http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
范振洪,李炳鎭 평택대학교 1999 論文集 Vol.13 No.-
本文??述了跨世紀韓國與中國山동省經貿合作的前景問題. (1) 跨世紀韓國與中國山東省經貿合作的有利條件 制約要所 (2) 跨世紀韓國與中國山東省經貿合作的重点 ; (3) 跨世紀韓國與中國山東省經貿合作的對策.
Atorvastatin pretreatment attenuates kainic acid
Zhen Jin,Yohan Jung,Chin-ok Yi,Jong Youl Lee,Eun Ae Jeong,Jung Eun Lee,Ki-Jong Park,Oh-Young Kwon,Byeong Hoon Lim,Nack-Cheon Choi,Gu Seob Roh 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.3
Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism for its protective effect in kainic acid (KA)-induced seizures. Here, we investigated the protective effects of atorvastatin pretreatment on KA-induced neuroinflammation and hippocampal cell death. Mice were treated via intragastric administration of atorvastatin for 7 days, injected with KA, and then sacrificed after 24 h. We observed that atorvastatin pretreatment reduced KA-induced seizure activity, hippocampal cell death, and neuroinflammation. Atorvastatin pretreatment also inhibited KA-induced lipocalin-2 expression in the hippocampus and attenuated KA-induced hippocampal cyclooxygenase-2 expression and glial activation. Moreover, AKT phosphorylation in KA-treated hippocampus was inhibited by atorvastatin pretreatment. These findings suggest that atorvastatin pretreatment may protect hippocampal neurons during seizures by controlling lipocalin-2-associated neuroinflammation.
Seismic Response of Two Site Models and Their Effects on the Railway Cable-Stayed Bridge
Jin Zhang,Zhen-yu Yang,Da-ping Yuan,Shi-xiong Zheng,Yi-ran Hu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.12
In order to accurately analyze the seismic response of the site and their effects on a railway cable-stayed bridge, the site condition of the railway cable-stayed bridge was surveyed, and geotechnical exploration holes ZK1 and ZK2 were set near the left and right tower of the bridge to gain the detailed geological data, then 32 representative ground motions records were selected corresponding to the site characteristics, and the equivalent linear and nonlinear model were established to analyze the site seismic response of 32 representative ground motions based on the Deepsoil Software. Next, to investigate the influence of site seismic response on the long-span railway cable-stayed bridge, the seismic response of the cable-stayed bridge considering site effect are calculated and evaluated via time history analysis under one-dimensional and multi-point excitation based on the ANSYS platform. At last, several critical and meaningful conclusions are drawn.
Yi Qin,Zhao-hui Jin,Zhen-ying Zhang,Ke-ke Chen,Xin Yu,Hong-jiao Yan,Rui-dan Wang,Yuan Su,Ai-xian Liu,Jia-ning Xi,Bo-yan Fang 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.1
Background and Purpose Orthostatic hypotension (OH) is common in patients with Parkinson’s disease (PD). Early recognition OH is required with sensitive assessments. The purpose of this study was to determine whether blood pressure (BP) changes during exercise can predict the occurrence of OH in PD. Methods This prospective cohort study included 80 consecutive patients with PD. All patients agreed to participate in a baseline evaluation and cardiopulmonary exercise test (CPET). According to the initial active standing test (AST), those without OH (PD-nonOH) at baseline had their AST results followed up for 6 months. The main outcome was defined as whether patients without OH at baseline would develop OH after 6 months. Logistic regression analysis was applied to identify the relevant variables. A nomogram was constructed based on clinical features and identified variables. The concordance index (C-index) and area under the receiver operating characteristic curve (AUC) were used to evaluate the accuracy and predictive ability of the nomogram, respectively. Results CPET results indicated that peak load, peak heart rate, heart rate recovery at 1 min, and systolic BP change (ΔSBP) were lower in those with OH than in the PD-nonOH group (p<0.05) at baseline. Logistic regression analysis indicated that peak load and ΔSBP during CPET had significant effects on OH (p<0.05). Age, sex, peak load, and ΔSBP were used to construct the nomogram model (C-index=0.761). The prediction model had an AUC of 0.782 (95% confidence interval=0.649–0.889) and a specificity and sensitivity of 70.0% and 81.8%, respectively. Conclusions This study has identified predictive factors for OH development in patients with PD. CPET could be used as a complementary examination to identify patients at a high risk of OH.
Jin, Zhen,Jung, Yohan,Yi, Chin-ok,Lee, Jong Youl,Jeong, Eun Ae,Lee, Jung Eun,Park, Ki-Jong,Kwon, Oh-Young,Lim, Byeong Hoon,Choi, Nack-Cheon,Roh, Gu Seob The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.3
Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism for its protective effect in kainic acid (KA)-induced seizures. Here, we investigated the protective effects of atorvastatin pretreatment on KA-induced neuroinflammation and hippocampal cell death. Mice were treated via intragastric administration of atorvastatin for 7 days, injected with KA, and then sacrificed after 24 h. We observed that atorvastatin pretreatment reduced KA-induced seizure activity, hippocampal cell death, and neuroinflammation. Atorvastatin pretreatment also inhibited KA-induced lipocalin-2 expression in the hippocampus and attenuated KA-induced hippocampal cyclooxygenase-2 expression and glial activation. Moreover, AKT phosphorylation in KA-treated hippocampus was inhibited by atorvastatin pretreatment. These findings suggest that atorvastatin pretreatment may protect hippocampal neurons during seizures by controlling lipocalin-2-associated neuroinflammation.
Wei Jin,Yu-Fei Lin,Zhen-Liang Xu,Ping-Ping Li,Jia-Yue Dai,Yi-Hao Tong,Xin Zhang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.122 No.-
Ultrafiltration (UF) membranes are commonly confronted with threats from pollutants during long-termoperation. The zwitterions with high hydrophilicity are expected to be the critical material to improve theanti-fouling and antibacterial abilities of membranes. Herein, a new zwitterionic polyethersulfone (PES)(zwitterionic PES - ZPES) was synthesized. The as-prepared ZPES was used to fabricate a zwitterionic UFmembrane via the non-solvent induced phase inversion (NIPS) method. Zwitterionic polymer skeletonenhanced the hydrophilicity, permeability and anti-fouling properties of the material. As a result, theZPES membrane exhibited doubled water flux growth (269.6 Lm2h1) compared with that of the PES(125.3 Lm2h1) and high protein rejection (98.6%). Besides, the ZPES membrane could maintain anexcellent flux recovery rate (94.1%) and antibacterial effect (more than 95%). Therefore, the excellentanti-fouling and antibacterial abilities of the ZPES membrane broaden its application scope further.
Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
( Ao Xuan Zhen ),( Mei Jing Piao ),( Kyoung Ah Kang ),( Pincha Devage Sameera Madushan Fernando ),( Hee Kyoung Kang ),( Young Sang Koh ),( Joo Mi Yi ),( Jin Won Hyun ) 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.6
Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that particulate matter 2.5 (PM<sub>2.5</sub>) induced reactive oxygen species (ROS), causing disruption of DNA, lipids, and protein, mitochondrial depolarization, and apoptosis of skin keratinocytes. Here, we investigated the protective effects of NIA on PM<sub>2.5</sub>-induced oxidative stress in human HaCaT keratinocytes. We found that NIA could inhibit the ROS generation induced by PM<sub>2.5</sub>, as well block the PM<sub>2.5</sub>-induced oxidation of molecules, such as lipids, proteins, and DNA. Furthermore, NIA alleviated PM<sub>2.5</sub>-induced accumulation of cellular Ca<sup>2+</sup>, which caused cell membrane depolarization and apoptosis, and reduced the number of apoptotic cells. Collectively, the findings show that NIA can protect keratinocytes from PM<sub>2.5</sub>-induced oxidative stress and cell damage.