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Zhiqiang Liu,Chaojie Chong,Zhewen Dong,Yaqi Wu,Wanying Li,Haokun Chen,Shumei Zhong,Junyang Liu,Qi Qi Pang,Jia-Le Song,Yanyuan Zhou 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To investigate the effect of ACP on letrozole-induced PCOS rats. All rats were divided into normal groups, PCOS group, metformin group and ACP group. The body weight (BW) was recorded every three days, and the final body weight as well as ovarian weight were recorded. Serum levels of TC, TG, HDL-C, LDL-C and E2, T, FSH and LH were measured by ELISA assay, and the LH/FSH ratio was calculated. The results showed that ACP decreased the BW and the ratio of ovarian to BW. Compared with the normal group, the serum levels of T, LH, LH/FSH, TG, TC, LDL-C increased, and the levels of FSH, E2, HDL-C decreased in PCOS group. ACP effectively improves the serum levels of FSH, LH/FSH, TG, TC, LDL-C and other related factors. The results of H&E staining of ovarian tissues showed that the ACP group showed different degrees of improvement in the reduced number of corpus luteum, thinning of granulosa cell layer, follicular capsular dilatation and follicular atresia. ACP not only reduces BW and the ratio of ovarian to BW, but also it can elevate the level of FSH and reduce LH/FSH, TG, TC and HDL-C levels. Furthermore, ACP can protect ovarian tissue to some extent.
Research progress and treatment of radiation enteritis and gut microbiota
Huiwen Ren(Huiwen Ren),Qi Wu(Qi Wu),Zhiqiang Sun(Zhiqiang Sun),Mingming Fang(Mingming Fang),Jun Liu(Jun Liu),Judong Luo(Judong Luo) 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2
Radiation enteritis is a kind of intestinal radiation injury in patients with pelvic and retroperitoneal malignancies after radiotherapy, and its occurrence and development process are very complicated. At present, studies have confirmed that intestinal microecological imbalance is an important factor in the formation of this disease. Abdominal radiation causes changes in the composition of the flora and a decrease in its diversity, which is mainly manifested by a decrease in beneficial bacterial species such as Lactobacilli and Bifidobacteria. Intestinal dysbacteriosis aggravates radiation enteritis, weakens the function of the intestinal epithelial barrier, and promotes the expression of inflammatory factors, thereby aggravating the occurrence of enteritis. Given the role of the microbiome in radiation enteritis, we suggest that the gut microbiota may be a potential biomarker for the disease. Treatment methods such as probiotics, antibiotics, and fecal microbiota transplantation are ways to correct the microbiota and may be an effective way to prevent and treat radiation enteritis. Based on a review of the relevant literature, this paper reviews the mechanism and treatment of intestinal microbes in radiation enteritis.
PRIAM: Privacy Preserving Identity and Access Management Scheme in Cloud
( Jinbo Xiong ),( Zhiqiang Yao ),( Jianfeng Ma ),( Ximeng Liu ),( Qi Li ),( Jun Ma ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.1
Each cloud service has numerous owners and tenants, so it is necessary to construct a privacy preserving identity management and access control mechanism for cloud computing. On one hand, cloud service providers (CSP) depend on tenant`s identity information to enforce appropriate access control so that cloud resources are only accessed by the authorized tenants who are willing to pay. On the other hand, tenants wish to protect their personalized service access patterns, identity privacy information and accessing newfangled cloud services by on-demand ways within the scope of their permissions. There are many identity authentication and access control schemes to address these challenges to some degree, however, there are still some limitations. In this paper, we propose a new comprehensive approach, called Privacy pReserving Identity and Access Management scheme, referred to as PRIAM, which is able to satisfy all the desirable security requirements in cloud computing. The main contributions of the proposed PRIAM scheme are threefold. First, it leverages blind signature and hash chain to protect tenant`s identity privacy and implement secure mutual authentication. Second, it employs the service-level agreements to provide flexible and on-demand access control for both tenants and cloud services. Third, it makes use of the BAN logic to formally verify the correctness of the proposed protocols. As a result, our proposed PRIAM scheme is suitable to cloud computing thanks to its simplicity, correctness, low overhead, and efficiency.
Preparation and Properties of Cellulose Nanocrystals Based Self-healing Polyurethane
Yang Qiao,Qi Xu,Shouxiang Liu,Zhiqiang Li,Yanyan Wei 한국고분자학회 2023 폴리머 Vol.47 No.3
First, cellulose nanocrystals were extracted from microcrystalline cellulose using the sulfuric acid hydrothermal method. Second, imine aromatic diol (Imine) was synthesized from p-hydroxybenzaldehyde and 4,4'-diaminodiphenylmethane as raw materials. Then the imine was introduced into the polyurethane, and the reversible covalent bond between the imine and the C = N group was used to endow the polyurethane with self-healing properties. Finally, cellulose nanocrystalline (CNC) was added into the self-healing polyurethane as the dispersed phase to prepare the composite. The experimental results show that with the increase of the amount of CNC, the properties of the composites increase first and then decrease, which is due to the physical cross-linking effect of proper CNC distribution in the self-healing polyurethane, it is beneficial to the mechanical properties, but the self-healing property is reduced by further increasing the content, which restricts the movement of the molecular chain. The mechanical properties of the composite with 0.049 g CNC are the best, with fracture strength reaching 20.59 MPa, approximately 1.56 times higher than that of pure self-healing polyurethane, and its elongation at break is 979%, and the self-healing efficiency reaches 84.7%, keeping an excellent level.
LncRNA MEG3 Regulates Imatinib Resistance in Chronic Myeloid Leukemia via Suppressing MicroRNA-21
( Xiangyu Zhou ),( Ping Yuan ),( Qi Liu ),( Zhiqiang Liu ) 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.5
Imatinib resistance has become a major clinical problem for chronic myeloid leukemia. The aim of the present study was to investigate the involvement of MEG3, a lncRNA, in imatinib resistance and demonstrate its underlying mechanisms. RNAs were extracted from CML patients` peripheral blood cells and human leukemic K562 cells, and the expression of MEG3 was measured by RT-qPCR. Cell proliferation and cell apoptosis were evaluated. Western blotting was used to measure the protein expression of several multidrug resistant transporters. Luciferase reporter assay was performed to determine the binding between MEG3 and miR-21. Our results showed that MEG3 was significantly decreased in imatinib-resistant CML patients and imatinib-resistant K562 cells. Overexpression of MEG3 in imatinib-resistant K562 cells markedly decreased cell proliferation, increased cell apoptosis, reversed imatinib resistance, and reduced the expression of MRP1, MDR1, and ABCG2. Interestingly, MEG3 binds to miR-21. MEG3 and miR-21 were negatively correlated in CML patients. In addition, miR-21 mimics reversed the phenotype of MEG3-overexpression in imatinib-resistant K562 cells. Taken together, MEG3 is involved in imatinib resistance in CML and possibly contributes to imatinib resistance through regulating miR-21, and subsequent cell proliferation, apoptosis and expression of multidrug resistant transporters.
Cheng Chen,Taotao Ding,Zhiqiang Qi,Wei Zhang,Jun Zhang,Juan Xu,Jingwen Chen,Jiangnan Dai,Changqing Chen 대한금속·재료학회 2018 ELECTRONIC MATERIALS LETTERS Vol.14 No.4
The periodically ordered ZnO nanorod (NR) arrays have been successfully synthesized via a hydrothermal approach on thesilicon substrates by templating of the TiO2ring deriving from the polystyrene (PS) nanosphere monolayer colloidal crystals(MCC). With the inverted MCC mask, sol–gel-derived ZnO seeds could serve as the periodic nucleation positions for thesite-specific growth of ZnO NRs. The large-scale patterned arrays of single ZnO NR with good side-orientation can be readilyproduced. According to the experimental results, the as-integrated ZnO NR arrays showed an excellent crystal quality andoptical property, very suitable for optoelectronic applications such as stimulated emitters and ZnO photonic crystal devices.
LncRNA MEG3 Regulates Imatinib Resistance in Chronic Myeloid Leukemia via Suppressing MicroRNA-21
Zhou, Xiangyu,Yuan, Ping,Liu, Qi,Liu, Zhiqiang The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.5
Imatinib resistance has become a major clinical problem for chronic myeloid leukemia. The aim of the present study was to investigate the involvement of MEG3, a lncRNA, in imatinib resistance and demonstrate its underlying mechanisms. RNAs were extracted from CML patients' peripheral blood cells and human leukemic K562 cells, and the expression of MEG3 was measured by RT-qPCR. Cell proliferation and cell apoptosis were evaluated. Western blotting was used to measure the protein expression of several multidrug resistant transporters. Luciferase reporter assay was performed to determine the binding between MEG3 and miR-21. Our results showed that MEG3 was significantly decreased in imatinib-resistant CML patients and imatinib-resistant K562 cells. Overexpression of MEG3 in imatinib-resistant K562 cells markedly decreased cell proliferation, increased cell apoptosis, reversed imatinib resistance, and reduced the expression of MRP1, MDR1, and ABCG2. Interestingly, MEG3 binds to miR-21. MEG3 and miR-21 were negatively correlated in CML patients. In addition, miR-21 mimics reversed the phenotype of MEG3-overexpression in imatinib-resistant K562 cells. Taken together, MEG3 is involved in imatinib resistance in CML and possibly contributes to imatinib resistance through regulating miR-21, and subsequent cell proliferation, apoptosis and expression of multidrug resistant transporters.
Huan Lan,Zhewen Dong,Yaqi Wu,Chaojie Chong,Zhiqiang Liu,Wanying Li,Zixian Wang,Junyang Liu,Qi Qi Pang,Jia-Le Song,Yanyuan Zhou 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study investigated the antifibrotic effects of SA on ovarian fibrosis in letrozole-induced PCOS in rats. SA treatment restored letrozole-induced alterations in the body weight (BW), relative weights of the ovaries, and visceral adipose tissues. Histological observation showed that SA reduced the number of atretic follicles, cystic follicles, and fibrosis of the ovaries in PCOS rats. SA treatment also modulated the serum levels of sex hormones, which decreased the luteinizing hormone (LH), and testosterone (T) and increased the follicle-stimulating hormone (FSH) in PCOS rats. Administration of SA reduced letrozole-induced metabolic dysfunction by decreasing the serum levels of triglyceride (TG) and total cholesterol (TC) and increasing the levels of high-density lipoprotein cholesterol (HDL-C) in PCOS rats. Finally, SA treatment appeared to increase the activity of PPAR-γ, reduce the activation of the TGF-β1/Smad pathway, and reduce the collagen I, α-SMA and CTGF levels in the ovaries of the PCOS rats. Our results demonstrated that SA significantly ameliorated ovarian fibrosis and abolic disturbances in the letrozole-induced PCOS rats.
Huan Lan,Zhewen Dong,Yaqi Wu,Chaojie Chong,Zhiqiang Liu,Wanying Li,Zixian Wang,Junyang Liu,Qi Qi Pang,Jia-Le Song,Yanyuan Zhou 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, we investigated the antifibrotic effects of Rha on letrozole-induced PCOS in rats. Rha treatment restored letrozole-induced alterations in the body weight (BW), relative weights of the ovaries, and relative weights of uterine and visceral adipose tissues. Histological observation showed that Rha reduced the number of atretic follicles, cystic follicles, and fibrosis of the ovaries in the PCOS rats. Administration of Rha reduced letrozole-induced metabolic dysfunction by decreasing the serum levels of TG and TC and increasing the levels of HDL-C in the PCOS rats. Rha treatment also modulated the serum levels of sex hormones, which decreased the LH, E2 and T and increased the FSH in PCOS rats. Finally, Rha treatment appeared to increase the activity of PPAR-γ, reduce the activation of the TGF-β1/Smad pathway, and reduce the collagen I, α-SMA and CTGF levels in the ovaries of the PCOS rats. Our results demonstrated that Rha significantly ameliorated metabolic disturbances and ovarian fibrosis in the letrozole-induced PCOS rats. Rha may be an effective compound in preventing ovarian fibrosis in the future.