Four new compounds from the bulbs of Lycoris aurea with neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell injuries

An Jin,Xuelian Xiang,Yun-Yun Zhu,Heng-Yi Yu,Hui-Fang Pi,Peng Zhang,Han-Li Ruan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3

Three new alkaloids, 2a-hydroxy-6-O-n-butyloduline,O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine(1–3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-20-methylbenzene-30,60-diol (14), along with ten known alkaloids (4–13), wereisolated from the bulbs of Lycoris aurea collected fromHuaihua County of Hunan Province, China. Their structureswere elucidated by spectroscopic methods includingHRESIMS, UV, IR, and NMR. All the isolated compoundswere tested for their neuroprotective effects against CoCl2and H2O2-induced SH-SY5Y cell death. Compounds 1–7and 10 exhibited significant neuroprotective effects againstCoCl2-induced SH-SY5Y cell injury, while compounds1–5, 7, 10 and 12 showed obvious neuroprotective effectsagainst H2O2-induced SH-SY5Y cell death.

대장에 발생한 샘암종에서 MUC1과 MUC2 점소 발현의 의의

이윤경,이주호,이용,심재영,박정훈,오수섭,박진실,기근홍 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Background : Mucins possess the unique function of protecting and lubricating the epithelial surface and other important functions such as call growth, direct implication in the fetal development, the epithelial renewal and differentiation, the epithelial integrity, carcinogenesis, immune regulation, cellular adhesion and metastasis. Purpose : This study was done to provide the significance of alteration of MUC1 and MUC2 expression in colorectal adenocarcinoma, A series of 131 colorectal adenocarcinomas including 11 mucinous carcinomas were screened immunohistochemically for their expression of MUCI and MUC2, Materials and mehtods : Of 131 carcinomas, 76 (58,5%) were MUCI positive and 91 (68, 9%) were MUC2 positive, In normal colonic goblet cells, MUCl was not expressed but MUC2 was expressed in cytoplasm, Conclusion There were up-regulation of MUCI and down-regulation of MUC2 in colorectal carcinomas, The frequency of MUC2 positivity according to differentiation was statistically reliable. (p=0.0001)

A NOVEL FUNCTIONAL MATERIAL OF Ag-S$i_3N_4$ NANOSTRUCTURED COMPOSITE

Zhu, Zhu, Yi-Hun,Zhu, Zhu, Hong-Jie,Han, Han, Jin-Yi,Hu, Li-Ming 한국재료학회 1995 Fabrication and Characterization of Advanced Mater Vol.1 No.1

$Ag-Si_3N_4$ nanostrutured composite has been investigated. The results show that it exhibits some novel properties such as strong piezpelectricity and high dielectricity. It can be constituted a battery using graphite and aluminum as the positive and the negative electrodes, respectively. The origins of these properties have been discussed.

Synthesis and Antiproliferative Activity of 1,4-Bis(dimethylamino)- 9,10-anthraquinone Derivatives against P388 Mouse Leukemic Tumor Cells

Guang-Zhu Jin,Hai-Shan Jin,Li-Li Jin 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7

A series of 2-substituted-1,4-bis(dimethylamino)-9,10-anthraquinone derivatives were synthesized and their in vitro antiproliferative activities against p388 mouse leukemic tumor cells were evaluated. In addition, the effect of substituents on the phenyl ring was investigated. Among the derivatives tested, seven showed a high antiproliferative effect and three showed a moderate effect. In addition, introduction of a series of substituted phenyl groups into 1,4-bis(dimethylamino)-9,10-anthraquinone at 2-position were shown to enhance its antiproliferative activity. The antiproliferative activity also increased upon substitution of the benzene ring by an electron donating group such as an amine or methoxyl group.

中日韓における形態素「~族」の比較研究

김금주(金錦珠)(Jin, Jin-Zhu) 한일일어일문학회 2012 한일어문논집 Vol.16 No.-

형태소 “족”은 “공통적인 특성을 가진 특정 사람”을 가리키는 의미에서 한중일 세 나라 언어로 공통된다. 본고에서는 형태소 “족”의 어의 “족”어의 중일한 비교 대조를 시도했다. 중국의 “족”어는 일본어와 한국어에 비해 외래어가 극소하고 그 95%가 한자로 표기되어 있다 특히“일족”라는 파생어를 생성하고있는 것도 한국어, 일본어와는 다르다. 일본어에 있어서 “족”어는 중국어와 한국어에 비해 당시의 인기 소설이나 잡지, 텔레비전 드라마의 제목에서 온 것이 많다. 또한 “족”어은 종종 마이너스의 어감을 띠고 있다. 일본에서는 “족”은 “계”로 대체되는 현상이 눈에 띄고, 일본어의 “족”어의 생성 메커니즘은 한중에 비해 쇠퇴의 길로 들어섰다 중국어와 일본어에 비해 한국어의 “족”어는 동물 이름으로 명명된 것이 많다. 또한 외래어 수용시“단축 + 합성” 형식의 다용, 한국산 영어가 범람함으로 말미암아 난해한 말이 많다. “족”어에는 한중일의 동의어가 많지만 그것은 인터넷의 보급이 “족”어의 전파에 박차를 가하고 있는 것이나 공통적인 생각, 행동 양식을 보이고 있는 이른바 “신·신 인류”가 세나라에 존재하는것에 기인하고 있다.

An Integrated FEM System Facilitated with Automatic Remeshing

Zhu, Jin,Gotoh, Manabu,Shang, Jian,Sun, Zhi Gang 대한금속재료학회(대한금속학회) 1998 METALS AND MATERIALS International Vol.4 No.4

Heavy distortion of elements in finite clement simulation of metal forming requires many times of remeshing during the computation. These remeshings should he performed automatically for both saving computation time and convenience. In this study, a fully automatic remeshing algorithm for two dimensional (2D) quadrilateral elements has been well established. A 2D rigid-plastic FEM code facilitated with the remeshing and refinement algorithm has been developed and applied to a two stage forging process. The system exhibited good performance during the simulation.

Effects of Tiam 1 on Invasive Capacity of Gastric Cancer Cells in vitro and Underlying Mechanisms

Zhu, Jin-Ming,Yu, Pei-Wu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Objective: To investigate changes in the invasive capacity of gastric cancer cells in vitro after expression inhibition of T lymphoma invasion and metastasis inducing factor 1 (Tiam 1) and underlying mechanisms. Methods: Using adhesion selection, two subpopulations with high ($M_H$) or low ($M_L$) invasive capacity were separated from the human gastric cancer cell line MKN-45 ($M_0$). Tiam 1 antisense oligodeoxynucleotide (ASODN) was transfected into $M_H$ cells with liposomes, and expression of Tiam 1 mRNA and protein was determined by RT-PCR and quantitative cellular-ELISA. Changes in the cytoskeleton, invasive capacity in vitro and expression of ras-related $C_3$ botulinum toxin substrate 1 (Rac 1), integrin ${\beta}1$ and matrix metalloproteinase 2 (MMP 2) between Tiam 1 ASODN transfected $M_H$ cells and non-transfected cells were observed by HE staining, cytoskeletal protein staining, scanning electron microscopy, Boyden chamber tests and cyto-immunohistochemistry. Results: A positive correlation existed between the expression level of Tiam l mRNA or protein and the invasion capacity of gastric cancer cells. After ASODN treatment ($0.43{\mu}M$ for 48 h), Tiam 1 mRNA transcription and protein expression in $M_H$ cells were decreased by 80% and 24% respectively (P < 0.05), compared with untreated controls, while invasive capacity in vitro was suppressed by 60% (P < 0.05). Morphologic and ultrastructural observation also showed that ASODN-treated $M_H$ cells exhibited smooth surfaces with obviously reduced filopodia and microspikes, which resembled $M_0$ and $M_L$ cells. Additionally, cytoskeletal distribution dramatically altered from disorder to regularity with reduced long filament-like structure, projections, pseudopodia on cell surface, and with decreased acitn-bodies in cytoplasm. After Tiam 1 ASODN treatment, the expression of Rac 1 and Integrin ${\beta}1$ in $M_H$ cells was not affected (P > 0.05), but that of MMP 2 in $M_H$ cells was significantly inhibited compared with untreated cells (P < 0.05). Conclusion: Over-expression of Tiam-1 contributes to the invasive phenotype of gastric cancer cells. Inhibition of Tiam 1 expression could impair the invasive capacity of gastric cancer cells through modulating reconstruction of the cytoskeleton and regulating expression of MMP 2.

A Study on the Development of Typhoon Track Forecast Model Based on the Past Track Data

Jin, Guo-Zhu,Song, Chae-Uk Korean Institute of Navigation and Port Research 2004 한국항해항만학회지 Vol.28 No.4

This paper is aimed to develop a mathematical model for making the forecast information of typhoon's movement such as the estimated movement direction and positions after 24 and 48 hours. The proposed model calculates such kind of information of a typhoon by similar past typhoon's track data which are selected with three similarity criteria among the database of typhoons' tracks for past fifty years. We carried out a simulation forecast with No.14 typhoon formed in 1997, and found that the results of the proposed model were reasonable and it would be suitable for a simulation system for training mariners so that they can take suitable actions to evade the typhoons.

Preparation of highly carbonized material from nanoparticle impregnated biomass

Jin-Woo Kim,신채호,Joong-Hwan Park,Wen-Zhu Jin,배관호,Maeng Joon Jung 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.5

In this study, we impregnated nanometal samples having various concentrations 0, 1000, 3000, and 5000 ppm in biomass in order to make carbonized biomass. We analyzed the properties of the impregnated samples through thermogravimetry/differential thermal analysis (TG–DTA), iodine adsorptivity, fixed carbon ratio, pore distribution, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The best results were observed for a nanometal concentration of 5000 ppm. After the first heat treatment, carbonization, and activation processes, the fixed carbon ratio and iodine adsorptivity were increased by 11.07% and 42 mg/g, 11.07% and 198 mg/g, and 46.7% and 1185 mg/g, respectively. Through repeated experiments, we established the most effective process for impregnating a nanometal in biomass.

Robust extended Kalman filter of discrete-time Markovian jump nonlinear system under uncertain noise

Jin Zhu,박준홍,이관수,Maksym Spiryagin 대한기계학회 2008 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.22 No.6

This paper examines the problem of robust extended Kalman filter design for discrete -time Markovian jump nonlinear systems with noise uncertainty. Because of the existence of stochastic Markovian switching, the state and measurement equations of underlying system are subject to uncertain noise whose covariance matrices are time-varying or un-measurable instead of stationary. First, based on the expression of filtering performance deviation, admissible uncertainty of noise covariance matrix is given. Secondly, two forms of noise uncertainty are taken into account: Non- Structural and Structural. It is proved by applying game theory that this filter design is a robust mini-max filter. A numerical example shows the validity of the method.