설화그림카드를 활용한 자기성장 집단 문학치료 프로그램 사례연구 : <해와 달>그림카드를 중심으로

배진형(Bae, Jin Hyoung),조은상(Cho, Eun Sang) 한국독서치료학회 2020 독서치료연구 Vol.12 No.2

이 연구에서는 자기성장을 원하는 참여자들이 설화 <해와 달이 된 오누이>와 <해와 달이 된 오누이>설화 그림카드를 활용한 ‘다시쓰기’ 활동을 하고, 이를 집단 문학치료프로그램에서 나누는 과정을 통해 ‘부모로부터의 심리적 독립’을 탐색해볼 수 있도록 하였다. 설화 선정은 참여자들이 <해와 달이 된 오누이>에 대해 ‘부모로부터의 심리적 독립’의 이야기로 읽고 반응한다는 기존 연구를 근거로 이루어졌다. 연구 결과는 다음과 같다. 첫째, 연구 참여자 대부분은 자신이 부모에게 바라는 욕구에 대해 알아차릴 수 있었다. 둘째, 참여자들은 부모와의 관계를 탐색하거나 재조정해보는 통찰을 얻을 수 있었다. 셋째, 설화뿐 아니라, 제시된 설화 그림카드는 참여자들이 정서적 갈등을 투사하고 촉진하도록 도울 수 있었다. 넷째, ‘다시쓰기’ 전과 후, 설화 그림카드 작업들은 참여자들이 이야기의 방향과 줄거리, 주인공을 선정하는 데에도 효과적인 역할을 하였다. 문학치료에서 이야기를 재구성하는 과정이 자신의 내면을 탐색하는 데 있어 효과적이라는 것은 조은상의 이전 논문에서 검증된 결과이나, 설화 그림카드를 개발하여 활용하는 것은 아직 연구 중에 있다. 추후 지속적인 연구를 통해 설화 그림카드의 유용성과 효과성에 대한 검증이 이루어져야 하겠지만, 이 연구를 통해 설화 그림카드를 설화와 함께 사용하는 것이 참여자들이 내면에 있는 갈등을 투사하는 데에 효과적이고, 보다 명확히 자신의 내면을 표현할 수 있도록 도움을 주었음이 밝혀졌다는 점이 이 연구의 의의라 하겠다. In this study, participants wanting to mature, engaged in ‘re-writing’ activities using a folktale “The Brother and Sister Who Became the Sun and the Moon” and folktale picture cards <The Brother and Sister Who Became the Sun and the Moon>, and explored their psychological independence from their parents through sharing their stories in a group setting. This specific folktale was selected based on existing research where participants read and responded to “The Brother and Sister Who Became the Sun and the Moon” as a story of psychological independence from parents. The results of the study are as follows. Firstly, most of the participants in the study were able to recognize what they need from their parents. Secondly, participants were able to gain insights necessary for exploring or readjusting the relationship with their parents. Thirdly, the suggested folktale picture cards along with the folktale were useful for the participants to project and examine their emotional conflicts. Lastly, before and after re-writing activities, the folktale picture card work played an effective role in participants choosing the direction, plot, and protagonists of their stories. Even though the effectiveness of reconstructing stories in literary therapy to explore one’s inner self has been researched in previous studies, such as Cho Eun Sang’s papers, the topic of developing and utilizing folktale picture cards is still being explored. This study examined the ways in which using folktale picture cards in a literary therapy group helped participants project their inner conflicts and express themselves more clearly and effectively. This study also suggests that future studies will verify the usefulness and effectiveness of folktale picture cards.

Analysis of high-fat diet-induced inflammatory responses in Rhbdf2 knockout mice

Sung-Jun Kim,Ki-Hoan Nam,Seul-Gi Park,Young-Sub Byun,Eun-Kyoung Kim,Sang-Mi Cho,Ha-rim-Kim,Hyoung-Chin Kim,Hu-Jang Lee,Beom Jun Lee 한국예방수의학회 2018 예방수의학회지 Vol.42 No.4

This study investigated the characteristics of obesity induced by a high-fat diet (HD) over 13 weeks in Rhbdf2 gene knockout (KO) mice. Forty 7-week-old Rhbdf2 wild and KO mice were used and the mice were divided into 4 groups: Wild-ND (n=10, Rhbdf2 wild mice, normal diet (ND)), Wild-HD (n=10, Rhbdf2 wild mice, HD), KO-ND (n=10, Rhbdf2 KO mice, ND) and KO-HD (n=10, Rhbdf2 KO mice, HD). The relative epididymal fat weight in KO-HD was significantly increased compared with that in KO-ND (P<0.01). The relative liver and spleen weights in KO-HD were decreased compared with those in Wild-HD (p < 0.05) and KO-ND (p < 0.01). The mRNA expression of SOD1 in KO-ND was significantly reduced compared with that in Wild-ND (p < 0.05). In Wild-ND and HD, the mRNA expressions of TNF-α and IL-6 in epididymal fat were significantly increased compared with those in KO-ND and HD (p < 0.01). A significant increase of TNF- α and IL-6 mRNA expression was observed in KO-HD compared with KO-ND (p < 0.01). These results indicated that Rhbdf2 genes may regulate high fat diet-induced obesity damage by anti-inflammatory and anti-oxidative roles in fat tissue of mice.

A Bivalent Inactivated Vaccine Prevents Enterovirus 71 and Coxsackievirus A16 Infections in the Mongolian Gerbil

( Eun-je Yi ),( Young-in Kim ),( Seung-yeon Kim ),( Sung Hyun Ahn ),( Hyoung Jin Lee ),( Bohyun Suh ),( Jaelim Yu ),( Jeehye Park ),( Yoon Jung Lee ),( Eunju Jung ),( Sun-young Chang ) 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.3

Hand-foot-and-mouth disease (HFMD) is a viral infectious disease that occurs in children under 5 years of age. Its main causes are coxsackievirus (CV) and enterovirus (EV). Since there are no efficient therapeutics for HFMD, vaccines are effective in preventing the disease. To develop broad coverage against CV and EV, the development of a bivalent vaccine form is needed. The Mongolian gerbil is an efficient and suitable animal model of EV71 C4a and CVA16 infection used to investigate vaccine efficacy following direct immunization. In this study, Mongolian gerbils were immunized with a bivalent inactivated EV71 C4a and inactivated CVA16 vaccine to test their effectiveness against viral infection. Bivalent vaccine immunization resulted in increased Ag-specific IgG antibody production; specifically, EV71 C4a-specific IgG was increased with medium and high doses and CVA16-specific IgG was increased with all doses of immunization. When gene expression of T cell-biased cytokines was analysed, Th1, Th2, and Th17 responses were found to be highly activated in the high-dose immunization group. Moreover, bivalent vaccine immunization mitigated paralytic signs and increased the survival rate following lethal viral challenges. When the viral RNA content was determined from various organs, all three doses of bivalent vaccine immunization were found to significantly decrease viral amplification. Upon histologic examination, EV71 C4a and CVA16 induced tissue damage to the heart and muscle. However, bivalent vaccine immunization alleviated this in a dose-dependent manner. These results suggest that the bivalent inactivated EV71 C4a/CVA16 vaccine could be a safe and effective candidate HFMD vaccine.

Evaluation of efficacy of an electronic constantspeed injector in reducing pain associated with local infiltrative anaesthesia

( Eun Ji Choi ),( Hyoung Min Na ),( Ik Jun Moon ),( Woo Jin Lee ),( Sung Eun Chang ),( Mi Woo Lee ),( Chong Hyun Won ),( Sung Joo Tommy Hwang ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.74 No.1

Empirical Design of an On and Off Type Solenoid Actuator For Valve Operation

Sung, Baek-Ju,Lee, Eun-Woong,Kim, Hyoung-Eui The Korean Institute of Electrical Engineers 2004 KIEE International Transactions on Electrical Mach Vol.b4 No.2

Modern users demand that the on and off type solenoid actuator should be smaller, lighter in weight, lower in consumption power, and higher in response time. The complete design satisfying such requirements can be achieved when electromagnetic theories and empirical knowledge are combined. This paper presents various types of empirical coefficients essentially needed for optimal design of a solenoid actuator. The values of these empirical coefficients are obtained through extensive experiments over a great length of time for various kinds of solenoid actuators. We have developed a design program that is composed by combination of governing equations and empirical coefficients, and have also manufactured a prototype solenoid actuator based on the final results of the design program. The propriety of the design program and empirical coefficients have been proven by experiments.

The Critical Roles of Zinc: Beyond Impact on Myocardial Signaling

Sung Ryul Lee,Su Jin Noh,Julius Ryan Pronto,Yu Jeong Jeong,Hyoung Kyu Kim,In Sung Song,Zhelong Xu,Hyog Young Kwon,Se Chan Kang,Eun-Hwa Sohn,Kyung Soo Ko,Byoung Doo Rhee,Nari Kim,Jin Han 대한생리학회-대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.5

Zinc has been considered as a vital constituent of proteins, including enzymes. Mobile reactive zinc (Zn²⁺) is the key form of zinc involved in signal transductions, which are mainly driven by its binding to proteins or the release of zinc from proteins, possibly via a redox switch. There has been growing evidence of zinc’s critical role in cell signaling, due to its flexible coordination geometry and rapid shifts in protein conformation to perform biological reactions. The importance and complexity of Zn²⁺ activity has been presumed to parallel the degree of calcium’s participation in cellular processes. Whole body and cellular Zn²⁺ levels are largely regulated by metallothioneins (MTs), Zn²⁺ importers (ZIPs), and Zn²⁺ transporters (ZnTs). Numerous proteins involved in signaling pathways, mitochondrial metabolism, and ion channels that play a pivotal role in controlling cardiac contractility are common targets of Zn²⁺. However, these regulatory actions of Zn²⁺ are not limited to the function of the heart, but also extend to numerous other organ systems, such as the central nervous system, immune system, cardiovascular tissue, and secretory glands, such as the pancreas, prostate, and mammary glands. In this review, the regulation of cellular Zn²⁺ levels, Zn²⁺-mediated signal transduction, impacts of Zn²⁺ on ion channels and mitochondrial metabolism, and finally, the implications of Zn²⁺ in health and disease development were outlined to help widen the current understanding of the versatile and complex roles of Zn²⁺.

Whitening Effects of Aerial Part of Pueraria Thunbergiana in vitro and in vivo

Eun Byeol Han(한은별),Bo Yoon Chang(장보윤),Svay Thida(디다스와이),Dae Sung Kim(김대성),Hyoung Kwon Cho(조형권),Sung Yeon Kim(김성연) 환경독성보건학회 2013 한국독성학회 심포지움 및 학술발표회 Vol.2013 No.10

Twelve-Month Post-Treatment Clinical Parameters Are Superior to Pre-Treatment Parameters in Predicting Hepatocellular Carcinoma in Patients with Chronic Hepatitis B

( Sang Bong Ahn ),( Jun Choi ),( Dae Won Jun ),( Hyunwoo Oh ),( Eileen L. Yoon ),( Hyoung Su Kim ),( Soung Won Jeong ),( Sung Eun Kim ),( Jae-jun Shim ),( Yong Kyun Cho ),( Hyo Young Lee ),( Sung Won 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: There are currently several prediction models for hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) receiving oral antiviral therapy. However, most models are based on pre-treatment clinical parameters. Therefore, using machine learning techniques and multicenter patient cohorts from Korea and the United States (US), the current study aimed to develop a novel and practical prediction model for HCC by using both pre- and post-treatment parameters in this population. Methods: We included two treatment-naïve CHB cohorts who were initiated on oral antiviral therapies: the derivation cohort (n=1,480, Korea prospective SAINT cohort comprising of 9 study centers) and the validation cohort (n=426, the US retrospective Stanford Bay cohort comprising of 4 centers). Included patients were followed for 3 years or until HCC, death or loss of follow-up whichever occurred first. We employed logistic regression, decision tree, lasso regression, support vector machine, and random forest algorithms to develop the HCC prediction model and selected the most optimal method. Results: We evaluated both pre-treatment and the 12-month clinical parameters on-treatment and found the 12-month on-treatment values to have superior HCC prediction performance. The lasso logistic regression algorithm using the presence of cirrhosis at baseline and alpha-fetoprotein and platelet at 12 months showed the best performance (AUROC=0.843 in the derivation cohort. The model performed well in the external validation cohort (AUROC=0.844) and better than other existing prediction models including the APA, PAGE-B, and GAG models (AUROC=0.769 to 0.818). Conclusions: We provided a simple-to-use HCC prediction model based on only two readily available and objective laboratory markers (AFP and platelets) measured 12 months after antiviral initiation. The model is highly accurate with excellent validation in an external cohort from a different country (AUROC 0.844).

Clinical Characteristics and Outcomes of Septic Acute Kidney Injury in Critically 3 Patients

( Eun Jung Cho ),( In Hye Cha ),( Ki Chul Yoon ),( Hye Min Choi ),( Sang Kyung Jo ),( Won Yong Cho ),( Hyoung Kyu Kim ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.3

Purpose: This study was to determine the clinical characteristics and outcomes of critically ill patients with septic acute kidney injury (AKI). Methods: We retrospectively collected data of patients with AKI who were ≥18 years of age and admitted to the intensive care unit (ICU) for ≥24 hours from April 2007 to December 2009, and compared the clinical characteristics and outcomes of patients with and without sepsis. Results: Of the 1,075 patients, 333 had AKI, as defined by the RIFLE criteria, and 134 of them had AKI with sepsis. Septic AKI had significantly higher SAPS II and SOFA scores, and required more mechanical ventilation and vasoactive drugs than non-septic AKI. Patients with septic AKI progressed more to the failure category of the RIFLE criteria. Patients with septic AKI had higher in-hospital mortality and required more RRT, compared to patients with non-septic AKI. Amongst survivors, patients with septic AKI were more likely to recover renal function. A higher SAPS II score and a greater requirement for vasoactive drugs and renal replacement therapy were independently associated with increased in-hospital mortality in septic AKI. Conclusion: Patients with septic AKI have a higher burden of illness with an increased risk of death, but renal function recovers better in survivors of septic AKI.

Efficacy and Safety of Entecavir and Tenofovir in Chronic Hepatitis B Patients with Chronic Kidney Disease: Multicenter, Retrospective Cohort Study

( Sung Eun Kim ),( Jae Yoon Jeong ),( Dae Won Jun ),( Eileen L. Yoon ),( Jae-jun Shim ),( Sang Bong Ahn ),( Yong Kyun Cho ),( Soung Won Jeong ),( Hyoung Su Kim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: We investigate the efficacy and safety of entecavir (ETV) versus tenofovir (TDF) in treatment-naïve chronic hepatitis B (CHB) patients with chronic kidney disease (CKD) in real life setting. Methods: A total of 1,349 naïve CHB patients treated with ETV or TDF at least 1 year in 9 academic hospitals from Jan. 2012 to Dec. 2015 were enrolled. Among them, 44 patients had CKD at enrollment. CKD was defined as glomerular filtration rate <60ml/min/1.73m2. Renal functional decline was defined when serum creatinine level increased by more than 50% from baseline or over than 0.3 mg/dL at 1 year Results: A total of 44 patients (ETV=30 and TDF 14) were followed up for a median 28 months. There were no significant differences in cumulative biochemical response rate and culmulative HBeAg seroconversion rate between the ETV group and the TDF group at weeks 12, 24, and 48 of treatment. However, there were significant differences in culmulative virologic response rate between the ETV group and the TDF group at weeks 12, 24, and 48 of treatment (14%/31%/55% vs.14%/64%/86%, P =0.022). Renal functional decline occurred in 13 (29.5%) patients. Renal functional decline showed no significant difference between the ETV group and TDF group (33% vs. 21%, P=0.420). In multivariate analysis, serum albumin was an independent factor associated with renal functional decline (odd ratio, 0.28; confidence interval, 0.08- 0.95; P=0.041). However, age, sex, BMI, DM, hypertention, baseline HBV-DNA level, HBeAg positivity, cirrhosis, baseline renal function, bilirubin level, platelet count, hemoglobin level, ascites and treatment regimen were not associated with renal functional decline in CHB patient with CKD. Conclusions: TDF had better clinical efficacy than ETV in CHB patient with CKD. This study suggests that close monitoring of renal function are required for CHB patients with CKD and low albuminemia who are receiving antiviral agents.