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( Zhen Cao ),( Ce Dou ),( Jianmei Li ),( Xiangyu Tang ),( Junyu Xiang ),( Chunrong Zhao ),( Lingyu Zhu ),( Yun Bai ),( Qiang Xiang ),( Shiwu Dong ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.10
Mesenchymal stem cells (MSCs) are widely used in cartilage tissue engineering to repair articular cartilage defects. However, hypertrophy of chondrocytes derived from MSCs might hinder the stabilization of hyaline cartilage. Thus, it is very important to find a suitable way to maintain the chondrogenic phenotype of chondrocytes. It has been reported that cordycepin has anti-inflammatory and anti-tumor functions. However, the role of cordycepin in chondrocyte hypertrophy remains unclear. Therefore, the objective of this study was to determine the effect of cordycepin on chondrogenesis and chondrocyte hypertrophy in MSCs and ATDC5 cells. Cordycepin upregulated chondrogenic markers including Sox9 and collagen type II while down-regulated hypertrophic markers including Runx2 and collagen type X. Further exploration showed that cordycepin promoted chondrogenesis through inhibiting Nrf2 while activating BMP signaling. Besides, cordycepin suppressed chondrocyte hypertrophy through PI3K/Bapx1 pathway and Notch signaling. Our results indicated cordycepin had the potential to maintain chondrocyte phenotype and reconstruct engineered cartilage. [BMB Reports 2016; 49(10): 548-553]
Cao,Jain Min,Wu,Chuan Liang,Shen,Wen ZhEng,Huang,Chang,Li,Yin Bo,Xu,Yang Zhen 대한전자공학회 1997 ICVC : International Conference on VLSI and CAD Vol.5 No.1
Start with 2D simulation of hot-carrier injection current. in this pier, we have discussed the influence of different silicon film thickness (Tsi), gate oxide thickness (Tox1) and substrate doping (Na) an the hot-carrier effects of thin-film deep submicron SOI/MOSFET. Simulation results indicate that, with reduction of Tsi, the hot-carrier current is reduced (by more than 2 orders); and in Tsi range of 0.05-0.1μ. the hot carrier carrent is smallest and insensitive to Tox1, Na and Tsi. These are helpful to the design of high reliability SOI/MOSFET.
Strength criterion of plain recycled aggregate concrete under biaxial compression
Zhen-Jun He,Gan-Wen Liu,Wan-Lin Cao,Chang-Yang Zhou,Zhang Jia-Xing 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.16 No.2
This paper presents results of biaxial compressive tests and strength criterion on two replacement percentages of recycled coarse aggregate (RPRCA) by mass for plain structural recycled aggregate concrete (RAC) at all kinds of stress ratios. The failure mode characteristic of specimens and the direction of the cracks were observed and described. The two principally static strengths in the corresponding stress state were measured. The influence of the stress ratios on the biaxial strengths of RAC was also analyzed. The experimental results showed that the ratios of the biaxial compressive strength 3f to the corresponding uniaxial compressive strength c for the two RAC are higher than that of the conventional concrete (CC), and dependent on the replacement percentages of recycled coarse aggregate, stress states and stress ratios; however, the differences of tensile-compressive ratios for the two RAC and CC are smaller. On this basis, a new failure criterion with the stress ratios is proposed for plain RAC under biaxial compressive stress states. It provides the experimental and theoretical foundations for strength analysis of RAC structures subject to complex loads.
( Zhen Guo ),( Xingchen Cai ),( Ruiqing Liu ),( Jianfeng Gong ),( Yi Li ),( Lei Cao ),( Weiming Zhu ) 대한장연구학회 2018 Intestinal Research Vol.16 No.2
Background/Aims: Resection of the diseased segment and suture of the victim segment is recommended for enteroenteric fistula in Crohn’s disease (CD). The main difficulty in this procedure remains reliable diagnosis of the victim segment, especially for fistulas found intraoperatively and inaccessible on endoscopic examination. We aimed to explore whether intraoperative inspection alone is reliable. Methods: Patients undergoing conservative surgery between 2011 and 2016 for enteroenteric fistulas complicating CD were identified from a prospectively maintained database. Patients were divided according to whether the victim segment was evaluated by preoperative endoscopy + intraoperative inspection (PI group) or by intraoperative inspection alone (I group). Outcomes were compared. Results: Of 65 patients eligible for the study, 37 were in in the PI group and 28 were in the I group. The baseline characteristics were similar between the groups, except for the rate of emergency surgery (0/37 in PI group vs. 5/28 in I group, P=0.012). Fistulas involved more small intestines (4/37 in PI group vs. 15/28 in I group, P< 0.001) and fewer sigmoid colons (17/37 in PI group vs. 4/28 in I group, P=0.008) in I group due to accessibility with endoscopy. No difference was found in postoperative complications, stoma rates, postoperative recurrence, or disease at the repair site between the 2 groups (P >0.05). Conclusions: For fistulas found intraoperatively and inaccessible on endoscopic examination, intraoperative inspection was a reliable guide when choosing between en bloc resection and a conservative procedure. (Intest Res 2018;16:282-287)
Zhen Tang,Lulu Gong,Dalin Wang,Xiaoqian Qiu,Zhizhong Cao,Xiaomei Li 대한치과보철학회 2015 The Journal of Advanced Prosthodontics Vol.7 No.3
PURPOSE To explore whether there is matching relation between the length and the tilting angle of terminal implants in the All-on-Four protocol by studying the effects of different implant configurations on stress distributions of implant, bone, and framework. MATERIALS AND METHODS Four implants were employed to support a full-arch fixed prosthesis and five three-dimensional finite element models were established with CT images, based on the length (S and L) and distal tilt angle (0°, 30° and 45°) of terminal implants for an edentulous mandible, which named: Tilt0-S, Tilt30-S, Tilt30-L, Tilt45-S and Tilt45-L. An oblique 240 N was loaded at second molar. The von Mises Stresses were analyzed. The implants were consecutively named #1 to #4 from the loading point. RESULTS 1) Tilt0-S had the greatest stress on the implants, with the other groups exhibiting variable reductions; the four implants of Tilt45-L demonstrated the greatest reduction in stress. 2) Tilt0-S had the greatest stress at bone around #1 implant neck, and Tilt45-L exhibited the least stress, which was a 36.3% reduction compared to Tilt0-S. 3) The greatest stress in the framework was found on the cantilevers distal to #1 implant. Tilt45-S exhibited the least stress. CONCLUSION Matching different length and tilting angle of the terminal implants led to variable stress reductions on implants, bone and the superstructure. By optimizing implant configuration, the reduction of stress on implants and surrounding bone could be maximized. Under the present condition, Tilt45-L was the preferred configuration. Further clinical testings are required.
Cao Ming,Fan Bo,Zhen Tianchang,Das Abhijit,Wang Junling 한국독성학회 2023 Toxicological Research Vol.39 No.3
Lung cancer is the most often reported cancer with a terrible prognosis worldwide. Flavonoid metal complexes have exhibited potential chemotherapeutic effects with substantially low adverse effects. This study investigated the chemotherapeutic effect of the ruthenium biochanin-A complex on lung carcinoma in both in vitro and in vivo model systems. The synthesized organometallic complex was characterized via UV‒visible spectroscopy, FTIR, mass spectrometry, and scanning electron microscopy. Moreover, the DNA binding activity of the complex was determined. The in vitro chemotherapeutic assessment was performed on the A549 cell line through MTT assay, flow cytometry, and western blot analysis. An in vivo toxicity study was performed to determine the chemotherapeutic dose of the complex, and subsequently, chemotherapeutic activity was assessed in benzo-α-pyrene-induced lung cancer mouse model by evaluating the histopathology, immunohistochemistry, and TUNEL assays. The IC50 value of the complex in A549 cells was found to be 20 μM. The complex demonstrated significant apoptosis induction, enhanced caspase-3 expression and cell cycle arrest with downregulated PI3K, PPARγ, TGF-β, and TNF-α expression in A549 cells. The in vivo study suggested that ruthenium biochanin-A therapy restored the morphological architecture of lung tissue in a benzo-α-pyrene-induced lung cancer model and inhibited the expression of Bcl2. Additionally, increased apoptotic events were identified with upregulation of caspase-3 and p53 expression. In conclusion, the ruthenium biochanin-A complex successfully amelioratedlung cancer incidence in both in vitro and in vivo models through the alteration of the TGF-β/PPARγ/PI3K/TNF-α axis with the induction of the p53/caspase-3-mediated apoptotic pathway.
Wenjing Cao,Gao Luo,Keying Wang,Chanhua Liang,Wen He,Zhen Zeng,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To observe the effect of SA on lipid metabolism induced by HFD in Syrian hamsters. Changes in body weight(BW) were observed. The serum and hepatic levels of TC, TG, LDL-C, HDL-C and NEFA were determined by ELISA kits. The levels of PPAR-γ, CPT-1, CYP7A1, FAS, ACC1, SREBP2, HMGCR were detected by Western Blotting. Compared with control (CON) group, the weight of hamsters in the HFD group increased, while the weight and gain of hamsters in SA group decreased significantly (P<0.05). The weight of fat was significantly decreased after intervention with SA (P<0.05). The levels of TC, TG, LDL-C and NEFA in serum and liver were increased by HFD (P<0.05); while the serum levels of TC, TG, NEFA and LDL-C in SA group were decreased and HDL-C level was increased. Western-blot results showed that the HFD group’s levels of PPAR-γ, CPT-1 and CYP7A1 were decreased, and the levels of FAS, ACC1, SREBP1, SREBP2 and HMGCR increased; and SA can ameliorates changes in protein levels caused by HFD.Our results suggested that SA reduced fat accumulation, improve lipid metabolism disorder in hamsters induced by HFD.
Simple synthesis of Biphosphonates with Excellent Flameproofing Properties
( Hui Zhen Zhi ),( Yang Cao ),( Wei Wei Zhang ),( Xu Feng Yang ),( Jin Fei Yang ) 한국화학공학회 2014 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.52 No.2
Four excellent halogen-free biphosphonate flame retardants (EBDMP, EBDEP, MBDMP, MBDEP) were synthesized through poly condensation and Arbuzov rearrangement reactions without using any solvents. The products were characterized by ESI-MS, FT-IR and 1H NMR. The application of EBDEP in polyurethane soft foam was studied and the results illustrated its excellent flame-proofing properties.