Korean Institute of Information Scientists and Eng 2016 정보과학회논문지 Vol.43 No.8
In Internet of Things (IoT) environments, users are required to search for IoT devices necessary to access services for accomplishing their tasks. As IoT technologies advance, a user task will utilize various types of IoT-based services that are deployed in an IoT environment. Therefore, to accomplish a user task effectively, the services that utilize IoT devices need to be found in a certain geographical region. In addition, the service discovery needs to be accomplished in a stable manner while considering dynamically changing IoT environments. To deal with these issues, we propose two service discovery methods that consider geographic cohesiveness of services in IoT environments. We compare the effectiveness of the proposed methods against a traditional service discovery algorithm that does not consider geographic cohesiveness.
Ru-Catalyzed Chemoselective Olefin Migration Reaction of Cyclic Allylic Acetals to Enol Acetals
Seo, Kyeongdeok,Kim, Ye ji,Rhee, Young Ho American Chemical Society 2018 ORGANIC LETTERS Vol.20 No.4
<P>A Ru-catalyzed olefin migration reaction of chiral cyclic allylic acetal is reported. The reaction generates cyclic enol acetal in a highly chemoselective manner. A variety of <I>O,O</I>- and <I>N,O</I>-acetals participated in the reaction with conservation of the stereochemical integrity of the acetal moiety. The utility of the reaction was demonstrated by the short and protective group-free syntheses of (<I>L</I>)-deoxyribonucleoside and β-amicetose glycoside.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2018/orlef7.2018.20.issue-4/acs.orglett.7b03900/production/images/medium/ol-2017-039007_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol7b03900'>ACS Electronic Supporting Info</A></P>
Scalable message translation mechanism for the environment of heterogeneous middleware
Donghee Kim,Chang-Eun Lee,Jun Hee Park,KyeongDeok Moon,Kyungshik Lim IEEE 2007 IEEE transactions on consumer electronics Vol.53 No.1
<P>Various home network middleware such as HAVi, LnCP, LonWorks, and UPnP have been designed. They coexist because one middleware cannot support diverse requests of services and devices. This circumstance creates an interoperability problem among devices based on various types of home network middleware. The Universal Middleware Bridge system is designed and implemented to solve this interoperability problem using a device conversion mechanism and a message translation mechanism among the middleware. These conversion mechanisms make it possible for devices to distinguish and control other devices connected to different middleware networks in the Universal Middleware Bridge system. These mechanisms also easily support new device and middleware by adding some XML files.</P>