직장 카르시노이드 종양에서 Ki-67 발현의 예후적 중요성

홍수민 ( Su Min Hong ),김유선 ( You Sun Kim ),문정섭 ( Jung Seop Moon ),김진남 ( Jin Nam Kim ),오명기 ( Myoung Ki Oh ),권선옥 ( Sun Ok Kwon ),정성연 ( Seong Yeon Jeong ),홍성우 ( Seong Woo Hong ),강윤경 ( Yun Kyung Kang ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Background/Aims: Rectal carcinoid tumors can be resected with endoscopy, and it is important to assess their prognostic factors. We evaluated the potential of Ki-67 expression as a prognostic factor in rectal carcinoid tumors. Methods: We retrospectively reviewed the medical records of 37 patients with rectal carcinoid tumors who got endoscopic resection from January 2001 to January 2011 at Inje University Seoul Paik Hospital. We analyzed their endoscopic and histologic findings, Ki-67 expression, clinical outcome, and prognosis. Results: The mean age (±SD) of the patients was 56.3±10.7 years, and the male : female ratio was 3.6:1. The mean tumor size was 0.5±0.4 cm, 33 patients showed grade 1 tumors (89.2%) and the average Ki-67 expression was 0.7±1.2%. Thirty five patients underwent endoscopic mucosal resection, and two required endoscopic submucosal dissection. Eight patients had positive margins after resection, but no cases of lymphovascular invasion were identified. The median follow-up duration was 21.4±25.4 months, and no recurrences were observed. Conclusions: In low grade rectal carcinoid tumors which are lack of central depression on colonoscopy, the expression of a molecular marker of malignant potential, Ki-67, was low. Therefore, endoscopic resection seemed to be a safe and effective treatment for these tumors.

Bowen`s disease originated from verruca

( Eun Sun Kwon ),( Byoung Yong Koh ),( Ki Bum Myung ),( Seung ),( Hyun Cheong ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Bowen’s disease is a precancerous condition that has the potential to progress to squamous cell carcinoma. The human papillomavirus(HPV) infection is associated with bowen’s disease. And recently HPV DNA has been detected to up to 30% on the extragenital bowen’s disease lesions. A 49-year-old woman presented solitary erythematous plaque with verrucous central region on the right calf. At first the lesion was just small verrucous papule, but gradually enlarged and became erythematous. The biopsy specimen from verrucous central region showed hyperkeratosis, parakeratotic tier within the stratum corneum, acanthosis and papillomatosis with inward bending of rete ridges. These findings were appropriate for verruca. But the specimen also revealed the features of bowen’s disease. Numerous atypical and pleomorphic cells showed mitotic figures and loss of polarity throughout stratum malpighi. The upper dermis was infiltrated by inflammatory cells. And specimen was stained weakly positive for p53 and strongly positive for p16 and Ki-67. Based on the clinical and histopathologic findings, the skin lesion simultaneously had the features of bowen’s disease and verruca. Therefore we suggest that the bowen’s disease may resulted from verruca and be associated with HPV infection. Here, we present a case of bowen’s disease originated from verruca.

Multiple giant keratoacanthoma treated with acitretin

( Eun Sun Kwon ),( Byoung Yong Koh ),( Kyung Geun Lee ),( Ki Bum Myung ),( Seung Hyun Cheong ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Giant keratoacanthoma is an uncommon variant of keratoacanthoma, which may attain the diameter of several centimeters. Although keratoacanthoma usually undergo spontaneous resolution, giant keratoacanthoma can be invasive and destructive. A 49-year-old man presented with a 5-year history of multiple large hyperkeratotic and crusted plaques and nodules on the sun exposed areas such as face, ear, hand and forearm. Some lesions were involuted spontaneoulsy, whereas other lesions were rather enlarged. The biopsy specimen revealed horn-filled crater formation, epidermal extending like a buttress and eosinophilic glassy appearance in kertinocytic cytoplasm. In immunohistochemical stain, the Ki-67 staining was restricted to the basal layer. And p16 staining occurred more diffuse pattern. We treated them with acitretin and the lesions were almost cleared after 13 weeks. Herein we describe a case of multiple giant keratoacanthoma treated with acitretin.

A case of cellular fibrous histiocytoma on the palm

( Eun Sun Kwon ),( Byoung Yong Koh ),( Kyong Geun Lee ),( Ki Bum Myung ),( Seung Hyun Cheong ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Dermatofibroma is a common benign skin tumor that usually occurs as small, firm and red to brown solitary or multiple nodules on the lower extremities. In addition to the lower extremities, it can be observed anywhere. But the involvement of palm or sole is rare. Dermatofibroma has various histologic variants. In these variants, cellular fibrous histiocyma is relatively rare and histopathologically exhibits the densely cellular tumor with a fascicular to storiform growth pattern. A 40-year-old man presented with a solitary firm and reddish nodule on the left palm. The biopsy specimen revealed a nodular tumor that composed of spindle cells, histiocytes and collagen bundles. Immunohistochemical stain showed negative for CD 34, S-100 and CK, diffused positive for vimentin and weakly positive for CD68. Also Ki-67 staining showed less than 5% positive reactivity. Herein we describe a case of cellular fibrous histiocytoma on the palm.

Acitretin으로 치료된 다발성 거대각질가시세포종 1예

권은선 ( Eun Sun Kwon ),이경근 ( Kyoung Geun Lee ),고병용 ( Byoung Yong Koh ),명기범 ( Ki Bum Myung ),정승현 ( Seung Hyun Cheong ) 대한피부과학회 2017 대한피부과학회지 Vol.55 No.4

Giant keratoacanthoma is an uncommon variant of keratoacanthoma, which may increase to a diameter of several centimeters. Although keratoacanthomas usually resolve spontaneously, giant keratoacanthoma can be invasive and destructive. A 49-year-old man presented with a 5-year history of multiple large hyperkeratotic and crusted plaques and nodules on sun-exposed areas such as the face, ear, hand, and forearm. Some lesions involuted spontaneously, whereas others became rather enlarged. The biopsy specimen revealed horn-filled crater formation, epidermal extending resembling a buttress, and an eosinophilic glassy appearance in the keratinocytic cytoplasm. We treated the lesions with acitretin, and they almost completely resolved after 13 weeks. Here we describe a case of multiple giant keratoacanthoma treated with acitretin. (Korean J Dermatol 2017;55(4):249∼252)

Investigation of Lipid Content Change in Microalgae Biomass by ripening Process after harvesting

Sun_Min KIM,Jong-Hee KWON,Ki-Won YANG 한국생물공학회 2014 한국생물공학회 학술대회 Vol.2014 No.4

급성 ST 분절 상승 심근경색증의 표준진료지침 설계

권선옥,김우식,오명기,나종천,이홍기,조욱현,최석구 인제대학교 2006 仁濟醫學 Vol.27 No.-

The use of critical pathways for a variety of clinical conditions has grown rapidly in recent years, particularly pathways for patients with acute myocardial infarction. We intend to determine the impact of a clinical pathway on ST-elevation myocardial infarction (STEMI) and to evaluate the efficacy and safety of facilitated percutaneous coronary intervention (PCI) compared with primary PCI. Low risk STEMI patients (ST elevation >0.1mV in more than 2 limb leads or ST elevation >0.2mV in contiguous precordial lead, chest pain lasting more than 30 min without response to nitroglycerin) will be included. All patients will be also treated medically according to critical pathway. STEMI is one of the common diseases in emergency medicine and so it is necessary to establish realistic treatment guidelines. The use of critical pathways will improve the quality of care.

예비교사의 교육실습에 대한 셀프내러티브 탐구

권선미,조철기 부산대학교 과학교육연구소 2013 교사교육연구 Vol.52 No.1

본 연구는 내러티브 탐구를 적용하여 예비교사가 교육실습기간 동안 겪게 되는 경험은 어떤 것이며, 이러한 경험은 어떤 의미를 가지는가를 알아보았다. 내러티브는 경험을 잘 나타낼 수 있는 도구로써 이를 수집ㆍ분석하기 위해 교육실습생인 연구자의 실습일지와 학생들의 학습일지를 활용했다. 이들 일지에 쓰여진 내러티브는 현장텍스트로서 교육실습생과 학생의 경험이 나타나게 되며, 이러한 내러티브의 의미를 분석한 것이 연구텍스트인데 이를 토대로 연구결과를 도출하면 다음과 같다. 첫째, 교육실습에서 가장 중요한 부분은 수업실습인데, 연구자는 스스로 작성한 실습일지와 학생들이 작성한 학습일지, 그리고 지도교사와의 협의를 통해 수업 전-중-후에 대한 고민과 반성적 사고할 수 있었다. 둘째, 연구자는 내러티브 탐구를 통해 예비교사로서의 한계를 경험하기도 하였지만, 그것은 점점 자신의 교직관을 재정립하게 되는 기제로 작용하였다. 셋째, 연구자는 실무실습이 수업실습에 비해 상대적으로 덜 중요하게 다루어지는 경향을 경험하였다. 그러나 이것은 교육실습을 통해서만 얻어질 수 있는 현장경험이므로 보다 실질적이면서도 비중 있게 이루어질 필요가 있음을 느꼈다. 마지막으로 연구자는 교육실습 초기에는 이론과 실제가 분리되고 있는 듯한 느낌을 받았지만, 내러티브 탐구를 통해 이는 실제로 분절적인 것이 아니라 경험을 통해서 이론을 확인하고 재수정하는 과정임을 깨닫게 되었다. 이러한 측면에서 볼 때, 교육실습에 대한 내러티브 탐구는 교육실습생자신의 경험을 이야기하고 또 이야기하는 과정 속에서 실천적 지식을 체득화하는 계기가 된다는 점에서 의의가 있다고 할 수 있다. The purposes of this study is to apply narrative inquiry to examine the experiences and its meanings that the student (geography) teacher goes through during student teaching. Narrative can be used to express individual experience excellently. So this study collected the student teacher’s teaching journal and students’ learning journals and analyzed their narrative as educational experiences. Narrative written in these journals is a field text showing the student teacher’s experience and students experiences. Research text is to analyze narrative written in the field text to examine meaning of the student teacher’s experience. The results obtained from research text can be summarized as follows: Firstly, a researcher as student teacher could do reflective thinking of teaching through narrative inquiry of the student teacher’s teaching journal, students learning journals and adviser’s comments. Secondly, though the researcher experienced limitations as the student teacher though narrative inquiry, it became gradually positive materials for him or her to be a good teacher. Thirdly, the researcher experienced that an administrative work was apt to be treated less importantly than the student teaching. But the researcher felt that this had to be treated more practically because this could be an experience only through the student teaching. Finally, though the researcher felt that the educational theory and practice was separated in the beginning of the student teaching, he or she thought gradually that it was to identify and to revise the theory through experience. Therefore, narrative inquiry of student teaching means that it is for the student teacher to obtain practical knowledge through the process of telling and retelling of his experience.

HFC-134a와 대체냉매 HFC-152a에 CF_3I를 혼합한 자동차냉매 특성

권일욱,박찬수,홍경한,문기선,최운수,서의경,윤갑식,이종인,하옥남 朝鮮大學校 機械技術硏究所 2002 機械技術硏究 Vol.5 No.1

These days, an attention of environment has been increasing all over the world. to prevent the green house effect and destruction of an ozone layer, an ozone destruction potential(ODP) be zero and a refrigerant for low global warming potential(GWP) is needed. HFC-134a, in which hydrogen is mixed instead of chlorine is a refrigerant used for automobile conditioners and its destruction potential is ecologically zero. However, it is not considered as a perfect substitutive refrigerant as its GWP is high. It is studied refrigerant mixtures in which HFC-134a, HFC-152a and CF_3I with low GWP and zero ODP are mixed by experimentally and concluded as follows; 1. with the variation of speed of compressor outside temperature and flow rate, the heat of evaporator and compressor and coefficient of performance was varied, and influenced the air conditioner. 2. The pressure of evaporator was decreased with increasing the speed of compressor and that of the refrigerant HFC-134a was higher 21% than that of azotrope refrigerant mixed with CF_3I. The overall capacity of condensor and evaporator was increased and HGC-134a was higher than azotrope refrigerant mixed with CF_3I 3. The capacity of evaporator with the refrigerant HFC-134a was higher 6% than azotrope refrigerant mixed with CF31 and the required power with zaotrope refrigerant mixed with CF_3I was higher 11% than that of HFC-134a. 4. The COP of the refrigerant FHC-134a was higher 31% in 1000RPM. when outside temperature was increased, COP was decreased. 5. Performance of HFC-134a is better than azotrope refrigerant mixed with CF_3I but prefered zaotrope refrigerant mixed with CF_3I considering the environment.

主觀的인 評價에 의한 靑少年의 肥滿傾向 分析

權善鈺,金基學,李東洙,鄭鎭國 慶北大學校 師範大學 體育學硏究會 1992 體育學會誌 Vol.20 No.-

This study was conducted to analyze the tendency of obesity by subjective evaluation method in measuring the skinfold thickness in adolescents. The validity norms were height, weight, the sum of skinfold thickness, Db1, %Fat1, %Fat2, and BMI. The subjects surveyed were 2,442 boy and girl students of middle and high school in medium and small city and big city. The results are summarized as follows; 1. Weight of adolescents evaluated as obesity was over 76㎏ in boy's middle, over 67㎏ in gril's middle school, over 79㎏ in boy's high school, and over 68㎏ in girl's high school, the sum of skinfold thickness was over 40㎜, over 39㎜, over 54㎜, and over 41㎜ respectively. 2. Except the case of height in girl's middle, boy's high and girl's high school, in height in boy's middle, weight, the skinfold thickness, Db1, %Fat1, %Fat2, and BMI, difference among the degree of obesity evaluated subjectively was significant(p<.05). 3. Except heigh in girl's middle, boy's and girl's high school, correlation between the degree of obesity evaluated subjectively and height in girl's middle school, weight, the sum of skinfold thickness, Db1, %Fat1, %Fat2, BMI respectively was high and significant(p<.01 or p<.001) Therefore, on the basis of above results, I think we can evaluate the tendency of obesity in adolescents validly by subjective evaluation method as well.