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프로토 타입 조직등가비례계수기의 중입자가속기연구소의 135 MeV/u 탄소 이온에 대한 선형에너지 스펙트럼 측정
남욱원 ( Uk Won Nam ),이재진 ( Jae Jin Lee ),표정현 ( Jeong Hyun Pyo ),박원기 ( Won Kee Park ),문봉곤 ( Bong Kon Moon ),임창휘 ( Chang Hwy Lim2,),문명국 ( Myung Kook Moon ),하시시키다무라 ( Hisashi Kitamure ),신고고바야시 ( Shingo Kob 한국센서학회 2014 센서학회지 Vol.23 No.3
TEPC (Tissue Equivalent Proportional Counter) was usually used for high LET radiation dosimetry. We developed a prototype TEPC for micro-dosimetry in the range of 0.2~300 keV/μm. And, the simulated site diameter of the TEPC is 2 μm, of similar size to a cell nucleus. For purposes of characterization the response for high LET radiation of the TEPC has been investigated under 135MeV/u Carbon ions in HIMAC (Heavy Ion Medical Accelerator). We determined the gas multiplication factor and measured the lineal energy spectrum [yd(y)] of 135 MeV/u Carbon ions. The value of the gas multiplication factor was 315 at 700 V bias voltage. As a result of the experiment, we could more understand the performance of the TEPC for high LET (Linear Energy Transfer) radiation. And the procedure of high LET radiation dosimetry using TEPC is established.
Kim, Mee-Young,Kim, Ju-Hyun,Lee, Jeong-Uk,Lee, Lim-Kyu,Yang, Seung-Min,Jeon, Hye-Joo,Lee, Won-Deok,Noh, Ji-Woong,Lee, Tae-Hyun,Kwak, Taek-Yong,Kim, Bokyung,Kim, Junghwan The Society of Physical Therapy Science 2014 JOURNAL OF PHYSICAL THERAPY SCIENCE Vol.26 No.3
<P> [Purpose] Immobilization-induced atrophy is a general phenomenon caused by prolonged muscle disuse associated with orthopaedic conditions. However, changes in the phosphorylation of atrophy-related cofilin and LIM kinases are still poorly understood. In this study, we examined whether or not phosphorylation of cofilin and LIM kinases is altered in the skeletal muscles of rats after 3, 7, 14, and 21 days of cast immobilization. [Methods] We used two-dimensional gel electrophoresis, mass spectrometry, and western blotting to examine protein expression and phosphorylation in atrophied rat gastrocnemius muscles. [Results] The expression of the cofilin was detected in gastrocnemius muscle strips using proteomic analysis. Cast immobilization after 3, 7, 14, and 21 days significantly diminished the phosphorylation of cofilin and LIM kinases. [Conclusion] The present results suggest that cast immobilization-induced atrophy may be in part related to changes in the phosphorylation of cofilin and LIM kinases in rat skeletal muscles.</P>
( Jeong Uk Lim ),( Jae Seung Lee ),( Ji-hyun Lee ),( Sang-do Lee ),( Yeon-mok Oh ),( Chin Kook Rhee ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.3
Background/Aims: Air trapping is associated with unfavorable outcomes in chronic obstructive pulmonary disease (COPD). The present study evaluated the association between longitudinal changes in air trapping with pulmonary function, computed tomography (CT) parameters and exacerbation. Methods: Patients enrolled in the Korean Obstructive Lung Disease (KOLD) study cohort from June 2005 to October 2015 were included. The study patients were categorized into four groups according to the change in residual volume to total lung capacity ratio (RV/TLC) over 3 years. The RV/TLC was considered abnormal when it was ≥ 40% and normal when it was < 40%. Results: A total of 279 patients were categorized into four groups: 76 in the “normal to normal” (N→N) group, 34 in the “abnormal to normal” (A→N) group, 33 in the “normal to abnormal” (N→A) group, and 136 in the “abnormal to abnormal” (A→A) group. For forced expiratory volume in 1 second and forced vital capacity (FVC), respectively, group A→N showed a large increase of 266 mL (p < 0.001) and 381 mL (p < 0.001), group N→A showed a marked decrease of 216 mL (p < 0.001) and 332 mL(p = 0.029), and group A→A showed a decrease of 16 mL (p = 0.426) and 6 mL (p = 0.011) compared to group N→N. Group A→N showed a significant decrease of -0.013 in expiratory to inspiratory ratio of the mean lung density (p < 0.001), while group A→N showed an increase of 0.005 (p < 0.001). Conclusions: Patients with COPD whose RV/TLC changed from normal to abnormal showed deterioration of pulmonary function and worsening of CT parameters simultaneously.
Lim Jeong Uk 대한결핵및호흡기학회 2023 Tuberculosis and Respiratory Diseases Vol.86 No.1
A significant proportion of patients with non-small cell lung cancer (NSCLC) is diagnosed in the early and resectable stage. Despite the use of platinum-based adjuvant chemotherapy, there was only a marginal increase in overall survival and a 15% decrease in relapse. With the advents of immunotherapy and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), the landscape of adjuvant treatment in completely resectable NSCLC is changing. Postoperative radiotherapy can be beneficial to patients who underwent surgical resection in certain clinical settings. In addition, new biomarkers that predict efficacy of EGFR TKI and immunotherapy as adjuvant treatment are also necessary. In this review, recent updates in adjuvant treatment in resectable NSCLC were briefly explained.
( Jeong Uk Lim ),( Deog Kyeom Kim ),( Myung Goo Lee ),( Yong-il Hwang ),( Kyeong-cheol Shin ),( Kwang Ho In ),( Sang Yeub Lee ),( Chin Kook Rhee ),( Kwang Ha Yoo ),( Hyoung Kyu Yoon ) 대한결핵 및 호흡기학회 2020 Tuberculosis and Respiratory Diseases Vol.83 No.-
Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a condition characterized by the overlapping clinical features of asthma and COPD. To evaluate the appropriateness of different sets of ACO definition, we compared the clinical characteristics of the previously defined diagnostic criteria and the specialist opinion in this study. Methods: Patients enrolled in the KOrea COpd Subgroup Study (KOCOSS) were evaluated. Based on the questionnaire data, the patients were categorized into the ACO and non-ACO COPD groups according to the four sets of the diagnostic criteria. Results: In total 1,475 patients evaluated: 202 of 1,475 (13.6%), 32 of 1,475 (2.2%), 178 of 1,113 (16.0%), and 305 of 1,250 (24.4%) were categorized as ACO according to the modified Spanish Society of Pneumonology and Thoracic Surgery (SEPAR), American Thoracic Society (ATS) Roundtable, Global Initiative for Asthma (GINA)/Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, and the specialists diagnosis, respectively. The ACO group defined according to the GINA/GOLD criteria showed significantly higher St. George's Respiratory Questionnaire and COPD Assessment Test scores than the non-ACO COPD group. When the modified SEPAR definition was applied, the ACO group showed a significantly larger decrease in the forced expiratory volume in 1 second (FEV<sub>1</sub>, %). The ACO group defined by the ATS Roundtable showed significantly larger decrease in the forced vital capacity values compared to the non-ACO COPD group (-18.9% vs. -2.2%, p=0.007 and -412 mL vs. -17 mL, p=0.036). The ACO group diagnosed by the specialists showed a significantly larger decrease in the FEV<sub>1</sub> (%) compared to the non-ACO group (-5.4% vs. -0.2%, p=0.003). Conclusion: In this study, the prevalence and clinical characteristics of ACO varied depending on the diagnostic criteria applied. With the criteria which are relatively easy to use, defining ACO by the specialists diagnosis may be more practical in clinical applications.
( Jeong Uk Lim ),( Chan Kwon Park ),( Solji Han ),( Chang Min Choi ),( Chi Young Jung ),( Deog Gon Cho ),( Jae Hyun Jeon ),( Jeong Eun Lee ),( Jin Seok Ahn ),( Yeongdae Kim ),( Yoo-duk Choi ),( Yang-g 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Purpose: The aim of this study was to compare clinical characteristics and prognosis between never and ever-smokers in female patients with lung cancer using nationwide registry in Korea. Materials and Methods: The Korean Association for Lung Cancer developed a registry in cooperation with the Korean Central Cancer Registry, and surveyed about 10% of lung cancer cases. For this first survey of cases diagnosed in 2014, cases were selected through a systematic sampling method. Results: Total of 2,621 lung cancer patients were surveyed and 744 female lung cancer patients were selected. After excluding 8 patients without data on smoking history, 736 patients were evaluated in this study. Among them, 644 (87.5%) were never-smokers, and 92 (12.5%) were ever-smokers. Median survival was compared between the two groups: median survival was not reached for the never smoker group, while it was 14.9 months for the ever-smoker group (P<0.001). During the study period, there were 635 non-small cell lung cancer (NSCLC), and 52 small cell lung cancer (SCLC). Among 635 NSCLC patients, 569 patients were never-smokers and 66 patients were ever-smokers. The ever smoker NSCLC group had significantly lower proportion of stage I patients and EGFR mutation when compared to the never-smokers (27.3% vs 41.7%, P=0.004, and 34.2% vs 50.3%, P=0.001, respectively). Among 469 patients with NSCLC, epidermal growth factor receptor (EGFR) mutation group (n=230) had higher proportion of clinical stage I (40.4% vs 29.1%, P=0.03), and patients who received targeted therapy as 1st line treatment (30.7% vs 1.8%, P<0.001) than wild-type group (n=239). From multivariable analysis for survival in 269 stage IV NSCLC patients, receiving only supportive care, and EGFR wild-type were significant predictors for shorter survival. Conclusion: From this nationwide cancer registry data, majority of female lung cancer patients were never-smokers, and showed different clinical characteristics and prognosis compared to ever-smoker patients.
( Jeong Uk Lim ),( Chang Dong Yeo ),( Hye Seon Kang ),( Ju Sang Kim ),( Chan Kwon Park ),( Jin Woo Kim ),( Seung Joon Kim ),( Sang Haak Lee ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Purpose While association between systemic inflammation and disease progression is suggested, we assessed potential predictability of early changes in neutrophil to lymphocyte ratio (NLR) and derived NLR (dNLR) in NSCLC under ICI. Method Among a multicenter cohort of lung cancer, patients with advanced (stage IIIB-IV) NSCLC who were under ICI between January 2016 and December 2019 were enrolled from six university hospitals. Complete blood count was measured just before 1st cycle of ICI and 2nd cycle of ICI. Differences in NLR, and dNLR were measured. When the increase in NLR was equal or more than 1, the patients were classified into the “NLR increase group” if otherwise, they were classified in to the “NLR non-increase group.” Likewise, when the increase in dNLR was equal or more than 1, the patients were classified into the “dNLR increase group”, if not, they were classified into the “dNLR non-increase group”. Results Total of 89 patients were selected for evaluation. Median progression free survival (PFS) was significantly longer for the NLR non-increase group when compared to the NLR increase group (9.5 vs 2.6 months, P<0.001). Derived NLR increase group showed significantly shorter median PFS when compared to the dNLR non-increase group (4.2 vs 9.2 months, P=0.001) (Figure). Using cox regression hazard model, association with PFS was analyzed. In the model 1, in which NLR increase was entered, increase ≥ 1 in NLR showed significant association (HR=3.007, 95% CI =1.610-5.617, P=0.001). In the model 2, in which dNLR increase was entered in the multivariate analysis, increase ≥ 1 in dNLR showed significant association (HR=2.601, 95% CI=1.331-5.079, P=0.005) (Table). Conclusion While early change in dNLR and NLR were shown to have prognostic value in patients undergoing immunotherapy, using multiple measurement points, they can be more accurate and comprehensive biomarkers in predicting ICI response.