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Ribociclib-Related Stevens–Johnson Syndrome: Oncologic Awareness, Case Report, and Literature Review
Victoria López-Gómez,Ramón Yarza,Héctor Muñoz-González,Enrique Revilla,Santos Enrech,Olga González-Valle,Pablo Tolosa,Eva Ciruelos 한국유방암학회 2019 Journal of breast cancer Vol.22 No.4
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis belong to a severe dermatopathic spectrum that includes frequently fatal mucocutaneous manifestations consisting of whole epidermal necrosis and sloughing with bullous transformation, blistering, and further skin detachment. Notably, cancer patients are at higher risk of developing SJS than the general population as a consequence of both the nature of neoplastic disease and frequent exposure to anticancer drugs. Ribociclib is a newly approved cycline-dependent kinase inhibitor that has been recently associated with a single case of SJS. We hereby present a case of ribociclib-related SJS. Early detection of threatening skin lesions is crucial to permit the immediate discontinuation of ribociclib given the predictable and unacceptable risk level. In cases of established SJS, early aggressive support should be initiated, ribociclib should be abruptly discontinued, and specific treatment based on actual evidence should be started.
Performance modelling of single and double absorption heat transformers
Rosa María Barragán Reyes,Víctor Manuel Arellano Gómez,Alfonso García-Gutiérrez 한국물리학회 2010 Current Applied Physics Vol.10 No.2
Absorption heat transformers (heat pump Type II) enable the temperature of a low heat source to be raised to a higher level. This process takes place by means of the absorption of a vaporized working fluid into a substance which has strong affinity for the vapor. The temperature lift and the coefficient of performance (a measure of the efficiency of the process), are important design parameters which depend on the thermodynamic properties of the working pair and also on the configuration of the equipment. In order to investigate the performance of readily available, not expensive and environmentally friendly fluids in heat transformers, the systems H2O/CaCl2 and H2O/LiCl were studied, by using a Fortran program. The theoretical performance of both systems in a single stage absorption heat transformer (SSHT), was derived and compared to results obtained previously for the system H2O/CaCl2 on a double absorption unit (DAHT).
Edgar López-Martínez,Octavio Vázquez-Gómez,Héctor Javier Vergara-Hernández,Sergio Serna,Bernardo Campillo 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.6
The microhardness and nanohardness of the welding zone of two experimental HSLA steels were determined. The first steel has a microstructure of martensite and bainite, and the second one has a microstructure of quasipolygonalferrite and acicular ferrite. In the bainitic - martensitic steel, softening of the heat affected zone wasobserved. This softening can be attributed to: the formation of polygonal ferrite in the recrystallization subzone,the formation of quasi-polygonal ferrite and the tempering of martensite in the intercritical subzone, andthe tempering of martensite in the subcritical subzone. Besides the softening, with nanoindentation technique, hardeningwas observed at the position where the peak temperature reached the critical temperature Ac1, which canbe attributed to a phenomenon of secondary hardening by precipitation of carbides of alloying elements. In theferritic steel, a softening phenomenon did not appear since there was no martensite in its initial microstructure. Finally, it was noted that both polygonal ferrite and the bainite have similar behavior and nanohardness, thiscoincidence can be attributed to the effect of grain boundary.
A note on the Fisher information matrix for the flexible generalized-skew-normal model
Venegas Osvaldo,Salinas Hugo S.,Gómez Héctor W. 한국통계학회 2020 Journal of the Korean Statistical Society Vol.49 No.2
The purpose of this paper is to derive the Fisher information matrix for the Flexible Generalized Skew-Normal distribution (FGSN). Initially we derive the score functions which lead to the maximum likelihood estimators. We then compute the information matrix and consider the special cases corresponding to the skew-normal distribution and the normal distribution.We provide an algorithm to generate FGSN random variables and carry out a simulation to investigate the behavior of the estimators. The paper concludes with an application of the FGSN model which fits a real dataset.
José De La Cruz Agüero,Víctor Manuel Cota Gómez 한국해양과학기술원 2008 Ocean science journal Vol.43 No.3
One specimen of Pteraclis aesticola was collected off San José del Cabo, Baja California Sur, México (22°54'N, 109°45'W), in March 2007. Present record is the first reported occurrence of the species in the Tropical Eastern Pacific biogeographic region (Gulf of California to southern Ecuadorian waters). Its large fan-like anal and dorsal fins and its counts of fin rays and vertebrae can distinguish the Pacific fanfish from the other species in the genus. This fish may have not yet been recorded in the region because its presence has been overlooked in the past because of rarity and lack of commercial value. One specimen of Pteraclis aesticola was collected off San José del Cabo, Baja California Sur, México (22°54'N, 109°45'W), in March 2007. Present record is the first reported occurrence of the species in the Tropical Eastern Pacific biogeographic region (Gulf of California to southern Ecuadorian waters). Its large fan-like anal and dorsal fins and its counts of fin rays and vertebrae can distinguish the Pacific fanfish from the other species in the genus. This fish may have not yet been recorded in the region because its presence has been overlooked in the past because of rarity and lack of commercial value.
Josefina Consuelo Morales-Guerrero,Reina Rosas-Romero,Ma Amanda Mariscal-Gálvez,Fabiola Ayala-Alcántara,Héctor Bourges-Rodríguez 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.6
Correct nutrition is important for keeping good health; to attain that, the diet has to include vegetables such as quelites. The objective of this study was to determine the glycemic index (GI) and glycemic load (GL) of rice and a tamal prepared with and without two species of quelites: “alache” (Anoda cristata) and “chaya” (Cnidoscolus aconitifolius). The GI was measured in 10 healthy subjects, 7 women and 3 men, with the following mean metrics: age, 23 years old; body weight, 61.3 kg; height, 1.65 m; body mass index, 22.7 kg/m2; and basal glycemia, 77.4 mg/dL. Capillary blood samples were collected within 2 h after the meal. White rice (rice with no quelites) had a GI of 75.35 ± 15.6 and a GL of 36.17 ± 7.8; rice with alache had a GI of 33.74 ± 5.85 and a GL 33.74 ± 1.85. White tamal had a GI of 57.33 ± 10.23 and a GC of 26.65 ± 5.12; tamal with chaya had a GI of 46.73 ± 22.1 and a GL of 23.36 ± 11. The GI and GL values recorded for the combination of quelites with rice and tamal confirmed that quelites could be a good alternative for healthy diets.
José De La Cruz-Agüero,Francisco Javier García-Rodríguez,Víctor Manuel Cota-Gómez,Felipe Neri Melo-Barrera,Rogelio González-Armas 한국해양과학기술원 2012 Ocean science journal Vol.47 No.2
Fresh and preserved (type material) specimens of the black ghost chimaera Hydrolagus melanophasma were compared for morphometric characteristics. A molecular comparison was also performed on two mitochondrial gene sequences (12S rRNA and 16S rRNA gene sequences). While significant differences in measurements were found, the differences were not attributable to sexual dimorphism or the quality of the specimens, but to the sample size and the type of statistical tests. The result of the genetic characterization showed that 12S rRNA and 16S rRNA genes represented robust molecular markers that characterized the species.
Salvatore Rudilosso,José Ríos,Alejandro Rodríguez,Meritxell Gomis,Víctor Vera,Manuel Gómez-Choco,Arturo Renú,Núria Matos,Laura Llull,Francisco Purroy,Sergio Amaro,Mikel Terceño,Víctor Obach,Joaquim Se 대한뇌졸중학회 2021 Journal of stroke Vol.23 No.3
Background and Purpose In real-world practice, the benefit of mechanical thrombectomy (MT) is uncertain in stroke patients with very favorable or poor prognostic profiles at baseline. We studied the effectiveness of MT versus medical treatment stratifying by different baseline prognostic factors. Methods Retrospective analysis of 2,588 patients with an ischemic stroke due to large vessel occlusion nested in the population-based registry of stroke code activations in Catalonia from January 2017 to June 2019. The effect of MT on good functional outcome (modified Rankin Score ≤2) and survival at 3 months was studied using inverse probability of treatment weighting (IPTW) analysis in three pre-defined baseline prognostic groups: poor (if pre-stroke disability, age >85 years, National Institutes of Health Stroke Scale [NIHSS] >25, time from onset >6 hours, Alberta Stroke Program Early CT Score <6, proximal vertebrobasilar occlusion, supratherapeutic international normalized ratio >3), good (if NIHSS <6 or distal occlusion, in the absence of poor prognostic factors), or reference (not meeting other groups’ criteria). Results Patients receiving MT (n=1,996, 77%) were younger, had less pre-stroke disability, and received systemic thrombolysis less frequently. These differences were balanced after the IPTW stratified by prognosis. MT was associated with good functional outcome in the reference (odds ratio [OR], 2.9; 95% confidence interval [CI], 2.0 to 4.4), and especially in the poor baseline prognostic stratum (OR, 3.9; 95% CI, 2.6 to 5.9), but not in the good prognostic stratum. MT was associated with survival only in the poor prognostic stratum (OR, 2.6; 95% CI, 2.0 to 3.3). Conclusions Despite their worse overall outcomes, the impact of thrombectomy over medical management was more substantial in patients with poorer baseline prognostic factors than patients with good prognostic factors.
Enrique Coss-Adame,Janette Furuzawa-Carballeda,Andric C Perez-Ortiz,Ana López-Ruiz,Miguel A Valdovinos,Josué Sánchez-Gómez,José Peralta-Figueroa,Héctor Olvera-Prado,Fidel López-Verdugo,Sofía Narváez-C 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.4
Background/AimsThe evidence suggests that a shorter esophageal length (EL) in gastroesophageal reflux disease (GERD) patients is associated with the presence of hiatal hernia (HH). However, there are no reports of this association in patients with achalasia. The aim is to (1) determine the prevalence of hiatal hernia in achalasia patients, (2) compare achalasia EL with GERD patients and healthy volunteers (HV), (3) measure achalasia manometric esophageal length to height (MELH) ratio, and (4) determine if there are differences in symptoms between patients with and without hiatal hernia. MethodsThis retrospective and cross-sectional study consist of 87 pre-surgical achalasia patients, 22 GERD patients, and 30 HV. High-resolution manometry (HRM), barium swallow, and upper endoscopy were performed to diagnose HH. The EL and MELH ratio were measured by HRM. Symptoms were assessed with Eckardt, Eating Assessment Tool, and GERD–health-related quality of life questionnaires. ResultsThe HH in GERD’s prevalence was 73% vs 3% in achalasia patients (P < 0.001). Achalasia patients had a longer esophagus and a higher MELH ratio than HV and GERD patients (P < 0.001). GERD patients had a lower MELH ratio than HV (P < 0.05). EAT-10 (P < 0.0001) and Eckardt (P < 0.05) scores were higher in achalasia without HH vs HH. ConclusionsThe prevalence of HH in achalasia is significantly lower than in GERD. The longer EL and the higher MELH ratio in achalasia could explain the lower prevalence of HH. Despite the low prevalence of HH in achalasia patients, the surgeon should be encouraged not to rule out HH since the risk of postoperative reflux may increase if this condition is not identified and corrected.