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안성훈,김양원,김미란,진헌철,안지영,이상래,류석용,김홍용,김성준,이병권,김경환 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2
Background: A hyperosmolar nonketotic state has been known to have a high mortality, and even now, despite this high mortality, only a few studies of this disease have been performed. We studied the prognostic factors for the hyperosmolar nonketotic state. Methods: We retrospectively studied the cases of 40 patients who were in a hypersomolar nonketotic state when admitted to Sanggye Paik Hospital during the 6-year Period from 1995 through 2000. We divided the hyperosmolar nonketotic patients into two groups, the complete recovery group and the incomplete recovery group, and compared the clinical features, the laboratory findings, and the precipitating factors between two groups. Results: 1) A total of 40 patients were studied: 24 in the complete recovery group and 16 patients in the incomplete recovery group. The mortality rate was 32.5%. 2) No significant statistical difference existed among the clinical features of the two groups, except for the sex(p<0.01). 3) Among the laboratory findings of both groups, analysis revealed that the effective osmolarity was significantly higher among those in the incomplete recovery group(p<0.01). Serum sodium concentration was also significantly higher among those in the incomplete recovery group(p<0.01). Serum creatinine was also significantly higher among those in the incomplete recovery group(p<0.05). Serum bicarbonate concentration, on the other hand, was significantly lower among those in that group(p<0.05).4) Infection was identified as the most common precipitating factor(62.5%). Among the precipitating factors of the two groups, there were significant statistical difference in pneumonia, UTI, and inappropriate glucose control. 5) A significant statistical difference existed among the initial level of consciousness of both groups(p<0.05). 6) The only significant independent factor responsible for prognosis of nonketotic hyperosmolar state patients was the sex. Conclusion: The sex was only significant independent prognostic factor of nonketotic hyperosmolar state patients.
Hong, Ji Heon,Jang, Sung Ho Taylor Francis 2010 Journal of rehabilitation medicine Vol.42 No.10
<P>OBJECTIVES: The cingulum and fornix are important structures for memory function. Using follow-up diffusion tensor tractography in a patient with traumatic brain injury we found degeneration of the cingulum and fornix. CASE REPORT: An 18-year-old male who had had a traffic accident underwent conservative management for diffuse axonal injury. Brain magnetic resonance imaging showed an encephalomalactic lesion in the posterior portion of the corpus callosum. The patient had severe cognitive problems at 3 months after onset. However, while his intelligence had improved, his memory impairment had been aggravated at 14 months from onset. RESULTS: On the first diffusion tensor tractographies, the integrity of both corticospinal tracts, right cingulum, and left fornix were preserved; however, compared with controls, there were disruptions in both ends of the left cingulum and right fornical crus. On the second diffusion tensor tracto-graphies, both the cingulum and fornix showed severe degeneration, although the integrities of both corticospinal tracts were well preserved. CONCLUSION: We conclude that patients with memory impairment following traumatic brain injury should be evaluated using diffusion tensor imaging. In addition, follow-up diffusion tensor imaging may be necessary in patients with sustained memory impairment.</P>
Hong, Ji Heon,Jang, Sung Ho The Society of Physical Therapy Science 2011 JOURNAL OF PHYSICAL THERAPY SCIENCE Vol.23 No.1
<P>[Purpose] Little is known about the detailed anatomical connections of the neural network related to hand movement in the human brain. We investigated the neural network using diffusion tensor tractography (DTT) data analyzed in conjunction with functional MRI (fMRI) activation results. [Subjects and Method] We recruited 19 healthy volunteers for this study. Probabilistic tractography was used to analyze diffusion tensor imaging (DTI) data that were collected using fMRI activation induced by grasp-release movements of the hand at a rate of 1 Hz. [Results] The brain areas connected to the primary sensorimotor cortex (SM1), which is activated by hand movements, were the premotor cortex (100%), superior parietal lobule (100%), intraparietal sulcus (100%), supramarginal gyrus (97.37%), supplementary motor area (89.47%), thalamus (86.84%), putamen (81.58%), pars opercularis (81.58%), pars triangularis (68.42%), angular gyrus (65.79%), and cerebellum (60.53%) in the same hemisphere and the contralateral primary motor cortex (60.53%) in the opposite hemisphere. No significant difference was observed in the total incidence of connected tracts between hemispheres. [Conclusion] These results reveal that more brain areas are involved in hand movements than were previously thought necessary for motor planning and execution in the human brain.</P>
Neural Tract Injuries by Brain Herniations After Head Trauma :
Hong, Ji Heon,Kim, Seong Ho,Kim, Oh Lyong,Byun, Woo Mok,Jang, Sung Ho Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2012 The journal of head trauma rehabilitation Vol.27 No.2
<P>: Little is known about the usefulness and findings of brain herniation on diffusion tensor tractography (DTT). Using DTT, we demonstrated neural tract injuries in 2 patients who showed subfalcine and trasntentorial herniations after subdural hematoma resulting from motor vehicle accident.</P>
Hong, Ji Heon,Jang, Sung Ho,Kim, Oh Lyong,Kim, Seong Ho,Ahn, Sang Ho,Byun, Woo Mok,Hong, Cheol Pyo,Lee, Dong Hoon Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2012 The journal of head trauma rehabilitation Vol.27 No.3
<P>The recent development of diffusion tensor imaging (DTI) allows visualization and estimation of the medial cholinergic pathway (MCP), which originates from the nucleus basalis of Meynert and provides cortical cholinergic innervation to the cerebral cortex. We investigated the injury to the MCP in patients with traumatic axonal injury (TAI), using DTI.</P>
Aberrant pyramidal tract in medial lemniscus of brainstem in the human brain
Hong, Ji Heon,Son, Su Min,Byun, Woo Mok,Jang, Han Won,Ahn, Sang Ho,Jang, Sung Ho Lippincott Williams Wilkins, Inc. 2009 NEUROREPORT - Vol.20 No.7
The aberrant pyramidal tract (APT) refers to the collateral pathway of the pyramidal tract through the medial lemniscus in the brainstem. We showed the presence of an APT in the normal human brain using diffusion tensor tractography. Diffusion tensor tractography showed that the motor tracts of the 28 hemispheres in 14 healthy normal individuals originated from the primary sensori-motor cortex and descended through the known pathway of the pyramidal tract. However, in five (17.9%) of the 28 hemispheres, we observed that the APT descended through the medial lemniscus from the midbrain to the pons, and then entered into the pyramidal tract at the upper medulla, after which it descended through the pyramidal tract to the lower medulla.
언어발달지체 영유아의 한국판 LDS(언어발달검사) 반응특성
홍지헌 ( Ji Heon Hong ),하은혜 ( Eun Hye Ha ) 한국놀이치료학회 2016 한국놀이치료학회지(놀이치료연구) Vol.19 No.2
본 연구에서는 심리장애 영유아를 대상으로 언어발달지체집단과 언어발달정상집단으로 구분하여 언어발달지체 영유아의 한국판 LDS(언어발달검사) 반응특성을 규명하였다. 연구대상은 소아정신과와 재활의학과 등 3곳에 발달평가가 의뢰된 18개월에서 35개월 영유아 135명이며, 연구도구는 한국판 LDS(Language Development Survey), 한국 Bayley 영유아 발달검사 II를 사용하였다. 본 연구의 결과는 다음과 같다. 첫째, 18-23개월 영유아의 LDS 어휘력 점수는 Bayley 영유아 발달검사의 인지척도와 유의한 상관관계가 나타났으며, 24-35개월 영유아의 LDS 어휘력과 문장길이 점수는 Bayely 영유아 발달검사의 인지척도와 유의한 상관관계가 나타났다. 둘째, 18-23개월 영유아의 LDS 어휘력점수는 언어발달지체집단과 언어발달정상집단에서 차이가 나타나지 않았으며, 효과크기도 낮은 수준으로 나타났다. 그러나 24-35개월 영유아의 경우 언어발달지체집단이 LDS의 어휘력에서 정상집단에 비해 두드러지게 낮은 수행을 나타냈으며, 효과크기는 중간정도의 수준으로 나타났다. 또한 24-35개월 영유아의 LDS 문장길이점수에서 언어발달지체집단이 언어발달정상집단에 비해 유의 하게 낮은 수행을 나타냈으나, 효과크기는 낮은 수준으로 산출되었다. 본 연구를 통해 한국판 LDS와 Bayley 영유아 발달검사의 높은 상관관계를 확인하였고, 언어발달지체집단과 언어발달정상집단으로 구분하였을 때 언어발달지체 영유아가 한국판 LDS에서 더 낮은 수행을 보이는 것을 확인하였다. 이에 따라 한국판 LDS의 언어발달지체 변별가능성을 확인하였다는 데 의의가 있다. The purpose of this study was to investigate the response characteristics of the Korean LDS of toddlers suffering from language developmental delay. The participants comprised 135 toddlers who were 18 to 35 months old. They were assessed at a child psychiatry clinic and rehabilitation centers in Seoul. The K-BSID-II and the Korean LDS were used as the measuring tools. The results were as follows: First, the Vocabulary scores and Mental scales of the 18 to 23 month old subjects showed a significantly positive correlation. The Vocabulary scores, Phrase length scores and Mental scales of the 24 to 35 months old subjects showed significantly positive correlations. Second, the Vocabulary scores revealed no differences between toddlers with or without language delay who were in the 18 to 23 months old group. The Vocabulary scores and Phrase length scores of -the 24 to 35 months group suffering from language delay was significantly lower than the normal language development group. In addition, the effect size of- Vocabulary scores was moderate compared to low Phrase length scores. This study verified the validity of the Korean LDS as a very useful tool for assessing language development delay in toddlers.