간호대생과 의대생의 간호사 이미지 비교

구민진,김수영,방정민,서아영,양희진,윤소람,이윤재,이재은,이지연,정윤경,최수정 이화여자대학교 간호과학대학 2014 이화간호학회지 Vol.- No.48

Purpose: This study aims to analyze the difference in the perception that nursing students and medical students have regarding the image of nurses. Method: The sampling group for this study was made up of 111 nursing students and 117 medicine students, conducted from the 19th August 2013 to 3rd September 2013. The tool used for this study is the “Nurse Image Scale”. The data is analyzed using the SPSS 21.0 program, technical stats, t-test and ANOVA with Scheffe test. Result: There was a notable difference in the results(t=6.94, p<001), with the average image perception score of nurses at 3.84±0.34 amongst nursing students being higher than the 3.50±0.38 amongst Medicine students. The average score of the 4 areas tested, “Qualification of a Nurse”, “Role of a Nurse”, “Social Participation of a Nurse” and “Interpersonal Skills of a Nurse” were all marked higher by the nursing students than the medicine students. The average score became notably higher as the period of practice became shorter with nursing students (F=4.21, p=.043). Furthermore, the average score for the “Qualification of a Nurse” was notably higher as the period of practice became shorter (F=3.98, p=.049). Medical students gave an average score for the “Qualification of a Nurse”(F=3.72, p=.027) and the “Interpersonal Skills of a Nurse”(F=4.11, p=.019) which was relative to the development of a nurse’s image, while the average score for the “Role of a Nurse” was notably higher with a longer period of practice(F=6.65, p=.011). Conclusion: The results of this study suggest that the image perception of a nurse can vary depending on the experience in period of practice. Therefore, together with this study conducted with nursing students and medicine students, there is a need for further studies conducted on image perception of nurses with various experience in period of practice.

Development of Sensitive Analytical Method of Rhodanthpyrone A by a LC-MS/MS and its Application to Bioavailability Study in Rats

Kang, Bitna,Yoon, Jeong A,Song, Im-Sook,Han, Young Taek,Choi, Min-Koo Korean Society for Mass Spectrometry 2019 Mass spectrometry letters Vol.10 No.3

A sensitive analytical method of rhodanthpyrone A in rat plasma was developed using a liquid chromatography-tandem mass spectrometry (LC-MS/MS). Rhodanthpyrone A and rhodanthpyrone B (internal standard) in rat plasma were extracted by a liquid-liquid extraction method with ethyl acetate. This extraction method gave results in high and reproducible extraction recovery in the range of 73.75-79.90% with no interfering peaks around the peak elution time of rhodanthpyrone A and B. The standard calibration curves for rhodanthpyrone A ranged from 0.5 to 2000 ng/mL were linear with $r^2$ > 0.994 and the inter- and intra-day accuracy and precision and the stability were within acceptance criteria. Using this validated analytical method, pharmacokinetics of rhodanthpyrone A following intravenous and oral administration of rhodanthpyrone A at doses of 2 mg/kg and 30 mg/kg, respectively, were investigated. Rhodanthpyrone A in rat plasma showed multi-exponential elimination pattern with high clearance and volume of distribution values. The absolute oral bioavailability of this compound was calculated as 3.7%. Collectively, the newly developed sensitive LC-MS/MS analytical method of rhodanthpyrone A could be successfully applied to investigate the pharmacokinetic properties of this compound and would be useful for the further studies on the efficacy, toxicity, and biopharmaceutics of rhodanthpyrone A.

Lebesgue’s criterion for the Riemann integration with respect to a state on a separable unital C*- algebra

A. I. Shtern 장전수학회 2016 Advanced Studies in Contemporary Mathematics Vol.26 No.2

In the paper “Semicontinuous envelopes, Riemann integral, and uniform distribution in C*-algebras” (Funct. Anal. Appl. 29 (4), 268– 275 (1995)(1996)), the author had constructed the Riemann integral with respect to a state on a separable unital C*-algebra A. In particular, the semicontinuous hulls of elements of the enveloping von Neumann algebra A of A were introduced and studied and, for a given state ! on A, a class of selfadjoint elements of the algebra A that are Riemann integrable with respect to the state ω were introduced. It was also proved that this class is the self-adjoint part of a C*-algebra, and relations to the uniform distribution of states of the C*-algebra A with respect to the state ω were indicated. In the present note, we supplement these results by a version of Lebesgue’s criterion for the Riemann integrability of self-adjoint elements of A.

Edge-to-vertex detour number of a graph

A. P. Santhakumaran,S. Athisayanathan 장전수학회 2011 Advanced Studies in Contemporary Mathematics Vol.21 No.4

For two vertices u and v in a graph G = (V,E), the detour distance D(u, v)is the length of a longest u–v path in G. A u–v path of length D(u, v) is called a u–v detour. For subsets A and B of V , the detour distance D(A,B)is defined as D(A,B) = min{D(x, y) : x ∈ A, y ∈ B}. A u–v path of length D(A,B) is called an A–B detour joining the sets A, B ⊆ V where u ∈ A and v ∈ B. A vertex x is said to lie on an A–B detour if x is a vertex of an A–B detour. A set S ⊆ E is called an edge-to-vertex detour set if every vertex of G is incident with an edge of S or lies on a detour joining a pair of edges of S. The edge-to-vertex detour number dn_2(G) of G is the minimum order of its edge-to-vertex detour sets and any edge-to-vertex detour set of order dn_2(G) is an edge-to-vertex detour basis of G. Certain general properties of these concepts are studied. The edge-to-vertex detour numbers of certain classes of graphs are determined. Its relationship with the detour diameter is discussed and it is proved that for each triple D, k, q of integers with 2 ≤ k ≤ q − D + 2 and D ≥ 4 there is a connected graph G of order p with detour diameter D and dn_2(G) = k. It is also proved that for any three positive integers a, b, k with k ≥ 2 and a < b ≤ 2a, there is a connected graph with detour radius a, detour diameter b and dn_2(G) = k.

A형 간염의 자연항체와 예방접종을 통한 항체 생성률의 역가 비교분석

권원현,김경화,조경아,문기춘,김정인,이인원,Kwon, Won Hyun,Kim, Kyung Hwa,Cho, Kyung A,Moon, Ki Choon,Kim, Jung In,Lee, In Won 대한핵의학기술학회 2013 핵의학 기술 Vol.17 No.2

2008년부터 A형 간염 환자들이 급속히 증가하고 본원에 내원하여 건진을 받는 대부분의 수검자들이 A형 간염(IgG) 항체 생성 유무에 관심이 많아지며 검사 건수가 증가하였다. 그에 따라 항체 검사결과가 cut-off값에 걸리는 검체가 많아져 원인을 분석하였더니 대부분 A형 간염 예방접종을 한 수검자들이었다. 이에 저자들은 건강증진센터에서 설문조사를 통하여 자연면역을 획득한 수검자들 그룹과 본원에서 A형 간염 예방접종(1차, 2차)을 실시한 직원들 그룹으로 나누어 검사를 시행하였고 cut-off값을 기준으로 항체 생성률과 그에 대한 역가를 비교하고 진단검사의학과와 핵의학과에서 사용하는 진단 시약간에 항체 생성률과 그에 대한 역가를 비교해 보고자 했고, 2012년 8월 한 달 동안 건진 수검자 185명을 설문조사하여 자연면역을 획득한 119명과 본원에서 예방 접종을 실시한 직원들을 대상으로 1차 접종자 53명, 2차 접종자 59명으로 대상을 분류했다. 항체 생성률은 cut-off값 1을 기준했을 때 0.90-1.10 (${\pm}$), 0.60-0.89 (1+), 0.30-0.59 (2+), 0.01-0.29 (3+)로 나누어 역가를 비교하고, 같은 기준으로 제조사별 백신 접종 후 항체 생성률에 대한 역가를 비교평가 해 보았다. 그 결과, 건진 수검자 중 자연 면역을 획득한 수검자는 cut-off값 1을 기준했을 때, 0.90-1.10 (${\pm}$)가 0%, 0.60-0.89 (1+)가 0%, 0.30-0.59 (2+)가 4.2%, 0.01-0.29 (3+)가 96%로 역가가 <0.60 ($${\geq_-}2+$$)가 100%였다. 그리고 예방접종을 실시한 직원들의 항체 생성률은 1차 접종자 중 ${\pm}$가 59.1%, 1+가 18.1%, 2+가 18.1%, 3+가 4.6%로 총 45.3%였고, 역가는 $${\geq_-}$$ 0.60 ($${\leq_-}1+$$)가 77.3%였다. 2차 접종자의 항체 생성률은 ${\pm}$가 1.9%, 1+가 15.4%, 2+가 36.54%, 3+가 46.2%로 총 88.1%였고 역가는 <0.60 ($${\geq_-}2+$$) 82.7%가 였다. 또한 제조사별로 비교 하였을 때 1차 접종자의 항체 생성률은 BNIBT 20.8% (${\pm}24.5%$), GB 15.7% (${\pm}7.8%$), RIAKEY 94.3% (${\pm}3.8%$), ROCHE 83% (${\pm}0%$), Abbot 73.1% (${\pm}5.8%$)였고, 2차 접종자의 항체 생성률은 BNIBT 86.4% (${\pm}1.7%$), GB 88.5% (${\pm}1.9%$), RIAKEY 100% (${\pm}0%$), ROCHE 98.3% (${\pm}0%$), Abbot 98.2% (${\pm}0%$)였다. 즉 자연면역 항체가 예방접종에 의한 항체보다 역가가 높다는 것을 알 수 있었고, 1차 접종 후 보다는 2차 접종 후 검사를 시행했을 때 항체 생성률과 역가가 대부분 높아짐을 알 수 있었다. 따라서 결과 보고시 negative, index (${\pm}$), weak positive (1+), positive (2+), strong positive (3+)로 역가를 나누어 보고를 하거나 결과값에 index값을 같이 적어서 결과를 상세히 보고한다면 과거결과와 비교도 가능할 것이다. 또 제조사별 비교 시 1차 예방접종 후의 항체 생성률과 역가에서 시약간에 많은 차이를 보이고 있었고, 매년 예방 접종률이 높아지고 있는 시점에서 이러한 차이를 줄이기 위해서 각 제조사들은 민감도나 재현성에 더 주의를 기울여야 하겠고, 자연면역항체와 예방접종을 통한 항체간에 생길 수 있는 미지의 차이를 감안하여 검사자들이 사용하는 시약을 신뢰할 수 있도록 더 연구하고 개발해야 할 것이다. Purpose: Since 2008, hepatitis A patients was rapidly increasing. So, Most of the health checkup examinees were interested in whether hepatitis A antibody was a lot. thereby The number of tests was increasing. In recent years, Antibody test results in the range of cut-off values were increased. According to the cause analysis, most examinees had a hepatitis A vaccine. This study was conducted to classify hepatitis A antibody as natural antibody and antibody after vaccination and compared the titer for seroconversion rate based on cut-off values. Materials and Methods: For a month in August 2012, First, We surveyed 185 health examinees and classified 119 health examinees who had acquired natural antibody. Second, for employees who were inoculated against hepatitis at our hospital, We classified into 53 primary inoculators and 59 secondary inculators. when the standard of cut-off value was 1, The seroconversion rate was compared the titer divided by 0.90-1.10 (${\pm}$), 0.60-0,89 (1+), 0.30-0.59 (2+), 0.01-0.29 (3+) and we compared the titer for seroconversion rate by each manufacturer after vaccination. Results: When the standard of cut-off value was 1, the titer of 119 health examinees who had acquired natural antibody was 0.90-1.10 (${\pm}$): 0%, 0.60-0.89 (1+): 0%, 0.30-0.59 (2+): 4.2%, 0.01-0.29 (3+): 96% and the titer of <0.60 ($${\geq_-}2+$$) was 100%. The titer of 53 primary inoculators was 0.90-1.10 (${\pm}:59.1%$), 0.60-0.89 (1+): 18.1%, 0.30-0.59 (2+): 18.1%, 0.01-0.29 (3+): 4.6% and the seroconversion rate was 45.3%. The titer of $${\geq_-}0.60$$ ($${\leq_-}1+$$) was 77.3%. The titer of 59 secondary inoculators was 0.90-1.10 (${\pm}:1.9%$), 0.60-0.89 (1+): 15.4%, 0.30-0.59 (2+): 36.54%, 0.01-0.29 (3+): 46.2% and the seroconversion rate was 88.1%. The titer of <0.60 ($${\geq_-}2+$$) was 82.7%. When we compared the titer for seroconversion rate by each manufacturer after vaccination, the seroconversion rate of 53 primary inoculators was BNIBT: 20.8% (${\pm}:24.5%$), GB: 15.7% (${\pm}:7.8%$), RIAKEY: 94.3% (${\pm}:3.8%$), ROCHE: 83% (${\pm}:0%$), ABBOTT: 73.1% (${\pm}:5.8%$) and the seroconversion rate of 59 secondary inoculators was BNIBT : 86.4% (${\pm}:1.7%$), GB: 88.5% (${\pm}:1.9%$), RIAKEY: 100% (${\pm}:0%$), ROCHE: 98.3% (${\pm}:0%$), ABBOTT: 98.2% (${\pm}:0%$). Conclusion: The study show that the titer of natural immune antibodies is higher than the titer of vaccination and the titer of secondary inoculation is mainly higher than the titer of primary inoculation. Consequently, if we know the titer of hepatitis A antibodies, it will help to give resullt reports. And then, when we compared the titer and the seroconversion rate by each manufacturer, There was a very distinct difference. As the test subjects inoculate against hepatitis A (HAV), it is considered BNIBT, GB will occur false negative rate and RIAKEY, ROCHE, ABOTT will occur false positive rate.

Temperature dependent structure formation and photoluminescence studies of a series of magnesium-based coordination networks

Calderone, P.J.,Banerjee, D.,Plonka, A.M.,Kim, S.J.,Parise, J.B. Elsevier Sequoia [etc.] 2013 Inorganica chimica acta Vol.394 No.-

A series of three magnesium trimesate coordination networks was synthesized from identical reaction mixtures by varying synthetic temperature. Mg(HBTC)(DMF)<SUB>2</SUB>.[(CH<SUB>3</SUB>)<SUB>2</SUB>NH] (1; BTC=trimesate; space group P6<SUB>3</SUB>/m, a=16.596(4)A, c=14.351(8)A) crystallizes at 65<SUP>o</SUP>C, Mg<SUB>3</SUB>(BTC)(HCOO)<SUB>3</SUB>(DMF)<SUB>3</SUB> (2; space group P@?3, a=13.928(2)A, c=8.025(6)A) crystallizes at 100<SUP>o</SUP>C, and Mg<SUB>3</SUB>(BTC)<SUB>2</SUB>(DMF)<SUB>4</SUB> (3; space group P2<SUB>1</SUB>/c, a=17.490(4)A, b=11.940(2)A, c=18.460(4)A, β=116.87(3)<SUP>o</SUP>) crystallizes at a temperature of 180<SUP>o</SUP>C. Each network contains metal-coordinated solvent DMF molecules, but thermodynamics and solvent hydrolysis play major roles in structure formation. Compounds 1 and 2 are two-dimensional networks which incorporate hydrolysis byproducts. Compound 3 is a three-dimensional network and shows no inclusion of byproducts. The series follows the trend of increased network connectivity resulting from increased temperature. Each of the networks show a weak photoluminescence response, suggesting that coordinated solvent molecules and interlayer species play a role in quenching photoluminescence.

초등학교 축구선수의 성격타입(A/B), 정신력과 운동몰입의 구조적 관계

김인수(Kim In-Soo),최정아(Choi Jeang-a) 한국체육교육학회 2016 한국체육교육학회지 Vol.20 No.4

이 연구는 초등학교 축구선수의 A/B 타입 성격과 정신력, 운동몰입 간에 어떤 인과관계가 있는지를 밝힘으로써 초등학교 축구선수의 경기력 향상에 도움을 주고자 수행되었다. 이러한 연구목적을 달성하기 위해 G광역시와 J도에 소재한 초등학교 축구선수로 등록된 236명과 중학교 축구 선수 110명을 대상으로 A/B 타입 성격척도, 정신력 척도, 운동몰입척도를 사용하여 집단 간 t-test 및 공변량 구조분석을 실시하였다. 변인 간의 구조적 관계분석을 위해 A/B 타입 성격을 외생변인으로 하고, 정신력과 운동몰입을 내생변인으로 한 구조모델을 설정하고 검증하였으며 그 결과 첫째, A/B 타입 성격 간 비교에서A 타입 성격소유자가 B타입 성격소유자에 비해 정신력과 운동몰입이 높은 것으로 나타났다. 입상경력유무집단 간 비교에서 입상경력이 있는 선수는 그렇지 못한 선수에 비해 A 타입 성격, 정신력, 운동몰입이 높았다. 초등학교 축구선수와 중학교 축구선수 간 비교에서는 성격타입, 정신력, 운동몰입에 차이가 없었다. 둘째, 변인 간 상관분석을 실기한 결과 A/B 타입 성격, 정신력, 운동몰입 간에는 서로 유의한(p<.01) 상관이 있었다. 셋째, 변인 간 구조관계를 분석한 결과 완전매개모형이 적합한 것으로 나타났고, A/B 타입 성격을 외생변인으로 하고 정신력과 운동몰입을 내생변인으로 한 구조모형은 이론모델로서 양호한 것으로 나타났으며(χ2=20.13, df=7, Q=2.88, RMR=.01, GFI=.97, TLI=.94, NFI=.96, CFI=.97, RMSEA=.08) 세부 구조경로에서는 A/B타입 성격 → 정신력, 정신력 → 운동몰입의 경로가 유의한(p<.01) 것으로 나타났다. 이를 요약하면 초등학교 축구선수의 경우 A타입 성격 성향이 강할수록 정신력과 운동몰입 수준이 높으며 지방대회 3위 이상의 입상경력을 가진 선수는 그렇지 않는 선수에 비해 A 타입 성격 성향이 강하고, 정신력과 운동몰입 수준이 높다. 또한, A/B 성격 성향은 정신력과 밀접한 관련이 있으며 정신력은 운동몰입과 인과관계가 있는 것으로 나타나 초등학교 축구선수의 운동몰입 수준을 증가시키기 위해서는 정신력의 강화가 필요함을 제시해 주고 있다. Purpose: The Purpose of this study was to define structural relation among A/B type behavior pattern, mental toughness, and sport commitment of elementary school soccer players. Methods: This study set up a structural relation model which was composed of exogenous variables as A/B type behavior pattern and endogenous variables were mental toughness, and sport commitment of soccer players. The participants were 236 elementary school and 110 middle school soccer players who lived in G city and J province. This study used A/B type behavior pattern scale, Mental toughness scale and commitment scale. Results: In analysis of t-test, A type players show higher mental toughness and sport commitment than those of B type. The players who had experienced more 3rd place in province soccer competition show higher A type behavior pattern, mental toughness, and behavioral commitment than those of the others. There were no differences between elementary school players and middle school players in A/B type behavior pattern, mental toughness and sport commitment. In analysis of correlation, there were significant relations between A/B type behavior pattern, mental toughness and sport commitment. In analysis structure equation, this model can be used as theoretical model because general indexes were proved(χ2=20.13, df=7, Q=2.88, RMR=.01, GFI=.97, TLI=.94, NFI=.96, CFI=.97, RMSEA=.08). In analysis details index, there were significant paths of A/B type behavior pattern → mental toughness, mental toughness → sport commitment. Conclusion: In this study define there are causal relationships among A/B type behavior pattern, mental toughness and sport commitment. To approve sport commitment of elementary school soccer players, players kept up A type behavior pattern and make strong mental toughness.

$n$-weak amenability and strong double limit property

A.R. Medghalchi,T. Yazdanpanah 대한수학회 2005 대한수학회보 Vol.42 No.2

Let {mathcal A} be a Banach algebra, we say that {mathcalA}has the strongly double limit property (SDLP) if for each boundednet (a_{alpha}) in {mathcal A} and each bounded net(a^*_{beta}) in {mathcal A}^*, lim_{alpha}lim_{beta}leftlangle a_{alpha} , a^*_{beta}rightrangle = lim_{beta} lim_{alpha} leftlangle a_{alpha}, a^*_{beta} rightrangle whenever both iterated limits exist. In this paperamong other results we show that if {mathcal A} has the SDLP and{mathcal A}^{**} is (n-2)-weakly amenable, then {mathcal A} isn-weakly amenable. In particular, it is shown that if {mathcalA}^{**} is weakly amenable and {mathcal A} has the SDLP, then ${\mathcal A}$ is weakly amenable

Comparative and Structural Analysis of the Interaction between β-Lactoglobulin type A and B with a New Anticancer Component (2,2'-Bipyridin n-Hexyl Dithiocarbamato Pd(II) Nitrate)

A. Divsalar,A. A. Saboury*,H. Mansoori-Torshizi,B. Hemmatinejad 대한화학회 2006 Bulletin of the Korean Chemical Society Vol.27 No.11

The interaction between whey carrier protein b-lactoglobulin type A and B (BLG-A and -B) and 2,2'-bipyridin n-hexyl dithiocarbamato Pd(II) nitrate (BPHDC-Pd(II)), a new heavy metal complex designed for anticancer property, was investigated by fluorescence spectroscopy combined with chemometry and circular dichroism (CD) techniques. A strong fluorescence quenching reaction of BPHDC-Pd(II) to BLG-A and -B was observed. Hence, BPHDC-Pd(II) complex can be bound to both BLG-A and -B, and quench the fluorescence spectra of the proteins. The quenching constant was determined using the modified Stern-Volmer equation. The binding parameters were evaluated by fluorescence quenching method. The results of binding study provided evidences presence of two and three sets of binding sites on the BLG-B and -A, respectively, for BPHDC-Pd(II) complex. Using fluorescence spectroscopy and chemometry, the ability of BLG-A and -B to form an intermediate upon interaction with BPHDC-Pd(II) complex was assessed. CD studies displayed that under influence of different concentrations of BPHDC-Pd(II) complex, the regular secondary structure of BLG-B had no significant changes, whereas for BLG-A a transition from a-helix to b-structure was appeared. The results for both of BLG-A and -B displayed that BPHDC-Pd(II) complex can induce a conformational transition from the native form to an intermediate state with a slightly opened conformation, which is detectable with chemometry analyses.

A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype

Kim, Hyun Jin,Li, Qin,Tjon-Kon-Sang, Sandra,So, Insuk,Kiselyov, Kirill,Soyombo, Abigail A,Muallem, Shmuel Wiley (John WileySons) 2008 The EMBO journal Vol.27 No.8

<P>TRPML3 belongs to the TRPML subfamily of the transient receptor potential (TRP) channels. The A419P mutation in TRPML3 causes the varitint-waddler phenotype as a result of gain-of-function mutation (GOF). Regulation of the channels and the mechanism by which the A419P mutation leads to GOF are not known. We report here that TRPML3 is a Ca(2+)-permeable channel with a unique form of regulation by extracytosolic (luminal) H(+) (H(+)(e-cyto)). Regulation by H(+)(e-cyto) is mediated by a string of three histidines (H252, H273, H283) in the large extracytosolic loop between transmembrane domains (TMD) 1 and 2. Each of the histidines has a unique role, whereby H252 and H273 retard access of H(+)(e-cyto) to the inhibitory H283. Notably, the H283A mutation has the same phenotype as A419P and locks the channel in an open state, whereas the H283R mutation inactivates the channel. Accordingly, A419P eliminates regulation of TRPML3 by H(+)(e-cyto), and confers full activation to TRPML3(H283R). Activation of TRPML3 and regulation by H(+)(e-cyto) are altered by both the alpha-helix-destabilizing A419G and the alpha-helix-favouring A419M and A419K. These findings suggest that regulation of TRPML3 by H(+)(e-cyto) is due to an effect of the large extracytosolic loop on the orientation of fifth TMD and thus pore opening and show that the GOF of TRPML3(A419P) is due to disruption of this communication.</P>