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폐렴구균에 의한 지역사회 획득 폐렴에서 페니실린 내성률과 내성에 따른 임상경과에 관한 연구
홍지현 ( Hong Ji Hyeon ),이형석 ( Lee Hyeong Seog ),정승현 ( Jeong Seung Hyeon ),김규원 ( Kim Gyu Won ),엄광석 ( Eom Gwang Seog ),이재명 ( Lee Jae Myeong ),장승훈 ( Jang Seung Hun ),김동규 ( Kim Dong Gyu ),현인규 ( Hyeon In Gyu 대한결핵 및 호흡기학회 2003 Tuberculosis and Respiratory Diseases Vol.54 No.3
Jang, Ji Eun,Cheong, June-Won,Kim, Soo-Jeong,Cho, Hyunsoo,Suh, Cheolwon,Lee, Hyewon,Eom, Hyeon-Seok,Yhim, Ho-Young,Lee, Won-Sik,Min, Chang-Ki,Lee, Jae Hoon,Park, Joon Seong,Kim, Jin Seok Informa UK (Informa Healthcare) 2016 Leukemia & lymphoma Vol.57 No.6
<P>To evaluate the feasibility of selecting a mobilization regimen based on the response to induction therapy, we retrospectively analyzed 179 multiple myeloma patients who underwent stem cell mobilization. In comparison with patients who achieved at least a very good partial response (VGPR) to induction therapy and received granulocyte-colony stimulating factor (G-CSF) alone and patients who did not achieve a VGPR and received cyclophosphamide (CY)+G-CSF, treatment-related toxicity was greater and neutrophil engraftment was slower in the CY than the G-CSF group. The rate of requisite mobilization (2.0x10(6)/kg) was similar in both groups. Overall and progression-free survival was not different between patients in the G-CSF group and patients who achieved at least VGPR and received CY+G-CSF. In conclusion, response-adapted selection of a mobilization regimen is appropriate. G-CSF alone should be the preferred treatment for patients who achieved at least a VGPR to induction therapy.</P>
Jang, Jung Im,Kim, Jin Seok,Eom, Jeong Seon,Kim, Hyeon Guk,Kim, Bae Hoon,Lim, Sangyong,Bang, Iel‐,Soo,Park, Yong Keun Blackwell Publishing Asia 2012 Microbiology and immunology Vol.56 No.9
<P><B>ABSTRACT</B></P><P>Live attenuated bacteria can be used as a carrier for the delivery of foreign antigens to a host's immune system. The N‐terminal domain of SipB, a translocon protein of the type III secretion system of <I>Salmonella enterica</I> serovar Typhimurium, is required for secretion and outer membrane localization. In the present study, vaccine plasmids for antigen delivery in which the non‐toxic tetanus toxin fragment C (TTFC), which contains a T cell epitope, is fused to the N‐terminal 160 amino acids of SipB were developed. It was found that the recombinant proteins are secreted into the culture media and localized to the bacterial surface. TTFC‐specific antibody responses are significantly increased in mice orally immunized with attenuated <I>S.</I> Typhimurium BRD509 strains carrying TTFC delivery plasmids. When the TTFC delivery cassettes were introduced into a low copy vector, the plasmid was stably maintained in the BRD509 strain and induced an immune response to the TTFC antigen in mice. These results suggest that expression and delivery of heterologous antigens fused to the N‐terminus of SipB enhance the induction of antigen‐specific immune responses, and that the N‐terminal domain of SipB can be used as a versatile delivery system for foreign antigens.</P>
Experimental study on the hybrid shear connection using headed studs and steel plates
Jang-Woon Baek,Hyeon-Keun Yang,Hong-Gun Park,Tae-Sung Eom,Hyeon-Jong Hwang 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.37 No.6
Although several types of rigid shear connectors have been developed particularly to increase load-carrying capacity, application is limited due to the complicated details of such connection. In this study, push-out tests were performed for specimens with hybrid shear connectors using headed studs and shear plates to identify the effects of each parameter on the structural performance of such shear connection. The test parameters included steel ratios of headed stud to shear plate, connection length, and embedded depth of shear plates. The peak strength and residual strength were estimated using various shear transfer mechanisms such as stud shear, concrete bearing, and shear friction. The hybrid shear connectors using shear plates and headed studs showed large load-carrying capacity and deformation capacity. The peak strength was predicted by the concrete bearing strength of the shear plates. The residual strength was sufficiently predicted by the stud shear strength of headed studs or by shear friction strength of dowel reinforcing bars. Further, the finite element analysis was performed to verify the shear transfer mechanism of the connection with hybrid shear connector.
이현호 ( Hyeon Ho Lee ),장지웅 ( Ji Woong Jang ),엄영환 ( Young Hwan Eom ),채문기 ( Moon Gi Chae ),조연하 ( Yeon Ha Cho ),안국진 ( Gook Jin An ),이재권 ( Jae Kwon Lee ),박병곤 ( Byong Gon Park ),신운섭 ( Woon Seob Shin ),남정환 ( 충북대학교 과학교육연구소 2017 과학교육연구논총 Vol.33 No.1
The purpose of this study is to investigate prevents hypertension effect of ethanol extract of Sigesbeckia pubescens. In this study, to determine prevents hypertension effect of ethanol extract S. pubescens on suppression of calcium mobilization force in vascular smooth muscle cell line. Ethanol extract of S. pubescens,showed a moderate suppression of calcium mobilization force effect vascular smooth muscle cell line. Therefore, treatment with ethanol extract of S. pubescens may accelerate blood flow through dilatation of the blood vessel. This result suggest a potential role of ethanol extract of S. pubescens as source of prevents hypertension agent.
자연의 아름다움과 고급스러움이 공존하는 마임 비에타 쇼룸 제안 -오감 (시각, 청각, 후각, 촉각, 미각)을 중심으로-
김보현,이서연,은다솜,엄연정,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-
본 연구는 국내 브랜드 ‘마임'의 뷰티와 연계한 뷰티 쇼룸을 제안함에 있어서 공간속에 오감을 담아내는 일련의 프로세스를 밝히는데 목적이 있다. 이는 브랜드가 소유하고 있는 다양한 감각과 가치가 결여된 채 시각적 요소만이 담긴 브랜드 뷰티 쇼룸이 대다수를 차지하는 오늘날, 이에 대한 문제를 해결하기 위해 ’융합 연출 디자인'적 시점에서 폭넓게 바라보고 브랜드의 정신과 오감의 결합을 통해 이를 해결하고자 하였다. 이에 본 연구는 2017년 3월~6월 15주간 숙명여대 환경디자인학과 <융합연출 디자인>수업에서 진행된 수업의 결과물로서 산학 연계된 화장품 브랜드의 쇼룸디자인 개발 프로세스를 제안한다. 또한 본 연구의 범위는 오감을 담고 있는 뷰티 쇼룸(4D)이 되기까지의 과정 전체로 한다. 그 결과, 마임 뷰티쇼룸은 공간 디자인과 오감을 융합하여 영상에서 공간에 이르기까지 오감의 조화와 브랜드의 정신을 녹여내고 확장시켰다. 끝으로 본 연구는 뷰티 쇼룸 공간 디자인을 제안함에 있어서 오감을 활용하여 통합된 시점에서 그래픽·제품·공간을 개발 및 제시한 것에 의의가 있다. 또한 향후 이와 관련된 쇼룸 공간 개발에 있어서 기초 자료로 활용될 것으로 기대된다.